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Staff photo Anders Hofer

Anders Hofer

Associate Professor and docent in Medical Biochemistry

 

Research qualifications: Docent
Educational qualifications: Recognised university teacher

Contact

E-mail
anders.hofer@umu.se
Phone
+46 70 297 40 96

Works as

Affiliation
Associate professor at Department of Medical Biochemistry and Biophysics Role: Director of studies
Location
KB.H6, Campus, Umeå, A6.50.15 Umeå universitet, 901 87 Umeå

I am researching nucleotide metabolism – enzymes, regulation and drug development.

Nucleotides have central roles in cellular metabolism by being energy donors and building blocks in DNA and RNA. In my research group, we are studying the regulation of some of the enzymes involved in the nucleotide metabolism with the focus on ribonucleotide reductase and nucleoside kinases.

This research includes the study of nucleotide metabolism in several pathogens where we try to exploit differences in nucleotide metabolism compared to mammalian cells in order to selectively kill the pathogens with minimized side effects.

Activating AMPK improves pathological phenotypes due to mtDNA depletion
The FEBS Journal
Carvalho, Gustavo; Nguyen, Tran V. H.; Repolês, Bruno Marçal; et al.
How tumors hijack macrophages for immune evasion
Nature Cancer, Springer Nature 2024, Vol. 5, (8) : 1134-1135
Hofer, Anders
A charged tail on anti-α-synuclein antibodies does not enhance their affinity to α-synuclein fibrils
PLOS ONE, Public Library of Science (PLoS) 2024, Vol. 19, (8)
Petersen, Inga; Godec, Ana; Ranjbarian, Farahnaz; et al.
A shorter linker in the bispecific antibody RmAb158-scFv8D3 improves TfR-mediated blood-brain barrier transcytosis in vitro
Scientific Reports, Springer Nature 2024, Vol. 14, (1)
Petersen, Inga; Morrison, Jamie I.; Petrovic, Alex; et al.
Quantification of all 12 canonical ribonucleotides by real-time fluorogenic in vitro transcription
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (1)
Purhonen, Janne; Hofer, Anders; Kallijärvi, Jukka
Tetramerization of deoxyadenosine kinase meets the demands of a DNA replication substrate challenge in Giardia intestinalis
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (22) : 14061-14076
Ranjbarian, Farahnaz; Rafie, Karim; Shankar, Kasturika; et al.
NUDT6 and NUDT9, two mitochondrial members of the NUDIX family, have distinct hydrolysis activities
Mitochondrion (Amsterdam. Print), Elsevier 2023, Vol. 71 : 93-103
Debar, Louis; Ishak, Layal; Moretton, Amandine; et al.
Targeting the nucleotide metabolism of Trypanosoma brucei and other trypanosomatids
FEMS Microbiology Reviews, Oxford University Press 2023, Vol. 47, (3)
Hofer, Anders
14-3-3 activated bacterial exotoxins AexT and ExoT share actin and the SH2 domains of CRK proteins as targets for ADP-ribosylation
Pathogens, MDPI 2022, Vol. 11, (12)
Ebenwaldner, Carmen; Hornyak, Peter; García-Saura, Antonio Ginés; et al.
HUG Domain Is Responsible for Active Dimer Stabilization in an NrdJd Ribonucleotide Reductase
Biochemistry, American Chemical Society (ACS) 2022, Vol. 61, (15) : 1633-1641
Fietze, Tobias; Wilk, Piotr; Kabinger, Florian; et al.
Giardia intestinalis thymidine kinase is a high-affinity enzyme crucial for DNA synthesis and an exploitable target for drug discovery
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2022, Vol. 298, (6)
Krakovka, Sascha; Ranjbarian, Farahnaz; Luján, Lucas A.; et al.
Zinc(II) Complex with Pyrazolone-Based Hydrazones is Strongly Effective against Trypanosoma brucei Which Causes African Sleeping Sickness
Inorganic Chemistry, American Chemical Society (ACS) 2022, Vol. 61, (34) : 13561-13575
Marchetti, Fabio; Tombesi, Alessia; Di Nicola, Corrado; et al.
Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (3)
Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.
Structural and Biochemical Investigation of Class i Ribonucleotide Reductase from the Hyperthermophile Aquifex aeolicus
Biochemistry, Vol. 61, (2) : 92-106
Rehling, Daniel; Scaletti, Emma Rose; Rozman Grinberg, Inna; et al.
Antitrypanosomal Activity of Anthriscus Nemorosa Essential Oils and Combinations of Their Main Constituents
