Anders Hofer

Nucleotide biosynthesis in the parasite Typanosoma brucei

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Works at

Associate professor at Department of Medical Biochemistry and Biophysics Role: Director of studies

KB.H6, Campus, Umeå, A6.50.15 Umeå universitet, 901 87 Umeå

African sleeping sickness is caused by Trypanosoma brucei. We study how this parasite makes the building blocks of RNA and DNA.

14-3-3 activated bacterial exotoxins AexT and ExoT share actin and the SH2 domains of CRK proteins as targets for ADP-ribosylation

Pathogens, MDPI 2022, Vol. 11, (12)

Ebenwaldner, Carmen; Hornyak, Peter; García-Saura, Antonio Ginés; et al.

HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase

Biochemistry, American Chemical Society (ACS) 2022, Vol. 61, (15) : 1633-1641

Fietze, Tobias; Wilk, Piotr; Kabinger, Florian; et al.

Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2022, Vol. 298, (6)

Krakovka, Sascha; Ranjbarian, Farahnaz; Luján, Lucas A.; et al.

Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness

Inorganic Chemistry, American Chemical Society (ACS) 2022, Vol. 61, (34) : 13561-13575

Marchetti, Fabio; Tombesi, Alessia; Di Nicola, Corrado; et al.

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples

Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (3)

Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.

Structural and Biochemical Investigation of Class i Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus

Biochemistry, Vol. 61, (2) : 92-106

Rehling, Daniel; Scaletti, Emma Rose; Rozman Grinberg, Inna; et al.

Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents

Antibiotics, MDPI 2021, Vol. 10, (11)

Baldassarri, Cecilia; Falappa, Giulia; Mazzara, Eugenia; et al.

Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr.

Molecules, MDPI 2020, Vol. 25, (14)

Frezza, Claudio; Venditti, Alessandro; Bianco, Armandodoriano; et al.

A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (46) : 15576-15587

Martinez-Carranza, Markel; Jonna, Venkateswara Rao; Lundin, Daniel; et al.

The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (33) : 11891-11901

Nemeth, Brigitta; Land, Henrik; Magnuson, Ann; et al.

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio

Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277

Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Nature Communications, Nature Publishing Group 2019, Vol. 10

Hulpia, Fabian; Mabille, Dorien; Campagnaro, Gustavo D.; et al.

Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects

Environmental Science and Pollution Research, Vol. 25, (11) : 10184-10206

Benelli, Giovanni; Maggi, Filippo; Pavela, Roman; et al.

Novel ATP-Cone-Driven Allosteric Regulation of Ribonucleotide Reductase Via the Radical-Generating Subunit

Protein Science, Wiley-Blackwell 2018, Vol. 27 : 87-88

Grinberg, Inna; McGann, Matthew; Lundin, Daniel; et al.

Formation of a Secretion-Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism

Journal of Molecular Biology, Elsevier 2018, Vol. 430, (18, Part B) : 3157-3169

Gupta, Arun A.; Reinartz, Ines; Karunanithy, Gogulan; et al.

Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family

Ecotoxicology and Environmental Safety, Elsevier 2018, Vol. 156 : 154-165

Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Cianfaglione, Kevin; et al.

Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit

eLIFE, ELIFE SCIENCES PUBLICATIONS LTD 2018, Vol. 7

Rozman Grinberg, Inna; Lundin, Daniel; Hasan, Mahmudul; et al.

A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (41) : 15889-15900

Rozman Grinberg, Inna; Lundin, Daniel; Sahlin, Margareta; et al.

PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction

Molecular Microbiology, John Wiley & Sons 2018, Vol. 109, (3) : 291-305

Schmitt, Andreas; Jiang, Kai; Camacho, Martha I.; et al.

Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation

Fitoterapia (Milano), Elsevier 2018, Vol. 124 : 145-151

Sut, Stefania; Dall'Acqua, Stefano; Baldan, Valeria; et al.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389

Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.

Global Disordering in Stereo-Specific Protein Association

Biophysical Journal, CELL PRESS 2017, Vol. 112, (3) : 33A-33A

Gupta, Arun; Reinartz, Ines; Spilotros, Alessandro; et al.

Trypanosoma brucei Inhibition by Essential Oils from Medicinal and Aromatic Plants Traditionally Used in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus)

International Journal of Environmental Research and Public Health, MDPI AG 2017, Vol. 14, (7)

Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Campagnaro, Gustavo Daniel; et al.

A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover

Journal of Biological Chemistry, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017, Vol. 292, (46) : 19044-19054

Loderer, Christoph; Jonna, Venkateswara Rao; Crona, Mikael; et al.

An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis

Parasitology international, Vol. 66, (2) : 146-151

Petrelli, Riccardo; Ranjbarian, Farahnaz; Dall'Acqua, Stefano; et al.

9-(2 '-Deoxy-2 '-Fluoro-beta-D-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance

Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2017, Vol. 61, (6)

Ranjbarian, Farahnaz; Vodnala, Munender; Alzahrani, Khalid J. H.; et al.

