Anders Olofsson

Forskningsassistent, förste vid Institutionen för medicinsk kemi och biofysik

anders.olofsson@umu.se

070-354 33 01

KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

Universitetslektor vid Institutionen för medicinsk kemi och biofysik

anders.olofsson@umu.se

070-354 33 01

KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

Senaste publikationer

2019

Pyridine-Fused 2-Pyridones via Povarov and A³ Reactions: Rapid Generation of Highly Functionalized Tricyclic Heterocycles Capable of Amyloid Fibril Binding

Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903

Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.

2018

Amyloid-beta 1-40 is associated with alterations in NG2+ pericyte population ex vivo and in vitro

Aging Cell, John Wiley & Sons 2018, Vol. 17, (3)

Schultz, Nina; Brännström, Kristoffer; Byman, Elin; et al.

2018

Interspecies variation between fish and human transthyretins in their binding of thyroid-disrupting chemicals

Environmental Science and Technology, American Chemical Society (ACS) 2018, Vol. 52, (20) : 11865-11874

Zhang, Jin; Grundström, Christin; Brännström, Kristoffer; et al.

2018

Scanning electron microscopy as a tool for evaluating morphology of amyloid structures formed on surface plasmon resonance chips

Data in Brief, Elsevier 2018, Vol. 19 : 1166-1170

Brännström, Kristoffer; Gharibyan, Anna L.; Islam, Tohidul; et al.

2018

The Properties of Amyloid-β Fibrils Are Determined by their Path of Formation

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (13) : 1940-1949

Brännström, Kristoffer; Islam, Tohidul; Gharibyan, Anna L.; et al.

2018

Transthyretin Interferes with Aβ Amyloid Formation by Redirecting Oligomeric Nuclei into Non-Amyloid Aggregates

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (17) : 2722-2733

Nilsson, Lina; Pamrén, Annelie; Islam, Tohidul; et al.

2017

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

2017

The role of histidines in amyloid β fibril assembly

FEBS Letters, Vol. 591, (8) : 1167-1175

Brännström, Kristoffer; Islam, Tohidul; Sandblad, Linda; et al.

2016

Modifications of the 7-Hydroxyl Group of the Transthyretin Ligand Luteolin Provide Mechanistic Insights into Its Binding Properties and High Plasma Specificity

PLoS ONE, Public Library Science 2016, Vol. 11, (4)

Nilsson, Lina; Larsson, Andreas; Begum, Afshan; et al.

2016

Structure-based Virtual Screening Protocol for in silico Identification of Potential Thyroid Disrupting Chemicals Targeting Transthyretin

Environmental Science and Technology, Vol. 50, (21) : 11984-11993

Zhang, Jin; Begum, Afshan; Brännström, Kristoffer; et al.

2016

Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer

PLoS ONE, Public Library Science 2016, Vol. 11, (4)

Iakovleva, Irina; Begum, Afshan; Brännström, Kristoffer; et al.

2015

Enthalpic Forces Correlate with Selectivity of Transthyretin-Stabilizing Ligands in Human Plasma

Journal of Medicinal Chemistry, Vol. 58, (16) : 6507-6515

Iakovleva, Irina; Brännström, Kristoffer; Nilsson, Lina; et al.

2015

The flavonoid luteolin, but not luteolin-7-o-glucoside, prevents a transthyretin mediated toxic response

PLoS ONE, Public Library Science 2015, Vol. 10, (5)

Iakovleva, Irina; Begum, Afshan; Pokrzywa, Malgorzata; et al.

2014

A Generic Method for Design of Oligomer-Specific Antibodies

PLoS ONE, Vol. 9, (3) : e90857-

Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.

2014

Interaction Studies of the Human and Arabidopsis thaliana Med25-ACID Proteins with the Herpes Simplex Virus VP16-and Plant-Specific Dreb2a Transcription Factors

PLoS ONE, Vol. 9, (5) : e98575-

Aguilar, Ximena; Blomberg, Jeanette; Brännström, Kristoffer; et al.

2014

The N-terminal Region of Amyloid β Controls the Aggregation Rate and Fibril Stability at Low pH Through a Gain of Function Mechanism

Journal of the American Chemical Society, American Chemical Society (ACS) 2014, Vol. 136, (31) : 10956-10964

Brännström, Kristoffer; Öhman, Anders; Nilsson, Lina; et al.

