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Umeå universitet
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Personalbild Helena Edlund

Helena Edlund

Vetenskaplig meritering: Docent

Kontakt

E-post
helena.edlund@umu.se
Telefon
090-786 67 99

Verksam vid

Anknytning
Professor vid Umeå centrum för molekylär medicin (UCMM) Roll: Föreståndare
Plats
MBC 6M, vån 4, Johan Bures Väg 12 Umeå universitet, 901 87 Umeå
O304 ameliorates hyperglycemia in mice by dually promoting muscle glucose effectiveness and preserving β-cell function
Communications Biology, Springer Nature 2023, Vol. 6, (1)
Norlin, Stefan; Axelsson, Jan; Ericsson, Madelene; et al.
AMPK activator O304 improves metabolic and cardiac function, and exercise capacity in aged mice
Communications Biology, Nature Publishing Group 2021, Vol. 4, (1)
Ericsson, Madelene; Steneberg, Pär; Nyrén, Rakel; et al.
Pan-AMPK activator O304 prevents gene expression changes and remobilisation of histone marks in islets of diet-induced obese mice
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
López-Pérez, Ana R.; Norlin, Stefan; Steneberg, Pär; et al.
alpha-Synuclein promotes IAPP fibril formation in vitro and beta-cell amyloid formation in vivo in mice
Scientific Reports, Nature Publishing Group 2020, Vol. 10, (1)
Mucibabic, Marija; Steneberg, Pär; Lidh, Emmelie; et al.
The 17,18-epoxyeicosatetraenoic acid-G protein-coupled receptor 40 axis ameliorates contact hypersensitivity by inhibiting neutrophil mobility in mice and cynomolgus macaques
Journal of Allergy and Clinical Immunology, MOSBY-ELSEVIER 2018, Vol. 142, (2) : 470-482.e12
Nagatake, Takahiro; Shiogama, Yumiko; Inoue, Asuka; et al.
The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival
Development, COMPANY OF BIOLOGISTS LTD 2018, Vol. 145, (1)
Norlin, Stefan; Parekh, Vishal; Edlund, Helena
PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients
JCI INSIGHT, American Society for Clinical Investigation 2018, Vol. 3, (12)
Steneberg, Pär; Lindahl, Emma; Dahl, Ulf; et al.
The anterior chamber of the eye is a transplantation site that supports and enables visualisation of beta cell development in mice
Diabetologia, Vol. 59, (5) : 1007-1011
Ali, Yusuf; Diez, Juan; Selander, Lars; et al.
Asna1/TRC40 Controls beta-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport
Diabetes, Vol. 65, (1) : 110-119
Norlin, Stefan; Parekh, Vishal S.; Naredi, Peter; et al.
Insulin-degrading enzyme prevents alpha-synuclein fibril formation in a nonproteolytical manner
Scientific Reports, Nature Publishing Group 2015, Vol. 5
Sharma, Sandeep K; Chorell, Erik; Steneberg, Pär; et al.
Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance
Journal of Biological Chemistry, Vol. 290, (31) : 19034-19043
Steneberg, Pär; Sykaras, Alexandros G.; Backlund, Fredrik; et al.
Pdx1 Maintains beta Cell Identity and Function by Repressing an alpha Cell Program
Cell Metabolism, Vol. 19, (2) : 259-271
Gao, Tao; McKenna, Brian; Li, Changhong; et al.
The Type 2 Diabetes-Associated Gene Ide Is Required for Insulin Secretion and Suppression of alpha-Synuclein Levels in beta-Cells
Diabetes, Vol. 62, (6) : 2004-2014
Steneberg, Pär; Bernardo, Lisandro; Edfalk, Sara; et al.
The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human β-cells and its targeted inactivation impairs insulin secretion
Endocrinology, Baltimore: Williams & Wilkins 2011, Vol. 152, (10) : 3717-3727
Medina, Mayrin C.; Molina, Judith; Gadea, Yelena; et al.
