Information till studenter och medarbetare med anledning av covid-19 (Uppdaterad: 20 januari 2021)

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Umeå universitet
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Personalbild Anders Olofsson

Anders Olofsson

Kontakt

E-post
anders.olofsson@umu.se
Plats
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå
Telefon
070-354 33 01

Verksam vid

Anknytning
Första forskningsassistent vid Institutionen för medicinsk kemi och biofysik
Anknytning
Universitetslektor (tjänstledig) vid Institutionen för medicinsk kemi och biofysik
2020
Intramolecular Povarov Reactions for the Synthesis of Chromenopyridine fused 2-Pyridone Polyheterocycles Binding to α-Synuclein and Amyloid-β fibrils
Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189
Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.
2020
Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity
Biomolecules, MDPI 2020, Vol. 10, (1)
Gharibyan, Anna; Islam, Tohidul; Pettersson, Nina; et al.
2020
Apolipoprotein E impairs amyloid-β fibril elongation and maturation
The FEBS Journal, Wiley-Blackwell 2020, Vol. 287, (6) : 1208-1219
Islam, Tohidul; Gharibyan, Anna L.; Golchin, Solmaz A.; et al.
2019
Morphological analysis of Apolipoprotein E binding to A beta Amyloid using a combination of Surface Plasmon Resonance, Immunogold Labeling and Scanning Electron Microscopy
BMC Biotechnology, BMC 2019, Vol. 19, (1)
Islam, Tohidul; Gharibyan, Anna L.; Lee, Cheng Choo; et al.
2019
Pyridine-Fused 2-Pyridones via Povarov and A3 Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
2018
Scanning electron microscopy as a tool for evaluating morphology of amyloid structures formed on surface plasmon resonance chips
Data in Brief, Elsevier 2018, Vol. 19 : 1166-1170
Brännström, Kristoffer; Gharibyan, Anna L.; Islam, Tohidul; et al.
2018
The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (13) : 1940-1949
Brännström, Kristoffer; Islam, Tohidul; Gharibyan, Anna L.; et al.
2018
Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (17) : 2722-2733
Nilsson, Lina; Pamrén, Annelie; Islam, Tohidul; et al.
2018
Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro
Aging Cell, John Wiley & Sons 2018, Vol. 17, (3)
Schultz, Nina; Brännström, Kristoffer; Byman, Elin; et al.
2018
Interspecies variation between fish and human transthyretins in their binding of thyroid-disrupting chemicals
Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874
Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.
2017
The role of histidines in amyloid β fibril assembly
FEBS Letters, Vol. 591, (8) : 1167-1175
Brännström, Kristoffer; Islam, Tohidul; Sandblad, Linda; et al.
2017
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
2016
Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer
PLoS ONE, Public Library Science 2016, Vol. 11, (4)
Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.
2016
Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity
PLoS ONE, Public Library Science 2016, Vol. 11, (4)
Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.
2016
Structure-based Virtual Screening Protocol for in silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin
Environmental Science and Technology, Vol. 50, (21) : 11984-11993
Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.
2015
The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response
PLoS ONE, Public Library Science 2015, Vol. 10, (5)
Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.
2015
Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma
Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515
Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.
2014
Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors
PLoS ONE, Vol. 9, (5) : e98575-
Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.
2014
A Generic Method for Design of Oligomer-Specific Antibodies
PLoS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
2014
The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism
Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964
Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.
2014
The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
2013
Ca2+ enhances Aβ polymerization rate and fibrillar stability in a dynamic manner
Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197
Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.
2013
Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure
Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90
Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.
2013
Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model
American Journal of Pathology, Elsevier 2013, Vol. 183, (5) : 1425-1436
Kalkunte, Satyan S.; Neubeck, Stefan; Norris, Wendy E.; et al.
2013
Structural topology and activation of an initial adenylate kinase-substrate complex
Biochemistry, Vol. 52, (6) : 1055-1061
Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.
2012
Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes
Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950
Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.
2012
Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis
Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377
Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.
2012
The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation
Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389
Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.
2012
Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
2011
Aβ peptide fibrillar architectures controlled by conformational constraints of the monomer
PLoS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-
Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders
2011
Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity
Journal of Molecular Biology, Vol. 414, (5) : 699-712
Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.
2011
Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds
Organic and biomolecular chemistry, The Royal Society of Chemistry 2011, Vol. 9, (4) : 1140-1147
Ouberai, Myriam; Brännström, Kristoffer; Vestling, Monika; et al.
2011
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast
Science, Washington: American association of advancement in science 2011, Vol. 334, (6060) : 1241-1245
Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L; et al.
2010
Amyloid-β oligomer specificity mediated by the IgM isotype: implications for a specific protective mechanism exerted by endogenous auto-antibodies
PLoS ONE, Public Library of Science 2010, Vol. 5, (11) : e13928-
Lindhagen-Persson, Malin; Brännström, Kristoffer; Vestling, Monika; et al.
2010
Designed fluorescent probes reveal interactions between Amyloid-β(1-40) Peptides and GM1 Gangliosides in Micelles and Lipid Vesicles
Biophysical Journal, Vol. 99, (5) : 1510-1519
Mikhalyov, I; Olofsson, Anders; Gröbner, Gerhard; et al.
2009
Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011
Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.
2009
Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu2+ or Zn2+
The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060
Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.
2009
Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance
Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376
Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders
2008
Disordered proteins: Biological membranes as two-dimensional aggregation matrices
Cell Biochemistry and Biophysics, Vol. 52, (3) : 175-189
Byström, Roberth; Aisenbrey, Christopher; Borowik, Tomasz; et al.
2008
Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form
Amyloid: Journal of Protein Folding Disorders, Vol. 15, (4) : 240-245
Lindhagen-Persson, Malin; Vestling, M; Reixach, N; et al.
2007
Negatively Charged Phospholipid Membranes Induce Amyloid Formation of Medin via an alpha-Helical Intermediate
Journal of Molecular Biology, Vol. 374, (1) : 186-94
Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.
2007
Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.
Biochem J, Vol. 404, (1) : 63-70
Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.
2006
The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.
Journal of Biological Chemistry, Vol. 281, (1) : 477-83
Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders
2005
The effect of iodide and chloride on transthyretin structure and stability
Biochemistry, Vol. 44, (26) : 9290-9299
Hörnberg, Andreas; Wikström Hultdin, Ulrika; Olofsson, Anders; et al.
2005
Cys114-linked dimers of transthyretin are compatible with amyloid formation.
Biochemistry, Vol. 44, (39) : 13063-70
Karlsson, Anders; Olofsson, Anders; Eneqvist, Therese; et al.
2005
Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of A beta-peptide aggregation inhibitors
Organic and biomolecular chemistry, London, U.K.: Royal Society of Chemistry 2005, Vol. 3, (15) : 2817-2823
Åberg, Veronica; Norman, Fredrik; Chorell, Erik; et al.
2004
The β-strand D of transthyretin trapped in two discrete conformations
Biochimica et Biophysica Acta, Amsterdam: Elsevier 2004, Vol. 1700, (1) : 93-104
Hörnberg, Andreas; Olofsson, Anders; Eneqvist, Therese; et al.
2004
Probing solvent accessibility of transthyretin amyloid by solution NMR spectroscopy.
J Biol Chem, Vol. 279, (7) : 5699-707
Olofsson, Anders; Ippel, Johannes H; Wijmenga, Sybren S; et al.
2002
Only amyloidogenic inermediates of transthyretin induce apoptosis
Biochemical and Biophysical Research Communications - BBRC, Carolina Academic Press 2002, Vol. 294, (2) : 309-314
Andersson, Karin; Olofsson, Anders; Holm Nielsen, Ellen; et al.
2002
Disulfide-bond formation in the transthyretin mutant Y114C prevents amyloid fibril formation in vivo and in vitro.
Biochemistry, Vol. 41, (44) : 13143-51
Eneqvist, Therese; Olofsson, Anders; Ando, Yukio; et al.
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Forskargrupper

Forskningsledare
Anders Olofsson
Publicerad: 07 feb, 2019
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