Nasim Sabouri

Researcher at Department of Medical Biochemistry and Biophysics

nasim.sabouri@umu.se

+46 72 566 25 05

KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

Maintenance of genome integrity by DNA Helicases

Presentation

One of the challenges in cancer biology is to understand what happens when the molecular mechanisms of a normal cell become dysfunctional and cause cancer. We are studying how genome integrity is preserved and the consequences of modifying the program of DNA replication.
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Latest publications

2018

Flexible Versus Rigid G-Quadruplex DNA Ligands: Synthesis of Two Series of Bis-indole Derivatives and Comparison of Their Interactions with G-Quadruplex DNA

Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 24, (31) : 7926-7938

Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; et al.

2018

The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity

Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (16) : 8516-8531

Mohammad, Jani B.; Wallgren, Marcus; Sabouri, Nasim

2017

Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA

Organic and biomolecular chemistry, Royal Society of Chemistry 2017, Vol. 15, (15) : 3265-3275

Livendahl, Madeleine; Jamroskovic, Jan; Hedenström, Mattias; et al.

2017

The functions of the multi‑tasking Pfh1^Pif1 helicase

Current Genetics, Vol. 63, (4) : 621-626

Sabouri, Nasim

2016

Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures

Chemistry - A European Journal, Vol. 22, (37) : 13004-13009

Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; et al.

2016

G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase

Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (13) : 6213-6231

Wallgren, Marcus; Mohammad, Jani B.; Yan, Kok-Phen; et al.

2016

Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool

Chemistry - A European Journal, Vol. 22, (52) : 18932-18943

Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; et al.

2016

Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity

PLoS Genetics, Copernicus GmbH 2016, Vol. 12, (9)

McDonald, Karin R.; Guise, Amanda J.; Pourbozorgi-Langroudi, Parham; et al.

2014

In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication

PLOS Genetics, Vol. 10, (12) : e1004832-

Miralles Fusté, Javier; Shi, Yonghong; Wanrooij, Sjoerd; et al.

2014

The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage

BMC biology, Vol. 12, (1)

Sabouri, Nasim; Capra, John A; Zakian, Virginia A

2014

The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening

DNA Repair, Vol. 24 : 80-86

McDonald, Karin R; Sabouri, Nasim; Webb, Christopher J; et al.

2012

DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase

Genes & Development, Vol. 26, (6) : 581-593

Sabouri, Nasim; McDonald, Karin R; Webb, Christopher J; et al.

2010

Unwinding the functions of the Pif1 family helicases

DNA Repair, Vol. 9, (3) : 237-249

Bochman, Matthew L; Sabouri, Nasim; Zakian, Virginia A

2009

Translesion synthesis of abasic sites by yeast DNA polymerase epsilon

The Journal of biological chemistry, Vol. 284, (46) : 31555-31563

Sabouri, Nasim; Johansson, Erik

2008

Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage

Nucleic Acids Research, Vol. 36, (17) : 5660-5667

Sabouri, Nasim; Viberg, Jörgen; Kumar, Dinesh; et al.

2006

Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.

Nature Structural & Molecular Biology, Vol. 13, (1) : 35-43

Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; et al.

2004

Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.

Genes & Development, Vol. 18, (22) : 2764-2773

Garg, Parie; Stith, Carrie M; Sabouri, Nasim; et al.

Biochemical analysis of the strand annealing activity of the S. pombe Pif1 helicase

Mohammad, Jani B.; Sabouri, Nasim

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Nasim Sabouri

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