Julia Otten Research Group

Our research group conducts clinical and epidemiological studies focused on lifestyle-based interventions for type 2 diabetes. In our clinical trials, treatments include weight loss, physical activity, and dietary modifications, with the aim of improving glucose metabolism and, in some cases, achieving diabetes remission.

Type 2 diabetes involves not only impaired insulin sensitivity and beta-cell function but also disturbances in several hormonal systems, including the glucagon and incretin axes. We investigate whether these hormonal alterations are reversible and to what extent they can be normalized through lifestyle interventions and weight reduction.

Using epidemiological data, we also study the development of prediabetes, a precursor state that often leads to type 2 diabetes and increased cardiovascular risk. Our work focuses particularly on how changes in insulin sensitivity, insulin clearance, and insulin secretion influence metabolic health over time.

Reduced lung function is an underrecognized complication of type 2 diabetes. We examine its prevalence and mechanisms both in population-based studies and in a clinical intervention study designed to assess whether targeted lifestyle treatments can improve pulmonary function.