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Umeå universitet
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Huvudmenyn dold.
Personalbild Sofie Degerman

Sofie Degerman

Professor i Biomedicinsk Laboratorievetenskap.
Cancerforskare

Vetenskaplig meritering: Docent
0000-0002-2783-0712

Kontakt

E-post
sofie.degerman@umu.se
Telefon
090-785 28 73

Verksam som

Anknytning
Professor vid Institutionen för klinisk mikrobiologi Enhet: Biomedicinsk laboratorievetenskap, Avdelningen för infektion och immunologi
Plats
6F och 6M, Universitetssjukhuset by 6 o 24 Umeå universitet, 901 85 Umeå
Anknytning
Anknuten som forskare till Institutionen för medicinsk biovetenskap Enhet: Patologi
Plats
By 6M, vån 2, Sjukhusområdet Umeå universitet, 901 85 Umeå

Sofie leder en translationell forskningsgrupp som undersöker de molekylära mekanismerna bakom blodcancer, med målet att utveckla precisionsmedicin genom förbättrade diagnostiska verktyg och mer målinriktade behandlingar.

Läs mer på Sofies forskargruppsida

Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
Leukemia
Amaral, Patrícia; Christie, Rhona; Gresham, Daisy O. F.; et al.
Telomerase activity in T-cells as a functional test for pathogenicity assessment of novel genetic variants in telomere biology disorders
Scientific Reports, Springer Nature 2025, Vol. 15, (1)
Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.
CpG island methylator phenotype classification improves risk assessment in pediatric T-cell acute lymphoblastic leukemia
Blood, Vol. 145, (19) : 2161-2178
Schäfer Hackenhaar, Fernanda; Refhagen, Nina; Hagleitner, Melanie; et al.
Semimethylation is a feature of diffuse large B-cell lymphoma, and subgroups with poor prognosis are characterized by global hypomethylation and short telomere length
Clinical Epigenetics, BioMed Central (BMC) 2024, Vol. 16, (1)
Carlund, Olivia; Thörn, Elina; Osterman, Pia; et al.
DNA methylation variations and epigenetic aging in telomere biology disorders
Scientific Reports, Springer Nature 2023, Vol. 13, (1)
Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.
Pre-clinical evaluation of the hypomethylating agent decitabine for the treatment of t-cell lymphoblastic lymphoma
Cancers, MDPI 2023, Vol. 15, (3)
Provez, Lien; Putteman, Tom; Landfors, Mattias; et al.
Sixteen-year longitudinal evaluation of blood-based DNA methylation biomarkers for early prediction of Alzheimer’s disease
Journal of Alzheimer's Disease, IOS Press 2023, Vol. 94, (4) : 1443-1464
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
DNA methylation changes and increased mRNA expression of coagulation proteins, factor V and thrombomodulin in Fuchs endothelial corneal dystrophy
Cellular and Molecular Life Sciences (CMLS), Springer 2023, Vol. 80, (3)
Westin, Ida Maria; Landfors, Mattias; Giannopoulos, Antonios; et al.
Long-Term Follow-Up of Newborns with 22q11 Deletion Syndrome and Low TRECs
Journal of Clinical Immunology, Springer 2022, Vol. 42 : 618-633
Framme, Jenny Lingman; Lundqvist, Christina; Lundell, Anna-Carin; et al.
A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer
Clinical Epigenetics, BioMed Central 2021, Vol. 13, (1)
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
A novel association between ykl-40, a marker of structural lung disease, and short telomere length in 10-year-old children with bronchopulmonary dysplasia
Children, MDPI 2021, Vol. 8, (2)
Henckel, Ewa; James, Anna; Konradsen, Jon R.; et al.
Short leukocyte telomeres, but not telomere attrition rates, predict memory decline in the 20-year longitudinal Betula study
The journals of gerontology. Series A, Biological sciences and medical sciences, Oxford University Press 2021, Vol. 76, (6) : 955-963
Pudas, Sara; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers
Alzheimer's Research & Therapy, BioMed Central (BMC) 2021, Vol. 13
Schäfer Hackenhaar, Fernanda; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Cell-of-origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B-cell lymphoma