2014

The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade

Acta Neuropathologica, Vol. 127, (4) : 507-522

Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.

2013

Ca2+ enhances Aβ polymerization rate and fibrillar stability in a dynamic manner

Biochemical Journal, Portland Press 2013, Vol. 450 : 189-197

Brännström, Kristoffer; Öhman, Anders; Lindhagen-Persson, Malin; et al.

2013

Modulation of α-synuclein fibrillization by ring-fused 2-pyridones: templation and inhibition involve oligomers with different structure

Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90

Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.

2013

Structural topology and activation of an initial adenylate kinase-substrate complex

Biochemistry, Vol. 52, (6) : 1055-1061

Ådén, Jörgen; Weise, Christoph; Brännström, Kristoffer; et al.

2013

Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model

American Journal of Pathology, Elsevier 2013, Vol. 183, (5) : 1425-1436

Kalkunte, Satyan S.; Neubeck, Stefan; Norris, Wendy E.; et al.

2012

Characterization of SPINK9, a KLK5-specific inhibitor expressed in palmo-plantar epidermis

Biological chemistry (Print), Walter de Gruyter 2012, Vol. 393, (5) : 369-377

Brännström, Kristoffer; Öhman, Anders; von Pawel-Rammingen, Ulrich; et al.

2012

Interactions between DNA, transcriptional regulator Dreb2a and the Med25 mediator subunit from Arabidopsis thaliana involve conformational changes

Nucleic Acids Research, Oxford: Oxford University Press 2012, Vol. 40, (13) : 5938-5950

Blomberg, Jeanette; Aguilar, Ximena; Brännström, Kristoffer; et al.

2012

Mechanisms of Protein Oligomerization: Inhibitor of Functional Amyloids Templates α-Synuclein Fibrillation

Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444

Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.

2012

The C-terminal repeating units of CsgB direct bacterial functional amyloid nucleation

Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389

Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.

2011

Aβ peptide fibrillar architectures controlled by conformational constraints of the monomer

PLoS ONE, San Francisco, CA: Public Library of Science 2011, Vol. 6, (9) : e25157-

Brännström, Kristoffer; Öhman, Anders; Olofsson, Anders

2011

Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds

Organic and biomolecular chemistry, The Royal Society of Chemistry 2011, Vol. 9, (4) : 1140-1147

Ouberai, Myriam; Brännström, Kristoffer; Vestling, Monika; et al.

2011

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

Science, Washington: American association of advancement in science 2011, Vol. 334, (6060) : 1241-1245

Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L; et al.

2011

Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity

Journal of Molecular Biology, Vol. 414, (5) : 699-712

Jia, Xueen; Gharibyan, Anna; Öhman, Anders; et al.

2010

Amyloid-β oligomer specificity mediated by the IgM isotype: implications for a specific protective mechanism exerted by endogenous auto-antibodies

PLoS ONE, Public Library of Science 2010, Vol. 5, (11) : e13928-

Lindhagen-Persson, Malin; Brännström, Kristoffer; Vestling, Monika; et al.

2010

Designed fluorescent probes reveal interactions between Amyloid-β(1-40) Peptides and G_M1 Gangliosides in Micelles and Lipid Vesicles

Biophysical Journal, Vol. 99, (5) : 1510-1519

Mikhalyov, I; Olofsson, Anders; Gröbner, Gerhard; et al.

2009

Amyloid fibril dynamics revealed by combined hydrogen/deuterium exchange and nuclear magnetic resonance

Analytical Biochemistry, Elsevier 2009, Vol. 385, (2) : 374-376

Olofsson, Anders; Sauer-Eriksson, A Elisabeth; Öhman, Anders

2009

Quenched hydrogen/deuterium exchange NMR characterization of amyloid-β peptide aggregates formed in the presence of Cu²⁺ or Zn²⁺

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (15) : 4051-4060

Olofsson, Anders; Lindhagen Persson, Malin; Vestling, Monika; et al.

2009

Stability and fibril formation properties of human and fish transthyretin, and of the Escherichia coli transthyretin-related protein

The FEBS Journal, Wiley InterScience 2009, Vol. 276, (7) : 1999-2011

Lundberg, Erik; Olofsson, Anders; Westermark, Gunilla T; et al.

