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Umeå universitet
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Personalbild Ulrika Andersson

Ulrika Andersson

Kontakt

E-post
ulrika.l.andersson@umu.se
Telefon
090-785 28 65, 070-339 15 24

Verksam vid

Anknytning
Forskningssamordnare vid Institutionen för strålningsvetenskaper Enhet: Onkologi
Plats
6M, 3 tr, Norrlands universitetssjukhus, 5066 Umeå universitet, 901 87 Umeå

Den mest elakartade typen av gliom är glioblastom, som har en mycket dålig prognos.
Orsakerna till varför man får gliom är ofta inte känt, det finns tre faktorer som är etablerade; joniserande strålning, en invers association med (minskad risk vid) astma och allergier samt genetiska faktorer.

Vår forskargrupp försöker förstå varför man får hjärntumör och hur det genetiska landskapet utvecklas från en normal cell till tumör.

Vi använder oss av ett flertal molekylärepidemiologiska metoder såsom registerstudier, genetiska analyser och metabolomik på tumör eller blodprov från patienter som kan vara insamlade både före och efter diagnos.

2019
The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.
2019
Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults: A Case-Control Study
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research 2019, Vol. 28, (7) : 1252-1258
Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.
2019
Sex-specific gene and pathway modeling of inherited glioma risk
Neuro-Oncology, Oxford University Press 2019, Vol. 21, (1) : 71-82
Ostrom, Quinn T.; Coleman, Warren; Huang, William; et al.
2019
The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes
Cancers, MDPI 2019, Vol. 11, (12)
Wu, Wendy Yi-Ying; Johansson, Gunnar; Wibom, Carl; et al.
2018
Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'‐like features associated with younger age
International Journal of Cancer, WILEY 2018, Vol. 143, (10) : 2359-2366
Ostrom, Quinn T.; Kinnersley, Ben; Armstrong, Georgina; et al.
2018
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21
Scientific Reports, NATURE PUBLISHING GROUP 2018, Vol. 8
Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; et al.
2017
TELOMERE LENGTH, ALLERGIES AND RISK OF GLIOMA
Neuro-Oncology, OXFORD UNIV PRESS INC 2017, Vol. 19, (Supplement: 3) : 23-23
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.
2017
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
Nature Genetics, Vol. 49, (5) : 789-794
Melin, Beatrice S.; Barnholtz-Sloan, Jill S.; Wrensch, Margaret R.; et al.
2016
Metabolomic screening of pre-diagnostic serum samples identifies association between alpha- and gamma-tocopherols and glioblastoma risk
OncoTarget, Vol. 7, (24) : 37043-37053
Björkblom, Benny; Wibom, Carl; Jonsson, Pär; et al.
2016
Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor
PLoS ONE, Public library science 2016, Vol. 11, (10)
Dahlin, Anna M.; Wibom, Carl; Ghasimi, Soma; et al.
2016
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma
Journal of Neuro-Oncology, Vol. 127, (3) : 483-492
Ghasimi, Soma; Wibom, Carl; Dahlin, Anna M.; et al.
2016
Recent developments in brain tumor predisposing syndromes
Acta Oncologica, Taylor & Francis 2016, Vol. 55, (4) : 401-411
Johansson, Gunnar; Andersson, Ulrika; Melin, Beatrice
2016
Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study
Tumor Biology, Vol. 37, (8) : 11065-11072
Späth, Florentin; Andersson, Ulrika; Dahlin, Anna M.; et al.
2015
CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma
Journal of Neuro-Oncology, Vol. 125, (1) : 75-78
Dahlin, Anna M.; Hollegaard, Mads V.; Wibom, Carl; et al.
2015
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types
Journal of the National Cancer Institute, Vol. 107, (12)
Sampson, Joshua N.; Wheeler, William A.; Yeager, Meredith; et al.
2015
Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data
Human Mutation, Vol. 36, (7) : 684-688
Wang, Zhaoming; Rajaraman, Preetha; Melin, Beatrice S.; et al.
2015
Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case-Control Study
Cancer Epidemiology, Biomarkers and Prevention, Vol. 24, (5) : 810-816
Wibom, Carl; Späth, Florentin; Dahlin, Anna M.; et al.
2014
Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer
Neuro-Oncology, Oxford University Press 2014, Vol. 16, (10) : 1333-1340
Andersson, Ulrika; Wibom, Carl; Cederquist, Kristina; et al.
2014
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33
Human Molecular Genetics, Vol. 23, (24) : 6616-6633
Wang, Zhaoming; Zhu, Bin; Zhang, Mingfeng; et al.
2014
Glioma Gwas Hits - Markers for Risk or for Prognosis?
Neuro-Oncology, Oxford University Press 2014, Vol. 16, (Suppl. 2) : ii109-ii110
Wibom, Carl; Spaeth, Florentin; Dahlin, Anna; et al.
2013
Known glioma risk loci are associated with glioma with a family history of brain tumours: a case-control gene association study
International Journal of Cancer, Vol. 132, (10) : 2464-2468
Melin, Beatrice; Dahlin, Anna M; Andersson, Ulrika; et al.
2012
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69
Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.
2012
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Journal of Neuro-Oncology, Vol. 108, (3) : 435-441
Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.
