Anders Öhman

Vetenskaplig meritering: Docent

Kontakt

090-786 72 11

Verksam som

Universitetslektor vid Institutionen för medicinsk och translationell biologi Enhet: Grupp Anders Öhman

hus H, Johan Bures väg 12, Biologihuset Umeå universitet, 901 87 Umeå

Min forskningsverksamhet är primärt fokuserad på att identifiera metabola markörer för neurodegenerativa sjukdomar i blod och ryggmärgsvätska. Detta kan öka förståelsen för de molekylära mekanismerna som ligger bakom sjukdomar såsom Parkinsons och Alzheimers sjukdom, underlätta diagnostik och leda till nya behandlingsstrategier. Kvantifiering av metaboliter utförs med metoderna kärnmagnetisk resonans (NMR) spektroskopi och mass spektrometri.

Metabolic profiles associated with exposure to ambient particulate air pollution: findings from the Betula cohort

Frontiers in Public Health, Frontiers Media S.A. 2024, Vol. 12

Raza, Wasif; Öhman, Anders; Kanninen, Katja M.; et al.

Plasma metabolite markers of parkinson’s disease and atypical parkinsonism

Metabolites, MDPI 2021, Vol. 11, (12)

Pathan, Meerakhan; Wu, Junfang; Lakso, Hans-Åke; et al.

Deep mining of oxysterols and cholestenoic acids in human plasma and cerebrospinal fluid: Quantification using isotope dilution mass spectrometry

Analytica Chimica Acta, Elsevier 2021, Vol. 1154

Yutuc, Eylan; Dickson, Alison L.; Pacciarini, Manuela; et al.

Serum Metabolite Markers of Dementia Through Quantitative NMR Analysis: The Importance of Threonine-Linked Metabolic Pathways

Journal of Alzheimer's Disease, IOS Press 2019, Vol. 69, (3) : 763-774

Figueira, Joao; Adolfsson, Rolf; Nordin Adolfsson, Annelie; et al.

Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS

Journal of Molecular Neuroscience, Springer 2019, Vol. 69, (4) : 643-657

Zhu, Shaochun; Wuolikainen, Anna; Wu, Junfang; et al.

Metabolite quantification by NMR and LC-MS/MS reveals differences between unstimulated, stimulated, and pure parotid saliva

Journal of Pharmaceutical and Biomedical Analysis, Elsevier 2017, Vol. 140 : 295-300

Figueira, João; Gouveia-Figueira, Sandra; Öhman, Carina; et al.

NMR analysis of the human saliva metabolome distinguishes dementia patients from matched controls

Molecular Biosystems, Vol. 12, (8) : 2562-2571

Figueira, Joao; Jonsson, Pär; Nordin Adolfsson, Annelie; et al.

NMR-based metabolite profiling of human milk: A pilot study of methods for investigating compositional changes during lactation

Biochemical and Biophysical Research Communications - BBRC, Vol. 469, (3) : 626-632

Wu, Junfang; Domellöf, Magnus; Zivkovic, Angela M.; et al.

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson's disease and control subjects

Metabolomics, Vol. 12, (6)

Wu, Junfang; Wuolikainen, Anna; Trupp, Miles; et al.

Structure of the N-terminal domain of the metalloprotease PrtV from Vibrio cholerae

Protein Science, Vol. 24, (12) : 2076-2080

Edwin, Aaron; Persson, Cecilia; Mayzel, Maxim; et al.

NMR metabonomics of cerebrospinal fluid distinguishes between Parkinson's disease and controls

Neuroscience Letters, Vol. 594 : 36-39

Öhman, Anders; Forsgren, Lars

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964

Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.

Domain isolation, expression, purification and proteolytic activity of the metalloprotease PrtV from Vibrio cholerae

Protein Expression and Purification, Elsevier 2014, Vol. 96 : 39-47

Edwin, Aaron; Grundström, Christin; Wai, Sun Nyunt; et al.

Ca2+ enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197

Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.

Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis

Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377

Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.

Expression and purification of SfaX_II, a protein involved in regulating adhesion and motility genes in extraintestinal pathogenic Escherichia coli

Protein Expression and Purification, Elsevier 2012, Vol. 86, (2) : 127-134

Paracuellos, Patricia; Öhman, Anders; Sauer-Eriksson, A Elisabeth; et al.

Aβ peptide fibrillar architectures controlled by conformational constraints of the monomer

PLOS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-

Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders

Tryptophan Residues Promote Membrane Association for a Plant Lipid Glycosyltransferase Involved in Phosphate Stress

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (8) : 6669-6684

Ge, Changrong; Georgiev, Alexander; Öhman, Anders; et al.

Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity

Journal of Molecular Biology, Vol. 414, (5) : 699-712

Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.

Purification, crystallization and preliminary data analysis of FocB, a transcription factor regulating fimbrial adhesin expression in uropathogenic Escherichia coli

Acta Crystallographica. Section F: Structural Biology and Crystallization Communications, Vol. 66, (Pt 3) : 337-341

Wikström Hultdin, Ulrika; Lindberg, Stina; Grundström, Christin; et al.

Solution structures and backbone dynamics of the ribosomal protein S6 and its permutant P(54-55)

Protein science : a publication of the Protein Society, Wiley 2010, Vol. 19, (1) : 183-9

Öhman, Anders; Öman, Tommy; Oliveberg, Mikael

The HD-exchange motions of ribosomal protein S6 are insensitive to reversal of the protein-folding pathway

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, (51) : 21619-21624

Haglund, Ellinor; Lind, Jesper; Öman, Tommy; et al.

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu²⁺ or Zn²⁺

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060

Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.

Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance

Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376

Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders

Folding of the αΙΙ-spectrin SH3 domain under physiological salt conditions

Archives of Biochemistry and Biophysics, Elsevier 2008, Vol. 474, (1) : 39-47

Petzold, Katja; Öhman, Anders; Backman, Lars

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.

Biochem J, Vol. 404, (1) : 63-70

Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.

The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

Journal of Biological Chemistry, Vol. 281, (1) : 477-83

Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders

Fibrillation of Carrier Protein Albebetin and Its Biologically Active Constructs. Multiple Oligomeric Intermediates and Pathways

Biochemistry, Vol. 43, (30) : 9610-9619

Morozova-Roche, Ludmilla; Zamotin, Vladimir; Malisauskas, Mantas; et al.

Probing solvent accessibility of transthyretin amyloid by solution NMR spectroscopy.

J Biol Chem, Vol. 279, (7) : 5699-707

Olofsson, Anders; Ippel, Johannes H; Wijmenga, Sybren S; et al.

Structural features of glycosyltransferases synthesizing major bilayer and nonbilayer-prone membrane lipids in Acholeplasma laidlawii and Streptococcus pneumoniae.

Journal of Biological Chemistry, Vol. 278, (10)

Edman, Maria; Berg, Stefan; Storm, Patrik; et al.

NMR structure of the ribosomal protein L23 from Thermus thermophilus.

Journal of Biomolecular NMR, Vol. 26, (2)

Öhman, Anders; Rak, Alexey; Dontsova, Maria; et al.

NMR study of the conformation and localization of porcine galanin in SDS micelles. Comparison with an inactive analog and a galanin receptor antagonist.

Biochemistry, Vol. 37, (25)

Öhman, Anders; Lycksell, P O; Juréus, A; et al.

A study of melittin, motilin and galanin in reversed micellar environments, using circular dichroism spectroscopy.

Biophysical Chemistry, Vol. 59, (1-2)

Öhman, Anders; Davydov, R; Backlund, B M; et al.

Solvent stabilized solution structures of galanin and galanin analogs, studied by circular dichroism spectroscopy.

Biochimica et Biophysica Acta, Vol. 1236, (2)

Öhman, Anders; Lycksell, P O; Andell, S; et al.

The structure of the rodent and porcine neuropeptide galanin and antagonists as determined by FTIR and CD spectroscopy

Canadian journal of chemistry (Print), Vol. 72, (6) : 1495-1499

Wennerberg, Anders B.A.; Jackson, Michael; Öhman, Anders; et al.

A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII.

European Biophysics Journal, Vol. 22, (5)

Öhman, Anders; Lycksell, P O; Gräslund, A

Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII.

European Journal of Biochemistry, Vol. 205, (1)

Lycksell, P O; Öhman, Anders; Bengtsson-Olivecrona, G; et al.

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Forskargrupper

Forskningsledare

Anders Öhman

Jag undervisar inom receptarieprogrammet, apotekarprogrammet och masterprogrammet i farmaci. För närvarande är jag kursansvarig för följande kurser: Galenisk farmaci 10.5 hp, Farmakokinetik och läkemedelsmetabolism 4.5 hp och Examensarbete i farmaci, 30 hp. Jag handleder och examinerar examensarbeten på både kandidatnivå och masternivå.

Publicerad: 14 okt, 2019

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