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Staff photo Erik Chorell

Erik Chorell

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Affiliation
Associate professor at Department of Chemistry
Location
KB.C3, Linnaeus väg 10, (rum: B3.05.09) Umeå universitet, 901 87 Umeå

Central to the projects is the development of small heterocyclic molecules with the aim to interfere with and study complex biological systems. Currently the main focus is on the development of compounds that selectively can bind and satbilize G-quadruplex DNA structures. The compounds are designed through structure-based techniques or screening-based strategies and are further optimized by organic chemistry, medicinal chemistry, computational design, and biophysical chemistry. Most projects are interdisciplinary and collaborations with other resaearch groups is common. 

The double stranded helix is the most well known secondary DNA structure but there are several additional types of DNA structures that also carry vital functions. The G-quadruplex (or G4) DNA structures is one such example. G4 structures are ubiquitous in both eukaryotes and prokaryotes. Their biological roles have over the last years started to be uncovered with links to various aspects of genome maintenance and regulation but also to human diseases (such as cancer). There are over 700,000 G-quadruplex motifs in the human genome that potentially can form G-quadruplexes. Details of which sequences in the human genome that form a G-quadruplex structure, when this happens, and also why this happens is not yet fully clear. The overall goal with the research performed in the lab is to design and synthesize compounds that selectively target certain, or even individual, G-quadruplexes to study their biological roles and investigate their potential as therapeutics.

