Pernilla Wikström

Research qualifications: Docent

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Works as

Professor at Department of Medical Biosciences Section: Pathology Role: Deputy head of department, Assistant head of department

By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

Other position at Wallenberg Centre for Molecular Medicine at Umeå University (WCMM) Role: Assistant director

Umeå universitet, 901 87 Umeå

Fibrillarin-dependent 2′-O-methylation modulates RPS28 ribosome incorporation and oncogenic translation

Cancer Letters, Elsevier 2026, Vol. 639

Groza, Paula; Kumari, Kanchan; Esteva-Socias, Margalida; et al.

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, John Wiley & Sons 2025, Vol. 19, (11) : 3035-3059

Classon, Johanna; Stenudd, Moa; Zamboni, Margherita; et al.

Metabolic readouts of tumor instructed normal tissues (TINT) identify aggressive prostate cancer subgroups for tailored therapy

Frontiers in Molecular Biosciences, Frontiers Media S.A. 2025, Vol. 12

Dudka, Ilona; Figueira, Joao; Wikström, Pernilla; et al.

Morphological heterogeneities in prostate cancer bone metastases are related to molecular subtypes and prognosis

Clinical and Experimental Metastasis, Springer Nature 2025, Vol. 42, (5)

Halin Bergström, Sofia; Semenas, Julius; Nordstrand, Annika; et al.

Adverse prognosis gene expression patterns in metastatic castration-resistant prostate cancer

Molecular Oncology, John Wiley & Sons 2025, Vol. 19, (8) : 2348-2365

Sharifi, Marina N.; Feng, Eric; Rydzewski, Nicholas R.; et al.

Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling

Frontiers in Immunology, Frontiers Media S.A. 2024, Vol. 15

Henning, Petra; Kassem, Ali; Westerlund, Anna; et al.

Molekylära subtyper och avancerad prostatacancer: nya möjligheter för anpassad behandling: [Molecular subtypes provide possibilities for precision medicine in a advanced prostate cancer]

Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121

Wikström, Pernilla; Bergh, Anders; Josefsson, Andreas; et al.

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes

Journal of Translational Medicine, BioMed Central (BMC) 2023, Vol. 21, (1)

Dudka, Ilona; Lundquist, Kristina; Wikström, Pernilla; et al.

Investigating microRNA Profiles in Prostate Cancer Bone Metastases and Functional Effects of microRNA-23c and microRNA-4328

Cancers, MDPI 2023, Vol. 15, (9)

Järemo, Helena; Semenas, Julius; Halin Bergström, Sofia; et al.

Ki67 and prostate specific antigen are prognostic in metastatic hormone naïve prostate cancer

Acta Oncologica, Taylor & Francis 2023, Vol. 6212 : 1698-1706

Spyratou, Vasiliki; Freyhult, Eva; Bergh, Anders; et al.

A novel radiographic pattern related to poor prognosis in patients with prostate cancer with metastatic spinal cord compression

European Urology Open Science, Elsevier 2023, Vol. 48 : 44-53

Wänman, Johan; Abul-Kasim, Kasim; Semenas, Julius; et al.

Co-evolution of AR gene copy number and structural complexity in endocrine therapy resistant prostate cancer

NAR Cancer, Oxford University Press 2023, Vol. 5, (3)

Zivanovic, Andrej; Miller, Jeffrey T.; Munro, Sarah A.; et al.

Clinical and biological relevance of the transcriptomic-based prostate cancer metastasis subtypes MetA-C

Molecular Oncology, John Wiley & Sons 2022, (4)

Thysell, Elin; Köhn, Linda; Semenas, Julius; et al.

Epithelial and stromal characteristics of primary tumors predict the bone metastatic subtype of prostate cancer and patient survival after androgen-deprivation therapy

Cancers, MDPI 2022, Vol. 14, (21)

Wikström, Pernilla; Halin Bergström, Sofia; Josefsson, Andreas; et al.

A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer

Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)

Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.

High-grade tumours promote growth of other less-malignant tumours in the same prostate

Journal of Pathology, John Wiley & Sons 2021, Vol. 253, (4) : 396-403

Halin Bergström, Sofia; Rudolfsson, Stina H.; Lundholm, Marie; et al.

Klk4t2 is a hormonally regulated transcript from the klk4 locus

International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (23)

Lundwall, Åke; Bovinder Ylitalo, Erik; Wikström, Pernilla; et al.

