Ulrika Andersson

Kontakt

ulrika.l.andersson@umu.se

090-785 28 65, 070-339 15 24

Verksam vid

Forskningssamordnare vid Institutionen för strålningsvetenskaper Enhet: Onkologi

6M, 3 tr, Norrlands universitetssjukhus, 5066 Umeå universitet, 901 87 Umeå

Den mest elakartade typen av gliom är glioblastom, som har en mycket dålig prognos.
Orsakerna till varför man får gliom är ofta inte känt, det finns tre faktorer som är etablerade; joniserande strålning, en invers association med (minskad risk vid) astma och allergier samt genetiska faktorer.

Vår forskargrupp försöker förstå varför man får hjärntumör och hur det genetiska landskapet utvecklas från en normal cell till tumör.

Vi använder oss av ett flertal molekylärepidemiologiska metoder såsom registerstudier, genetiska analyser och metabolomik på tumör eller blodprov från patienter som kan vara insamlade både före och efter diagnos.

2020

A genome-wide association study on medulloblastoma

Journal of Neuro-Oncology

Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.

2019

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.

2019

Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults: A Case-Control Study

Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research 2019, Vol. 28, (7) : 1252-1258

Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.

2019

Sex-specific gene and pathway modeling of inherited glioma risk

Neuro-Oncology, Oxford University Press 2019, Vol. 21, (1) : 71-82

Ostrom, Quinn T.; Coleman, Warren; Huang, William; et al.

2019

The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes

Cancers, MDPI 2019, Vol. 11, (12)

Wu, Wendy Yi-Ying; Johansson, Gunnar; Wibom, Carl; et al.

2018

Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'‐like features associated with younger age

International Journal of Cancer, WILEY 2018, Vol. 143, (10) : 2359-2366

Ostrom, Quinn T.; Kinnersley, Ben; Armstrong, Georgina; et al.

2018

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

Scientific Reports, NATURE PUBLISHING GROUP 2018, Vol. 8

Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; et al.

2017

Telomere length, allergies and risk of Glioma

Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 23-23

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.

2017

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Nature Genetics, Vol. 49, (5) : 789-794

Melin, Beatrice S.; Barnholtz-Sloan, Jill S.; Wrensch, Margaret R.; et al.

2016

Metabolomic screening of pre-diagnostic serum samples identifies association between alpha- and gamma-tocopherols and glioblastoma risk

OncoTarget, Vol. 7, (24) : 37043-37053

Björkblom, Benny; Wibom, Carl; Jonsson, Pär; et al.

2016

Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor

PLoS ONE, Public library science 2016, Vol. 11, (10)

Dahlin, Anna M.; Wibom, Carl; Ghasimi, Soma; et al.

2016

Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma

Journal of Neuro-Oncology, Vol. 127, (3) : 483-492

Ghasimi, Soma; Wibom, Carl; Dahlin, Anna M.; et al.

2016

Recent developments in brain tumor predisposing syndromes

Acta Oncologica, Taylor & Francis 2016, Vol. 55, (4) : 401-411

Johansson, Gunnar; Andersson, Ulrika; Melin, Beatrice

2016

Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study

Tumor Biology, Vol. 37, (8) : 11065-11072

Späth, Florentin; Andersson, Ulrika; Dahlin, Anna M.; et al.

2015

CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma

Journal of Neuro-Oncology, Vol. 125, (1) : 75-78

Dahlin, Anna M.; Hollegaard, Mads V.; Wibom, Carl; et al.

2015

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Journal of the National Cancer Institute, Vol. 107, (12)

Sampson, Joshua N.; Wheeler, William A.; Yeager, Meredith; et al.

2015

Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data

Human Mutation, Vol. 36, (7) : 684-688

Wang, Zhaoming; Rajaraman, Preetha; Melin, Beatrice S.; et al.

2015

Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case-Control Study

Cancer Epidemiology, Biomarkers and Prevention, Vol. 24, (5) : 810-816

Wibom, Carl; Späth, Florentin; Dahlin, Anna M.; et al.

2014

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer

Neuro-Oncology, Oxford University Press 2014, Vol. 16, (10) : 1333-1340

Andersson, Ulrika; Wibom, Carl; Cederquist, Kristina; et al.

2014

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Human Molecular Genetics, Vol. 23, (24) : 6616-6633

Wang, Zhaoming; Zhu, Bin; Zhang, Mingfeng; et al.

2014

Glioma Gwas Hits - Markers for Risk or for Prognosis?

Neuro-Oncology, Oxford University Press 2014, Vol. 16, (Suppl. 2) : ii109-ii110

Wibom, Carl; Spaeth, Florentin; Dahlin, Anna; et al.

2013

Known glioma risk loci are associated with glioma with a family history of brain tumours: a case-control gene association study

International Journal of Cancer, Vol. 132, (10) : 2464-2468

Melin, Beatrice; Dahlin, Anna M; Andersson, Ulrika; et al.

2012

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69

Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.

2012

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Journal of Neuro-Oncology, Vol. 108, (3) : 435-441

Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.

2012

Detectable clonal mosaicism and its relationship to aging and cancer.

Nature Genetics, New York: Nature Publishing Group 2012, Vol. 44, (6) : 651-658

Jacobs, Kevin B; Yeager, Meredith; Zhou, Weiyin; et al.

2012

Association between adult height, genetic susceptibility and risk of glioma.

International Journal of Epidemiology, Vol. 41, (4) : 1075-1085

Kitahara, Cari M; Wang, Sophia S; Melin, Beatrice S; et al.

