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Umeå University
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Staff photo Felipe Cava

Felipe Cava

I am a group leader at MIMS and researching the cell walls of bacteria.

Contact

E-mail
felipe.cava@umu.se
Phone
+46 90 785 67 55

Works at

Affiliation
Professor at Department of Molecular Biology Units: Research group Felipe Cava
Location
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as professor at Molecular Infection Medicine Sweden (MIMS) Units: Research groups
Location
6L, Institutionen för molekylärbiologi Institutionen för molekylärbiologi, 90187 Umeå

The Cava lab aims at deciphering new knowledge on one of the most remarkable structures of bacteria – their cell wall – both to provide answers to scientific fundamental questions and to improve our options to combat long-standing and emerging infectious diseases.

We have launched an integrative research program to uncover and exploit the unnoticed variability of the bacterial cell wall. This investigation is imperative for a realistic understanding of cell wall biology in nature, in particular its role in environmental adaptation and signaling.

More information about projects, publications, and open positions in my group

I am also affiliated researcher at Icelab at Umeå University

Identification of genes required for long-term survival of Legionella Pneumophila in water
mSphere, Washington: American Society for Microbiology 2023, Vol. 8, (2)
Aurass, Philipp; Kim, Seongok; Pinedo, Victor; et al.
At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study
Eurosurveillance, European Centre for Disease Control and Prevention (ECDC) 2023, Vol. 28, (13)
Wigren, Julia; Vikström, Linnea; Rosendal, Ebba; et al.
LD-transpeptidases: the great unknown among the peptidoglycan cross-linkers
The FEBS Journal, John Wiley & Sons 2022, Vol. 289, (16) : 4718-4730
Aliashkevich, Alena; Cava, Felipe
Transient glycolytic complexation of arsenate enhances resistance in the enteropathogen Vibrio cholerae
mBio, American Society for Microbiology 2022, Vol. 13, (5)
Bueno, Emilio; Pinedo, Victor; Shinde, Dhananjay D.; et al.
Genetic screens identify additional genes implicated in envelope remodeling during the engulfment stage of bacillus subtilis sporulation
mBio, American Society for Microbiology 2022, Vol. 13, (5)
Chan, Helena; Taib, Najwa; Gilmore, Michael C.; et al.
Bacterial developmental checkpoint that directly monitors cell surface morphogenesis
Developmental Cell, Elsevier 2022, Vol. 57, (3) : 344-360
Delerue, Thomas; Anantharaman, Vivek; Gilmore, Michael C.; et al.
Induction of AmpC-Mediated β-Lactam Resistance Requires a Single Lytic Transglycosylase in Agrobacterium tumefaciens
Applied and Environmental Microbiology, American Society for Microbiology 2022, Vol. 88, (12)
Figueroa-Cuilan, Wanda M.; Howell, Matthew; Richards, Christopher; et al.
Hydroxyl Radical Overproduction in the Envelope: An Achilles' Heel in Peptidoglycan Synthesis
Microbiology Spectrum, American Society for Microbiology 2022, Vol. 10, (1)
Giacomucci, Sean; Alvarez, Laura; Rodrigues, Christopher D.A.; et al.
Peptidoglycan recycling mediated by an ABC transporter in the plant pathogen Agrobacterium tumefaciens
Nature Communications, Nature Publishing Group 2022, Vol. 13, (1)
Gilmore, Michael C.; Cava, Felipe
Peptidoglycan editing in non-proliferating intracellular Salmonella as source of interference with immune signaling
PLoS Pathogens, Public Library of Science 2022, Vol. 18, (1)
Hernández, Sara B.; Castanheira, Sónia; Graciela Pucciarelli, M.; et al.
Brucella melitensis Wzm/Wzt System: Changes in the Bacterial Envelope Lead to Improved Rev1Δwzm Vaccine Properties
Frontiers in Microbiology, Frontiers Media S.A. 2022, Vol. 13
Mena-Bueno, Sara; Poveda-Urkixo, Irati; Irazoki, Oihane; et al.
Evolution of longitudinal division in multicellular bacteria of the Neisseriaceae family
Nature Communications, Springer Nature 2022, Vol. 13, (1)
Nyongesa, Sammy; Weber, Philipp M.; Bernet, Ève; et al.
Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products
eLIFE, eLife Sciences Publications Ltd 2022, Vol. 11
Weaver, Anna; Alvarez, Laura; Rosch, Kelly; et al.
