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Umeå University
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Staff photo Patrik Rydén

Patrik Rydén

I am Professor of Mathematical Statistics and my research is about developing and applying statistical methods to analyze large and complex data.

Contact

E-mail
patrik.ryden@umu.se
Phone
+46 90 786 95 62, +46 70 482 35 55

Works at

Affiliation
Professor at Department of Mathematics and Mathematical Statistics
Location
MIT-huset, plan 3, Matematik och matematisk statistik, MIT.F.345 Umeå universitet, 901 87 Umeå
Affiliation
Affiliated as other position at Industrial Doctoral School for Research and Innovation

My research is about developing and applying statistical methods to analyze large and complex data, with the goal of transforming data into information and knowledge. We conduct theoretical research, but also work with applications in, among other things, ambulance care, cancer diagnostics and the automotive industry. I am also the director of the Industrial Doctoral School for Research and Innovation at Umeå University.

In Silico Identification of Potential Thyroid Hormone System Disruptors among Chemicals in Human Serum and Chemicals with a High Exposure Index
Environmental Science and Technology, American Chemical Society (ACS) 2022, Vol. 56, (12) : 8363-8372
Dracheva, Elena; Norinder, Ulf; Rydén, Patrik; et al.
A comparison of local explanation methods for high-dimensional industrial data: a simulation study
Expert systems with applications, Elsevier 2022, Vol. 207
Fries, Niklas; Rydén, Patrik
A genome-wide test for paternal indirect genetic effects on lifespan in Drosophila melanogaster
Proceedings of the Royal Society of London. Biological Sciences, The Royal Society 2022, Vol. 289, (1974)
Shenoi, Vinesh Naresh; Brengdahl, Martin I.; Grace, Jaime L.; et al.
Healthy ecosystems for human and animal health: Science diplomacy for responsible development in the Arctic
Polar Record, Cambridges Institutes Press 2021, Vol. 57
Evengård, Birgitta; Destouni, G.; Kalantari, Z.; et al.
Comparison of Methods for Feature Selection in Clustering of High-Dimensional RNA-Sequencing Data to Identify Cancer Subtypes
Frontiers in Genetics, Frontiers Media S.A. 2021, Vol. 12
Källberg, David; Vidman, Linda; Rydén, Patrik
Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma
Journal of Translational Medicine, Vol. 18, (1)
Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.
Large-scale modelling and forecasting of ambulance calls in northern Sweden using spatio-temporal log-Gaussian Cox processes
Spatial Statistics, Elsevier 2020, Vol. 39
Bayisa, Fekadu; Ådahl, Markus; Rydén, Patrik; et al.
Whole genome profiling refines a panel of correlates to predict vaccine efficacy against Mycobacterium tuberculosis
Tuberculosis, Elsevier 2020, Vol. 120
Kurtz, Sherry L.; Gardina, Paul J.; Myers, Timothy G.; et al.
Centralization Within Sub-Experiments Enhances the Biological Relevance of Gene Co-expression Networks: A Plant Mitochondrial Case Study
Frontiers in Plant Science, Frontiers Media S.A. 2020, Vol. 11
Law, Simon R; Kellgren, Therese; Björk, Rafael; et al.
Vaccine-Mediated Mechanisms Controlling Francisella tularensis SCHU S4 Growth in a Rat Co-Culture System
Pathogens, MDPI 2020, Vol. 9, (5)
Lindgren, Helena; Eneslätt, Kjell; Golovliov, Igor; et al.
Temporal and long-term gut microbiota variation in allergic disease: a prospective study from infancy to school age
Allergy. European Journal of Allergy and Clinical Immunology, John Wiley & Sons 2019, Vol. 74, (1) : 176-185
Simonyté Sjödin, Kotryna; Hammarström, Marie-Louise; Rydén, Patrik; et al.
Gene expression profiles define molecular subtypes of prostate cancer bone metastases with different outcomes and morphology traceable back to the primary tumor
Molecular Oncology, John Wiley & Sons 2019, Vol. 13, (8) : 1763-1777
Thysell, Elin; Vidman, Linda; Bovinder Ylitalo, Erik; et al.
Cluster analysis on high dimensional RNA-seq data with applications to cancer research: An evaluation study
PLOS ONE, San Francisco: Public Library of Science 2019, Vol. 14, (12)
Vidman, Linda; Källberg, David; Rydén, Patrik
