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Staff photo Lars-Anders Carlson

Lars-Anders Carlson

I lead a research group that studies human viruses and the molecular mechanisms that they use to replicate themselves.

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Affiliation
Location
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå
Affiliation
Location
Umeå universitet, 901 87 Umeå

I am a researcher and lecturer at the Department of Medical Biochemistry and Biophysics. My research group studies how viruses reshape the cells they infect. Our main interest is the drastic rearrangements of host-cell membranes that positive-sense RNA viruses carry out within hours of entering a cell.

Positive-sense RNA viruses are a vast group of viruses that causes human diseases ranging from common cold to covid-19 and tropical fevers such as chikungunya, dengue and zika fevers. All such viruses replicate their genome by hijacking host-cell membranes and reshaping them to a kind of “viral factories” often referred to as replication complexes. We employ a mix of biophysical, biochemical and cell biological methods to understand the molecular intricacies of how replication complexes look and how they function. Much of our research is centred on imaging methods, specifically fluorescence microscopy and cryo-electron microscopy.

Read more about our research

Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2021, Vol. 118, (3)
Persson, B. David; Lijo, John; Rafie, Karim; et al.
Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (2)
Rafie, Karim; Lenman, Annasara; Fuchs, J.; et al.
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (46) : 15576-15587
Martinez-Carranza, Markel; Jonna, Venkateswara Rao; Lundin, Daniel; et al.
Cell Host and Microbe, Cell Press 2018, Vol. 24, (3) : 417-+
Jin, Jing; Galaz-Montoya, Jesus G.; Sherman, Michael B.; et al.
PLoS Neglected Tropical Diseases, PUBLIC LIBRARY SCIENCE 2018, Vol. 12, (7)
Jin, Jing; Sherman, Michael B.; Chafets, Daniel; et al.
Science, American Association for the Advancement of Science 2018, Vol. 362, (6421) : 1423-+
Schoneberg, Johannes; Pavlin, Mark Remec; Yan, Shannon; et al.

Research groups

Head of research
Lars-Anders Carlson Lab