D-canavanine affects peptidoglycan structure, morphogenesis and fitness in Rhizobiales
Environmental Microbiology, John Wiley & Sons 2021, Vol. 23, (10) : 5823-5836
Aliashkevich, Alena; Howell, Matthew; Brown, Pamela J. B.; et al.
Cell Wall Biology of Vibrio cholerae
Annual Review of Microbiology, ANNUAL REVIEWS 2021, Vol. 75 : 151-174
Alvarez, Laura; Hernandez, Sara B.; Cava, Felipe
Accumulation of succinyl coenzyme a perturbs the methicillin-resistant staphylococcus aureus (Mrsa) succinylome and is associated with increased susceptibility to beta-lactam antibiotics
mBio, American Society for Microbiology 2021, Vol. 12, (3)
Campbell, Christopher; Fingleton, Claire; Zeden, Merve S.; et al.
A New Class of Cell Wall-Recycling L,D-Carboxypeptidase Determines β-Lactam Susceptibility and Morphogenesis in Acinetobacter baumannii
mBio, American Society for Microbiology 2021, Vol. 12, (6)
Dai, Yunfei; Pinedo, Victor; Tang, Amy Y.; et al.
BipA exerts temperature-dependent translational control of biofilm-associated colony morphology in Vibrio cholerae
eLIFE, eLife Sciences Publications Ltd. 2021, Vol. 10
del Peso Santos, Teresa; Alvarez, Laura; Sit, Brandon; et al.
Binding of non-canonical peptidoglycan controls Vibrio cholerae broad spectrum racemase activity
Computational and Structural Biotechnology Journal, Elsevier 2021, Vol. 19 : 1119-1126
Espaillat, Akbar; Carrasco-López, Cesar; Bernardo-García, Noelia; et al.
L-Arabinose Induces the Formation of Viable Nonproliferating Spheroplasts in Vibrio cholerae
Applied and Environmental Microbiology, American Society for Microbiology 2021, Vol. 87, (5)
Espinosa, Elena; Daniel, Sandra; Hernández, Sara B.; et al.
New approaches and techniques for bacterial cell wall analysis
Current Opinion in Microbiology, Elsevier 2021, Vol. 60 : 88-95
Hernandez, Sara B.; Cava, Felipe
Killing of Gram-negative and Gram-positive bacteria by a bifunctional cell wall-targeting T6SS effector
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Science 2021, Vol. 118, (40)
Le, Nguyen-Hung; Pinedo, Victor; Lopez, Juvenal; et al.
Class a penicillin-binding protein-mediated cell wall synthesis promotes structural integrity during peptidoglycan endopeptidase insufficiency in vibrio cholerae
mBio, American Society for Microbiology 2021, Vol. 12, (2)
Murphy, Shannon G.; Murtha, Andrew N.; Zhao, Ziyi; et al.
Chemically Induced Cell Wall Stapling in Bacteria
Cell Chemical Biology, Cell Press 2021, Vol. 28, (2) : 213-e4
Rivera, Sylvia L.; Espaillat, Akbar; Aditham, Arjun K.; et al.
Acinetobacter baumannii Can Survive with an Outer Membrane Lacking Lipooligosaccharide Due to Structural Support from Elongasome Peptidoglycan Synthesis
mBio, American Society for Microbiology 2021, Vol. 12, (6)
Simpson, Brent W.; Nieckarz, Marta; Pinedo, Victor; et al.
Pbp4 is likely involved in cell division of the longitudinally dividing bacterium candidatus thiosymbion oneisti
Antibiotics, MDPI 2021, Vol. 10, (3) : 1-17
Wang, Jinglan; Alvarez, Laura; Bulgheresi, Silvia; et al.
Unipolar Peptidoglycan Synthesis in the Rhizobiales Requires an Essential Class A Penicillin-Binding Protein
mBio, ASM International 2021, Vol. 12, (5)
Williams, Michelle A.; Aliashkevich, Alena; Krol, Elizaveta; et al.
Analysis of Gram-negative Bacteria Peptidoglycan by Ultra-performance Liquid Chromatography
Bio-protocol, Bio-protocol 2020, Vol. 10, (19)
Alvarez, Laura; Cordier, Baptiste; van Teeffelen, Sven; et al.
SwsB and SafA Are Required for CwlJ-Dependent Spore Germination in Bacillus subtilis
Journal of Bacteriology, American Society for Microbiology 2020, Vol. 202, (6)
Amon, Jeremy D.; Yadav, Akhilesh K.; Ramirez-Guadiana, Fernando H.; et al.
Adaptation of Vibrio cholerae to Hypoxic Environments
Frontiers in Microbiology, Frontiers Media S.A. 2020, Vol. 11
Bueno, Emilio; Pinedo, Victor; Cava, Felipe
Genetic Dissection of the Fermentative and Respiratory Contributions Supporting Vibrio cholerae Hypoxic Growth
Journal of Bacteriology, American Society for Microbiology 2020, Vol. 202, (24)
Bueno, Emilio; Sit, Brandon; Waldor, Matthew K.; et al.
Modulation of Peptidoglycan Synthesis by Recycled Cell Wall Tetrapeptides
Cell reports, Cell Press 2020, Vol. 31, (4)
