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Staff photo Fatima Pedrosa-Domellöf

Fatima Pedrosa-Domellöf

I am a professor with two main resarch tracks: the extraocular muscles and aniridia-related keratopathy. Research is my passion and the reason I came to Sweden from Portugal 30 years ago. 

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Works at

Affiliation
Professor, senior consultant (attending) physician at Department of Clinical Sciences Units: Ophthalmology
Location
4, 7 tr, Norrlands Universitetssjukhus, Ögonkliniken Umeå universitet, Klinisk vetenskap, 901 85 Umeå
Affiliation
Affiliated as professor at Department of Integrative Medical Biology (IMB) Units: Teachers A-wing
Location
Umeå universitet, 901 87 Umeå

My research focuses mainly on the extraocular muscles (EOMs), the effectors for ocular motility. These muscles have physiological properties that separate them from other muscles, not least their distinct behavior in disease, in particular their relative insensitivity in muscular dystrophies. The main goals are to understand how the unusual molecular composition of the EOMs may contribute to their resistance to muscular dystrophies and to identify novel approaches to optimize the effect of strabismus surgery. These are important goals, since there are no good therapeutic tools to help patients with muscular dystrophies. The outcome of strabismus surgery is often unsatisfactory with very high re-operation rates, important economic burden and loss of quality of life.

Another focus of my research is aniridia-related keratopathy. Aniridia is a rare disorder caused by mutations in the PAX6 gene, a gene essential for the development of the eye. One of the most visually significant consequences is aniridia related keratopathy (ARK). Aniridia causes significant and progressive suffering leading to severe visual impairment. There is no effective therapy for ARK but because the patients get their aniridia diagnosis many years prior to the development of ARK, there is a window of opportunity for novel therapeutic approaches aimed at maintaining epithelial integrity and corneal transparency. The present project aims at identifying such possible targets!

