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Personalbild Fredrik Almqvist

Fredrik Almqvist

Jag är professor i organisk kemi och min forskargrupp letar nya lösningar för infektions- och neurodegenerativa sjukdomar. Jag är också biträdande föreståndare för Umeå Centre for Microbial Research.

Verksam vid

Anknytning
Professor vid Kemiska institutionen
Plats
KB.C4, Linnaeus väg 10, (rum: B4.37.07) Umeå universitet, 901 87 Umeå

The research interests in Fredrik Almqvist’s (FA) lab focus on method developments in organic synthesis and design and synthesis of molecules that interact with macromolecules, in particular inhibition of protein-protein interactions. Examples of the latter involve development of inhibitors of bacterial macromolecular assembly and amyloid formation. The FA lab has pioneered the design and synthesis of ring-fused 2-pyridone compounds as peptidomimetics and together with Dr. Hultgren’s lab at Washington University in St. Louis they have shown that these mimetics are ideal for the development of antivirulence compounds. FA has developed small molecules called “pilicides” that inhibit chaperone-usher pathway (CUP) pili, which are important virulence factors of uropathogenic E. coli (UPEC) and this has resulted in a deeper understanding of regulation of CUP pili biosynthesis and  the ability of UPEC to establish biofilm formation. In addition, together with Dr. Chapman at the University of Michigan FA have further studied a subset of the pilicides called “curlicides” that dependent upon the substitution pattern on the central fragment have the ability to affect curli assembly in E. coli. These compounds are excellent tools in the strive for a greater understanding of the mechanisms behind amyloid assembly in general but curli assembly in particular. Both pili and curli are important constituents in different bacterial biofilms and the group has a general interest in developing biofilm inhibitors. In this context FA started a few years ago a collaboration with Dr. Christina Stallings at Washington University in St. Louis to develop their discovery of mycobaterial tolerance inhibitors (MTIs) and investigate and understand the exact mode of action of the MTIs. These new compounds have great potential to improve treatment regimens for Tuberculosis, the deadliest infectious disese in the world. The wide range of inhibitors that have been developed in the lab has led to several cross disciplinary collaborations and among these FA has ongoing research with UCMR researchers Dr. Sven Bergström and Åsa Gylfe (Chlamydia), Jörgen Johansson and Elisabeth Sauer-Eriksson (Listeria) and Johan Normark (Tuberculosis) with the aim to improve efficacy and disect exact mode of action.

