Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon.
Vimal Parkash1, Yashraj Kulkarni2, Josy ter Beek1, Polina V. Shcherbakova3, Shina Caroline Lynn Kamerlin2, and Erik Johansson1
1Department of Medical Biochemistry and Biophysics, Umeå University, SE-90187 Umeå, Sweden
2Department of Chemistry - BMC, Uppsala University, Box 576, S-751 23 Uppsala, Sweden
3Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA