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Umeå universitet
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Personalbild Thomas Brännström
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Thomas Brännström

Vetenskaplig meritering: Docent

Kontakt

E-post
thomas.brannstrom@umu.se
Telefon
090-785 15 23

Verksam som

Anknytning
Professor, överläkare vid Institutionen för medicinsk biovetenskap Enhet: Patologi Roll: Avdelningschef
Plats
By 6M, vån , Sjukhusområdet Umeå universitet, 901 85 Umeå
SOD1 protein content in human central nervous system and peripheral tissues
Journal of Neurochemistry, John Wiley & Sons 2025, Vol. 169, (6)
Leykam, Laura; Jonsson, Andreas P.; Forsberg, Karin M. E.; et al.
Diverse effects of coexpression of human SOD1 variants on motor neuron disease
Human Molecular Genetics, Oxford University Press 2025, Vol. 34, (16) : 1380-1391
Tokuda, Eiichi; Leykam, Laura; Zetterström, Per; et al.
Myofiber type shift in extraocular muscles in amyotrophic lateral sclerosis
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2023, Vol. 64, (5)
Behzadi, Arvin; Tjust, Anton Erik; Liu, Jing-Xia; et al.
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.
Distinct metabolic hallmarks of WHO classified adult glioma subtypes
Neuro-Oncology, Oxford University Press 2022, Vol. 24, (9) : 1454-1468
Björkblom, Benny; Wibom, Carl; Eriksson, Maria; et al.
Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
European Journal of Neurology, John Wiley & Sons 2022, Vol. 29, (4) : 1279-1283
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; et al.
Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
Acta neuropathologica communications, BioMed Central 2021, Vol. 9, (1)
Keskin, Isil; Ekhtiari Bidhendi, Elaheh; Marklund, Matthew; et al.
Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice
Acta neuropathologica communications, BMC 2020, Vol. 8, (1)
Lehmann, Manuela; Marklund, Matthew; Bolender, Anna-Lena; et al.
Mutant SOD1 aggregates from human ventral horn transmit templated aggregation and fatal ALS-like disease
Brain Pathology, John Wiley & Sons 2019, Vol. 29 : 90-90
Brännström, Thomas; Andersen, Peter M.; Bergh, Johan; et al.
Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2019, Vol. 90, (8) : 861-869
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Pakkenberg, Bente; et al.
The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension
Acta Neuropathologica, New York: Springer 2019, Vol. 138, (1) : 85-101
Keskin, Isil; Forsgren, Elin; Lehmann, Manuela; et al.
The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes
Cancers, MDPI 2019, Vol. 11, (12)
Wu, Wendy Yi-Ying; Johansson, Gunnar; Wibom, Carl; et al.
Mutant superoxide dismutase aggregates from human spinal cord transmit amyotrophic lateral sclerosis
Acta Neuropathologica, Springer 2018, Vol. 136, (6) : 939-953
Ekhtiari Bidhendi, Elaheh; Bergh, Johan; Zetterström, Per; et al.
Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis
Scientific Reports, Nature Publishing Group 2018, Vol. 8
Paré, Bastien; Lehmann, Manuela; Beaudin, Marie; et al.
Telomere length, allergies and risk of Glioma
Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 23-23
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna; et al.
Molecular classification of malignat glioma
Neuro-Oncology, Oxford University Press 2017, Vol. 19, (S3) : 88-88
Johansson, Gunnar; Brännström, Thomas; Andersson, Ulrika; et al.
Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation: a large multinational screening study
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 18, (3-4) : 256-264
Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna; et al.
Radiotherapy induces an immediate inflammatory reaction in malignant glioma: a clinical microdialysis study
