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Staff photo Anders Olofsson

Anders Olofsson

Amyloid Fibrils and Cytotoxic Oligomers

Works at

Affiliation
Location
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

Amyloidosis denotes a pathological condition characterized by fibrillar deposition of proteins and peptides. Up to date more than 25 human disorders have been linked to formation of amyloid. The fibrillar depositions may accumulate locally or systemic and depending on the associated protein as well as site of deposition, it can result in many different symptoms. The overall aim with our work is to understand the mechanism by which native, endogenous, polypeptides transforms into a pathological assembly and further to develop means for intervention. We focus on the complete chain of events spanning from a monomeric polypeptide to mature amyloid with a specific focus on the intermediate formation of oligomeric assemblies. Our established techniques involve recombinant expression and purification of proteins and peptides, CD, fluorescence, NMR, AFM, SPR, X-ray as well as immunological techniques. Moreover, using cell-based system for analysis of viability, correlations between structural properties and cytotoxic propensity can be made. Our work is focused on Familial Amyloidosis with Polyneuropathy as well as Alzheimer's and Parkinson's disease.

Biomolecules, MDPI 2021, Vol. 11, (3)
Jayaweera, Sanduni Wasana; Surano, Solmaz; Pettersson, Nina; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189
Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.
Biomolecules, MDPI 2020, Vol. 10, (1)
Gharibyan, Anna; Islam, Tohidul; Pettersson, Nina; et al.
The FEBS Journal, Wiley-Blackwell 2020, Vol. 287, (6) : 1208-1219
Islam, Tohidul; Gharibyan, Anna L.; Golchin, Solmaz A.; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
Data in Brief, Elsevier 2018, Vol. 19 : 1166-1170
Brännström, Kristoffer; Gharibyan, Anna L.; Islam, Tohidul; et al.
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (13) : 1940-1949
Brännström, Kristoffer; Islam, Tohidul; Gharibyan, Anna L.; et al.
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (17) : 2722-2733
Nilsson, Lina; Pamrén, Annelie; Islam, Tohidul; et al.
Aging Cell, John Wiley & Sons 2018, Vol. 17, (3)
Schultz, Nina; Brännström, Kristoffer; Byman, Elin; et al.
Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874
Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.
FEBS Letters, Vol. 591, (8) : 1167-1175
Brännström, Kristoffer; Islam, Tohidul; Sandblad, Linda; et al.
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
PLOS ONE, Public Library Science 2016, Vol. 11, (4)
Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.
PLOS ONE, Public Library Science 2016, Vol. 11, (4)
Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.
Environmental Science and Technology, Vol. 50, (21) : 11984-11993
Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.
PLOS ONE, Public Library Science 2015, Vol. 10, (5)
Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.
Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515
Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.
PLOS ONE, Vol. 9, (5) : e98575-
Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.
PLOS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964
Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197
Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.
Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90
Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.
American Journal of Pathology, Elsevier 2013, Vol. 183, (5) : 1425-1436
Kalkunte, Satyan S.; Neubeck, Stefan; Norris, Wendy E.; et al.
Biochemistry, Vol. 52, (6) : 1055-1061
Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.
Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950
Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.
Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377
Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.
Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389
Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
PLOS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-
Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders
Journal of Molecular Biology, Vol. 414, (5) : 699-712
Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.
Organic and biomolecular chemistry, The Royal Society of Chemistry 2011, Vol. 9, (4) : 1140-1147
Ouberai, Myriam; Brännström, Kristoffer; Vestling, Monika; et al.
Science, Washington: American association of advancement in science 2011, Vol. 334, (6060) : 1241-1245
Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L; et al.
PLOS ONE, Public Library of Science 2010, Vol. 5, (11) : e13928-
Lindhagen-Persson, Malin; Brännström, Kristoffer; Vestling, Monika; et al.
Biophysical Journal, Vol. 99, (5) : 1510-1519
Mikhalyov, I; Olofsson, Anders; Gröbner, Gerhard; et al.
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011
Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060
Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.
Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376
Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders
Cell Biochemistry and Biophysics, Vol. 52, (3) : 175-189
Byström, Roberth; Aisenbrey, Christopher; Borowik, Tomasz; et al.
Amyloid: Journal of Protein Folding Disorders, Vol. 15, (4) : 240-245
Lindhagen-Persson, Malin; Vestling, M; Reixach, N; et al.
Journal of Molecular Biology, Vol. 374, (1) : 186-94
Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.
Biochem J, Vol. 404, (1) : 63-70
Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.
Journal of Biological Chemistry, Vol. 281, (1) : 477-83
Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders
Biochemistry, Vol. 44, (26) : 9290-9299
Hörnberg, Andreas; Wikström Hultdin, Ulrika; Olofsson, Anders; et al.
Biochemistry, Vol. 44, (39) : 13063-70
Karlsson, Anders; Olofsson, Anders; Eneqvist, Therese; et al.
Organic and biomolecular chemistry, London, U.K.: Royal Society of Chemistry 2005, Vol. 3, (15) : 2817-2823
Åberg, Veronica; Norman, Fredrik; Chorell, Erik; et al.
Biochimica et Biophysica Acta, Amsterdam: Elsevier 2004, Vol. 1700, (1) : 93-104
Hörnberg, Andreas; Olofsson, Anders; Eneqvist, Therese; et al.
J Biol Chem, Vol. 279, (7) : 5699-707
Olofsson, Anders; Ippel, Johannes H; Wijmenga, Sybren S; et al.
Biochemical and Biophysical Research Communications - BBRC, Carolina Academic Press 2002, Vol. 294, (2) : 309-314
Andersson, Karin; Olofsson, Anders; Holm Nielsen, Ellen; et al.

Research groups

Head of research
Anders Olofsson