Hernandez, Sara B.; Dorr, Tobias; Waldor, Matthew K.; et al.
Unexpected Cell Wall Alteration-Mediated Bactericidal Activity of the Antifungal Caspofungin against Vancomycin-Resistant Enterococcus faecium
Antimicrobial Agents and Chemotherapy, AMER SOC MICROBIOLOGY 2020, Vol. 64, (10)
Isnard, Christophe; Hernandez, Sara B.; Guerin, Francois; et al.
Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare
Science Advances, American Association for the Advancement of Science 2020, Vol. 6, (30)
Le, Nguyen-Hung; Peters, Katharina; Espaillat, Akbar; et al.
Structural basis of peptidoglycan endopeptidase regulation
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (21) : 11692-11702
Shin, Jung-Ho; Sulpizio, Alan G.; Kelley, Aaron; et al.
Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects
eLIFE, eLife Sciences Publications 2020, Vol. 9
Vigouroux, Antoine; Cordier, Baptiste; Aristov, Andrey; et al.
The conserved transcriptional regulator CdnL is required for metabolic homeostasis and morphogenesis in Caulobacter
PLOS Genetics, Public Library of Science (PLOS) 2020, Vol. 16, (1)
Woldemeskel, Selamawit Abi; Daitch, Allison K.; Alvarez, Laura; et al.
Cold-induced aldimine bond cleavage by Tris in Bacillus subtilis alanine racemase
Organic and biomolecular chemistry, Royal Society of Chemistry 2019, Vol. 17, (17) : 4350-4358
Bernardo-Garcia, Noelia; Sánchez-Murcia, Pedro A.; Espaillat, Akbar; et al.
Amino Acid-Dependent Alterations in Cell Wall and Cell Morphology of Deinococcus indicus DR1
Frontiers in Microbiology, Frontiers Media S.A. 2019, Vol. 10
Chauhan, Deepika; Srivastava, Pulkit Anupam; Ritzl, Barbara; et al.
A Vibrio cholerae BolA-Like Protein Is Required for Proper Cell Shape and Cell Envelope Integrity
mBio, American Society for Microbiology (ASM) 2019, Vol. 10, (4)
Fleurie, Aurore; Zoued, Abdelrahim; Alvarez, Laura; et al.
Agrobacterium tumefaciens divisome proteins regulate the transition from polar growth to cell division
Molecular Microbiology, John Wiley & Sons 2019, Vol. 111, (4) : 1074-1092
Howell, Matthew; Aliashkevich, Alena; Sundararajan, Kousik; et al.
Fluorogenic D-amino acids enable real-time monitoring of peptidoglycan biosynthesis and high-throughput transpeptidation assays
Nature Chemistry, Nature Publishing Group 2019, Vol. 11, (4) : 335-341
Hsu, Yen-Pang; Hall, Edward; Booher, Garrett; et al.
Peptidoglycan Muropeptides: Release, Perception, and Functions as Signaling Molecules
Frontiers in Microbiology, Frontiers Media S.A. 2019, Vol. 10
Irazoki, Oihane; Hernandez, Sara B.; Cava, Felipe
A SpoIID Homolog Cleaves Glycan Strands at the Chlamydial Division Septum
mBio, American Society for Microbiology (ASM) 2019, Vol. 10, (4)
Jacquier, Nicolas; Yadav, Akhilesh K.; Pillonel, Trestan; et al.
Muropeptides Stimulate Growth Resumption from Stationary Phase in Escherichia coli
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Joers, Arvi; Vind, Kristiina; Hernandez, Sara B.; et al.
Chromatographic analysis of peptidoglycan samples with the aid of a chemometric technique: introducing a novel analytical procedure to classify bacterial cell wall collection
Analytical Methods, Vol. 11, (12) : 1671-1679
Kumar, Keshav; Cava, Felipe
Mechanisms of Incorporation for D-Amino Acid Probes That Target Peptidoglycan Biosynthesis
ACS Chemical Biology, American Chemical Society (ACS) 2019, Vol. 14, (12) : 2745-2756
Kuru, Erkin; Radkov, Atanas; Meng, Xin; et al.
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response
mBio, American Society for Microbiology 2019, Vol. 10, (1)
Murphy, Shannon G.; Alvarez, Laura; Adams, Myfanwy C.; et al.
Regulation of AmpC-Driven beta-Lactam Resistance in Pseudomonas aeruginosa: Different Pathways, Different Signaling
mSystems, American Society for Microbiology 2019, Vol. 4, (6)
Torrens, Gabriel; Hernandez, Sara B.; Ayala, Juan Alfonso; et al.
New Insights Into the Mechanisms and Biological Roles of D-Amino Acids in Complex Eco-Systems
Frontiers in Microbiology, Frontiers Media S.A. 2018, Vol. 9
Aliashkevich, Alena; Alvarez, Laura; Cava, Felipe
View publications in DiVA

Research groups

Head of research
Felipe Cava lab
The aim is to develop new antibiotics

Felipe Cava wants to learn more about the small and complex microbes.