Investigative Ophthalmology and Visual Science, ARVO journals 2021, Vol. 62, (2) : 1-10
Liu, Jing-Xia; Domellöf, Fatima Pedrosa
Developmental Dynamics
Nord, Hanna; Kahsay, Abraha; Dennhag, Nils; et al.
Translational Vision Science & Technology, Association for Research in Vision and Ophthalmology 2020, Vol. 9, (10)
Dennhag, Nils; Liu, Jing-Xia; Nord, Hanna; et al.
Investigative Ophthalmology and Visual Science, The Association for Research in Vision and Ophthalmology (ARVO) 2020, Vol. 61, (7)
Domellöf, Fatima Pedrosa; Liu, Jing-Xiu
The Biochemist, Portland Press 2020, Vol. 42, (5) : 52-57
Liu, Jing-Xia; Dennhag, Nils; Domellöf, Fatima Pedrosa
Investigative Ophthalmology and Visual Science, The Association for Research in Vision and Ophthalmology, Inc. (ARVO) 2020, Vol. 61, (3)
Liu, Jing-Xia; Domellöf, Fatima Pedrosa
Amyotrophic Lateral Sclerosis: Recent Advances and Therapeutic Challenges
Pedrosa Domellöf, Fatima
Viruses, MDPI 2019, Vol. 11, (3)
Chandra, Naresh; Liu, Yan; Liu, Jing-Xia; et al.
Experimental Eye Research, Elsevier 2019, Vol. 182 : 182-193
Rodríguez, Maria Angels; Sandgren Hochhard, Karin; Vicente, André; et al.
Investigative Ophthalmology and Visual Science, The Association for Research in Vision and Ophthalmology, Inc. 2018, Vol. 59, (9)
Byström, Berit; Vicente, André; Domellöf, Fatima Pedrosa
Frontiers in Neurology, Frontiers Media S.A. 2018, Vol. 9
Crippa, Sylvain, V; Domellöf, Fatima Pedrosa; Kawasaki, Aki
Investigative Ophthalmology and Visual Science, The Association for Research in Vision and Ophthalmology, Inc. 2018, Vol. 59, (9)
Domellöf, Fatima Pedrosa; Rodriguez Garcia, Maria Angels; Vicente, André; et al.
Investigative Ophthalmology and Visual Science, Rockville: The Association for Research in Vision and Ophthalmology 2018, Vol. 59, (1) : 539-548
Liu, Jing-Xia; Pedrosa-Domellöf, Fatima
Investigative Ophthalmology and Visual Science, Rockville: The Association for Research in Vision and Ophthalmology 2018, Vol. 59, (1) : 322-329
McLoon, Linda K.; Vicente, André; Fitzpatrick, Krysta R.; et al.
European Journal of Neurology, Vol. 25, (6) : 841-847
Nilipour, Y.; Nafissi, S.; Tjust, Anton E.; et al.
Investigative Ophthalmology and Visual Science, Vol. 59, (12) : 4847-4855
Rodríguez, Maria Angels; Liu, Jing-Xia; Parkkonen, Kimmo; et al.
Acta Ophthalmologica, Wiley-Blackwell 2018, Vol. 96, (S261) : 135-135
Vicente, André; Byström, B.; Domellöf, Fatima Pedrosa
Investigative Ophthalmology and Visual Science, The Association for Research in Vision and Ophthalmology 2018, Vol. 59, (13) : 5531-5541
Vicente, André; Byström, Berit; Domellöf, Fatima Pedrosa
PLOS ONE, Public Library of Science 2018, Vol. 13, (6)
Vicente, André; Byström, Berit; Lindström, Mona; et al.
Acta Ophthalmologica, John Wiley & Sons 2018, Vol. 96 : 425-428
Vicente, André; Pedrosa Domellöf, Fátima; Byström, Berit
Journal of Virology, Vol. 91, (5)
Storm, Rickard J; Persson, David B; Skalman, Lars Nygård; et al.
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017, Vol. 58, (9) : 3708-3715
Tjust, Anton E.; Danielsson, Adam; Andersen, Peter M.; et al.
Investigative Ophthalmology and Visual Science, Rockville: The association for research in vision and ophthalmology 2016, Vol. 57, (15) : 6831-6842
Harandi, Vahid M; Gaied, Aida RN; Brännström, Thomas; et al.
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2016, Vol. 57, (12)
Pedrosa-Domellöf, Fatima; McLoon, Linda K.; Lindström, Mona
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2016, Vol. 57, (12)
Tjust, Anton E.; Danielsson, Adam; Andersen, Peter M.; et al.
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY 2015, Vol. 56, (7)
Domellöf, Fatima Pedrosa; Parkkonen, Kimmo; Lindström, Mona; et al.
Investigative Ophthalmology and Visual Science, Vol. 56, (10) : 6132-6143
Lindström, Mona; Tjust, Anton E.; Domellöf, Fatima Pedrosa
Journal of Anatomy, Vol. 226, (6) : 542-548
Radovanovic, Dina; Peikert, Kevin; Lindström, Mona; et al.
Journal of Anatomy, John Wiley & Sons 2015, Vol. 227, (2) : 136-156
Thornell, Lars-Eric; Carlsson, Lena; Eriksson, Per-Olof; et al.
Investigative Ophthalmology and Visual Science, Vol. 55, (8) : 5151-5159
Janbaz, Adrihan H.; Lindström, Mona; Liu, Jingxia; et al.
PLOS ONE, Vol. 8, (2) : e57473-
Liu, Jing-Xia; Brännström, Thomas; Andersen, Peter M; et al.
Craniofacial Muscles: A New Framework for Understanding the Effector Side of Craniofacial Muscle Control, New York: Springer-Verlag New York 2013 : 75-90
Pedrosa-Domellöf, Fatima
Craniofacial muscles: A new framework for understanding the effector side of craniofacial muscle control, New York: Springer-Verlag New York 2012 : 75-90
Pedrosa Domellöf, Fatima
Frontiers in bioscience (Scholar edition), Frontiers in Bioscience 2012, Vol. 4 : 1547-1555
Tjust, Anton E; Brännstrom, Thomas; Pedrosa Domellöf, Fatima
BMC Musculoskeletal Disorders, BioMed Central 2011, Vol. 12, (181) : 11-
Hadrevi, Jenny; Hellström, Fredrik; Kieselbach, Thomas; et al.
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology 2011, Vol. 52, (7) : 4842-4852
Liu, Jing-Xia; Brännström, Thomas; Andersen, Peter M; et al.
Journal of applied physiology, Bethesda, Md.: American Physiological Society 2011, Vol. 111, (4) : 1178-1189
McLoon, Linda K.; Park, Han Na; Kim, Jong-Hee; et al.
Nature Medicine, Vol. 17, (1) : 105-109
Nilsson, Emma C; Storm, Rickard J; Bauer, Johannes; et al.
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2010, Vol. 51, (7) : 3494-3501
Ahmadi, Mahboobah; Liu, Jing-Xia; Brännström, Thomas; et al.
Cells Tissues Organs, Vol. 192, (5) : 303-313
Granberg, I; Lindell, Björn; Eriksson, Per-Olof; et al.
Histochemistry and Cell Biology, Vol. 134, (4) : 371-385
Lindström, Mona; Pedrosa-Domellöf, Fatima; Thornell, Lars-Eric
Encyclopedia of the eye, Amsterdam: Elsevier 2010 : 99-104
Pedrosa-Domellöf, Fatima
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2009, Vol. 50, (11) : 5044-5053
Byström, Berit; Carracedo, Sergio; Behndig, Anders; et al.
Investigative Ophthalmology and Visual Science, Vol. 50, (7) : 3226-3232
Liu, Jing-Xia; Willison, Hugh J; Pedrosa-Domellof, Fatima
Thule: norrländsk kulturtidskrift
Pedrosa Domellöf, Fatima
The Scandinavian Journal of Clinical & Laboratory Investigation, Informa Healthcare 2008, Vol. 68, (8) : 793-800
Malm, Christer; Hadrevi, Jenny; Bergström, Sven-Anders; et al.
Histochemistry and Cell Biology, Vol. 127, (6) : 657-667
Byström, Berit; Virtanen, Ismo; Rousselle, Patricia; et al.
Molecular Vision, Vol. 13 : 1285-1290
Olofsson, Eva M; Marklund, Stefan L; Pedrosa-Domellöf, Fatima; et al.
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology 2006, Vol. 47, (3) : 777-785
Byström, Berit; Virtanen, Ismo; Rousselle, Patricia; et al.
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology 2006, Vol. 47, (10) : 4188-4193
Kjellgren, Daniel; Stål, Per; Larsson, Lars; et al.

Research groups

Head of research
Fatima Pedrosa Domellöf
Head of research
Per Stål-research group