"False"
Umeå universitet
printicon
Huvudmenyn dold.
Personalbild Lars-Anders Carlson

Lars-Anders Carlson

Universitetslektor i medicinsk kemi

Vetenskaplig meritering: Docent

Kontakt

E-post
lars-anders.carlson@umu.se
Telefon
076-117 97 79

Verksam som

Anknytning
Universitetslektor vid Institutionen för medicinsk kemi och biofysik
Plats
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå
Anknytning
Anknuten som övrig/annan befattning till Molekylär Infektionsmedicin, Sverige (MIMS)
Plats
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

Jag är forskare och lärare vid Institutionen för medicinsk kemi och biofysik. Min forskargrupp studerar hur virus omformar de celler som de infekterar. Vårt huvudintresse är de drastiska förändringar av värdcellens membraner som plussträngade RNA-virus kan utföra inom ett fåtal timmar.

Plussträngade RNA-virus är en stor grupp virus som orsakar så vitt skilda sjukdomar som förkylningar, covid-19 och tropiska febersjukdomar som chikungunya-, dengue- och zikafeber. Alla virus i den här gruppen förökar sin arvsmassa genom att ta över värdcellens membraner och omforma dem till ett slags ”virusfabriker” som ofta kallas replikationskomplex. Vi använder olika biofysikaliska, biokemiska och cellbiologiska metoder för att förstå i molekylär detalj hur replikationskomplex ser ut och hur de fungerar. I vår forskning har vi ett start fokus på mikroskopimetoder, specifikt fluorescensmikroskopi och kryo-elektronmikroskopi.

Läs gärna mer om vår forskning 

 