ARKIVOC, Arkat 2021, Vol. 2020, (7) : 365-378
Cairns, Andrew G.; Sarkar, Souvik; Singh, Pardeep; et al.
Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2021, Vol. 65, (5)
Núñez-Otero, Carlos; Bahnan, Wael; Vielfort, Katarina; et al.
Scientific Reports, Springer Nature 2021, Vol. 11, (1)
Tükenmez, Hasan; Sarkar, Souvik; Anoosheh, Saber; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189
Adolfsson, Dan E.; Tyagi, Mohit; Singh, Pardeep; et al.
mBio, American Society for Microbiology 2020, Vol. 11, (6)
Reithuber, Elisabeth; Nannapaneni, Priyanka; Rzhepishevska, Olena I; et al.
Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Scionces of the United States of America 2019, Vol. 116, (21) : 10510-10517
Flentie, Kelly; Harrison, Gregory A.; Tükenmez, Hasan; et al.
MedChemComm, Royal Society of Chemistry 2019, Vol. 10, (11) : 1966-1987
Kulén, Martina; Núñez-Otero, Carlos; Cairns, Andrew G.; et al.
Brain, behavior, and immunity, Elsevier 2019, Vol. 80 : 525-535
Olsen, Laura K.; Cairns, Andrew G.; Ådén, Jörgen; et al.
Angewandte Chemie International Edition, John Wiley & Sons 2019, Vol. 58 : 8577-8580
Petzold, Daniel; Singh, Pardeep; Almqvist, Fredrik; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950
Singh, Pardeep; Cairns, Andrew G.; Adolfsson, Dan E.; et al.
Proceedings of the National Academy of Sciences of the United States of America, Washington: Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2019, Vol. 116, (13) : 6463-6472
Vain, Thomas; Raggi, Sara; Ferro, Noel; et al.
ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (11) : 2542-2547
Cairns, Andrew G.; Vazquez-Romero, Ana; Mahdi-Moein, Mohammad; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (9) : 4165-4175
Kulén, Martina; Lindgren, Marie; Hansen, Sabine; et al.
Nature Microbiology, NATURE PUBLISHING GROUP 2018, Vol. 3, (12) : 1362-1368
Omattage, Natalie S.; Deng, Zengqin; Pinkner, Jerome S.; et al.
Current Organocatalysis, Bentham Science Publishers 2017, Vol. 4, (1) : 48-61
Basu, Basudeb; Paul, Susmita; Kundu, Samir; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2017, Vol. 60, (22) : 9393-9399
Good, James A. D.; Kulén, Martina; Silver, Jim; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (46) : 12184-12189
Jain, Neha; Ådén, Jörgen; Nagamatsu, Kanna; et al.
PLOS ONE, Vol. 12, (9)
Pokrzywa, Malgorzata; Pawelek, Katarzyna; Kucia, Weronika Elzbieta; et al.
Tetrahedron Letters, Elsevier 2017, Vol. 58, (34) : 3350-3352
Wixe, Torbjörn; Almqvist, Fredrik
Organic Letters, Vol. 18, (24) : 6228-6231
Barange, Deepak Kumar; Johnson, Magnus T.; Cairns, Andrew G.; et al.
Cell chemical biology, Vol. 23, (3) : 404-414
Good, James A. D.; Andersson, Christopher; Hansen, Sabine; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2016, Vol. 59, (5) : 2094-2108
Good, James A. D.; Silver, Jim; Núñez-Otero, Carlos; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (51) : 14733-14738
Hall, Michael; Grundström, Christin; Begum, Afshan; et al.
mBio, Vol. 7, (2)
Shaffer, Carrie L.; Good, James A. D.; Kumar, Santosh; et al.
Oncogene, Nature Publishing Group 2016, Vol. 35, (48) : 6262-6269
Varga, M G; Shaffer, C L; Sierra, J C; et al.
Parkinson's Disease, Vol. 1
Chermenina, Maria; Chorell, Erik; Pokrzywa, Malgorzata; et al.
PLOS ONE, Vol. 10, (10) : 1-11
Chorell, Erik; Andersson, Emma; Evans, Margery L.; et al.
International Journal of Medical Microbiology, Vol. 305, (3) : 378-382
Engström, Patrik; Bergström, Malin; Alfaro, Astrid C.; et al.
mBio, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
PLoS Pathogens, Vol. 11, (3)
Floyd, Kyle A.; Moore, Jessica L.; Eberly, Allison R.; et al.
Scientific Reports, Springer 2015, Vol. 5
Perdersen, Martin Nors; Fodera, Vito; Horvath, Istvan; et al.
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
Organic and biomolecular chemistry, Vol. 12, (12) : 1942-1956
Dang, Hung The; Chorell, Erik; Uvell, Hanna; et al.
mBio, Vol. 5, (6) : UNSP e02038-
Greene, Sarah E.; Pinkner, Jerome S.; Chorell, Erik; et al.
ChemMedChem, Vol. 9, (10) : 2309-2326
Horvath, Dragos; Lisurek, Michael; Rupp, Bernd; et al.
Marine Drugs, MDPI 2014, Vol. 12, (2) : 799-821
Strand, Mårten; Carlsson, Marcus; Uvell, Hanna; et al.
Chemistry and Biology, Elsevier 2013, Vol. 20, (10) : 1245-1254
Andersson, Emma K.; Bengtsson, Christoffer; Evans, Margery L.; et al.
Abstracts of Papers of the American Chemical Society, Vol. 245
Bengtsson, Christoffer; Chorell, Erik; Krishnan, Syam; et al.
Chemistry - A European Journal, Vol. 19, (30) : 9916-9922
Bengtsson, Christoffer; Nelander, Hanna; Almqvist, Fredrik
Archives of Biochemistry and Biophysics, Elsevier 2013, Vol. 532, (2) : 84-90
Horvath, Istvan; Sellstedt, Magnus; Weise, Christoph; et al.
Organic Letters, Vol. 15, (1) : 54-57
Hussain, Munawar; Banchelin, Thomas Sainte-Luce; Andersson, Hans; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2013, Vol. 78, (23) : 12207-12213
Krishnan, K. Syam; Bengtsson, Christoffer; Good, James A. D.; et al.
European Journal of Organic Chemistry, John Wiley & Sons 2013, Vol. 2013, (33) : 7476-7479
Sellstedt, Magnus; Dang, Hung The; Prasad, G. Krishna; et al.
European Journal of Medicinal Chemistry, Elsevier 2012, Vol. 54 : 637-646
Bengtsson, Christoffer; Lindgren, Anders EG; Uvell, Hanna; et al.
Bioorganic & Medicinal Chemistry, Elsevier 2012, Vol. 20, (9) : 3128-3142
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
Chemistry - A European Journal, Berlin: Wiley-VCH Verlagsgesellschaft 2012, Vol. 18, (15) : 4522-4532
Chorell, Erik; Pinkner, Jerome S; Bengtsson, Christoffer; et al.
Journal of Molecular Biology, Elsevier 2012, Vol. 422, (3) : 376-389
Hammer, Neal D; McGuffie, Bryan A; Zhou, Yizhou; et al.
Journal of the American Chemical Society, American Chemical Society (ACS) 2012, Vol. 134, (7) : 3439-3444
Horvath, Istvan; Weise, Christoph F; Andersson, Emma K; et al.

Forskargrupper

Forskningsledare
Fredrik Almqvist Lab

Filmade föreläsningar:

Vetenskapslunch: Antibiotikaresistens – är slaget förlorat?

Vetenskapslunch 6 oktober 2016.