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Umeå University
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Staff photo Anna Överby Wernstedt

Anna Överby Wernstedt

Professor of immunology with focus on viral infections

Contact

E-mail
anna.overby@umu.se
Phone
+46 90 785 09 22

Works at

Affiliation
Professor at Department of Clinical Microbiology Units: Section of Virology
Location
Virologi, Plan 4, Universitetssjukhuset by 6M, 6111 Umeå universitet, 901 85 Umeå
Affiliation
Affiliated as research fellow at Molecular Infection Medicine Sweden (MIMS) Units: Research groups
Location
6F, Virologi, Universitetssjukhuset, 414 Klinisk mikrobiologi - virologi, 90185 Umeå
Type I interferon shapes brain distribution and tropism of tick-borne flavivirus
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Chotiwan, Nunya; Rosendal, Ebba; Willekens, Stefanie M. A.; et al.
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Mihalič, Filip; Simonetti, Leandro; Giudice, Girolamo; et al.
Simultaneous membrane and RNA binding by tick-borne encephalitis virus capsid protein
PLoS Pathogens, Public Library of Science 2023, Vol. 19, (2)
Pulkkinen, Lauri Ilmari Aurelius; Barrass, Sarah Victoria; Lindgren, Marie; et al.
At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study
Eurosurveillance, European Centre for Disease Control and Prevention (ECDC) 2023, Vol. 28, (13)
Wigren, Julia; Vikström, Linnea; Rosendal, Ebba; et al.
A syntenin inhibitor blocks endosomal entry of SARS-CoV-2 and a panel of RNA viruses
Viruses, MDPI 2022, Vol. 14, (10)
Lindquist, Richard; Benz, Caroline; Sereikaite, Vita; et al.
Convalescent plasma treatment in severely immunosuppressed patients hospitalized with COVID-19: an observational study of 28 cases
Infectious Diseases, Taylor & Francis Group 2022, Vol. 54, (4) : 283-291
Ljungquist, Oskar; Lundgren, Maria; Iliachenko, Elena; et al.
Molecular Organisation of Tick-Borne Encephalitis Virus
Viruses, MDPI 2022, Vol. 14, (4)
Pulkkinen, Lauri I. A.; Barrass, Sarah V.; Domanska, Aušra; et al.
Serine protease inhibitors restrict host susceptibility to SARS-CoV-2 infections
mBio, American Society for Microbiology 2022, Vol. 13, (3)
Rosendal, Ebba; Mihai, Ionut Sebastian; Becker, Miriam; et al.
Re: Chen Dong, Sung-Lang Chen, and Wen-Wei Sung's Letter to the Editor re: Karin Welén, Ebba Rosendal, Magnus Gisslén, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. 2022;81:285–93.
European Urology, Elsevier 2022, Vol. 81, (5) : e124-e125
Welen, Karin; Rosendal, Ebba; Freyhult, Eva; et al.
Reply to Carlos G. Wambier and Gerard J. Nau's Letter to the Editor re: Karin Welén, Ebba Rosendal, Magnus Gisslén, et al. A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data. Eur Urol. 2022;81:285–93. Positive Effects of Enzalutamide for Hospitalized COVID-19 Patients: Still No Positive Effect of Enzalutamide for Hospitalized COVID-19 Patients
European Urology, Elsevier 2022, Vol. 81, (6) : e143-e144
Welén, Karin; Rosendal, Ebba; Freyhult, Eva; et al.
A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data
European Urology, Elsevier 2022, Vol. 81, (3) : 285-293
Welén, Karin; Rosendal, Ebba; Gisslén, Magnus; et al.
Convalescence plasma treatment of COVID-19: results from a prematurely terminated randomized controlled open-label study in Southern Sweden
BMC Research Notes, BioMed Central 2021, Vol. 14, (1)
Holm, Karin; Lundgren, Maria N.; Kjeldsen-Kragh, Jens; et al.
Large scale discovery of coronavirus-host factor protein interaction motifs reveals SARS-CoV-2 specific mechanisms and vulnerabilities
Nature Communications, Nature Publishing Group 2021, Vol. 12, (1)
Kruse, Thomas; Benz, Caroline; Garvanska, Dimitriya H.; et al.
BAF45b is required for efficient zika virus infection of HAP1 cells
Viruses, MDPI 2021, Vol. 13, (10)
Persson, B. David; Nord, Stefan; Lindquist, Richard; et al.
PKR kinase directly regulates tau expression and Alzheimer's disease-related tau phosphorylation
