Ulrika Andersson

Kontakt

ulrika.l.andersson@umu.se

Verksam vid

Projektsamordnare vid Enheten för biobanksforskning

5 B, 1 tr Målpunkt P11, NUS, Försörjningsvägen 7 B Umeå universitet, S-90187 Umeå

Den mest elakartade typen av gliom är glioblastom, som har en mycket dålig prognos.
Orsakerna till varför man får gliom är ofta inte känt, det finns tre faktorer som är etablerade; joniserande strålning, en invers association med (minskad risk vid) astma och allergier samt genetiska faktorer.

Vår forskargrupp försöker förstå varför man får hjärntumör och hur det genetiska landskapet utvecklas från en normal cell till tumör.

Vi använder oss av ett flertal molekylärepidemiologiska metoder såsom registerstudier, genetiska analyser och metabolomik på tumör eller blodprov från patienter som kan vara insamlade både före och efter diagnos.

A genome-wide association study on medulloblastoma

Journal of Neuro-Oncology, Springer 2020, Vol. 147, (2) : 309-315

Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.

The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking

Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.

Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults: A Case-Control Study

Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research 2019, Vol. 28, (7) : 1252-1258

Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.

Sex-specific gene and pathway modeling of inherited glioma risk

Neuro-Oncology, Oxford University Press 2019, Vol. 21, (1) : 71-82

Ostrom, Quinn T.; Coleman, Warren; Huang, William; et al.

The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes

Cancers, MDPI 2019, Vol. 11, (12)

Wu, Wendy Yi-Ying; Johansson, Gunnar; Wibom, Carl; et al.

Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'‐like features associated with younger age

International Journal of Cancer, WILEY 2018, Vol. 143, (10) : 2359-2366

Ostrom, Quinn T.; Kinnersley, Ben; Armstrong, Georgina; et al.

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21

Scientific Reports, NATURE PUBLISHING GROUP 2018, Vol. 8

Ostrom, Quinn T.; Kinnersley, Ben; Wrensch, Margaret R.; et al.

Telomere length, allergies and risk of Glioma

Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 23-23

Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.

Molecular classification of malignat glioma

Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 88-88

Johansson, Gunnar; Brännström, Thomas; Andersson, Ulrika; et al.

Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors

Nature Genetics, Vol. 49, (5) : 789-794

Melin, Beatrice S.; Barnholtz-Sloan, Jill S.; Wrensch, Margaret R.; et al.

Metabolomic screening of pre-diagnostic serum samples identifies association between alpha- and gamma-tocopherols and glioblastoma risk

OncoTarget, Vol. 7, (24) : 37043-37053

Björkblom, Benny; Wibom, Carl; Jonsson, Pär; et al.

Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor

PLoS ONE, Public library science 2016, Vol. 11, (10)

Dahlin, Anna M.; Wibom, Carl; Ghasimi, Soma; et al.

Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma

Journal of Neuro-Oncology, Vol. 127, (3) : 483-492

Ghasimi, Soma; Wibom, Carl; Dahlin, Anna M.; et al.

Recent developments in brain tumor predisposing syndromes

Acta Oncologica, Taylor & Francis 2016, Vol. 55, (4) : 401-411

Johansson, Gunnar; Andersson, Ulrika; Melin, Beatrice

Pre-diagnostic serum levels of EGFR and ErbB2 and genetic glioma risk variants: a nested case-control study

Tumor Biology, Vol. 37, (8) : 11065-11072

Späth, Florentin; Andersson, Ulrika; Dahlin, Anna M.; et al.

CCND2, CTNNB1, DDX3X, GLI2, SMARCA4, MYC, MYCN, PTCH1, TP53, and MLL2 gene variants and risk of childhood medulloblastoma

Journal of Neuro-Oncology, Vol. 125, (1) : 75-78

Dahlin, Anna M.; Hollegaard, Mads V.; Wibom, Carl; et al.

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Journal of the National Cancer Institute, Vol. 107, (12)

Sampson, Joshua N.; Wheeler, William A.; Yeager, Meredith; et al.

Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data

Human Mutation, Vol. 36, (7) : 684-688

Wang, Zhaoming; Rajaraman, Preetha; Melin, Beatrice S.; et al.

Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case-Control Study

Cancer Epidemiology, Biomarkers and Prevention, Vol. 24, (5) : 810-816

Wibom, Carl; Späth, Florentin; Dahlin, Anna M.; et al.

Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer

Neuro-Oncology, Oxford University Press 2014, Vol. 16, (10) : 1333-1340

Andersson, Ulrika; Wibom, Carl; Cederquist, Kristina; et al.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Human Molecular Genetics, Vol. 23, (24) : 6616-6633

Wang, Zhaoming; Zhu, Bin; Zhang, Mingfeng; et al.

Glioma Gwas Hits - Markers for Risk or for Prognosis?

Neuro-Oncology, Oxford University Press 2014, Vol. 16, (Suppl. 2) : ii109-ii110

Wibom, Carl; Spaeth, Florentin; Dahlin, Anna; et al.

Known glioma risk loci are associated with glioma with a family history of brain tumours: a case-control gene association study

International Journal of Cancer, Vol. 132, (10) : 2464-2468

Melin, Beatrice; Dahlin, Anna M; Andersson, Ulrika; et al.

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69

Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.

Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression

Journal of Neuro-Oncology, Vol. 108, (3) : 435-441

Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.

Detectable clonal mosaicism and its relationship to aging and cancer.

Nature Genetics, New York: Nature Publishing Group 2012, Vol. 44, (6) : 651-658

Jacobs, Kevin B; Yeager, Meredith; Zhou, Weiyin; et al.

Association between adult height, genetic susceptibility and risk of glioma.

