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Improving Cancer Immunotherapy – A Quantitative Model of Human T Cell Activation and Proliferation

PhD project within the Industrial Doctoral School at Umeå University.

Ionut Sebastian Mihai's PhD project focuses on studying the genetic features of T cell activation and differentiation, to then create a computational model that will help pre-clinical and clinical researchers better apply treatments, and deepen the knowledge about our immune system.

Head of project

Ionut Sebastian Mihai
Doctoral student
E-mail
Email

Project overview

Project period:

2020-08-01 2024-08-02

Funding

Sartorius Stedim Data Analytics 50 %

Industrial Doctoral Svhool 50 %

Participating departments and units at Umeå University

Department of Molecular Biology

Research area

Molecular biology and genetics

Project description

T-cells are key components of the immune system, and are involved in a vast amount of clinically relevant conditions - from fighting minor pathogenic infections, to directly being involved in complex adaptive immune dynamics that characterize cancers, allergies and autoimmune disorders.

Furthermore, the interaction between T-lymphocytes and other cell types induces a “shaping” effect on the overall fate and role of the naive T cell. Naive T-cells have been isolated from patients' peripheral blood and genetically re-programmed to present a chimeric antigen T cell receptor (CAR T cells), which ultimately leads to enhanced immune defence against cancer. However, to perform this process efficiently, across different ages and sexes, requires an understanding of how T cell activation and associated process are connected. Much effort has already gone into this research.

Ionut Sebastian's research focuses on studying the genetic features of T cell activation and differentiation, to then create a computational model that will help pre-clinical and clinical researchers better apply treatments, and deepen the knowledge about our immune system.