Brain Pathology, John Wiley & Sons 2021, Vol. 31, (1) : 103-119
Reimer, Lasse; Betzer, Cristine; Kofoed, Rikke Hahn; et al.
COVIDENZA - A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19): a structured summary of a study protocol for a randomised controlled trial
Trials, BioMed Central 2021, Vol. 22, (1)
Welén, Karin; Överby, Anna K.; Ahlm, Clas; et al.
Fluvastatin mitigates SARS-CoV-2 infection in human lung cells
iScience, Elsevier 2021, Vol. 24, (12)
Zapatero-Belinchón, Francisco J.; Moeller, Rebecca; Lasswitz, Lisa; et al.
Antiviral Activity of Benzavir-2 against Emerging Flaviviruses
Viruses, MDPI 2020, Vol. 12, (3)
Gwon, Yong-Dae; Strand, Mårten; Lindquist, Richard; et al.
The envelope protein of tick-borne encephalitis virus influences neuron entry, pathogenicity, and vaccine protection
Journal of Neuroinflammation, BioMed Central (BMC) 2020, Vol. 17, (1)
Lindquist, Richard; Rosendal, Ebba; Weber, Elvira; et al.
Revealing new tick-borne encephalitis virus foci by screening antibodies in sheep milk
Parasites & Vectors, BMC 2020, Vol. 13, (1)
Wallenhammar, Amelie; Lindquist, Richard; Asghar, Naveed; et al.
N-glycosylation in the Pre-Membrane Protein Is Essential for the Zika Virus Life Cycle
Viruses, MDPI 2020, Vol. 12, (9)
Yong-Dae, Kwon; Zusinaite, Eva; Merits, Andres; et al.
Characterizing the cellular attachment receptor for Langat virus
PLOS ONE, Public Library Science 2019, Vol. 14, (6)
Rodrigues, Raquel; Danskog, Katarina; Överby, Anna K.; et al.
Tick-borne encephalitis in Europe and Russia: review of pathogenesis, clinical features, therapy, and vaccines
Antiviral Research, Elsevier 2019, Vol. 164 : 23-51
Ruzek, Daniel; Zupanc, Tatjana Avsic; Borde, Johannes; et al.
Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses
Molecular & Cellular Proteomics, American Society for Biochemistry and Molecular Biology 2019, Vol. 18, (12) : 2401-2417
Uckeley, Zina M.; Moeller, Rebecca; Kuhn, Lars I.; et al.
Model System for the Formation of Tick-Borne Encephalitis Virus Replication Compartments without Viral RNA Replication
Journal of Virology, AMER SOC MICROBIOLOGY 2019, Vol. 93, (18)
Yau, Wai-Lok; Nguyen-Dinh, Van; Larsson, Elin; et al.
Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice
Emerging Infectious Diseases, Centers for Disease control and Prevention 2018, Vol. 24, (9) : 1709-1712
Kurhade, Chaitanya; Schreier, Sarah; Lee, Yi-Ping; et al.
The Role of Viperin in Antiflavivirus Responses
DNA and Cell Biology, Mary Ann Liebert 2018, Vol. 37, (9) : 725-730
Lindquist, Richard; Överby, Anna K.
Cell-type- and region-specific restriction of neurotropic flavivirus infection by viperin
Journal of Neuroinflammation, BioMed Central 2018, Vol. 15
Lindqvist, Richard; Kurhade, Chaitanya; Gilthorpe, Jonathan D.; et al.
Tick-Borne Flaviviruses and the Type I Interferon Response
Viruses, MDPI 2018, Vol. 10, (7)
Lindqvist, Richard; Upadhyay, Arunkumar S.; Överby, Anna K.
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Nature Communications, Nature Publishing Group 2018, Vol. 9
Lund, Harald; Pieber, Melanie; Parsa, Roham; et al.
Viperin restricts Zika virus and tick-borne encephalitis virus replication by targeting NS3 for proteasomal degradation
Journal of Virology, American Society for Microbiology 2018, Vol. 92, (7)
Panayiotou, Christakis; Lindqvist, Richard; Kurhade, Chaitanya; et al.
The interplay between viperin antiviral activity, lipid droplets and Junín mammarenavirus multiplication
Virology, Elsevier 2018, Vol. 514 : 216-229
Peña Cárcamo, José R.; Morell, María L.; Vázquez, Cecilia A.; et al.
Viperin targets flavivirus virulence by inducing assembly of non-infectious capsid particles
Journal of Virology, American Society of Microbiology 2018, Vol. 92, (1)
Vonderstein, Kirstin; Nilsson, Emma; Hubel, Philipp; et al.
Cellular requirements for iron-sulfur cluster insertion into the antiviral radical SAM protein viperin
