Nasim Sabouri group

Sequences rich in Guanine and their complementary sequences rich in Cytosine in the genome have the ability to form unique 3D-structures called G-quadruplexes (G4s) and intercalated motifs (iMs), respectively. The high prevalence of these sequences in particular genomic regions, like telomeres and oncogene promoter regions, has led to them being the center of a new research field. While G4s have been the subject of more extensive research compared to iMs, and identified as potential targets for cancer treatment, our understanding of G4 regulation is still evolving.

Our research goal is to examine the interaction and impact of G4s and iMs on DNA metabolism. We’re also interested in understanding the potential roles of proteins (such as helicases) and small organic molecules in regulating the folding and unfolding of these secondary structures in human and yeast model systems. Additionally, we’re investigating compounds activated by light that target G4s or iMs, which could be used for therapeutic and diagnostic applications in cancer.

For more information, please also check www.sabourilab.com