The homeodomain-interacting protein kinase 2 regulates insulin promoter factor-1/pancreatic duodenal homeobox-1 transcriptional activity
Endocrinology, Vol. 150, (1) : 87-97
Boucher, Marie-Josée; Simoneau, Mélanie; Edlund, Helena
MicroRNA miR-7 is preferentially expressed in endocrine cells of the developing and adult human pancreas.
Gene Expression Patterns, Vol. 9, (4) : 193-9
Correa-Medina, Mayrin; Bravo-Egana, Valia; Rosero, Samuel; et al.
Endocrine cell clustering during human pancreas development
Journal of Histochemistry and Cytochemistry, Vol. 57, (9) : 811-824
Jeon, Jongmin; Correa-Medina, Mayrin; Ricordi, Camillo; et al.
MFng is dispensable for mouse pancreas development and function
Molecular and Cellular Biology, Vol. 29, (8) : 2129-2138
Svensson, Per; Bergqvist, Ingela; Norlin, Stefan; et al.
Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion.
Diabetes, Vol. 57, (9) : 2280-7
Edfalk, Sara; Steneberg, Pär; Edlund, Helena
Retinoic acid promotes the generation of pancreatic endocrine progenitor cells and their further differentiation into beta-cells
PLoS ONE, Vol. 3, (7) : e2841-
Oström, Maria; Loffler, Kelly A; Edfalk, Sara; et al.
Toward a renewable source of pancreatic beta-cells.
Nature biotechnology, Vol. 26, (4) : 397-8
Ricordi, Camillo; Edlund, Helena
BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Cell Metabolism, Vol. 5, (3) : 207-219
Goulley, Joan; Dahl, Ulf; Baeza, Nathalie; et al.
Gene array identification of Ipf1/Pdx1 -/- regulated genes in pancreatic progenitor cells.
BMC Developmental Biology, Vol. 7, (1) : 129-
Svensson, Per; Williams, Cecilia; Lundeberg, Joakim; et al.
Phosphorylation marks IPF1/PDX1 protein for degradation by glycogen synthase kinase 3-dependent mechanisms.
The Journal of Biological Chemistry, Vol. 281, (10) : 6395-403
Boucher, Marie-Josée; Selander, Lars; Carlsson, Lennart; et al.
Ptf1a determines horizontal and amacrine cell fates during mouse retinal development.
Development, Vol. 133, (22) : 4439-50
Fujitani, Yoshio; Fujitani, Shuko; Luo, Huijun; et al.
TAT-mediated neurogenin 3 protein transduction stimulates pancreatic endocrine differentiation in vitro.
Diabetes, Vol. 54, (3) : 720-6
Domínguez-Bendala, Juan; Klein, Dagmar; Ribeiro, Melina; et al.
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Diabetes, Vol. 54, (2) : 482-91
Li, Yazhou; Cao, Xiemin; Li, Li-Xin; et al.
sox4b is a key player of pancreatic alpha cell differentiation in zebrafish.
Developmental Biology, Vol. 285, (1) : 211-23
Mavropoulos, Anastasia; Devos, Nathalie; Biemar, Frédéric; et al.
Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion.
Diabetes, Vol. 54, (1) : 125-32
Norlin, Stefan; Ahlgren, Ulf; Edlund, Helena
Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.
Diabetes, Vol. 54, (10) : 2844-2851
Papadopoulou, Stella; Edlund, Helena
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse.
Cell Metabolism, Vol. 1, (4) : 245-58
Steneberg, Pär; Rubins, Nir; Bartoov-Shifman, Reut; et al.
Of mice and MEN1: Insulinomas in a conditional mouse knockout.
Molecular and Cellular Biology, Vol. 23, (17) : 6075-6085
Crabtree, Judy S; Scacheri, Peter C; Ward, Jerrold M; et al.
Fgf10 maintains notch activation, stimulates proliferation, and blocks differentiation of pancreatic epithelial cells.
Developmental Dynamics, Vol. 228, (2) : 185-193
Hart, Alan; Papadopoulou, Stella; Edlund, Helena
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Forskargrupper

Forskningsledare
Helena Edlund