2012
Detectable clonal mosaicism and its relationship to aging and cancer.
Nature Genetics, New York: Nature Publishing Group 2012, Vol. 44, (6) : 651-658
Jacobs, Kevin B; Yeager, Meredith; Zhou, Weiyin; et al.
2012
Association between adult height, genetic susceptibility and risk of glioma.
International Journal of Epidemiology, Vol. 41, (4) : 1075-1085
Kitahara, Cari M; Wang, Sophia S; Melin, Beatrice S; et al.
2012
Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma
Human Genetics, Vol. 131, (9) : 1507-1517
Liu, Yanhong; Melin, Beatrice S; Rajaraman, Preetha; et al.
2012
hTERT Cancer Risk Genotypes Are Associated With Telomere Length
Genetic Epidemiology, Malden: Wiley-Blackwell 2012, Vol. 36, (4) : 368-372
Melin, Beatrice S.; Nordfjall, Katarina; Andersson, Ulrika; et al.
2012
Genome-wide association study of glioma and meta-analysis
Human Genetics, Vol. 131, (12) : 1877-1888
Rajaraman, Preetha; Melin, Beatrice S; Wang, Zhaoming; et al.
2012
EGFR expression and glioblastoma outcome
Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 19-19
Sjöström, Sara; Ghasimi, Soma; Broholm, H.; et al.
2012
EGFR gene variants are associated with specific somatic aberrations in glioma
Neuro-Oncology, Vol. 14, (Suppl. 3) : 46-46
Wibom, Carl; Ghasimi, Soma; Van Loo, P.; et al.
2012
EGFR gene variants are associated with specific somatic aberrations in glioma
PLoS ONE, plosone.org 2012, Vol. 7, (12) : e47929-
Wibom, Carl; Ghasimi, Soma; Van Loo, Peter; et al.
2012
DNA-repair gene variants are associated with glioblastoma survival
Acta Oncologica, Informa Healthcare 2012, Vol. 51, (3) : 325-332
Wibom, Carl; Sjöström, Sara; Henriksson, Roger; et al.
2011
Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas
Journal of Neuro-Oncology, Vol. 105, (3) : 531-538
Berntsson, Shala Ghaderi; Wibom, Carl; Sjöström, Sara; et al.
2011
Common variation at 10p12.31 near MLLT10 influences meningioma risk
Nature Genetics, London: Nature America, Inc. 2011, Vol. 43, (9) : 825-827
Dobbins, Sara E.; Broderick, Peter; Melin, Beatrice; et al.
2011
Genetic variations in VEGF and VEGFR2 and glioblastoma outcome
Journal of Neuro-Oncology, Boston: Nijhoff 2011, Vol. 104, (2) : 523-527
Sjöström, Sara; Wibom, Carl; Andersson, Ulrika; et al.
2010
A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk
Acta Oncologica, Informa Healthcare 2010, Vol. 49, (6) : 767-775
Andersson, Ulrika; Schwartzbaum, Judith; Wiklund, Fredrik; et al.
2010
Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival
Journal of Clinical Oncology, American Society of Clinical Oncology 2010, Vol. 28, (14) : 2467-2474
Liu, Yanhong; Shete, Sanjay; Etzel, Carol J; et al.
2010
Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation
Familial Cancer, Vol. 9, (3) : 413-421
Robertson, Lindsay B; Armstrong, Georgina N; Olver, Bianca D; et al.
2010
Genetic variations in EGF and EGFR and glioblastoma outcome
Neuro-Oncology, Vol. 12, (8) : 815-821
Sjöström, Sara; Andersson, Ulrika; Liu, Yanhong; et al.
2009
Genetic variants in association studies: review of strengths and weaknesses in study design and current knowledge of impact on cancer risk
Acta Oncologica, Vol. 48, (7) : 948-954
Andersson, Ulrika; McKean-Cowdin, Roberta; Hjalmars, Ulf; et al.
2009
MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome.
International journal of cancer. Journal international du cancer, Vol. 125, (4) : 968-972
Andersson, Ulrika; Osterman, Pia; Sjöström, Sara; et al.
2009
Genome-wide association study identifies five susceptibility loci for glioma.
Nature Genetics, Vol. 41, (8) : 899-904
Shete, Sanjay; Hosking, Fay J; Robertson, Lindsay B; et al.
2007
Treatment schedule is of importance when gefitinib is combined with irradiation of glioma and endothelial cells in vitro.
Acta Oncologica, Vol. 46, (7) : 951-960
Andersson, Ulrika; Johansson, David; Behnam-Motlagh, Parviz; et al.
2006
Verotoxin-1 Induction of Apoptosis in Gb3-Expressing Human Glioma Cell Lines
Cancer Biology & Therapy, Vol. 5, (9) : 1211-1217
Johansson, David; Johansson, Anders; Grankvist, Kjell; et al.
2005
Experimental studies in brain tumours: with special regard to multidrug resistance and the ErbB-family
Umeå University medical dissertations, 959
Andersson, Ulrika
2004
Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas
Acta Neuropathologica, Vol. 108, (2) : 135-142
Andersson, Ulrika; Guo, Dongsheng; Malmer, Beatrice; et al.
2004
Heterogeneity in the expression of markers for drug resistance in brain tumors
Clinical Neuropathology, Vol. 23, (1) : 21-27
Andersson, Ulrika; Malmer, Beatrice; Bergenheim, A Tommy; et al.
2004
The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model
British Journal of Cancer, Vol. 91, (6) : 1174-1180
Sandström, Maria; Johansson, Mikael; Andersson, Ulrika; et al.
2002
Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation
Medical Oncology, Vol. 19, (1) : 1-9
Andersson, Ulrika; Grankvist, Kjell; Bergenheim, A. Tommy; et al.
Genetic variants in EGF, EGFR, ERBB2, LRIG2, LRIG3 and meningioma risk
Ghasimi, Soma; Wibom, Carl; Brännström, Thomas; et al.
Visa publikationer i DiVA

Forskargrupper

Gruppmedlem
Beatrice Melin

Forskningsprojekt

1 september 2010
U-CAN