A panel of correlates predicts vaccine-induced protection of rats against respiratory challenge with virulent Francisella tularensis
PLOS ONE, Public Library of Science 2018, Vol. 13, (5)
De Pascalis, Roberto; Hahn, Andrew; Brook, Helen M.; et al.
Vaccine-mediated mechanisms controlling replication of Francisella tularensis in human peripheral blood mononuclear cells using a co-culture system
Frontiers in Cellular and Infection Microbiology, Frontiers Media S.A. 2018, Vol. 8
Eneslätt, Kjell; Golovliov, Igor; Rydén, Patrik; et al.
A moment-distance hybrid method for estimating a mixture of two symmetric densities
Modern Stochastics: Theory and Applications, Vol. 5, (1) : 1-36
Källberg, David; Belyaev, Yuri; Rydén, Patrik
High-risk regions and outbreak modelling of tularemia in humans
Epidemiology and Infection, CAMBRIDGE UNIV PRESS 2017, Vol. 145, (3) : 482-490
Desvars-Larrive, Amélie; Liu, X.; Hjertqvist, M.; et al.
Results of application of the ISPD guidelines to the management of peritoneal dialysis in a single center in Sudan
Journal of Infection and Public Health, ELSEVIER SCIENCE LONDON 2017, Vol. 10, (3) : 348-352
Kheir, Sahar M.; Kafi, Shamsoun K.; Ryden, Patrik; et al.
A new concept and a comprehensive evaluation of SYSMEX UF-1000i flow cytometer to identify culture-negative urine specimens in patients with UTI
European Journal of Clinical Microbiology and Infectious Diseases, Springer 2017, Vol. 36, (9) : 1691-1703
Monsen, Tor; Ryden, Patrik
The HRD-Algorithm: a general method for parametric estimation of two-component mixture models
Lecture Notes in Computer Science, Springer 2017, Vol. 10684 : 497-508
Rydén, Patrik; Källberg, David; Belyaev, Yu. K.
A statistically compiled test battery for feasible evaluation of knee function after rupture of the Anterior Cruciate Ligament - derived from long-term follow-up data.
PLOS ONE, Vol. 12, (5)
Schelin, Lina; Tengman, Eva; Ryden, Patrik; et al.
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
Scientific Reports, Nature Publishing Group 2017, Vol. 7
Stattin, Eva-Lena; Henning, Petra; Klar, Joakim; et al.
Emerging evidence of the role of gut microbiota in the development of allergic diseases
Current Opinion in Allergy and Clinical Immunology, Vol. 16, (4) : 390-395
Sjödin, Kotryna Simonyte; Vidman, Linda; Rydén, Patrik; et al.
Epidemiology and Ecology of Tularemia in Sweden
International Journal of Epidemiology, Vol. 44 : 58-58
Desvars, Amélie; Furberg, Maria; Hjertqvist, Marika; et al.
Epidemiology and Ecology of Tularemia in Sweden, 1984-2012
Emerging Infectious Diseases, Vol. 21, (1) : 32-39
Desvars, Amélie; Furberg, Maria; Hjertqvist, Marika; et al.
Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)
Human Mutation, John Wiley & Sons 2015, Vol. 36, (4) : 463-473
Jonsson, Frida; Byström, Berit; Davidson, Alice E.; et al.
Flow Cytometry Analysis Using Sysmex UF-1000i Classifies Uropathogens Based on Bacterial, Leukocyte, and Erythrocyte Counts in Urine Specimens among Patients with Urinary Tract Infections
Journal of Clinical Microbiology, Vol. 53, (2) : 539-545
Monsen, Tor; Ryden, Patrik
Gut microbiome and innate immune response patterns in IgE-associated eczema
Clinical and Experimental Allergy, Vol. 45, (9) : 1419-1429
West, Christina E.; Ryden, Patrik; Lundin, D.; et al.
Models Derived from In Vitro Analyses of Spleen, Liver, and Lung Leukocyte Functions Predict Vaccine Efficacy against the Francisella tularensis Live Vaccine Strain (LVS)
mBio, Vol. 5, (2)
De Pascalis, Roberto; Chou, Alicia Y.; Ryden, Patrik; et al.
Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias
Neoplasia, Vol. 16, (7) : 606-615
Degerman, Sofie; Landfors, Mattias; Siwicki, Jan Konrad; et al.
Within-population distribution of trimethoprim resistance in Escherichia coli before and after a community-wide intervention on trimethoprim use
Antimicrobial Agents and Chemotherapy, Vol. 58, (12) : 7492-7500
Sundqvist, Martin; Granholm, Susanne; Naseer, Umaer; et al.
The Shared Genome Is a Pervasive Constraint on the Evolution of Sex-Biased Gene Expression
Molecular biology and evolution, Vol. 30, (9) : 2168-2176