American Journal of Hematology, Wiley-Blackwell 2020, Vol. 95, (1) : 57-67
Abdulla, Maysaa; Hollander, Peter; Pandzic, Tatjana; et al.
Combining epigenetic and clinicopathological variables improves specificity in prognostic prediction in clear cell renal cell carcinoma
Journal of Translational Medicine, Vol. 18, (1)
Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.
DNA methylation and copy number variation profiling of T-cell lymphoblastic leukemia and lymphoma
Blood Cancer Journal, Nature Publishing Group 2020, Vol. 10, (4)
Haider, Zahra; Landfors, Mattias; Golovleva, Irina; et al.
Hematopoietic cellular aging is not accelerated during the first 2 years of life in children born preterm
Pediatric Research, Nature Publishing Group 2020, Vol. 88
Henckel, Ewa; Landfors, Mattias; Haider, Zahra; et al.
SIX6 is a TAL1-regulated transcription factor in T-ALL and associated with inferior outcome
Leukemia and Lymphoma, Taylor & Francis 2020, Vol. 61, (13) : 3089-3100
Laukkanen, Saara; Oksa, Laura; Nikkilä, Atte; et al.
Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia
Blood cancer discovery, American Association for Cancer Research 2020, Vol. 1, (3) : 274-289
Roels, Juliette; Thénoz, Morgan; Szarzyńska, Bronisława; et al.
DNA methylation associates with survival in non-metastatic clear cell renal cell carcinoma
BMC Cancer, BioMed Central 2019, Vol. 19
Andersson Evelönn, Emma; Landfors, Mattias; Haider, Zahra; et al.
The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.
An integrated transcriptome analysis in T-cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression
Cancer Medicine, John Wiley & Sons 2019, Vol. 8, (1) : 311-324
Haider, Zahra; Larsson, Pär; Landfors, Mattias; et al.
Characterization of an X-chromosome-linked telomere biology disorder in females with DKC1 mutation
Leukemia, Nature Publishing Group 2019, Vol. 33, (1) : 275-278
Hirvonen, Elina A. M.; Peuhkuri, Saara; Norberg, Anna; et al.
Growth-inhibition of cell lines derived from B cell lymphomas through antagonism of serotonin receptor signaling
Scientific Reports, Nature Publishing Group 2019, Vol. 9
Kolan, Shrikant S; Lidström, Tommy; Mediavilla, Tomás; et al.
DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia
Clinical Epigenetics, BioMed Central 2018, Vol. 10
Borssén, Magnus; Nordlund, Jessica; Haider, Zahra; et al.
Telomere length was similar in school-age children with bronchopulmonary dysplasia and allergic asthma
Acta Paediatrica, John Wiley & Sons 2018, Vol. 107, (8) : 1395-1401
Henckel, E.; Svenson, Ulrika; Nordlund, B.; et al.
Novel variants in Nordic patients referred for genetic testing of telomere-related disorders
European Journal of Human Genetics, Nature Publishing Group 2018, Vol. 26, (6) : 858-867
Norberg, Anna; Rosén, Anna; Raaschou-Jensen, Klas; et al.
Diagnostics of rare disorders: whole-exome sequencing deciphering locus heterogeneity in telomere biology disorders
Orphanet Journal of Rare Diseases, BioMed Central (BMC) 2018, Vol. 13
Trotta, Luca; Norberg, Anna; Taskinen, Mervi; et al.
Telomere length, allergies and risk of Glioma
Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 23-23
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.
Maintained memory in aging is associated with young epigenetic age
Neurobiology of Aging, Elsevier 2017, Vol. 55 : 167-171
Degerman, Sofie; Josefsson, Maria; Nordin Adolfsson, Annelie; et al.
Short telomere length is associated with impaired cognitive performance in European ancestry cohorts
Translational Psychiatry, Vol. 7
Hagg, S.; Zhan, Y.; Karlsson, R.; et al.
Decreased telomere length in children with cartilage-hair hypoplasia
Journal of Medical Genetics, BMJ PUBLISHING GROUP 2017, Vol. 54, (5) : 365-370
Kostjukovits, Svetlana; Degerman, Sofie; Pekkinen, Minna; et al.
DNA methylation status defines clinicopathological parameters including survival for patients with clear cell renal cell carcinoma (ccRCC)