Biochemical Characterization of Kat1: a Domesticated hAT-Transposase that Induces DNA Hairpin Formation and MAT-Switching

Scientific Reports, Nature Publishing Group 2016, Vol. 6

Chiruvella, Kishore K; Rajaei, Naghmeh; Jonna, Venkateswara Rao; et al.

A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity

Molecular Oncology, Vol. 10, (9) : 1375-1386

Crona, Mikael; Codo, Paula; Jonna, Venkateswara Rao; et al.

Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones

Structure, Vol. 24, (6) : 906-917

Johansson, Renzo; Jonna, Venkateswara Rao; Kumar, Rohit; et al.

Biological Activities of the Essential Oil from Erigeron floribundus

Molecules, Vol. 21, (8)

Petrelli, Riccardo; Orsomando, Giuseppe; Sorci, Leonardo; et al.

VP3 is crucial for the stability of Nora virus virions

Virus Research, Elsevier 2016, Vol. 223 : 20-27

Sadanandan, Sajna Anand; Ekström, Jens-Ola; Jonna, Venkateswara Rao; et al.

Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES

Journal of Biological Chemistry, Vol. 291, (22) : 11717-11726

Vodnala, Munender; Ranjbarian, Farahnaz; Pavlova, Anna; et al.

Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa

PLOS ONE, Vol. 10, (7)

Crona, Mikael; Hofer, Anders; Astorga-Wells, Juan; et al.

Diversity in Overall Activity Regulation of Ribonucleotide Reductase

Journal of Biological Chemistry, Vol. 290, (28) : 17339-17348

Jonna, Venkateswara Rao; Crona, Mikael; Rofougaran, Reza; et al.

From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine

Bioorganic & Medicinal Chemistry Letters, Vol. 24, (22) : 5304-5309

Petrelli, Riccardo; Meli, Maria; Vita, Patrizia; et al.

Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine

Journal of Biological Chemistry, Vol. 289, (19) : 13054-13065

Vande Voorde, Johan; Sabuncuoglu, Suna; Noppen, Sam; et al.

Transmitting the allosteric signal in methylglyoxal synthase

Protein Engineering Design & Selection, Oxford University Press 2013, Vol. 26, (7) : 445-452

Falahati, Hanieh; Pazhang, Mohammad; Zareian, Shekufeh; et al.

Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase

Phytochemistry, Vol. 79 : 39-45

Decker, Daniel; Meng, Meng; Gornicka, Agnieszka; et al.

DNA building blocks: keeping control of manufacture

Critical reviews in biochemistry and molecular biology, London: Informa Healthcare 2012, Vol. 47, (1) : 50-63

Hofer, Anders; Crona, Mikael; Logan, Derek T; et al.

Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding

Journal of Biological Chemistry, Vol. 287, (21) : 17628-17636

Ranjbarian, Farahnaz; Vodnala, Munender; Vodnala, Sharvani Munender; et al.

Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.

Nucleic Acids Research, Oxford Journals 2011, Vol. 39, (4) : 1381-9

Crona, Mikael; Moffatt, Connor; Friedrich, Nancy C; et al.

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis

Journal of Biological Chemistry, Bethesda, Md.: American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (38) : 33053-33060

Crona, Mikael; Torrents, Eduard; Rohr, Asmund K.; et al.

Ribosylurea accumulates in yeast urc4 mutants

Nucleosides, Nucleotides & Nucleic Acids, Vol. 29, (4-6) : 433-437

Björnberg, O; Vodnala, Munender; Domkin, Vladimir; et al.

Cryo-EM reveals promoter DNA binding and conformational flexibility of the general transcription factor TFIID

Structure, Vol. 17, (11) : 1442-1452

Elmlund, Hans; Baraznenok, Vera; Linder, Tomas; et al.

A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes.

Journal of Molecular Biology, Vol. 380, (4) : 656-66

Andersen, Gorm; Björnberg, Olof; Polakova, Silvia; et al.

The N-terminal domain of TWINKLE contributes to single-stranded DNA binding and DNA helicase activities.

Nucleic Acids Research, Vol. 36, (2) : 393-403

Farge, Géraldine; Holmlund, Teresa; Khvorostova, Julia; et al.

Oligomerization status directs overall activity regulation of the Escherichia coli class Ia ribonucleotide reductase

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2008, Vol. 283, (51) : 35310-35318

Rofougaran, Reza; Crona, Mikael; Vodnala, Munender; et al.

Adenosine kinase mediates high affinity adenosine salvage in Trypanosoma brucei

Journal of Biological Chemistry, Vol. 283, (9) : 5380-5388

Vodnala, Munender; Fijolek, Artur; Rofougaran, Reza; et al.

Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.

Journal of biological chemistry, Vol. 282, (16) : 11858-11865

Fijolek, Artur; Hofer, Anders; Thelander, Lars

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells.

Journal of Biological Chemistry, Vol. 281, (12) : 7834-7841

Håkansson, Pelle; Hofer, Anders; Thelander, Lars

View publications in DiVA

Research groups

Head of research

Anders Hofer

Research projects

21 July 2016 until 1 January 2020

Nucleotide metabolism - enzymes, pathways and drug discovery