2008

Disordered proteins: Biological membranes as two-dimensional aggregation matrices

Cell Biochemistry and Biophysics, Vol. 52, (3) : 175-189

Byström, Roberth; Aisenbrey, Christopher; Borowik, Tomasz; et al.

2008

Formation of cytotoxic transthyretin is not dependent on inter-molecular disulphide bridges commonly found within the amyloid form

Amyloid: Journal of Protein Folding Disorders, Vol. 15, (4) : 240-245

Lindhagen-Persson, Malin; Vestling, M; Reixach, N; et al.

2007

Amide solvent protection analysis demonstrates that amyloid-beta(1-40) and amyloid-beta(1-42) form different fibrillar structures under identical conditions.

Biochem J, Vol. 404, (1) : 63-70

Olofsson, Anders; Lindhagen-Persson, Malin; Sauer-Eriksson, Elisabeth; et al.

2007

Negatively Charged Phospholipid Membranes Induce Amyloid Formation of Medin via an alpha-Helical Intermediate

Journal of Molecular Biology, Vol. 374, (1) : 186-94

Olofsson, Anders; Borowik, Tomasz; Gröbner, Gerhard; et al.

2006

The solvent protection of alzheimer amyloid-beta-(1-42) fibrils as determined by solution NMR spectroscopy.

Journal of Biological Chemistry, Vol. 281, (1) : 477-83

Olofsson, Anders; Sauer-Eriksson, Elisabeth; Öhman, Anders

2005

Cys114-linked dimers of transthyretin are compatible with amyloid formation.

Biochemistry, Vol. 44, (39) : 13063-70

Karlsson, Anders; Olofsson, Anders; Eneqvist, Therese; et al.

2005

Microwave-assisted decarboxylation of bicyclic 2-pyridone scaffolds and identification of A beta-peptide aggregation inhibitors

Organic and biomolecular chemistry, London, U.K.: Royal Society of Chemistry 2005, Vol. 3, (15) : 2817-2823

Åberg, Veronica; Norman, Fredrik; Chorell, Erik; et al.

2005

The effect of iodide and chloride on transthyretin structure and stability

Biochemistry, Vol. 44, (26) : 9290-9299

Hörnberg, Andreas; Wikström Hultdin, Ulrika; Olofsson, Anders; et al.

2004

Probing solvent accessibility of transthyretin amyloid by solution NMR spectroscopy.

J Biol Chem, Vol. 279, (7) : 5699-707

Olofsson, Anders; Ippel, Johannes H; Wijmenga, Sybren S; et al.

2004

The β-strand D of transthyretin trapped in two discrete conformations

Biochimica et Biophysica Acta, Amsterdam: Elsevier 2004, Vol. 1700, (1) : 93-104

Hörnberg, Andreas; Olofsson, Anders; Eneqvist, Therese; et al.

2002

Disulfide-bond formation in the transthyretin mutant Y114C prevents amyloid fibril formation in vivo and in vitro.

Biochemistry, Vol. 41, (44) : 13143-51

Eneqvist, Therese; Olofsson, Anders; Ando, Yukio; et al.

2002

Only amyloidogenic inermediates of transthyretin induce apoptosis

Biochemical and Biophysical Research Communications - BBRC, Carolina Academic Press 2002, Vol. 294, (2) : 309-314

Andersson, Karin; Olofsson, Anders; Holm Nielsen, Ellen; et al.

2000

A comparative analysis of 23 structures of the amyloidogenic protein transthyretin.

J Mol Biol, Vol. 302, (3) : 649-69

Hörnberg, Andreas; Eneqvist, Therese; Olofsson, Anders; et al.

2000

The beta-slip: a novel concept in transthyretin amyloidosis.

Mol Cell, Vol. 6, (5) : 1207-18

Eneqvist, Therese; Andersson, Karin; Olofsson, Anders; et al.

1999

Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 1999, Vol. 96, (6) : 3108-3113

Goldsteins, Gundars; Persson, Håkan; Andersson, Karin; et al.

1997

Characterisation of two highly amyloidogenic mutants of transthyretin

Biochemistry, American Chemical Society (ACS) 1997, Vol. 36, (18) : 5346-5352

Goldsteins, Gundars; Andersson, Karin; Olofsson, Anders; et al.

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Anders Olofsson

Senaste publikationer