Anna Överby Wernstedt

Contact

anna.overby@umu.se

+46 90 785 09 22

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Associate professor at Department of Clinical Microbiology Units: Section of Virology

Virologi, Plan 4, Universitetssjukhuset by 6M, 6111 Umeå universitet, 901 85 Umeå

Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS) Units: Research groups

6F, Virologi, Universitetssjukhuset, 414 Klinisk mikrobiologi - virologi, 90185 Umeå

PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation

Brain Pathology, John Wiley & Sons 2021, Vol. 31, (1) : 103-119

Reimer, Lasse; Betzer, Cristine; Kofoed, Rikke Hahn; et al.

COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial

Trials, BioMed Central 2021, Vol. 22, (1)

Welén, Karin; Överby, Anna K.; Ahlm, Clas; et al.

Antiviral Activity of Benzavir-2 against Emerging Flaviviruses

Viruses, MDPI 2020, Vol. 12, (3)

Gwon, Yong-Dae; Strand, Mårten; Lindquist, Richard; et al.

The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection

Journal of Neuroinflammation, BMC 2020, Vol. 17, (1)

Lindquist, Richard; Rosendal, Ebba; Weber, Elvira; et al.

Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk

Parasites & Vectors, BMC 2020, Vol. 13, (1)

Wallenhammar, Amelie; Lindquist, Richard; Asghar, Naveed; et al.

N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle

Viruses, MDPI 2020, Vol. 12, (9)

Yong-Dae, Kwon; Zusinaite, Eva; Merits, Andres; et al.

Characterizing the cellular attachment receptor for Langat virus

PLOS ONE, Public Library Science 2019, Vol. 14, (6)

Rodrigues, Raquel; Danskog, Katarina; Överby, Anna K.; et al.

Tick-borne encephalitis in Europe and Russia: review of pathogenesis, clinical features, therapy, and vaccines

Antiviral Research, Elsevier 2019, Vol. 164 : 23-51

Ruzek, Daniel; Zupanc, Tatjana Avsic; Borde, Johannes; et al.

Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses

Molecular & Cellular Proteomics, American Society for Biochemistry and Molecular Biology 2019, Vol. 18, (12) : 2401-2417

Uckeley, Zina M.; Moeller, Rebecca; Kuhn, Lars I.; et al.

Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication

Journal of Virology, AMER SOC MICROBIOLOGY 2019, Vol. 93, (18)

Yau, Wai-Lok; Nguyen-Dinh, Van; Larsson, Elin; et al.

Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice

Emerging Infectious Diseases, Centers for Disease control and Prevention 2018, Vol. 24, (9) : 1709-1712

Kurhade, Chaitanya; Schreier, Sarah; Lee, Yi-Ping; et al.

The Role of Viperin in Antiflavivirus Responses

DNA and Cell Biology, Mary Ann Liebert 2018, Vol. 37, (9) : 725-730

Lindquist, Richard; Överby, Anna K.

Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin

Journal of Neuroinflammation, BioMed Central 2018, Vol. 15

Lindqvist, Richard; Kurhade, Chaitanya; Gilthorpe, Jonathan D.; et al.

Tick-Borne Flaviviruses and the Type I Interferon Response

Viruses, MDPI 2018, Vol. 10, (7)

Lindqvist, Richard; Upadhyay, Arunkumar S.; Överby, Anna K.

Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells

Nature Communications, Nature Publishing Group 2018, Vol. 9

Lund, Harald; Pieber, Melanie; Parsa, Roham; et al.

Viperin restricts Zika virus and tick-borne encephalitis virus replication by targeting NS3 for proteasomal degradation

Journal of Virology, American Society for Microbiology 2018, Vol. 92, (7)

Panayiotou, Christakis; Lindqvist, Richard; Kurhade, Chaitanya; et al.

The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication

Virology, Elsevier 2018, Vol. 514 : 216-229

Peña Cárcamo, José R.; Morell, María L.; Vázquez, Cecilia A.; et al.

Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles

Journal of Virology, American Society of Microbiology 2018, Vol. 92, (1)

Vonderstein, Kirstin; Nilsson, Emma; Hubel, Philipp; et al.

Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin

Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2017, Vol. 292, (33) : 13879-13889

Upadhyay, Arunkumar S.; Stehling, Oliver; Panayiotou, Christakis; et al.

The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus

Scientific Reports, Vol. 6

Asghar, Naveed; Lee, Yi-Ping; Nilsson, Emma; et al.

Complete Genome Sequence of a Low-Virulence Tick-Borne Encephalitis Virus Strain

Microbiology Resource Announcements, Washington: American Society for Microbiology 2016, Vol. 4, (5)

Dobler, G.; Bestehorn, M.; Antwerpen, M.; et al.

Human Tick-Borne Encephalitis and Characterization of Virus from Biting Tick

Emerging Infectious Diseases, Centers for Disease Control and Prevention 2016, Vol. 22, (8) : 1485-1487

Henningsson, Anna J.; Lindqvist, Richard; Norberg, Peter; et al.

High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection

Journal of Biomolecular Screening, Sage Publications 2016, Vol. 21, (4) : 354-362

Islam, Md. Koushikul; Baudin, Maria; Eriksson, Jonas; et al.

Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1

Journal of Neuroinflammation, Vol. 13

Kurhade, Chaitanya; Zegenhagen, Loreen; Weber, Elvira; et al.

Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects

Journal of Neuroinflammation, Vol. 13

Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; et al.

Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections

Cytokine & growth factor reviews, Vol. 30 : 95-101

Zegenhagen, Loreen; Kurhade, Chaitanya; Koniszewski, Nikolaus; et al.

Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonist.