High monocyte count and expression of s100a9 and s100a12 in peripheral blood mononuclear cells are associated with poor outcome in patients with metastatic prostate cancer

Cancers, MDPI 2021, Vol. 13, (10)

Åberg, Anna-Maja; Halin Bergström, Sofia; Thysell, Elin; et al.

Marked response to cabazitaxel in prostate cancer xenografts expressing androgen receptor variant 7 and reversion of acquired resistance by anti-androgens

The Prostate, John Wiley & Sons 2020, Vol. 80, (2) : 214-224

Bovinder Ylitalo, Erik; Thysell, Elin; Thellenberg-Karlsson, Camilla; et al.

Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status

BMC Cancer, BioMed Central 2020, Vol. 20, (1)

Dudka, Ilona; Thysell, Elin; Lundquist, Kristina; et al.

Tumor-educated platelets for early prostate cancer diagnosis, and therapy stratification in patients with metastasized castration resistant prostate cancer

Clinical Cancer Research, American Association for Cancer Research 2020, Vol. 26, (11) : 73-74

Tjon-Kon-Fat, Lee-Ann; Köhn, Linda; Best, Myron; et al.

Regulation of cell-cell adhesion in prostate cancer cells by microRNA-96 through upregulation of E-Cadherin and EpCAM

Carcinogenesis, Oxford University Press 2020, Vol. 41, (7) : 865-874

Voss, Gjendine; Haflidadottir, Benedikta S.; Järemo, Helena; et al.

Immunoreactivity for prostate specific antigen and Ki67 differentiates subgroups of prostate cancer related to outcome

Modern Pathology, Vol. 32, (9) : 1310-1319

Hammarsten, Peter; Josefsson, Andreas; Thysell, Elin; et al.

Vitamin A decreases the anabolic bone response to mechanical loading by suppressing bone formation

The FASEB Journal, Federation of American Societies for Experimental Biology 2019, Vol. 33, (4) : 5237-5247

Lionikaite, Vikte; Henning, Petra; Drevinge, Christina; et al.

Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor

Molecular Oncology, John Wiley & Sons 2019, Vol. 13, (8) : 1763-1777

Thysell, Elin; Vidman, Linda; Bovinder Ylitalo, Erik; et al.

Bone remodeling in relation to androgen receptor activity in prostate cancer bone metastases

Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 50-50

Bovinder Ylitalo, Erik; Nordstrand, Annika; Thysell, Elin; et al.

High inducible nitric oxide synthase in prostate tumor epithelium is associated with lethal prostate cancer

Scandinavian journal of urology, Taylor & Francis 2018, Vol. 52, (2) : 129-133

Erlandsson, Ann; Carlsson, Jessica; Andersson, Sven-Olof; et al.

The proteome of prostate cancer bone metastases

Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 91-92

Iglesias-Gato, Diego; Thysell, Elin; Crnalic, Sead; et al.

The Proteome of Prostate Cancer Bone Metastasis Reveals Heterogeneity with Prognostic Implications

Clinical Cancer Research, American Association for Cancer Research 2018, Vol. 24, (21) : 5433-5444

Iglesias-Gato, Diego; Thysell, Elin; Tyanova, Stefka; et al.

Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity

International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (4)

Nordstrand, Annika; Bovinder Ylitalo, Erik; Thysell, Elin; et al.

Clinically relevant molecular subgroups of prostate cancer bone metastases

Cancer Research, American Association for Cancer Research 2018, Vol. 78, (16) : 123-123

Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.

Platelets harbor prostate cancer biomarkers and the ability to predict therapeutic response to abiraterone in castration resistant patients

The Prostate, Wiley-Blackwell 2018, Vol. 78, (1) : 48-53

Tjon-Kon-Fat, Lee-Ann; Lundholm, Marie; Schröder, Mona; et al.

Subgroups of castration-resistant prostate cancer bone metastases defined through an inverse relationship between androgen receptor activity and immune response

European Urology, Vol. 71, (5) : 776-787

Bovinder Ylitalo, Erik; Thysell, Elin; Jernberg, Emma; et al.

High Levels of the AR-V7 Splice Variant and Co-Amplification of the Golgi Protein Coding YIPF6 in AR Amplified Prostate Cancer Bone Metastases

The Prostate, Wiley-Blackwell Publishing Inc. 2017, Vol. 77, (6) : 625-638

Djusberg, Erik; Jernberg, Emma; Thysell, Elin; et al.

