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Umeå University
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Nasim Sabouri

Maintenance of genome integrity by DNA Helicases

Research qualifications: Docent

Contact

E-mail
nasim.sabouri@umu.se
Phone
+46 72 566 25 05

Works at

Affiliation
Associate professor at Department of Medical Biochemistry and Biophysics Role: Deputy head of department, Director of studies
Location
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

One of the challenges in cancer biology is to understand what happens when the molecular mechanisms of a normal cell become dysfunctional and cause cancer. We are studying how genome integrity is preserved and the consequences of modifying the program of DNA replication.

A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (12) : 6264-6285
Deiana, Marco; Andrés Castán, José María; Josse, Pierre; et al.
Parallel G-quadruplex DNA structures from nuclear and mitochondrial genomes trigger emission enhancement in a nonfluorescent nano-aggregated fluorine-boron-based dye
Journal of Physical Chemistry Letters, American Chemical Society (ACS) 2023, Vol. 14, (7) : 1862-1869
Deiana, Marco; Chand, Karam; Chorell, Erik; et al.
Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy
Communications Chemistry, Springer Nature 2022, Vol. 5
Deiana, Marco; Josse, Pierre; Dalinot, Clément; et al.
Probing the folding pathways of four-stranded intercalated cytosine-rich motifs at single base-pair resolution
Biochimie, Elsevier 2022, Vol. 199 : 81-91
Jamroskovic, Jan; Deiana, Marco; Sabouri, Nasim
Light-induced in situ chemical activation of a fluorescent probe for monitoring intracellular G-quadruplex structures
Nanoscale, Royal Society of Chemistry 2021, Vol. 13, (32) : 13795-13808
Deiana, Marco; Mosser, Maëlle; Le Bahers, Tangui; et al.
A Minimalistic Coumarin Turn-On Probe for Selective Recognition of Parallel G-Quadruplex DNA Structures
ACS Chemical Biology, American Chemical Society (ACS) 2021, Vol. 16, (8) : 1365-1376
Deiana, Marco; Obi, Ikenna; Andréasson, Måns; et al.
The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (14) : 8339-8354
Yan, Kok-Phen; Obi, Ikenna; Sabouri, Nasim
A Site-Specific Self-Assembled Light-up Rotor Probe for Selective Recognition and Stabilization of c-MYC G-Quadruplex DNA
Nanoscale, Royal Society of Chemistry 2020, Vol. 12, (24) : 12950-12957
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59, (2) : 896-902
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
Unravelling the cellular emission fingerprint of the benchmark G-quadruplex-interactive compound Phen-DC3
Chemical Communications, Royal Society of Chemistry 2020, Vol. 56, (91) : 14251-14254
Deiana, Marco; Jamroskovic, Jan; Obi, Ikenna; et al.
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (19) : 10998-11015
Obi, Ikenna; Rentoft, Matilda; Singh, Vandana; et al.
The Relation Between Position and Chemical Composition of Bis-Indole Substituents Determines Their Interactions With G-Quadruplex DNA
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2020, Vol. 26, (43) : 9561-9572
Prasad, Bagineni; Das, Rabindra Nath; Jamroskovic, Jan; et al.
Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay
DNA Repair, Vol. 82
Jamroskovic, Jan; Obi, Ikenna; Movahedi, Anahita; et al.
The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (16) : 8516-8531
Mohammad, Jani B.; Wallgren, Marcus; Sabouri, Nasim
Flexible Versus Rigid G-Quadruplex DNA Ligands: Synthesis of Two Series of Bis-indole Derivatives and Comparison of Their Interactions with G-Quadruplex DNA
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 24, (31) : 7926-7938
Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; et al.
Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA
Organic and biomolecular chemistry, Royal Society of Chemistry 2017, Vol. 15, (15) : 3265-3275
Livendahl, Madeleine; Jamroskovic, Jan; Hedenström, Mattias; et al.
The functions of the multi‑tasking Pfh1Pif1 helicase
Current Genetics, Vol. 63, (4) : 621-626
Sabouri, Nasim
Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool
Chemistry - A European Journal, Vol. 22, (52) : 18932-18943
Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; et al.
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Chemistry - A European Journal, Vol. 22, (37) : 13004-13009
Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; et al.
Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity
PLOS Genetics, Copernicus GmbH 2016, Vol. 12, (9)
McDonald, Karin R.; Guise, Amanda J.; Pourbozorgi-Langroudi, Parham; et al.
G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase
Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (13) : 6213-6231
Wallgren, Marcus; Mohammad, Jani B.; Yan, Kok-Phen; et al.
The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening
DNA Repair, Vol. 24 : 80-86
McDonald, Karin R; Sabouri, Nasim; Webb, Christopher J; et al.
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication
PLOS Genetics, Vol. 10, (12) : e1004832-
Miralles Fusté, Javier; Shi, Yonghong; Wanrooij, Sjoerd; et al.
The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
BMC biology, Vol. 12, (1)
Sabouri, Nasim; Capra, John A; Zakian, Virginia A
DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase
Genes & Development, Vol. 26, (6) : 581-593
Sabouri, Nasim; McDonald, Karin R; Webb, Christopher J; et al.
Unwinding the functions of the Pif1 family helicases
DNA Repair, Vol. 9, (3) : 237-249
Bochman, Matthew L; Sabouri, Nasim; Zakian, Virginia A
Translesion synthesis of abasic sites by yeast DNA polymerase epsilon
The Journal of biological chemistry, Vol. 284, (46) : 31555-31563
Sabouri, Nasim; Johansson, Erik
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
Nucleic Acids Research, Vol. 36, (17) : 5660-5667
Sabouri, Nasim; Viberg, Jörgen; Kumar, Dinesh; et al.
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.
Nature Structural & Molecular Biology, Vol. 13, (1) : 35-43
Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; et al.
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.
Genes & Development, Vol. 18, (22) : 2764-2773
Garg, Parie; Stith, Carrie M; Sabouri, Nasim; et al.
Biochemical analysis of the strand annealing activity of the S. pombe Pif1 helicase
Mohammad, Jani B.; Sabouri, Nasim
View publications in DiVA

Research groups

Head of research
Nasim Sabouri
Four-stranded DNA in a new type of cancer therapy

Nasim Sabouris research findings are forming the basis for efforts to develop new cancer therapeutics.