Flotation assay with fluorescence readout to study membrane association of the enteroviral peripheral membrane protein 2C
Bio-protocol, Bio-protocol LLC 2025, Vol. 15, (7)
Shankar, Kasturika; Lin, Yuyang; Carlson, Lars-Anders
Illuminating druggable dark matter in RNA virus replication using in situ cryo-EM
Current Opinion in Virology, Elsevier 2025, Vol. 72
Sharma, Himanshu; Sorin, Marie N.; Sharma, Kiran B; et al.
Structural basis for lipid transfer by the ATG2A–ATG9A complex
Nature Structural & Molecular Biology, Springer Nature 2025, Vol. 32 : 35-47
Wang, Yang; Dahmane, Selma; Ti, Rujuan; et al.
The ACBD3 protein coordinates ER-Golgi contacts to enable productive TBEV infection
Journal of Virology, American Society for Microbiology 2025, Vol. 99, (5)
Yau, Wai-Lok; Peters, Marie B. A.; Rönfeldt, Sebastian; et al.
A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2024, Vol. 121, (17)
Knyazeva, Anastasia; Li, Shuang; Corkery, Dale P.; et al.
Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (22) : 14061-14076
Ranjbarian, Farahnaz; Rafie, Karim; Shankar, Kasturika; et al.
In vitro reconstitution reveals membrane clustering and RNA recruitment by the enteroviral AAA+ ATPase 2C
PLoS Pathogens, Public Library of Science (PLoS) 2024, Vol. 20, (8)
Shankar, Kasturika; Sorin, Marie; Sharma, Himanshu; et al.
Ultrastructural insights into the microsporidian infection apparatus reveal the kinetics and morphological transitions of polar tube and cargo during host cell invasion
PLoS biology, Public Library of Science (PLoS) 2024, Vol. 22, (2)
Sharma, Himanshu; Jespersen, Nathan; Ehrenbolger, Kai; et al.
Type I interferon shapes brain distribution and tropism of tick-borne flavivirus
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Chotiwan, Nunya; Rosendal, Ebba; Willekens, Stefanie M. A.; et al.
A 3D view of how enteroviruses hijack autophagy
Autophagy, Taylor & Francis Group 2023, Vol. 19, (7) : 2156-2158
Dahmane, Selma; Shankar, Kasturika; Carlson, Lars-Anders
The organization of double-stranded RNA in the chikungunya virus replication organelle
PLoS Neglected Tropical Diseases, Public Library of Science (PLoS) 2023, Vol. 17, (7)
Laurent, Timothée; Carlson, Lars-Anders
Membrane-assisted assembly and selective secretory autophagy of enteroviruses
Nature Communications, Nature Publishing Group 2022, Vol. 13, (1)
Dahmane, Selma; Kerviel, Adeline; Morado, Dustin R.; et al.
V. cholerae MakA is a cholesterol-binding pore-forming toxin that induces non-canonical autophagy
Journal of Cell Biology, Rockefeller University Press 2022, Vol. 221, (12)
Jia, Xiaotong; Knyazeva, Anastasia; Zhang, Yu; et al.
Clinically observed deletions in SARS-CoV-2 Nsp1 affect its stability and ability to inhibit translation
FEBS Letters, John Wiley & Sons 2022, Vol. 596, (9) : 1203-1213
Kumar, Pravin; Schexnaydre, Erin; Rafie, Karim; et al.
The tetraspanin CD81 is a host factor for Chikungunya virus replication
mBio, ASM International 2022, Vol. 13, (3)
Lasswitz, Lisa; Zapatero-Belinchón, Francisco J.; Moeller, Rebecca; et al.
Architecture of the chikungunya virus replication organelle
eLIFE, eLife Sciences Publications 2022, Vol. 11
Laurent, Timothée; Kumar, Pravin; Liese, Susanne; et al.
Human species D adenovirus hexon capsid protein mediates cell entry through a direct interaction with CD46
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2021, Vol. 118, (3)
Persson, B. David; Lijo, John; Rafie, Karim; et al.
The structure of enteric human adenovirus 41: A leading cause of diarrhea in children
Science Advances, American Association for the Advancement of Science 2021, Vol. 7, (2)
Rafie, Karim; Lenman, Annasara; Fuchs, J.; et al.
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (46) : 15576-15587
Martinez-Carranza, Markel; Jonna, Venkateswara Rao; Lundin, Daniel; et al.
Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane
Cell Host and Microbe, Cell Press 2018, Vol. 24, (3) : 417-+
Jin, Jing; Galaz-Montoya, Jesus G.; Sherman, Michael B.; et al.
An attenuated replication-competent chikungunya virus with a fluorescently tagged envelope
PLoS Neglected Tropical Diseases, PUBLIC LIBRARY SCIENCE 2018, Vol. 12, (7)
Jin, Jing; Sherman, Michael B.; Chafets, Daniel; et al.
ATP-dependent force generation and membrane scission by ESCRT-III and Vps4
Science, American Association for the Advancement of Science 2018, Vol. 362, (6421) : 1423-+
Schoneberg, Johannes; Pavlin, Mark Remec; Yan, Shannon; et al.
Chemogenetic inhibition of IST1-CHMP1B interaction impairs endosomal recycling and promotes unconventional LC3 lipidation at stalled endosomes
Knyazeva, Anastasia; Corkery, Dale; Shankar, Kasturika; et al.
Kinetics of the adenosine triphosphatase and helicase activity of the chikungunya virus polyprotein and nsP2
Laurent, Timothée; Nenzén, Louise; Rafie, Karim; et al.
Giardia intestinalis deoxyadenosine kinase has a unique tetrameric structure that enables high substrate affinity and makes the parasite sensitive to deoxyadenosine analogues
Ranjbarian, Farahnaz; Rafie, Karim; Shankar, Kasturika; et al.
In vitro reconstitution reveals membrane clustering and double-stranded RNA recruitment by the enteroviral AAA+ ATPase 2C
Shankar, Kasturika; Sorin, Marie; Skoglund, Oskar; et al.
Ribosome clustering and surface layer reorganization in the microsporidian host-invasion apparatus
Sharma, Himanshu; Jespersen, Nathan; Ehrenbolger, Kai; et al.
The ACBD3 protein coordinates ER-Golgi contacts to enable productive TBEV infection
Yau, Wai-Lok; Peters, Marie B. A.; Rönfeldt, Sebastian; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Lars-Anders Carlson Lab