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Leon Jona Schierholz

PhD Student in Molecular Biology with a focus on structural and biochemical principles for enzymatic adaptation. Shared PhD in the groups of Magnus Wolf-Watz and Andre Mateus.



Works at

Doctoral student at Department of Molecular Biology Section: Group Jonas Barandun
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå

I began my scientific journey by studying Biochemistry at the Georg-August-Universität in Göttingen. While working on my thesis project at the Max Planck Institute for Biophysical Chemistry, I developed an interest in the biology of proteins on a structural level.

This newfound passion motivated me to pursue a Masters degree in Molecular Biology for which I moved to Umeå, Sweden, to challenge myself with an international environment. I decided to join the group of Jonas Barandun, where I began to investigate fungal protein complexes of eukaryotic pathogens and their roles in health and disease as potential drug targets.

With a growing interest for structural biology and its applications, I switched to Magnus Wolf-Watz lab and André Mateus lab, where I began to characterize structural principles that facilitate protein funcitonality in extreme environments.

To do so, I employ x-ray crystallography and cryo-electron microscopy to solve the 3D structure of target proteins such as Adenylate Kinase and characterize their biochemical properties using methods such as ITC and NMR.

Molecular biology and evolution, Oxford University Press 2024, Vol. 41, (1)
Schierholz, Léon; Brown, Charlotte R.; Helena-Bueno, Karla; et al.

Research groups

Group member