Book of abstracts: 9th European Variety in University Chemistry Education Conference EUROVARIETY 2021, University of Ljubljana 202160
Broman, Karolina; Chorell, Erik; Holmboe, Michael
Den 8:e utvecklingskonferensen för Sveriges ingenjörsutbildningar: Detaljerat program
Broman, Karolina; Chorell, Erik; Holmboe, Michael
Universitetspedagogiskakonferensen 2021. Den goda utbildningsmiljön 2.1: Abstracts : 12-13
Broman, Karolina; Chorell, Erik; Holmboe, Michael; et al.
ACS Chemical Biology, American Chemical Society (ACS) 2021, Vol. 16, (8) : 1365-1376
Deiana, Marco; Obi, Ikenna; Andréasson, Måns; et al.
Chemical Science, Royal Society of Chemistry 2020, Vol. 11, (38) : 10529-10537
Das, Rabindra Nath; Andréasson, Måns; Kumar, Rajendra; et al.
Nanoscale, Royal Society of Chemistry 2020, Vol. 12, (24) : 12950-12957
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59, (2) : 896-902
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (3) : 1108-1119
Kumar, Rajendra; Chand, Karam; Bhowmik, Sudipta; et al.
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (19) : 10998-11015
Obi, Ikenna; Rentoft, Matilda; Singh, Vandana; et al.
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2020, Vol. 26, (43) : 9561-9572
Prasad, Bagineni; Das, Rabindra Nath; Jamroskovic, Jan; et al.
7:e Utvecklingskonferensen för Sveriges ingenjörsutbildningar
Broman, Karolina; Mårell-Olsson, Eva; Johnels, Dan; et al.
Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Scionces of the United States of America 2019, Vol. 116, (21) : 10510-10517
Flentie, Kelly; Harrison, Gregory A.; Tükenmez, Hasan; et al.
DNA Repair, Vol. 82
Jamroskovic, Jan; Obi, Ikenna; Movahedi, Anahita; et al.
International Journal of Biological Macromolecules, Elsevier 2018, Vol. 118 : 629-639
Bhattacharjee, Snehasish; Chakraborty, Sandipan; Chorell, Erik; et al.
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 24, (31) : 7926-7938
Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; et al.
ChemistrySelect, John Wiley & Sons 2017, Vol. 2, (11) : 3293-3296
Kumar, Vipan; Chand, Karam; Chorell, Erik
Organic and biomolecular chemistry, Royal Society of Chemistry 2017, Vol. 15, (15) : 3265-3275
Livendahl, Madeleine; Jamroskovic, Jan; Hedenström, Mattias; et al.
PLOS ONE, Vol. 12, (9)
Pokrzywa, Malgorzata; Pawelek, Katarzyna; Kucia, Weronika Elzbieta; et al.
Cell chemical biology, Vol. 23, (3) : 404-414
Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.
Chemistry - A European Journal, Vol. 22, (52) : 18932-18943
Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; et al.
Chemistry - A European Journal, Vol. 22, (37) : 13004-13009
Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; et al.
Parkinson's Disease, Vol. 1
Chermenina, Maria; Chorell, Erik; Pokrzywa, Malgorzata; et al.
PLOS ONE, Vol. 10, (10) : 1-11
Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.
mBio, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Sharma, Sandeep K; Chorell, Erik; Steneberg, Pär; et al.
Biochemical and Biophysical Research Communications - BBRC, Vol. 466, (2) : 192-195
Sharma, Sandeep K.; Chorell, Erik; Wittung-Stafshede, Pernilla
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
Organic and biomolecular chemistry, Vol. 12, (12) : 1942-1956
Dang, Hung The; Chorell, Erik; Uvell, Hanna; et al.
mBio, Vol. 5, (6) : UNSP e02038-
Greene, Sarah E.; Pinkner, Jerome S.; Chorell, Erik; et al.
European Journal of Organic Chemistry, (28) : 6175-6182
Kindahl, Tomas; Chorell, Elin; Chorell, Erik
Organic and biomolecular chemistry, Vol. 12, (25) : 4461-4470
Kindahl, Tomas; Chorell, Erik
Chemistry and Biology, Elsevier 2013, Vol. 20, (10) : 1245-1254
Andersson, Emma K.; Bengtsson, Christoffer; Evans, Margery L.; et al.
Abstracts of Papers of the American Chemical Society, Vol. 245
Bengtsson, Christoffer; Chorell, Erik; Krishnan, Syam; et al.
European Journal of Organic Chemistry, Wiley-VCH Verlagsgesellschaft 2013, Vol. 2013, (33) : 7512-7516
Chorell, Erik; Chorell, Elin
Journal of Organic Chemistry, American Chemical Society (ACS) 2013, Vol. 78, (23) : 12207-12213
Krishnan, K. Syam; Bengtsson, Christoffer; Good, James A. D.; et al.
Bioorganic & Medicinal Chemistry, Elsevier 2012, Vol. 20, (9) : 3128-3142
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
Chemistry - A European Journal, Berlin: Wiley-VCH Verlagsgesellschaft 2012, Vol. 18, (15) : 4522-4532
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
European Journal of Medicinal Chemistry, Elsevier Masson SAS 2011, Vol. 46, (4) : 1103-1116
Chorell, Erik; Bengtsson, Christoffer; Sainte-Luce Banchelin, Thomas; et al.
Tetrahedron Letters, Elsevier Ltd 2010, Vol. 51, (18) : 2461-2463
Chorell, Erik; Edvinsson, Sofie; Almqvist, Fredrik
Journal of Medicinal Chemistry, Washington, USA: American Chemical Society 2010, Vol. 53, (15) : 5690-5695
Chorell, Erik; Pinkner, Jerome S; Phan, Gilles; et al.
Nature Chemical Biology, Nature Publishing Group 2009, Vol. 5, (12) : 913-919
Cegelski, Lynette; Pinkner, Jerome S; Hammer, Neal D; et al.
Bioorganic & Medicinal Chemistry Letters, Elsevier Ltd 2008, Vol. 18, (12) : 3536-3540
Åberg, Veronica; Das, Pralay; Chorell, Erik; et al.
Journal of Organic Chemistry, Washington, DC 20036, USA: American Chemical Society 2007, Vol. 72, (13) : 4917-4924
Chorell, Erik; Das, Pralay; Almqvist, Fredrik
Microwave-assisted synthesis of hetreocycles, Springer-Verlag 2006 : 1-30
Pemberton, Nils; Chorell, Erik; Almqvist, Fredrik
Organic and biomolecular chemistry, London, U.K.: Royal Society of Chemistry 2005, Vol. 3, (15) : 2817-2823
Åberg, Veronica; Norman, Fredrik; Chorell, Erik; et al.