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Image: Foto: Markus Marcetic © Knut och Alice Wallenbergs Stiftelse/Kungl. Vetenskapsakademien

Nasim Sabouri group

Research group Quadruplex Biochemistry and Dynamics Lab


Nasim Sabouri
Associate professor

Sequences rich in Guanine and their complementary sequences rich in Cytosine in the genome have the ability to form unique 3D-structures called G-quadruplexes (G4s) and intercalated motifs (iMs), respectively. The high prevalence of these sequences in particular genomic regions, like telomeres and oncogene promoter regions, has led to them being the center of a new research field. While G4s have been the subject of more extensive research compared to iMs, and identified as potential targets for cancer treatment, our understanding of G4 regulation is still evolving.

Our research goal is to examine the interaction and impact of G4s and iMs on DNA metabolism. We’re also interested in understanding the potential roles of proteins (such as helicases) and small organic molecules in regulating the folding and unfolding of these secondary structures in human and yeast model systems. Additionally, we’re investigating compounds activated by light that target G4s or iMs, which could be used for therapeutic and diagnostic applications in cancer.

For more information, please also check www.sabourilab.com

Head of research

Nasim Sabouri
Associate professor


Participating departments and units at Umeå University

Department of Medical Biochemistry and Biophysics

Research area

Cancer, Infection biology, Molecular biology and genetics
Four-stranded DNA in a new type of cancer therapy

Nasim Sabouris research findings are forming the basis for efforts to develop new cancer therapeutics.

Research on cells' power plants and cancer receives funding

Paulina Wanrooij named new Wallenberg Academy Fellow and Nasim Sabouri gets another five-years of funding.

Umeå researchers discover molecule for cancer diagnostics

Four-stranded DNA associated with the onset of cancer can be detected with a fluorescent molecule.

Latest update: 2023-12-21