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Staff photo Niklas Arnberg

Niklas Arnberg

Virus-host cell interactions: implications for tropism, treatment, and targeting

Contact

Works at

Affiliation
Professor at Department of Clinical Microbiology Units: Section of Virology
Location
6M, Universitetssjukhuset, Virologi Umeå universitet, 901 85 Umeå
Affiliation
Affiliated as professor at Faculty of Medicine, Dean's Office
Location
Förvaltningshuset, Plan 7 Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as professor at Molecular Infection Medicine Sweden (MIMS)
Location
Virologi, By 6F, NUS, Klinisk mikrobiologi Klinisk mikrobiologi, 90187 Umeå

Viral infections constitute a major burden to society and healthcare. Besides causing illness and death they also cause huge costs. Antibiotics function against bacterial infections but have no effect on viral infections. Vaccines and antiviral drugs are available for prevention and treatment of a few viral infections, but the vast majority of viral infections can neither be prevented by vaccines nor treated with antiviral drugs.

The main challenges with antiviral drug development is that viruses are relatively small in relation to e.g. bacteria, which means that there are fewer targets for treatment of viral infections. Viruses also replicate inside host cells, which means that antiviral drugs have to reach remote compartments of the cell to exert their effect

The main interest of our group is to explore the molecules and mechanisms involved in the early stage of the viral life cycle: attachment and entry. This is a critical step in the life cycle that sometimes determine the tropism of the virus, i.e. the cells, tissues and organs that are infected, but this step is also essential for subsequent replication and transmission to other cells and to other hosts. We also consider the importance of soluble molecules in surrounding body fluids, which may either prevent infection by serving as a barrier or as decoy receptors, but they may also function as a bridge to the target cells and thus facilitate infection.

Viruses are also used as tools, or ”vectors” in order to treat e.g. cancer and hereditary disorders, but also to prevent infections of heterologous pathogenes, i.e. as vaccine vectors. Our research is important to understand, and to improve the targeting of such vectors.

Hitherto, we have identified cellular receptors for different types of adenovirus and picornavirus. We have also developed an antiviral drug candidate for treatment of ocular adenoviruses, which have reached clinical trials.

To address the questions above we use advanced, 3D organoid cell models derived from primary cells and we also use transformed cell lines that correspond to the tropism of the virus. We use state-of-the-art technologies, including CRISPR/Cas9-engineered cells and viruses, surface plasmon resonance, advanced microcopy, and flow cytometry. We also collaborate with leading scientists in the areas of chemistry, structural biology, and glycobiology.

The current projects are funded mainly by grants from The European Union, The Swedish Research Council, The Swedish Cancer Society, and The Medical Faculty, Umeå University.