International Journal of Epidemiology, Vol. 41, (4) : 1075-1085

Kitahara, Cari M; Wang, Sophia S; Melin, Beatrice S; et al.

Insight in glioma susceptibility through an analysis of 6p22.3, 12p13.33-12.1, 17q22-23.2 and 18q23 SNP genotypes in familial and non-familial glioma

Human Genetics, Vol. 131, (9) : 1507-1517

Liu, Yanhong; Melin, Beatrice S; Rajaraman, Preetha; et al.

hTERT Cancer Risk Genotypes Are Associated With Telomere Length

Genetic Epidemiology, Malden: Wiley-Blackwell 2012, Vol. 36, (4) : 368-372

Melin, Beatrice S.; Nordfjall, Katarina; Andersson, Ulrika; et al.

Genome-wide association study of glioma and meta-analysis

Human Genetics, Vol. 131, (12) : 1877-1888

Rajaraman, Preetha; Melin, Beatrice S; Wang, Zhaoming; et al.

EGFR expression and glioblastoma outcome

Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 19-19

Sjöström, Sara; Ghasimi, Soma; Broholm, H.; et al.

EGFR gene variants are associated with specific somatic aberrations in glioma

Neuro-Oncology, Vol. 14, (Suppl. 3) : 46-46

Wibom, Carl; Ghasimi, Soma; Van Loo, P.; et al.

EGFR gene variants are associated with specific somatic aberrations in glioma

PLoS ONE, plosone.org 2012, Vol. 7, (12) : e47929-

Wibom, Carl; Ghasimi, Soma; Van Loo, Peter; et al.

DNA-repair gene variants are associated with glioblastoma survival

Acta Oncologica, Informa Healthcare 2012, Vol. 51, (3) : 325-332

Wibom, Carl; Sjöström, Sara; Henriksson, Roger; et al.

Analysis of DNA repair gene polymorphisms and survival in low-grade and anaplastic gliomas

Journal of Neuro-Oncology, Vol. 105, (3) : 531-538

Berntsson, Shala Ghaderi; Wibom, Carl; Sjöström, Sara; et al.

Common variation at 10p12.31 near MLLT10 influences meningioma risk

Nature Genetics, London: Nature America, Inc. 2011, Vol. 43, (9) : 825-827

Dobbins, Sara E.; Broderick, Peter; Melin, Beatrice; et al.

Genetic variations in VEGF and VEGFR2 and glioblastoma outcome

Journal of Neuro-Oncology, Boston: Nijhoff 2011, Vol. 104, (2) : 523-527

Sjöström, Sara; Wibom, Carl; Andersson, Ulrika; et al.

A comprehensive study of the association between the EGFR and ERBB2 genes and glioma risk

Acta Oncologica, Informa Healthcare 2010, Vol. 49, (6) : 767-775

Andersson, Ulrika; Schwartzbaum, Judith; Wiklund, Fredrik; et al.

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival

Journal of Clinical Oncology, American Society of Clinical Oncology 2010, Vol. 28, (14) : 2467-2474

Liu, Yanhong; Shete, Sanjay; Etzel, Carol J; et al.

Survey of familial glioma and role of germline p16INK4A/p14ARF and p53 mutation

Familial Cancer, Vol. 9, (3) : 413-421

Robertson, Lindsay B; Armstrong, Georgina N; Olver, Bianca D; et al.

Genetic variations in EGF and EGFR and glioblastoma outcome

Neuro-Oncology, Vol. 12, (8) : 815-821

Sjöström, Sara; Andersson, Ulrika; Liu, Yanhong; et al.

Genetic variants in association studies: review of strengths and weaknesses in study design and current knowledge of impact on cancer risk

Acta Oncologica, Vol. 48, (7) : 948-954

Andersson, Ulrika; McKean-Cowdin, Roberta; Hjalmars, Ulf; et al.

MNS16A minisatellite genotypes in relation to risk of glioma and meningioma and to glioblastoma outcome.

International journal of cancer. Journal international du cancer, Vol. 125, (4) : 968-972

Andersson, Ulrika; Osterman, Pia; Sjöström, Sara; et al.

Genome-wide association study identifies five susceptibility loci for glioma.

Nature Genetics, Vol. 41, (8) : 899-904

Shete, Sanjay; Hosking, Fay J; Robertson, Lindsay B; et al.

Treatment schedule is of importance when gefitinib is combined with irradiation of glioma and endothelial cells in vitro.

Acta Oncologica, Vol. 46, (7) : 951-960

Andersson, Ulrika; Johansson, David; Behnam-Motlagh, Parviz; et al.

Verotoxin-1 Induction of Apoptosis in Gb3-Expressing Human Glioma Cell Lines

Cancer Biology & Therapy, Vol. 5, (9) : 1211-1217

Johansson, David; Johansson, Anders; Grankvist, Kjell; et al.

Experimental studies in brain tumours: with special regard to multidrug resistance and the ErbB-family

Umeå University medical dissertations, 959

Andersson, Ulrika

Epidermal growth factor receptor family (EGFR, ErbB2-4) in gliomas and meningiomas

Acta Neuropathologica, Vol. 108, (2) : 135-142

Andersson, Ulrika; Guo, Dongsheng; Malmer, Beatrice; et al.

Heterogeneity in the expression of markers for drug resistance in brain tumors

Clinical Neuropathology, Vol. 23, (1) : 21-27

Andersson, Ulrika; Malmer, Beatrice; Bergenheim, A Tommy; et al.

The tyrosine kinase inhibitor ZD6474 inhibits tumour growth in an intracerebral rat glioma model

British Journal of Cancer, Vol. 91, (6) : 1174-1180

Sandström, Maria; Johansson, Mikael; Andersson, Ulrika; et al.

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Forskningsprojekt

1 september 2010

U-CAN