2012

Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma

Human Genetics, Vol. 131, (9) : 1507-1517

Liu, Yanhong; Melin, Beatrice S; Rajaraman, Preetha; et al.

2012

hTERT Cancer Risk Genotypes Are Associated With Telomere Length

Genetic Epidemiology, Malden: Wiley-Blackwell 2012, Vol. 36, (4) : 368-372

Melin, Beatrice S.; Nordfjall, Katarina; Andersson, Ulrika; et al.

2012

Genome-wide association study of glioma and meta-analysis

Human Genetics, Vol. 131, (12) : 1877-1888

Rajaraman, Preetha; Melin, Beatrice S; Wang, Zhaoming; et al.

2012

EGFR expression and glioblastoma outcome

Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 19-19

Sjöström, Sara; Ghasimi, Soma; Broholm, H.; et al.

2012

EGFR gene variants are associated with specific somatic aberrations in glioma

Neuro-Oncology, Vol. 14, (Suppl. 3) : 46-46

Wibom, Carl; Ghasimi, Soma; Van Loo, P.; et al.

2012

EGFR gene variants are associated with specific somatic aberrations in glioma

PLoS ONE, plosone.org 2012, Vol. 7, (12) : e47929-

Wibom, Carl; Ghasimi, Soma; Van Loo, Peter; et al.

2012

DNA-repair gene variants are associated with glioblastoma survival

Acta Oncologica, Informa Healthcare 2012, Vol. 51, (3) : 325-332

Wibom, Carl; Sjöström, Sara; Henriksson, Roger; et al.

2011

Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas

Journal of Neuro-Oncology, Vol. 105, (3) : 531-538

Berntsson, Shala Ghaderi; Wibom, Carl; Sjöström, Sara; et al.

2011

Common variation at 10p12.31 near MLLT10 influences meningioma risk

Nature Genetics, London: Nature America, Inc. 2011, Vol. 43, (9) : 825-827

Dobbins, Sara E.; Broderick, Peter; Melin, Beatrice; et al.

2011

Genetic variations in VEGF and VEGFR2 and glioblastoma outcome

Journal of Neuro-Oncology, Boston: Nijhoff 2011, Vol. 104, (2) : 523-527

Sjöström, Sara; Wibom, Carl; Andersson, Ulrika; et al.

2010

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk

Acta Oncologica, Informa Healthcare 2010, Vol. 49, (6) : 767-775

Andersson, Ulrika; Schwartzbaum, Judith; Wiklund, Fredrik; et al.

2010

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival

Journal of Clinical Oncology, American Society of Clinical Oncology 2010, Vol. 28, (14) : 2467-2474

Liu, Yanhong; Shete, Sanjay; Etzel, Carol J; et al.

2010

Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation

Familial Cancer, Vol. 9, (3) : 413-421

Robertson, Lindsay B; Armstrong, Georgina N; Olver, Bianca D; et al.

2010

Genetic variations in EGF and EGFR and glioblastoma outcome

Neuro-Oncology, Vol. 12, (8) : 815-821

Sjöström, Sara; Andersson, Ulrika; Liu, Yanhong; et al.

2009

Genetic variants in association studies: review of strengths and weaknesses in study design and current knowledge of impact on cancer risk

Acta Oncologica, Vol. 48, (7) : 948-954

Andersson, Ulrika; McKean-Cowdin, Roberta; Hjalmars, Ulf; et al.

2009

MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome.

International journal of cancer. Journal international du cancer, Vol. 125, (4) : 968-972

Andersson, Ulrika; Osterman, Pia; Sjöström, Sara; et al.

2009

Genome-wide association study identifies five susceptibility loci for glioma.

Nature Genetics, Vol. 41, (8) : 899-904

Shete, Sanjay; Hosking, Fay J; Robertson, Lindsay B; et al.

2007

Treatment schedule is of importance when gefitinib is combined with irradiation of glioma and endothelial cells in vitro.

Acta Oncologica, Vol. 46, (7) : 951-960

Andersson, Ulrika; Johansson, David; Behnam-Motlagh, Parviz; et al.

2006

Verotoxin-1 Induction of Apoptosis in Gb3-Expressing Human Glioma Cell Lines

Cancer Biology & Therapy, Vol. 5, (9) : 1211-1217

Johansson, David; Johansson, Anders; Grankvist, Kjell; et al.

2005

Experimental studies in brain tumours: with special regard to multidrug resistance and the ErbB-family

Umeå University medical dissertations, 959

Andersson, Ulrika

2004

Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas

Acta Neuropathologica, Vol. 108, (2) : 135-142

Andersson, Ulrika; Guo, Dongsheng; Malmer, Beatrice; et al.

2004

Heterogeneity in the expression of markers for drug resistance in brain tumors

Clinical Neuropathology, Vol. 23, (1) : 21-27

Andersson, Ulrika; Malmer, Beatrice; Bergenheim, A Tommy; et al.

2004

The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model

British Journal of Cancer, Vol. 91, (6) : 1174-1180

Sandström, Maria; Johansson, Mikael; Andersson, Ulrika; et al.

2002

Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation

Medical Oncology, Vol. 19, (1) : 1-9

Andersson, Ulrika; Grankvist, Kjell; Bergenheim, A. Tommy; et al.

Visa publikationer i DiVA

Forskargrupper

Gruppmedlem

Beatrice Melin

Forskningsprojekt

1 september 2010

U-CAN