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Staff photo Fredrik Almqvist

Fredrik Almqvist

Works at

Affiliation
Location
KB.C4, Linnaeus väg 10, (rum: B4.37.07) Umeå universitet, 901 87 Umeå

The research interests in Fredrik Almqvist’s (FA) lab focus on method developments in organic synthesis and design and synthesis of molecules that interact with macromolecules, in particular inhibition of protein-protein interactions. Examples of the latter involve development of inhibitors of bacterial macromolecular assembly and amyloid formation. The FA lab has pioneered the design and synthesis of ring-fused 2-pyridone compounds as peptidomimetics and together with Dr. Hultgren’s lab at Washington University in St. Louis they have shown that these mimetics are ideal for the development of antivirulence compounds. FA has developed small molecules called “pilicides” that inhibit chaperone-usher pathway (CUP) pili, which are important virulence factors of uropathogenic E. coli (UPEC) and this has resulted in a deeper understanding of regulation of CUP pili biosynthesis and  the ability of UPEC to establish biofilm formation. In addition, together with Dr. Chapman at the University of Michigan FA have further studied a subset of the pilicides called “curlicides” that dependent upon the substitution pattern on the central fragment have the ability to affect curli assembly in E. coli. These compounds are excellent tools in the strive for a greater understanding of the mechanisms behind amyloid assembly in general but curli assembly in particular. Both pili and curli are important constituents in different bacterial biofilms and the group has a general interest in developing biofilm inhibitors. In this context FA started a few years ago a collaboration with Dr. Christina Stallings at Washington University in St. Louis to develop their discovery of mycobaterial tolerance inhibitors (MTIs) and investigate and understand the exact mode of action of the MTIs. These new compounds have great potential to improve treatment regimens for Tuberculosis, the deadliest infectious disese in the world. The wide range of inhibitors that have been developed in the lab has led to several cross disciplinary collaborations and among these FA has ongoing research with UCMR researchers Dr. Sven Bergström and Åsa Gylfe (Chlamydia), Jörgen Johansson and Elisabeth Sauer-Eriksson (Listeria) and Johan Normark (Tuberculosis) with the aim to improve efficacy and disect exact mode of action.

