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Fredrik Almqvist

I am a professor of organic chemistry and my research group looks for new solutions for infectious and neurodegenerative diseases. I am director of the Umeå Center for Microbial Research, UCMR.

Research qualifications: Docent

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Works at

Affiliation
Location
KB.C4, Linnaeus väg 10, C4-37-07 Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as other position at Department of Clinical Microbiology
Location
6F och 6M, Universitetssjukhuset by 6 o 24 Umeå universitet, 901 85 Umeå
Affiliation
Affiliated as professor at Molecular Infection Medicine Sweden (MIMS) Section: Research groups
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

The research interests in Fredrik Almqvist’s (FA) lab focus on method developments in organic synthesis and design and synthesis of molecules that interact with macromolecules, in particular inhibition of protein-protein interactions. Examples of the latter involve development of inhibitors of bacterial macromolecular assembly and amyloid formation. The FA lab has pioneered the design and synthesis of ring-fused 2-pyridone compounds as peptidomimetics and together with Dr. Hultgren’s lab at Washington University in St. Louis they have shown that these mimetics are ideal for the development of antivirulence compounds. FA has developed small molecules called “pilicides” that inhibit chaperone-usher pathway (CUP) pili, which are important virulence factors of uropathogenic E. coli (UPEC) and this has resulted in a deeper understanding of regulation of CUP pili biosynthesis and  the ability of UPEC to establish biofilm formation. In addition, together with Dr. Chapman at the University of Michigan FA have further studied a subset of the pilicides called “curlicides” that dependent upon the substitution pattern on the central fragment have the ability to affect curli assembly in E. coli. These compounds are excellent tools in the strive for a greater understanding of the mechanisms behind amyloid assembly in general but curli assembly in particular. Both pili and curli are important constituents in different bacterial biofilms and the group has a general interest in developing biofilm inhibitors. In this context FA started a few years ago a collaboration with Dr. Christina Stallings at Washington University in St. Louis to develop their discovery of mycobaterial tolerance inhibitors (MTIs) and investigate and understand the exact mode of action of the MTIs. These new compounds have great potential to improve treatment regimens for Tuberculosis, the deadliest infectious disese in the world. The wide range of inhibitors that have been developed in the lab has led to several cross disciplinary collaborations and among these FA has ongoing research with UCMR researchers Dr. Sven Bergström and Åsa Gylfe (Chlamydia), Jörgen Johansson and Elisabeth Sauer-Eriksson (Listeria) and Johan Normark (Tuberculosis) with the aim to improve efficacy and disect exact mode of action.