Antibiotics, MDPI 2021, Vol. 10, (11)
Baldassarri, Cecilia; Falappa, Giulia; Mazzara, Eugenia; et al.
Phytochemical Analysis and Trypanocidal Activity of Marrubium incanum Desr.
Molecules, MDPI 2020, Vol. 25, (14)
Frezza, Claudio; Venditti, Alessandro; Bianco, Armandodoriano; et al.
A ribonucleotide reductase from Clostridium botulinum reveals distinct evolutionary pathways to regulation via the overall activity site
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (46) : 15576-15587
Martinez-Carranza, Markel; Jonna, Venkateswara Rao; Lundin, Daniel; et al.
The maturase HydF enables [FeFe] hydrogenase assembly via transient, cofactor-dependent interactions
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2020, Vol. 295, (33) : 11891-11901
Nemeth, Brigitta; Land, Henrik; Magnuson, Ann; et al.
Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness
Nature Communications, Nature Publishing Group 2019, Vol. 10
Hulpia, Fabian; Mabille, Dorien; Campagnaro, Gustavo D.; et al.
Mosquito control with green nanopesticides: towards the One Health approach? A review of non-target effects
Environmental Science and Pollution Research, Vol. 25, (11) : 10184-10206
Benelli, Giovanni; Maggi, Filippo; Pavela, Roman; et al.
Novel ATP-Cone-Driven Allosteric Regulation of Ribonucleotide Reductase Via the Radical-Generating Subunit
Protein Science, Wiley-Blackwell 2018, Vol. 27 : 87-88
Grinberg, Inna; McGann, Matthew; Lundin, Daniel; et al.
Formation of a Secretion-Competent Protein Complex by a Dynamic Wrap-around Binding Mechanism
Journal of Molecular Biology, Elsevier 2018, Vol. 430, (18, Part B) : 3157-3169
Gupta, Arun A.; Reinartz, Ines; Karunanithy, Gogulan; et al.
Identification of highly effective antitrypanosomal compounds in essential oils from the Apiaceae family
Ecotoxicology and Environmental Safety, Elsevier 2018, Vol. 156 : 154-165
Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Cianfaglione, Kevin; et al.
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
eLIFE, ELIFE SCIENCES PUBLICATIONS LTD 2018, Vol. 7
Rozman Grinberg, Inna; Lundin, Daniel; Hasan, Mahmudul; et al.
A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2018, Vol. 293, (41) : 15889-15900
Rozman Grinberg, Inna; Lundin, Daniel; Sahlin, Margareta; et al.
PrgB promotes aggregation, biofilm formation, and conjugation through DNA binding and compaction
Molecular Microbiology, John Wiley & Sons 2018, Vol. 109, (3) : 291-305
Schmitt, Andreas; Jiang, Kai; Camacho, Martha I.; et al.
Identification of tagitinin C from Tithonia diversifolia as antitrypanosomal compound using bioactivity-guided fractionation
Fitoterapia (Milano), Elsevier 2018, Vol. 124 : 145-151
Sut, Stefania; Dall'Acqua, Stefano; Baldan, Valeria; et al.
Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
Cell Host and Microbe, CELL PRESS 2017, Vol. 21, (3) : 376-389
Bugaytsova, Jeanna A.; Björnham, Oscar; Chernov, Yevgen A.; et al.
Global Disordering in Stereo-Specific Protein Association
Biophysical Journal, CELL PRESS 2017, Vol. 112, (3) : 33A-33A
Gupta, Arun; Reinartz, Ines; Spilotros, Alessandro; et al.
Trypanosoma brucei Inhibition by Essential Oils from Medicinal and Aromatic Plants Traditionally Used in Cameroon (Azadirachta indica, Aframomum melegueta, Aframomum daniellii, Clausena anisata, Dichrostachys cinerea and Echinops giganteus)
International Journal of Environmental Research and Public Health, MDPI AG 2017, Vol. 14, (7)
Kamte, Stephane L. Ngahang; Ranjbarian, Farahnaz; Campagnaro, Gustavo Daniel; et al.
A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover
Journal of Biological Chemistry, AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 2017, Vol. 292, (46) : 19044-19054
Loderer, Christoph; Jonna, Venkateswara Rao; Crona, Mikael; et al.
An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis
Parasitology international, Vol. 66, (2) : 146-151
Petrelli, Riccardo; Ranjbarian, Farahnaz; Dall'Acqua, Stefano; et al.
9-(2 '-Deoxy-2 '-Fluoro-beta-D-Arabinofuranosyl) Adenine Is a Potent Antitrypanosomal Adenosine Analogue That Circumvents Transport-Related Drug Resistance
Antimicrobial Agents and Chemotherapy, American Society for Microbiology 2017, Vol. 61, (6)