2019
Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Scionces of the United States of America 2019, Vol. 116, (21) : 10510-10517
Flentie, Kelly; Harrison, Gregory A.; Tükenmez, Hasan; et al.
2019
MedChemComm, Royal Society of Chemistry 2019, Vol. 10, (11) : 1966-1987
Kulén, Martina; Núñez-Otero, Carlos; Cairns, Andrew G.; et al.
2019
Brain, behavior, and immunity, Elsevier 2019, Vol. 80 : 525-535
Olsen, Laura K.; Cairns, Andrew G.; Ådén, Jörgen; et al.
2019
Angewandte Chemie International Edition, John Wiley & Sons 2019, Vol. 58 : 8577-8580
Petzold, Daniel; Singh, Pardeep; Almqvist, Fredrik; et al.
2019
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
2019
Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950
Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.
2019
Proceedings of the National Academy of Sciences of the United States of America, Washington: Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2019, Vol. 116, (13) : 6463-6472
Vain, Thomas; Raggi, Sara; Ferro, Noel; et al.
2018
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (11) : 2542-2547
Cairns, Andrew G.; Vazquez-Romero, Ana; Mahdi-Moein, Mohammad; et al.
2018
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (9) : 4165-4175
Kulén, Martina; Lindgren, Marie; Hansen, Sabine; et al.
2018
Nature Microbiology, NATURE PUBLISHING GROUP 2018, Vol. 3, (12) : 1362-1368
Omattage, Natalie S.; Deng, Zengqin; Pinkner, Jerome S.; et al.
2017
Current Organocatalysis, Bentham Science Publishers 2017, Vol. 4, (1) : 48-61
Basu, Basudeb; Paul, Susmita; Kundu, Samir; et al.
2017
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2017, Vol. 60, (22) : 9393-9399
Good, James A. D.; Kulén, Martina; Silver, Jim; et al.
2017
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (46) : 12184-12189
Jain, Neha; Ådén, Jörgen; Nagamatsu, Kanna; et al.
2017
PLoS ONE, Vol. 12, (9)
Pokrzywa, Malgorzata; Pawelek, Katarzyna; Kucia, Weronika Elzbieta; et al.
2017
Tetrahedron Letters, Elsevier 2017, Vol. 58, (34) : 3350-3352
Wixe, Torbjörn; Almqvist, Fredrik
2016
Organic Letters, Vol. 18, (24) : 6228-6231
Barange, Deepak Kumar; Johnson, Magnus T.; Cairns, Andrew G.; et al.
2016
Cell chemical biology, Vol. 23, (3) : 404-414
Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.
2016
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2016, Vol. 59, (5) : 2094-2108
Good, James A. D.; Silver, Jim; Núñez-Otero, Carlos; et al.
2016
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (51) : 14733-14738
Hall, Michael; Grundström, Christin; Begum, Afshan; et al.
2016
mBio, Vol. 7, (2)
Shaffer, Carrie L.; Good, James A. D.; Kumar, Santosh; et al.
2016
Oncogene, Nature Publishing Group 2016, Vol. 35, (48) : 6262-6269
Varga, M G; Shaffer, C L; Sierra, J C; et al.
2015
Parkinson's Disease, Vol. 1
Chermenina, Maria; Chorell, Erik; Pokrzywa, Malgorzata; et al.
2015
PLoS ONE, Vol. 10, (10) : 1-11
Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.
2015
International Journal of Medical Microbiology, Vol. 305, (3) : 378-382
Engström, Patrik; Bergström, Malin; Alfaro, Astrid C.; et al.
2015
mBio, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
2015
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
2015
PLoS Pathogens, Vol. 11, (3)
Floyd, Kyle A.; Moore, Jessica L.; Eberly, Allison R.; et al.
2015
Scientific Reports, Springer 2015, Vol. 5
Perdersen, Martin Nors; Fodera, Vito; Horvath, Istvan; et al.
2015
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
2014
Organic and biomolecular chemistry, Vol. 12, (12) : 1942-1956
Dang, Hung The; Chorell, Erik; Uvell, Hanna; et al.
2014
mBio, Vol. 5, (6) : UNSP e02038-
Greene, Sarah E.; Pinkner, Jerome S.; Chorell, Erik; et al.
2014
ChemMedChem, Vol. 9, (10) : 2309-2326
Horvath, Dragos; Lisurek, Michael; Rupp, Bernd; et al.
2014
Marine Drugs, MDPI 2014, Vol. 12, (2) : 799-821
Strand, Mårten; Carlsson, Marcus; Uvell, Hanna; et al.
2013
Chemistry and Biology, Elsevier 2013, Vol. 20, (10) : 1245-1254
Andersson, Emma K.; Bengtsson, Christoffer; Evans, Margery L.; et al.
2013
Abstracts of Papers of the American Chemical Society, Vol. 245
Bengtsson, Christoffer; Chorell, Erik; Krishnan, Syam; et al.
2013
Chemistry - A European Journal, Vol. 19, (30) : 9916-9922
Bengtsson, Christoffer; Nelander, Hanna; Almqvist, Fredrik
2013
Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90
Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.
2013
Organic Letters, Vol. 15, (1) : 54-57
Hussain, Munawar; Banchelin, Thomas Sainte-Luce; Andersson, Hans; et al.
2013
Journal of Organic Chemistry, American Chemical Society (ACS) 2013, Vol. 78, (23) : 12207-12213
Krishnan, K. Syam; Bengtsson, Christoffer; Good, James A. D.; et al.
2013
European Journal of Organic Chemistry, John Wiley & Sons 2013, Vol. 2013, (33) : 7476-7479
Sellstedt, Magnus; Dang, Hung The; Prasad, G. Krishna; et al.
2012
European Journal of Medicinal Chemistry, Elsevier 2012, Vol. 54 : 637-646
Bengtsson, Christoffer; Lindgren, Anders EG; Uvell, Hanna; et al.
2012
Bioorganic & Medicinal Chemistry, Elsevier 2012, Vol. 20, (9) : 3128-3142
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
2012
Chemistry - A European Journal, Berlin: Wiley-VCH Verlagsgesellschaft 2012, Vol. 18, (15) : 4522-4532
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
2012
Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389
Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.
2012
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.
2012
European Biophysics Journal, Berlin: Springer 2012, Vol. 41, (3) : 285-295
Klinth, Jeanna E; Pinkner, Jerome S; Hultgren, Scott J; et al.
2012
Tetrahedron Letters, Elsevier 2012, Vol. 53, (45) : 6022-6024
Sellstedt, Magnus; Prasad, G Krishna; Krishnan, K Syam; et al.
2012
Journal of Biological Chemistry, ROCKVILLE PIKE, BETHESDA, MD: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2012, Vol. 287, (42) : 35092-35103
Zhou, Yizhou; Smith, Daniel; Leong, Bryan J; et al.
2011
Frontiers in Medicinal Chemistry (FMC2011) June 19-21, 2011, Stockholm
Almqvist, Fredrik
2011
Organic and biomolecular chemistry, Vol. 9 : 337-346
Andersson, Hans; Olsson, Roger; Almqvist, Fredrik