Griffin, Robert M.; Dean, Rebecca; Grace, Jaime L.; et al.
Functional Studies of the Yeast Med5, Med15 and Med16 Mediator Tail Subunits
PLOS ONE, Vol. 8, (8) : e73137-
Larsson, Miriam; Uvell, Hanna; Sandström, Jenny; et al.
Correlates of protection following vaccination of mice with gene deletion mutants of Francisella tularensis subspecies tularensis strain, SCHU S4 that elicit varying degrees of immunity to systemic and respiratory challenge with wild-type bacteria
Molecular Immunology, Vol. 54, (1) : 58-67
Rydén, Patrik; Twine, Susan; Shen, Hua; et al.
OnPLS integration of transcriptomic, proteomic and metabolomic data shows multi-level oxidative stress responses in the cambium of transgenic hipI- superoxide dismutase Populus plants
BMC Genomics, BioMed Central 2013, Vol. 14
Srivastava, Vaibhav; Obudulu, Ogonna; Bygdell, Joakim; et al.
Cycles of light and dark co-ordinate reversible colony differentiation in Listeria monocytogenes
Molecular Microbiology, Vol. 87, (4) : 909-924
Tiensuu, Teresa; Andersson, Christopher; Ryden, Patrik; et al.
Pr is a member of a restricted class of σ70-dependent promoters that lack a recognizable -10 element
Nucleic Acids Research, Vol. 40, (22) : 11308-11320
Del Peso-Santos, Teresa; Landfors, Mattias; Skärfstad, Eleonore; et al.
Outbreaks of tularemia in a boreal forest region depends on mosquito prevalence
Journal of Infectious Diseases, Vol. 205, (2) : 297-304
Rydén, Patrik; Björk, Rafael; Schäfer, Martina L; et al.
BALB/c mice, but not C57BL/6 mice immunized with a Delta clpB mutant of Francisella tularensis subspecies tularensis are protected against respiratory challenge with wild-type bacteria: Association of protection with post-vaccination and post-challenge immune responses
Vaccine, Vol. 30, (24) : 3634-3645
Twine, Susan; Shen, Hua; Harris, Gregory; et al.
EGFR gene variants are associated with specific somatic aberrations in glioma
Neuro-Oncology, Vol. 14, (Suppl. 3) : 46-46
Wibom, Carl; Ghasimi, Soma; Van Loo, P.; et al.
EGFR gene variants are associated with specific somatic aberrations in glioma
PLOS ONE, plosone.org 2012, Vol. 7, (12) : e47929-
Wibom, Carl; Ghasimi, Soma; Van Loo, Peter; et al.
DNA-repair gene variants are associated with glioblastoma survival
Acta Oncologica, Informa Healthcare 2012, Vol. 51, (3) : 325-332
Wibom, Carl; Sjöström, Sara; Henriksson, Roger; et al.
Elongator Complex Influences Telomeric Gene Silencing and DNA Damage Response by Its Role in Wobble Uridine tRNA Modification
PLoS genetics, Public Library of Science 2011, Vol. 7, (9) : e1002258-
Chen, Changchun; Huang, Bo; Eliasson, Mattias; et al.
Persistence of cell-mediated immunity three decades after vaccination with the live vaccine strain of Francisella tularensis
European Journal of Immunology, Weinheim: Wiley-VCH Verlagsgesellschaft 2011, Vol. 41, (4) : 974-980
Eneslätt, Kjell; Rietz, Cecilia; Rydén, Patrik; et al.
Normalization of high dimensional genomics data where the distribution of the altered variables is skewed
PLOS ONE, Vol. 6, (11) : e27942-
Landfors, Mattias; Philip, Philge; Rydén, Patrik; et al.
miRNA analysis of formalin-fixed squamous cell carcinomas of the tongue is affected by age of the samples
International Journal of Oncology, Spandidos Publ. Ltd 2011, Vol. 38, (1) : 61-69
Rentoft, Matilda; Fahlén, Jessica; Coates, PJ; et al.
Classification of microarrays: synergistic effects between normalization, gene selection and machine learning
BMC Bioinformatics, BioMed Central 2011, Vol. 12, (1)
Önskog, Jenny; Freyhult, Eva; Landfors, Mattias; et al.
MicroRNA-microarray data analysis in the precence of FFPE storage time effects
Fahlén, Jessica; Rentoft, Matilda; Rydén, Patrik
Challenges in microarray class discovery: a comprehensive examination of normalization, gene selection and clustering
BMC Bioinformatics, BioMed Central 2010, Vol. 11
Freyhult, Eva; Landfors, Mattias; Önskog, Jenny; et al.
Molecular immune responses to aerosol challenge with Francisella tularensis in mice inoculated with live vaccine candidates of varying efficacy
PloS one, Vol. 5, (10) : e13349-
Shen, Hua; Harris, Gregory; Chen, Wangxue; et al.
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