Ranjbarian, Farahnaz; Vodnala, Munender; Alzahrani, Khalid J. H.; et al.
Biochemical Characterization of Kat1: a Domesticated hAT-Transposase that Induces DNA Hairpin Formation and MAT-Switching
Scientific Reports, Nature Publishing Group 2016, Vol. 6
Chiruvella, Kishore K; Rajaei, Naghmeh; Jonna, Venkateswara Rao; et al.
A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity
Molecular Oncology, Vol. 10, (9) : 1375-1386
Crona, Mikael; Codo, Paula; Jonna, Venkateswara Rao; et al.
Structural Mechanism of Allosteric Activity Regulation in a Ribonucleotide Reductase with Double ATP Cones
Structure, Vol. 24, (6) : 906-917
Johansson, Renzo; Jonna, Venkateswara Rao; Kumar, Rohit; et al.
Biological Activities of the Essential Oil from Erigeron floribundus
Molecules, Vol. 21, (8)
Petrelli, Riccardo; Orsomando, Giuseppe; Sorci, Leonardo; et al.
VP3 is crucial for the stability of Nora virus virions
Virus Research, Elsevier 2016, Vol. 223 : 20-27
Sadanandan, Sajna Anand; Ekström, Jens-Ola; Jonna, Venkateswara Rao; et al.
Trypanosoma brucei Methylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine: IMPLICATIONS FOR THE PHARMACOLOGY OF ADENOSINE ANTIMETABOLITES
Journal of Biological Chemistry, Vol. 291, (22) : 11717-11726
Vodnala, Munender; Ranjbarian, Farahnaz; Pavlova, Anna; et al.
Biochemical Characterization of the Split Class II Ribonucleotide Reductase from Pseudomonas aeruginosa
PLOS ONE, Vol. 10, (7)
Crona, Mikael; Hofer, Anders; Astorga-Wells, Juan; et al.
Diversity in Overall Activity Regulation of Ribonucleotide Reductase
Journal of Biological Chemistry, Vol. 290, (28) : 17339-17348
Jonna, Venkateswara Rao; Crona, Mikael; Rofougaran, Reza; et al.
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase: Synthesis and biological evaluation of valproic esters of 3'-C-methyladenosine
Bioorganic & Medicinal Chemistry Letters, Vol. 24, (22) : 5304-5309
Petrelli, Riccardo; Meli, Maria; Vita, Patrizia; et al.
Nucleoside-catabolizing Enzymes in Mycoplasma-infected Tumor Cell Cultures Compromise the Cytostatic Activity of the Anticancer Drug Gemcitabine
Journal of Biological Chemistry, Vol. 289, (19) : 13054-13065
Vande Voorde, Johan; Sabuncuoglu, Suna; Noppen, Sam; et al.
Transmitting the allosteric signal in methylglyoxal synthase
Protein Engineering Design & Selection, Oxford University Press 2013, Vol. 26, (7) : 445-452
Falahati, Hanieh; Pazhang, Mohammad; Zareian, Shekufeh; et al.
Substrate kinetics and substrate effects on the quaternary structure of barley UDP-glucose pyrophosphorylase
Phytochemistry, Vol. 79 : 39-45
Decker, Daniel; Meng, Meng; Gornicka, Agnieszka; et al.
DNA building blocks: keeping control of manufacture
Critical reviews in biochemistry and molecular biology, London: Informa Healthcare 2012, Vol. 47, (1) : 50-63
Hofer, Anders; Crona, Mikael; Logan, Derek T; et al.
Trypanosoma brucei thymidine kinase is tandem protein consisting of two homologous parts, which together enable efficient substrate binding
Journal of Biological Chemistry, Vol. 287, (21) : 17628-17636
Ranjbarian, Farahnaz; Vodnala, Munender; Vodnala, Sharvani Munender; et al.
Assembly of a fragmented ribonucleotide reductase by protein interaction domains derived from a mobile genetic element.
Nucleic Acids Research, Oxford Journals 2011, Vol. 39, (4) : 1381-9
Crona, Mikael; Moffatt, Connor; Friedrich, Nancy C; et al.
NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
Journal of Biological Chemistry, Bethesda, Md.: American Society for Biochemistry and Molecular Biology 2011, Vol. 286, (38) : 33053-33060
Crona, Mikael; Torrents, Eduard; Rohr, Asmund K.; et al.
View publications in DiVA

Research groups

Head of research
Anders Hofer

Research projects

1 January 2020 until 31 December 2025
Targeting human pathogens dependent on the host for nucleotide supply
21 July 2016 until 1 January 2020
Nucleotide metabolism - enzymes, pathways and drug discovery

I am teaching in semester 1-3 of the Medical Programme and in the first semester of the Dentistry Programme. I am also responsible for the first semester of the Medical Programme and a member of the programme board (PRL).