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2017, Vol. 292, (33) : 13879-13889
Upadhyay, Arunkumar S.; Stehling, Oliver; Panayiotou, Christakis; et al.
The role of the poly(A) tract in the replication and virulence of tick-borne encephalitis virus
Scientific Reports, Vol. 6
Asghar, Naveed; Lee, Yi-Ping; Nilsson, Emma; et al.
Complete Genome Sequence of a Low-Virulence Tick-Borne Encephalitis Virus Strain
Microbiology Resource Announcements, Washington: American Society for Microbiology 2016, Vol. 4, (5)
Dobler, G.; Bestehorn, M.; Antwerpen, M.; et al.
Human Tick-Borne Encephalitis and Characterization of Virus from Biting Tick
Emerging Infectious Diseases, Centers for Disease Control and Prevention 2016, Vol. 22, (8) : 1485-1487
Henningsson, Anna J.; Lindqvist, Richard; Norberg, Peter; et al.
High-Throughput Screening Using a Whole-Cell Virus Replication Reporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection
Journal of Biomolecular Screening, Sage Publications 2016, Vol. 21, (4) : 354-362
Islam, Md. Koushikul; Baudin, Maria; Eriksson, Jonas; et al.
Type I Interferon response in olfactory bulb, the site of tick-borne flavivirus accumulation, is primarily regulated by IPS-1
Journal of Neuroinflammation, Vol. 13
Kurhade, Chaitanya; Zegenhagen, Loreen; Weber, Elvira; et al.
Fast type I interferon response protects astrocytes from flavivirus infection and virus-induced cytopathic effects
Journal of Neuroinflammation, Vol. 13
Lindqvist, Richard; Mundt, Filip; Gilthorpe, Jonathan D.; et al.
Brain heterogeneity leads to differential innate immune responses and modulates pathogenesis of viral infections
Cytokine & growth factor reviews, Vol. 30 : 95-101
Zegenhagen, Loreen; Kurhade, Chaitanya; Koniszewski, Nikolaus; et al.
Generation of mutant Uukuniemi viruses lacking the nonstructural protein NSs by reverse genetics indicates that NSs is a weak interferon antagonist.
Journal of Virology, Vol. 89, (9) : 4849-4856
Rezelj, Veronica V; Överby, Anna K; Elliott, Richard M
Differential innate immune responses in various brain regions regulate antiviral response in the CNS during Tick-borne encephalitis virus infection
Cytokine, Vol. 76, (1) : 91-91
Zegenhagen, Loreen; Weber, Elvira; Kurade, Chaitanya; et al.
Tick-borne encephalitis virus sequenced directly from questing and blood-feeding ticks reveals quasispecies variance
PLOS ONE, Public library science 2014, Vol. 9, (7) : e103264-
Asghar, Naveed; Lindblom, Pontus; Melik, Wessam; et al.
Viperin is an iron-sulfur protein that inhibits genome synthesis of tick-borne encephalitis virus via radical SAM domain activity
Cellular Microbiology, Vol. 16, (6) : 834-848
Upadhyay, Arunkumar S.; Vonderstein, Kirstin; Pichlmair, Andreas; et al.
Type I interferon protects mice from fatal neurotropic infection with Langat virus by systemic and local antiviral responses
Journal of Virology, American Society for Microbiology 2014, Vol. 89, (21) : 12202-12212
Weber, Elvira; Finsterbusch, Katja; Lindquist, Richard; et al.
Det tidiga immunförsvaret nyckel i kampen mot TBE-virus
Neurologi i Sverige, Vol. 2, (14) : 68-74
Överby, Anna; Nilsson, Emma
Viperin vs. tick-borne encephalitis virus: Mechanisms of a potent antiviral protein
Cytokine, Academic Press 2013, Vol. 63, (3) : 305-305
Upadhyay, Arunkumar S.; Vonderstein, Kirstin; Pichlmair, Andreas; et al.
Type I interferon protects against lethal Langat virus infection
Cytokine, Academic Press 2013, Vol. 63, (3) : 308-308
Weber, Elvira; Finsterbusch, Katja; Lindqvist, Richard; et al.
Interferon antagonist NSs of La Crosse virus triggers a DNA damage response-like degradation of transcribing RNA polymerase II
Journal of Biological Chemistry, Vol. 286, (5) : 3681-3692
Verbruggen, Paul; Ruf, Marius; Blakqori, Gjon; et al.
View publications in DiVA

Research groups

Head of research
Anna Överby Wernstedt
Aiming to outsmart the TBE virus

The purpose of Anna Överby Wernstedt`s research is finding methods to stop the TBE virus before it spreads.