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Staff photo Erik Chorell

Erik Chorell

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Affiliation
Assistant professor at Department of Chemistry
Location
KB.C3, Linnaeus väg 10, (rum: B3.05.09) Umeå universitet, 901 87 Umeå

Central to the projects is the development of small heterocyclic molecules with the aim to interfere with and study complex biological systems. Currently the main focus is on the development of compounds that selectively can bind and satbilize G-quadruplex DNA structures. The compounds are designed through structure-based techniques or screening-based strategies and are further optimized by organic chemistry, medicinal chemistry, computational design, and biophysical chemistry. Most projects are interdisciplinary and collaborations with other resaearch groups is common. 

The double stranded helix is the most well known secondary DNA structure but there are several additional types of DNA structures that also carry vital functions. The G-quadruplex (or G4) DNA structures is one such example. G4 structures are ubiquitous in both eukaryotes and prokaryotes. Their biological roles have over the last years started to be uncovered with links to various aspects of genome maintenance and regulation but also to human diseases (such as cancer). There are over 700,000 G-quadruplex motifs in the human genome that potentially can form G-quadruplexes. Details of which sequences in the human genome that form a G-quadruplex structure, when this happens, and also why this happens is not yet fully clear. The overall goal with the research performed in the lab is to design and synthesize compounds that selectively target certain, or even individual, G-quadruplexes to study their biological roles and investigate their potential as therapeutics.

2020
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59, (2) : 896-902
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
2020
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
2020
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (3) : 1108-1119
Kumar, Rajendra; Chand, Karam; Bhowmik, Sudipta; et al.
2019
7:e Utvecklingskonferensen för Sveriges ingenjörsutbildningar
Broman, Karolina; Mårell-Olsson, Eva; Johnels, Dan; et al.
2019
Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Scionces of the United States of America 2019, Vol. 116, (21) : 10510-10517
Flentie, Kelly; Harrison, Gregory A.; Tükenmez, Hasan; et al.
2019
DNA Repair, Vol. 82
Jamroskovic, Jan; Obi, Ikenna; Movahedi, Anahita; et al.
2018
International Journal of Biological Macromolecules, Elsevier 2018, Vol. 118 : 629-639
Bhattacharjee, Snehasish; Chakraborty, Sandipan; Chorell, Erik; et al.
2018
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 24, (31) : 7926-7938
Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; et al.
2017
ChemistrySelect, John Wiley & Sons 2017, Vol. 2, (11) : 3293-3296
Kumar, Vipan; Chand, Karam; Chorell, Erik
2017
Organic and biomolecular chemistry, Royal Society of Chemistry 2017, Vol. 15, (15) : 3265-3275
Livendahl, Madeleine; Jamroskovic, Jan; Hedenström, Mattias; et al.
2017
PLoS ONE, Vol. 12, (9)
Pokrzywa, Malgorzata; Pawelek, Katarzyna; Kucia, Weronika Elzbieta; et al.
2016
Cell chemical biology, Vol. 23, (3) : 404-414
Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.
2016
Chemistry - A European Journal, Vol. 22, (52) : 18932-18943
Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; et al.
2016
Chemistry - A European Journal, Vol. 22, (37) : 13004-13009
Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; et al.
2015
Parkinson's Disease, Vol. 1
Chermenina, Maria; Chorell, Erik; Pokrzywa, Malgorzata; et al.
2015
PLoS ONE, Vol. 10, (10) : 1-11
Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.
2015
mBio, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
2015
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
2015
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Sharma, Sandeep K; Chorell, Erik; Steneberg, Pär; et al.
2015
Biochemical and Biophysical Research Communications - BBRC, Vol. 466, (2) : 192-195
Sharma, Sandeep K.; Chorell, Erik; Wittung-Stafshede, Pernilla
2015
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
2014
Organic and biomolecular chemistry, Vol. 12, (12) : 1942-1956
Dang, Hung The; Chorell, Erik; Uvell, Hanna; et al.
2014
mBio, Vol. 5, (6) : UNSP e02038-
Greene, Sarah E.; Pinkner, Jerome S.; Chorell, Erik; et al.
2014
European Journal of Organic Chemistry, (28) : 6175-6182
Kindahl, Tomas; Chorell, Elin; Chorell, Erik
2014
Organic and biomolecular chemistry, Vol. 12, (25) : 4461-4470
Kindahl, Tomas; Chorell, Erik
2013
Chemistry and Biology, Elsevier 2013, Vol. 20, (10) : 1245-1254
Andersson, Emma K.; Bengtsson, Christoffer; Evans, Margery L.; et al.
2013
Abstract of Papers of the American Chemical Society, Vol. 245
Bengtsson, Christoffer; Chorell, Erik; Krishnan, Syam; et al.
2013
European Journal of Organic Chemistry, Wiley-VCH Verlagsgesellschaft 2013, Vol. 2013, (33) : 7512-7516
Chorell, Erik; Chorell, Elin
2013
Journal of Organic Chemistry, American Chemical Society (ACS) 2013, Vol. 78, (23) : 12207-12213
Krishnan, K. Syam; Bengtsson, Christoffer; Good, James A. D.; et al.
2012
Bioorganic & Medicinal Chemistry, Elsevier 2012, Vol. 20, (9) : 3128-3142
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
2012
Chemistry - A European Journal, Berlin: Wiley-VCH Verlagsgesellschaft 2012, Vol. 18, (15) : 4522-4532
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
2012
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
2011
European Journal of Medicinal Chemistry, Elsevier Masson SAS 2011, Vol. 46, (4) : 1103-1116
Chorell, Erik; Bengtsson, Christoffer; Sainte-Luce Banchelin, Thomas; et al.
2010
Tetrahedron Letters, Elsevier Ltd 2010, Vol. 51, (18) : 2461-2463
Chorell, Erik; Edvinsson, Sofie; Almqvist, Fredrik
2010
Journal of Medicinal Chemistry, Washington, USA: American Chemical Society 2010, Vol. 53, (15) : 5690-5695
Chorell, Erik; Pinkner, Jerome S; Phan, Gilles; et al.
2009
Nature Chemical Biology, Nature Publishing Group 2009, Vol. 5, (12) : 913-919
Cegelski, Lynette; Pinkner, Jerome S; Hammer, Neal D; et al.
2008
Bioorganic & Medicinal Chemistry Letters, Elsevier Ltd 2008, Vol. 18, (12) : 3536-3540
Åberg, Veronica; Das, Pralay; Chorell, Erik; et al.
2007
Journal of Organic Chemistry, Washington, DC 20036, USA: American Chemical Society 2007, Vol. 72, (13) : 4917-4924
Chorell, Erik; Das, Pralay; Almqvist, Fredrik
2006
Microwave-assisted synthesis of hetreocycles, Springer-Verlag 2006 : 1-30
Pemberton, Nils; Chorell, Erik; Almqvist, Fredrik
2005
Organic and biomolecular chemistry, London, U.K.: Royal Society of Chemistry 2005, Vol. 3, (15) : 2817-2823
Åberg, Veronica; Norman, Fredrik; Chorell, Erik; et al.