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Maria Fällman Lab

Research group Our research aims at understanding molecular mechanisms behind the ability of bacteria to adapt to different environments. The diverse and complex pathways involved in adaption are attractive as targets for new antimicrobial agents.

The research in the Fallman Lab aims at understanding molecular mechanisms behind the ability of bacteria to adapt to different environments. The diverse and complex pathways involved in adaption are attractive as targets for new antimicrobials.

The lab was behind the finding that sub-lethal doses of Yersinia result in persistent infection in mice and that reprogramming of Yersinia gene expression occurs during the persistent state. This involves downregulation of classical virulence genes and upregulation of genes important for adaption to external stress. Mouse infections models of Yersinia pseudotuberculosis and Salmonella enterica Typhimurium are commonly used experimental models.

Current focus is on gene regulation critical for establishment and maintenance of infection in host tissue, involving bacterial adaption mechanisms critical for maintenance of infection. Methodological approaches involve transcriptomic analyses combined with classical molecular biology methods and diverse bacterial functional studies. They recently launced a database PATHOgenex (http://www.pathogenex.org) with gene expression data of more than 30 human pathogens exposed to different stress conditions. The group has put a lot of efforts to develop advanced methods for RNA extraction from complex tissue samples and performs in vivo gene expression analyses of both Yersinia and Salmonella. Data analyses are now expanded to include analyses of heterogenous gene expression and system biology and machine learning, approaches to resolve complexity.

Another interest in the group is regulation of and molecular mechanism behind induction of expression and translation of genes on the Yersinia virulence plasmid, with subsequent virulence effector translocation by the Type Three Secretion System (T3SS). Together with the Wolf-Watz lab they previously demonstrated the alternative mechanism for T3SS delivery from the bacterial surface. Current work focuses on the molecular mechanisms behind the on/off switch for expression and translocation of T3SS as well as other regulatory mechanisms involved in virulence induction.

More information:

Fällman lab

About Maria Fällman's research on MIMS website

 

Recent Publications

Bioinformatics, UK: Oxford University Press 2021, Vol. 37, (1) : 126-128
Mahmud, A. K. M. Firoj; Delhomme, Nicolas; Nandi, Soumyadeep; et al.
Nature Communications, Springer Nature 2021, Vol. 12, (1)
Avican, Kemal; Aldahdooh, Jehad; Togninalli, Matteo; et al.
Infection and Immunity, American Society for Microbiology 2021, Vol. 89, (4)
Schneiders, Stephan; Hechard, Tifaine; Edgren, Tomas; et al.
Molecular Oncology, John Wiley & Sons 2021, Vol. 15, (4) : 968-986
Semenas, Julius; Wang, Tianyan; Khaja, Azharuddin Sajid Syed; et al.
mSystem, Vol. 5, (6)
Mahmud, A. K. M. Firoj; Nilsson, Kristina; Fahlgren, Anna; et al.
Journal of Proteomics, Vol. 195 : 33-40
Taheri, Nayyer; Fällman, Maria; Wai, Sun Nyunt; et al.
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Taheri, Nayyer; Mahmud, A K M Firoj; Sandblad, Linda; et al.
Science, Vol. 353, (6298) : 492-495
Wang, He; Avican, Kemal; Fahlgren, Anna; et al.
Frontiers in Cellular and Infection Microbiology, Vol. 6
Ekestubbe, Sofie; Bröms, Jeanette E.; Edgren, Tomas; et al.
Infection and Immunity, Vol. 84, (12) : 3369-3378
Taheri, Nayyer; Fahlgren, Anna; Fällman, Maria
PLOS ONE, Vol. 10, (8)
Bahnan, Wael; Boettner, Douglas R.; Westermark, Linda; et al.
PLoS Pathogens, Vol. 11, (1)
Avican, Kemal; Fahlgren, Anna; Huss, Mikael; et al.
PLOS ONE, Vol. 9, (1) : e87859-
Erttmann, Saskia F.; Gekara, Nelson O.; Fällman, Maria
Infection and Immunity, American Society for Microbiology 2014, Vol. 82, (8) : 3471-3482
Fahlgren, Anna; Avican, Kemal; Westermark, Linda; et al.
Infection and Immunity, Vol. 82, (3) : 1181-1191
Westermark, Linda; Fahlgren, Anna; Fällman, Maria
PLOS ONE, Vol. 8, (2)
Antti, Henrik; Fahlgren, Anna; Näsström, Elin; et al.
Infection and Immunity, Vol. 81, (1) : 11-22
Thorslund, Sara E; Ermert, David; Fahlgren, Anna; et al.
Cellular Microbiology, Wiley-Blackwell 2013, Vol. 15, (7) : 1088-1110
Costa, Tiago; Amer, Ayad; Farag, Salah; et al.
Infection, Genetics and Evolution, Elsevier 2012, Vol. 12, (8) : 1729-1742
Costa, Tiago R. D.; Amer, Ayad A. A.; Fällman, Maria; et al.

Head of research

Maria Fällman
Research fellow, professor
E-mail
Email

Overview

Participating departments and units at Umeå University

Department of Molecular Biology

Research area

Infection biology
MIMS Spotlight Series: Nóra meets post doctor Barbara Forró

Barbaras goal was to work with bioinformatics, programing, sequence data analyses.

A new way to uncover targets for future antibiotics

Maria Fällman and Kemal Avican made their idea into a interdisciplinary project together with Icelab.

Latest update: 2023-01-31