2019
Viruses, MDPI 2019, Vol. 11, (3)
Chandra, Naresh; Frängsmyr, Lars; Arnberg, Niklas
2019
Viruses, MDPI 2019, Vol. 11, (5)
Chandra, Naresh; Frängsmyr, Lars; Imhof, Sophie; et al.
2019
Viruses, MDPI 2019, Vol. 11, (3)
Chandra, Naresh; Liu, Yan; Liu, Jing-Xia; et al.
2019
PLoS ONE, Public Library Science 2019, Vol. 14, (6)
Rodrigues, Raquel; Danskog, Katarina; Överby, Anna K.; et al.
2018
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2018, Vol. 115, (2) : 397-402
Baggen, Jim; Hurdiss, Daniel L.; Zocher, Georg; et al.
2018
Journal of General Virology, Vol. 99 : 135-147
Duffy, Margaret R.; Alonso-Padilla, Julio; John, Lijo; et al.
2018
PLoS ONE, Public Library Science 2018, Vol. 13, (12)
Kaján, Gyõzõ L.; Lipiec, Agnieszka; Bartha, Daniel; et al.
2018
Journal of Molecular Biology, Vol. 430, (13) : 1863-1882
Lasswitz, Lisa; Chandra, Naresh; Arnberg, Niklas; et al.
2018
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, (18) : E4264-E4273
Lenman, Annasara; Liaci, A. Manuel; Liu, Yan; et al.
2018
Scientific Reports, Springer Nature 2018, Vol. 8, (1)
Rajan, Anandi; Persson, B. David; Frängsmyr, Lars; et al.
2017
Virus Research, Elsevier 2017, Vol. 242 : 79-84
Kaján, Gyõzõ L.; Kajon, Adriana E.; Pinto, Alexis Castillo; et al.
2017
Journal of Virology, Vol. 91, (5)
Storm, Rickard J; Persson, David B; Skalman, Lars Nygård; et al.
2015
Organic and biomolecular chemistry, Vol. 13, (35) : 9194-9205
Caraballo, Rémi; Saleeb, Michael; Bauer, Johannes; et al.
2015
PLoS Pathogens, Vol. 11, (2)
Lenman, Annasara; Liaci, A. Manuel; Liu, Yan; et al.
2014
PLoS Pathogens, Public library science 2014, Vol. 10, (10) : e1004401-
Zocher, Georg; Mistry, Nitesh; Frank, Martin; et al.
2013
Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, (50) : 19976-19977
Arnberg, Niklas
2013
Cellular Microbiology, Wiley-Blackwell 2013, Vol. 15, (1) : 16-23
Greber, Urs F.; Arnberg, Niklas; Wadell, Göran; et al.
2012
TIPS - Trends in Pharmacological Sciences, Elsevier 2012, Vol. 33, (8) : 442-448
Arnberg, Niklas
2012
PLoS Pathogens, San Francisco: Public Library of Science 2012, Vol. 8, (7) : e1002738-
Neu, Ursula; Hengel, Holger; Blaum, Bärbel S; et al.
2011
Journal of Medicinal Chemistry, Easton, Pa.: American Chemical Society 2011, Vol. 54, (19) : 6670-6675
Aplander, Karolina; Marttila, Marko; Manner, Sophie; et al.
2011
Journal of Virology, Washington: The American Society For Microbiology 2011, Vol. 85, (24) : 13420-13431
Lenman, Annasara; Mueller, Steffen; Nygren, Mari I; et al.
2011
Journal of Virology, Baltimore: American Society for Microbiology 2011, Vol. 85, (21) : 11283-11290
Mistry, Nitesh; Inoue, Hirotoshi; Jamshidi, Fariba; et al.
2011
Nature Medicine, Vol. 17, (1) : 105-109
Nilsson, Emma C; Storm, Rickard J; Bauer, Johannes; et al.
2011
Angewandte Chemie International Edition, Wiley 2011, Vol. 50, (29) : 6519-6521
Spjut, Sara; Qian, Weixing; Bauer, Johannes; et al.
2010
Journal of Virology, American Society for Microbiology 2010, Vol. 84, (7) : 3189-3200
Cupelli, Karolina; Müller, Steffen; Persson, David B; et al.
2009
Reviews in Medical Virology, John Wiley & Sons 2009, Vol. 19, (3) : 165-178
Arnberg, Niklas
2009
Journal of Medicinal Chemistry, Vol. 52, (12) : 3666-3678
Johansson, Susanne; Nilsson, Emma; Qian, Weixing; et al.
2009
Journal of Virology, Vol. 83, (8) : 3816-3825
Jonsson, Mari; Lenman, Annasara E; Frängsmyr, Lars; et al.
2009
Journal of Virology, Vol. 83, (2) : 673-686
Persson, B David; Müller, Steffen; Reiter, Dirk M; et al.
2008
Influenza and other respiratory viruses, Wiley 2008, Vol. 2, (5) : 147-154
Kumlin, Urban; Olofsson, Sigvard; Dimock, Ken; et al.
2008
Journal of Virology, Baltimore: American Society for Microbiology 2008, Vol. 82, (6) : 3061-3068
Nilsson, Emma C; Jamshidi, Fariba; Johansson, Susanne M. C.; et al.
2007
Journal of Virology, American Society for Microbiology 2007, Vol. 81, (2) : 954-963
Johansson, Cecilia; Jonsson, Mari; Marttila, Marko; et al.
2007
Antiviral Research, Vol. 73, (2) : 92-100
Johansson, Susanne M C; Nilsson, Emma C; Elofsson, Mikael; et al.
2007
Nature Structural & Molecular Biology, Vol. 14, (2) : 164-166
Persson, B David; Reiter, Dirk M; Marttila, Marko; et al.
2005
ChemBioChem (Print), Vol. 6, (2) : 358-364
Johansson, Susanne M C; Arnberg, Niklas; Elofsson, Mikael; et al.
2005
Journal of Virology, American Society for Microbiology 2005, Vol. 79, (22) : 14429-14436
Marttila, Marko; Persson, David; Gustafsson, Dan; et al.
2005
Lancet. Infectious diseases (Print), Vol. 5, (3) : 184-8
Olofsson, Sigvard; Kumlin, Urban; Dimock, Ken; et al.
2004
Journal of Virology, American Society for Microbiology 2004, Vol. 78, (14) : 7727-7736
Burmeister, Wim P; Guilligay, Delphine; Cusack, Stephen; et al.
2003
Journal of Virology, Vol. 77, (17) : 9183-9191
Segerman, Anna; Atkinson, John P.; Marttila, Marko; et al.
2002
Virology, Elsevier 2002, Vol. 302, (1) : 33-43
Arnberg, Niklas; Kidd, Alistair H; Edlund, Karin; et al.
2002
Journal of Virology, American Society for Microbiology 2002, Vol. 76, (17) : 8834-8841
Arnberg, Niklas; Pring-Akerblom, Patricia; Wadell, Göran
2000
Journal of Virology, Vol. 74, (1) : 42-48
Arnberg, Niklas; Edlund, Karin; Kidd, Alistair H; et al.
2000
Journal of Virology, Vol. 74, (16) : 7691-3
Arnberg, Niklas; Kidd, Alistair H; Edlund, Karin; et al.
1997
Virology, Vol. 227, (1) : 239-244
Arnberg, Niklas; Mei, Ya Fang; Wadell, Göran

Research projects

1 October 2016 until 30 September 2020