Journal of Virology, Vol. 89, (9) : 4849-4856

Rezelj, Veronica V; Överby, Anna K; Elliott, Richard M

Differential innate immune responses in various brain regions regulate antiviral response in the CNS during Tick-borne encephalitis virus infection

Cytokine, Vol. 76, (1) : 91-91

Zegenhagen, Loreen; Weber, Elvira; Kurade, Chaitanya; et al.

Tick-borne encephalitis virus sequenced directly from questing and blood-feeding ticks reveals quasispecies variance

PLOS ONE, Public library science 2014, Vol. 9, (7) : e103264-

Asghar, Naveed; Lindblom, Pontus; Melik, Wessam; et al.

Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity

Cellular Microbiology, Vol. 16, (6) : 834-848

Upadhyay, Arunkumar S.; Vonderstein, Kirstin; Pichlmair, Andreas; et al.

Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses

Journal of Virology, American Society for Microbiology 2014, Vol. 89, (21) : 12202-12212

Weber, Elvira; Finsterbusch, Katja; Lindquist, Richard; et al.

Det tidiga immunförsvaret nyckel i kampen mot TBE-virus

Neurologi i Sverige, Vol. 2, (14) : 68-74

Överby, Anna; Nilsson, Emma

Viperin vs. tick-borne encephalitis virus: Mechanisms of a potent antiviral protein

Cytokine, Academic Press 2013, Vol. 63, (3) : 305-305

Upadhyay, Arunkumar S.; Vonderstein, Kirstin; Pichlmair, Andreas; et al.

Type I interferon protects against lethal Langat virus infection

Cytokine, Academic Press 2013, Vol. 63, (3) : 308-308

Weber, Elvira; Finsterbusch, Katja; Lindqvist, Richard; et al.

Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II

Journal of Biological Chemistry, Vol. 286, (5) : 3681-3692

Verbruggen, Paul; Ruf, Marius; Blakqori, Gjon; et al.

Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion

Virulence, Vol. 2, (3) : 238-240

Överby Wernstedt, Anna; Weber, Friedemann

Hiding from intracellular pattern recognition receptors, a passive strategy of flavivirus immune evasion

Cytokine, Vol. 56 Issue 1

Överby Wernstedt, Anna; Weber, Friedemann

Entry of bunyaviruses into mammalian cells

Cell host & microbe, Vol. 7, (6) : 488-499

Lozach, Pierre-Yves; Mancini, Roberta; Bitto, David; et al.

Tick-borne encephalitis virus delays interferon induction and hides its double-stranded RNA in intracellular membrane vesicles

Journal of Virology, Vol. 84, (17) : 8470-8483

Överby, Anna K; Popov, Vsevolod L; Niedrig, Matthias; et al.

Efficient production of Rift Valley fever virus-like particles: the antiviral protein MxA can inhibit primary transcription of bunyaviruses

Virology, Vol. 385, (2) : 400-408

Habjan, Matthias; Penski, Nicola; Wagner, Valentina; et al.

NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinase

Journal of Virology, Vol. 83, (9) : 4365-4375

Habjan, Matthias; Pichlmair, Andreas; Elliott, Richard M; et al.

Electron cryo-microscopy and single-particle averaging of Rift Valley fever virus: evidence for GN-GC glycoprotein heterodimers

Journal of Virology, Vol. 83, (8) : 3762-3769

Huiskonen, Juha T; Överby, Anna K; Weber, Friedemann; et al.

Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus

Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, (7) : 2375-2379

Överby, Anna K; Pettersson, R F; Grünewald, K; et al.

The glycoprotein cytoplasmic tail of Uukuniemi virus (Bunyaviridae) interacts with ribonucleoproteins and is critical for genome packaging

Journal of Virology, Vol. 81, (7) : 3198-3205

Överby, Anna K; Pettersson, Ralf F; Neve, Etienne P A

The cytoplasmic tails of Uukuniemi Virus (Bunyaviridae) G(N) and G(C) glycoproteins are important for intracellular targeting and the budding of virus-like particles

Journal of Virology, Vol. 81, (20) : 11381-11391

Överby, Anna K; Popov, Vsevolod L; Pettersson, Ralf F; et al.

Regions of importance for interaction of puumala virus nucleocapsid subunits

Virus genes, Vol. 33, (2) : 169-174

Lindgren, Lena; Lindkvist, Marie; Överby, Anna; et al.

Generation and analysis of infectious virus-like particles of uukuniemi virus (bunyaviridae): a useful system for studying bunyaviral packaging and budding

Journal of Virology, American Society for Microbiology 2006, Vol. 80, (21) : 10428-10435

Överby, Anna K; Popov, Vsevolod; Neve, Etienne P A; et al.

Functional analysis of the noncoding regions of the Uukuniemi virus (Bunyaviridae) RNA segments

Journal of Virology, Vol. 78, (21) : 11726-11738

Flick, Kirsten; Katz, Anna; Överby, Anna; et al.

Correlation of disease severity in human tick-borne encephalitis and pathogenicity in mice

Kurhade, Chaitanya; Lee, Yi-Ping; Schreier, Sarah; et al.

Viperin restrict neurotropic flavivirus infection in cell type and region-specific manner

Lindqvist, Richard; Kurhade, Chaitanya; Gilthorpe, Jonathan; et al.

View publications in DiVA

Research groups

Head of research

Anna Överby Wernstedt

Published: 13 May, 2020

Umeå researchers take up the fight against covid-19 with SciLifeLab support

Published: 08 May, 2019

Anna Överby Wernstedt

Published: 14 Dec, 2018

The Swedish Research Council grants 25.2 MSEK to flavivirus project

Aiming to outsmart the TBE virus

The purpose of Anna Överby Wernstedt`s research is finding methods to stop the TBE virus before it spreads.