Clinical relevance of androgen receptor alterations in prostate cancer

Endocrine Connections, Vol. 6, (8) : R146-R161

Jernberg, Emma; Bergh, Anders; Wikström, Pernilla

Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone

Clinical and Experimental Metastasis, Springer 2017, Vol. 34, (3-4) : 261-271

Nordstrand, Annika; Halin Bergström, Sofia; Thysell, Elin; et al.

Long leukocyte telomere length in prostate cancer patients at diagnosis is associated with poor metastasis-free and cancer-specific survival

Tumor Biology, SAGE PUBLICATIONS LTD 2017, Vol. 39, (2)

Svenson, Ulrika; Roos, Göran; Wikström, Pernilla

A Systems Approach to Prostate Cancer Classification: Letter

Cancer Research, American Association for Cancer Research 2017, Vol. 77, (24) : 7131-7132

Thysell, Elin; Bovinder Ylitalo, Erik; Jernberg, Emma; et al.

Reply to Isabel Heidegger, Renate Pichler, and Andreas Pircher's Letter to the Editor: re: Erik Bovinder Ylitalo, Elin Thysell, Emma Jernberg, et al. Subgroups of Castration-resistant Prostate Cancer Bone Metastases Defined Through an Inverse Relationship Between Androgen Receptor Activity and Immune Response. Eur Urol 2017;71:776-87

European Urology, Elsevier 2017, Vol. 72, (4) : e104-e105

Thysell, Elin; Ylitalo, Erik B.; Jernberg, Emma; et al.

Extracellular Vesicles from Metastatic Rat Prostate Tumors Prime the Normal Prostate Tissue to Facilitate Tumor Growth

Scientific Reports, Nature Publishing Group 2016, Vol. 6

Halin Bergström, Sofia; Hägglöf, Christina; Thysell, Elin; et al.

Extratumoral Heme Oxygenase-1 (HO-1) Expressing Macrophages Likely Promote Primary and Metastatic Prostate Tumor Growth

PLOS ONE, Vol. 11, (6)

Halin Bergström, Sofia; Nilsson, Maria; Adamo, Hanibal; et al.

High Caveolin-1 Expression in Tumor Stroma Is Associated with a Favourable Outcome in Prostate Cancer Patients Managed by Watchful Waiting

PLOS ONE, Vol. 11, (10)

Hammarsten, Peter; Scherdin, Tove Dahl; Hagglöf, Christina; et al.

The Proteome of Primary Prostate Cancer

European Urology, Vol. 69, (5) : 942-952

Iglesias-Gato, Diego; Wikström, Pernilla; Tyanova, Stefka; et al.

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Molecular Cancer, BioMed Central (BMC) 2015, Vol. 14

Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo (vol 14, 8, 2015)

Molecular Cancer, Vol. 14, (1)

Iglesias-Gato, Diego; Chuan, Yin-Choy; Jiang, Ning; et al.

Constrained randomization and multivariate effect projections improve information extraction and biomarker pattern discovery in metabolomics studies involving dependent samples

Metabolomics, Springer 2015, Vol. 11, (6) : 1667-1678

Jonsson, Pär; Wuolikainen, Anna; Thysell, Elin; et al.

Secreted Factors from Colorectal and Prostate Cancer Cells Skew the Immune Response in Opposite Directions

Scientific Reports, Nature Publishing Group 2015, Vol. 5

Lundholm, Marie; Hägglöf, Christina; Wikberg, Maria L.; et al.

High Lysyl Oxidase (LOX) in the Non-Malignant Prostate Epithelium Predicts a Poor Outcome in Prostate Cancer Patient Managed by Watchful Waiting

PLOS ONE, Public library science 2015, Vol. 10, (10)

Nilsson, Maria; Hägglöf, Christina; Hammarsten, Peter; et al.

SOCS2 mediates the cross talk between androgen and growth hormone signaling in prostate cancer

Carcinogenesis, Oxford University Press 2014, Vol. 35, (1) : 24-33

Iglesias-Gato, Diego; Chuan, Yin-Choy; Wikström, Pernilla; et al.

Prostate Tumor-Derived Exosomes Down-Regulate NKG2D Expression on Natural Killer Cells and CD8(+) T Cells: Mechanism of Immune Evasion

PLOS ONE, Vol. 9, (9) : e108925-

Lundholm, Marie; Schröder, Mona; Nagaeva, Olga; et al.

View publications in DiVA

Research groups

Head of research

Pernilla Wikström Lab

Research projects

1 September 2023

SPRINTR project

28 February 2007 until 31 December 2010

Biomarkers for aggressive prostate cancer

Published: 06 Dec, 2024

New Cancer Fund millions for UMU research