Tumor Biology, Vol. 37, (8) : 10219-10228
Andersson Evelönn, Emma; Degerman, Sofie; Köhn, Linda; et al.
DNA Methylation Adds Prognostic Value to Minimal Residual Disease Status in Pediatric T-Cell Acute Lymphoblastic Leukemia
Pediatric Blood & Cancer, Vol. 63, (7) : 1185-1192
Borssén, Magnus; Haider, Zahra; Landfors, Mattias; et al.
Long telomeres are associated with clonality in wild populations of the fissiparous starfish Coscinasterias tenuispina
Heredity, Vol. 115, (5) : 437-443
Garcia-Cisneros, A.; Perez-Portela, R.; Almroth, B. C.; et al.
Long Leukocyte Telomere Length at Diagnosis Is a Risk Factor for Dementia Progression in Idiopathic Parkinsonism
PLOS ONE, Vol. 9, (12)
Degerman, Sofie; Domellöf, Magdalena; Landfors, Mattias; et al.
Immortalization of T-Cells Is Accompanied by Gradual Changes in CpG Methylation Resulting in a Profile Resembling a Subset of T-Cell Leukemias
Neoplasia, Vol. 16, (7) : 606-615
Degerman, Sofie; Landfors, Mattias; Siwicki, Jan Konrad; et al.
Prognostic Implications of Mutations in NOTCH1 and FBXW7 in Childhood T-ALL Treated According to the NOPHO ALL-1992 and ALL-2000 Protocols
Pediatric Blood & Cancer, Wiley-Blackwell 2014, Vol. 61, (3) : 424-430
Fogelstrand, Linda; Staffas, Anna; Wasslavik, Carina; et al.
Promoter DNA methylation pattern identifies prognostic subgroups in childhood T-cell acute lymphoblastic leukemia
PLOS ONE, Vol. 8, (6) : e65373-
Borssen, Magnus; Palmqvist, Lars; Karrman, Kristina; et al.
Short telomere length is associated with NOTCH1/SF3B1/TP53 aberrations and poor outcome in newly diagnosed chronic lymphocytic leukemia patients
American Journal of Hematology, Vol. 88, (8) : 647-651
Mansouri, Larry; Grabowski, Pawel; Degerman, Sofie; et al.
Telomerase upregulation is a postcrisis event during senescence bypass and immortalization of two Nijmegen breakage syndrome T cell cultures
Aging Cell, John Wiley & Sons 2010, Vol. 9 : 220-235
Degerman, Sofie; Siwicki, Jan Konrad; Osterman, Pia; et al.
Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways
British Journal of Cancer, Vol. 103, (8) : 1255-1262
Sitaram, Raviprakash T; Degerman, Sofie; Ljungberg, Börje; et al.
Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event
Genes, Chromosomes and Cancer, Vol. 41, (2) : 133-144
Siwicki, Jan Konrad; Berglund, Mattias; Rygier, Jolanta; et al.
Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients
Experimental Cell Research, Vol. 287, (1) : 178-189
Siwicki, Jan Konrad; Degerman, Sofie; Chrzanowska, Krystyna H; et al.
Combining epigenetic and clinicopathological variables improves prognostic prediction in clear cell Renal Cell Carcinoma
Andersson-Evelönn, Emma; Vidman, Linda; Källberg, David; et al.
Integrated DNA methylation and gene expression analysis of molecular heterogeneity in prostate cancer bone metastasis
Bovinder Ylitalo, Erik; Thysell, Elin; Landfors, Mattias; et al.
Functional analysis of telomerase activity in T-lymphocytes as a diagnostic tool for pathogenicity assessment of novel genetic variants in telomere biology disorders
Carlund, Olivia; Norberg, Anna; Osterman, Pia; et al.
Senescence bypass and immortalization of T cell cultures are linked to stepwise DNA methylation changes
Degerman, Sofie; Borssen, Magnus; Andersson, Emma; et al.
The NBS1 gene is overexpressed and regulated by DJ-1 in clear cell renal cell carcinoma
Degerman, Sofie; Tumkur Sitaram, Raviprakash; Ljungberg, Börje; et al.
Epigenetic and genetic distinctions between T-cell acute lymphoblastic leukemia and lymphoma
Haider, Zahra; Landfors, Mattias; Golovleva, Irina; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Sofie Degermans labb

Forskningsprojekt

1 januari 2022 till 1 januari 2025
Epigenetiska klockor: modellering av biomarkörer för att mäta och förutsäga biologiskt åldrande
Sofie Degerman: DNA-mönster avslöjar risk för återfall vid barnleukemi

Idag överlever drygt 8 av 10 barn som drabbas av leukemi, och forskarna försöker öka överlevnaden och minska b...