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Birendra Singh

I am a protein chemist, working on molecular mechanisms of protein aggregation (SOD1) causing neurodegenerative disease amylotrophic lateral sclerosis.



Verksam vid

6M, Målpunkt M31, Norrlands universitetssjukhus Umeå universitet, 901 85 Umeå

The progression of ALS is directly related to disperson of unfolded protein from cell to cell. Our aim is to find out the secretion and uptake mechanism of cells that causes ALS to spread in nervous system. One of the cell secretion route is exosomes that are 30-150 vesicles secreted by almost all kind of the cells. These vesicles can carry normal folded SOD1 or aggregation inducer (unfolded SOD1). We analyse exosome associated cargo that may affect the progression of ALS. In addition, we also work on cargo proteome of exosomes that may effect cell signalling and stress response in cells.

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2024, Vol. 121, (17)
Knyazeva, Anastasia; Li, Shuang; Corkery, Dale P.; et al.
Current opinion in structural biology, Elsevier 2020, Vol. 64 : 166-173
Söderholm, Niklas; Singh, Birendra; Uhlin, Bernt Eric; et al.
Journal of Visualized Experiments, Cambride, USA: Journal of Visualized Experiments 2018, (140)
Singh, Birendra; Mostajeran, Maryam; Su, Yu-Ching; et al.