Journal of Organic Chemistry, American Chemical Society (ACS) 2024, Vol. 89, (1) : 731-739
Sarkar, Souvik; Singh, Pardeep; Edin, Simon; et al.
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (14) : 7631-7648
Hainzl, Tobias; Bonde, Mari; Almqvist, Fredrik; et al.
Journal of Medicinal Chemistry, American Chemical Society (ACS) 2023, Vol. 66, (16) : 11056-11077
Sarkar, Souvik; Mayer Bridwell, Anne E.; Good, James A. D.; et al.
mBio, American Society for Microbiology 2023, Vol. 14, (3)
Tükenmez, Hasan; Singh, Pardeep; Sarkar, Souvik; et al.
Proceedings of the National Academy of Sciences of the United States of America, PNAS 2022, Vol. 119, (43)
Nye, Taylor M.; Tükenmez, Hasan; Singh, Pardeep; et al.
Microbiology Resource Announcements, American Society for Microbiology 2022, Vol. 11, (10)
Tükenmez, Hasan; Nye, Taylor M.; Bonde, Mari; et al.
Organic and biomolecular chemistry, The Royal Society of Chemistry 2021, Vol. 19, (44) : 9758-9772
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ARKIVOC, Arkat 2021, Vol. 2020, (7) : 365-378
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Biomolecules, MDPI 2021, Vol. 11, (11)
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Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2021, Vol. 65, (5)
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Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences of the United States of America 2021, Vol. 118, (47)
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Journal of Organic Chemistry, American Chemical Society (ACS) 2021, Vol. 86, (23) : 16582-16592
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Scientific Reports, Springer Nature 2021, Vol. 11, (1)
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Journal of Organic Chemistry, American Chemical Society (ACS) 2020, Vol. 85, (21) : 14174-14189
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mBio, American Society for Microbiology 2020, Vol. 11, (6)
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Proceedings of the National Academy of Sciences of the United States of America, The National Academy of Scionces of the United States of America 2019, Vol. 116, (21) : 10510-10517
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MedChemComm, Royal Society of Chemistry 2019, Vol. 10, (11) : 1966-1987
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Brain, behavior, and immunity, Elsevier 2019, Vol. 80 : 525-535
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Angewandte Chemie International Edition, John Wiley & Sons 2019, Vol. 58 : 8577-8580
Petzold, Daniel; Singh, Pardeep; Almqvist, Fredrik; et al.
Journal of Organic Chemistry, American Chemical Society (ACS) 2019, Vol. 84, (7) : 3887-3903
Singh, Pardeep; Adolfsson, Dan E.; Ådén, Jörgen; et al.
Organic Letters, American Chemical Society (ACS) 2019, Vol. 21 : 6946-6950
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Proceedings of the National Academy of Sciences of the United States of America, Washington: Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2019, Vol. 116, (13) : 6463-6472
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ACS Chemical Neuroscience, American Chemical Society (ACS) 2018, Vol. 9, (11) : 2542-2547
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Journal of Medicinal Chemistry, American Chemical Society (ACS) 2018, Vol. 61, (9) : 4165-4175
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Nature Microbiology, NATURE PUBLISHING GROUP 2018, Vol. 3, (12) : 1362-1368
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Current Organocatalysis, Bentham Science Publishers 2017, Vol. 4, (1) : 48-61
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Journal of Medicinal Chemistry, American Chemical Society (ACS) 2017, Vol. 60, (22) : 9393-9399
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Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (46) : 12184-12189
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PLOS ONE, Vol. 12, (9)
Pokrzywa, Malgorzata; Pawelek, Katarzyna; Kucia, Weronika Elzbieta; et al.
Tetrahedron Letters, Elsevier 2017, Vol. 58, (34) : 3350-3352
Wixe, Torbjörn; Almqvist, Fredrik
Organic Letters, Vol. 18, (24) : 6228-6231
Barange, Deepak Kumar; Johnson, Magnus T.; Cairns, Andrew G.; et al.
Cell chemical biology, Vol. 23, (3) : 404-414
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Journal of Medicinal Chemistry, American Chemical Society (ACS) 2016, Vol. 59, (5) : 2094-2108
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Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (51) : 14733-14738
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mBio, Vol. 7, (2)
Shaffer, Carrie L.; Good, James A. D.; Kumar, Santosh; et al.
Oncogene, Nature Publishing Group 2016, Vol. 35, (48) : 6262-6269
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Parkinson's Disease, Vol. 1
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PLOS ONE, Vol. 10, (10) : 1-11
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International Journal of Medical Microbiology, Vol. 305, (3) : 378-382
Engström, Patrik; Bergström, Malin; Alfaro, Astrid C.; et al.
mBio, Vol. 6, (1)
Engström, Patrik; Krishnan, K. Syam; Ngyuen, Bidong D.; et al.
Molecular Cell, Vol. 57, (3) : 445-455
Evans, Margery L.; Chorell, Erik; Taylor, Jonathan D.; et al.
PLoS Pathogens, Vol. 11, (3)
Floyd, Kyle A.; Moore, Jessica L.; Eberly, Allison R.; et al.
Scientific Reports, Springer 2015, Vol. 5
Perdersen, Martin Nors; Fodera, Vito; Horvath, Istvan; et al.
Organic Letters, American Chemical Society (ACS) 2015, Vol. 17, (24) : 6194-6197
Singh, Pardeep; Chorell, Erik; Krishnan, K Syam; et al.
Organic and biomolecular chemistry, Vol. 12, (12) : 1942-1956
Dang, Hung The; Chorell, Erik; Uvell, Hanna; et al.
mBio, Vol. 5, (6) : UNSP e02038-
Greene, Sarah E.; Pinkner, Jerome S.; Chorell, Erik; et al.
ChemMedChem, Vol. 9, (10) : 2309-2326
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Marine Drugs, MDPI 2014, Vol. 12, (2) : 799-821
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Chemistry and Biology, Elsevier 2013, Vol. 20, (10) : 1245-1254
Andersson, Emma K.; Bengtsson, Christoffer; Evans, Margery L.; et al.
Abstracts of Papers of the American Chemical Society, Vol. 245
Bengtsson, Christoffer; Chorell, Erik; Krishnan, Syam; et al.