Journal of Neuro-Oncology, Springer 2017, Vol. 131, (1) : 83-92
Tabatabaei, Pedram; Visse, Eward; Bergström, Per; et al.
Impact of Amyotrophic Lateral Sclerosis on Slow Tonic Myofiber Composition in Human Extraocular Muscles
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017, Vol. 58, (9) : 3708-3715
Tjust, Anton E.; Danielsson, Adam; Andersen, Peter M.; et al.
The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium
American Journal of Epidemiology, Vol. 183, (2) : 85-91
Amirian, E. Susan; Armstrong, Georgina N.; Zhou, Renke; et al.
Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor
PLOS ONE, Public library science 2016, Vol. 11, (10)
Dahlin, Anna M.; Wibom, Carl; Ghasimi, Soma; et al.
Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease
Journal of Clinical Investigation, Vol. 126, (6) : 2249-2253
Ekhtiari Bidhendi, Elaheh; Bergh, Johan; Zetterström, Per; et al.
Genetic risk variants in the CDKN2A/B, RTEL1 and EGFR genes are associated with somatic biomarkers in glioma
Journal of Neuro-Oncology, Vol. 127, (3) : 483-492
Ghasimi, Soma; Wibom, Carl; Dahlin, Anna M.; et al.
Unchanged neurotrophic factors and their receptors correlate with sparing in extraocular muscles in amyotrophic lateral sclerosis
Investigative Ophthalmology and Visual Science, Rockville: The association for research in vision and ophthalmology 2016, Vol. 57, (15) : 6831-6842
Harandi, Vahid M; Gaied, Aida RN; Brännström, Thomas; et al.
Low autophagy capacity implicated in motor system vulnerability to mutant superoxide dismutase
Acta neuropathologica communications, Vol. 4
Tokuda, Eiichi; Brännström, Thomas; Andersen, Peter M.; et al.
Structural and kinetic analysis of protein-aggregate strains in vivo using binary epitope mapping
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2015, Vol. 112, (14) : 4489-4494
Bergh, Johan; Zetterström, Per; Andersen, Peter M.; et al.
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Nature Neuroscience, Vol. 18, (5) : 631-+
Freischmidt, Axel; Wieland, Thomas; Richter, Benjamin; et al.
SOD1 aggregation in ALS mice shows simplistic test tube behavior
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (32) : 9878-9883
Lang, Lisa; Zetterström, Per; Brännström, Thomas; et al.
Metabolomic screening of tumor tissue and serum in glioma patients reveals diagnostic and prognostic information
Metabolites, MDPI 2015, Vol. 5, (3) : 502-520
Mörén, Lina; Bergenheim, A Tommy; Ghasimi, Soma; et al.
Extensive size variability of the GGGGCC expansion in C9orf72 in both neuronal and non-neuronal tissues in 18 patients with ALS or FTD
Human Molecular Genetics, Vol. 24, (11) : 3133-3142
Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna; et al.
Targeting glucosylceramide synthase induction of cell surface globotriaosylceramide (Gb3) in acquired cisplatin-resistance of lung cancer and malignant pleural mesothelioma cells
Experimental Cell Research, Vol. 336, (1) : 23-32
Tyler, Andreas; Johansson, Anders; Karlsson, Terese; et al.
A Generic Method for Design of Oligomer-Specific Antibodies
PLOS ONE, Vol. 9, (3) : e90857-
Brännström, Kristoffer; Lindhagen-Persson, Malin; Gharibyan, Anna L.; et al.
Induction of ubiquilin differs between different SOD1 transgenic strains
Neuropathology and Applied Neurobiology, Vol. 40, (S1) : 22-22
Brännström, Thomas; Sirkka, S.
Wnt and Extraocular Muscle Sparing in Amyotrophic Lateral Sclerosis
Investigative Ophthalmology and Visual Science, ARVO, The Association for Reserach in Vision and Ophthalmology 2014, Vol. 55, (9) : 5482-5496
McLoon, Linda K; Harandi, Vahid M; Brännstrom, Thomas; et al.
Analysis of Neurotrophic Factors in Limb and Extraocular Muscles of Mouse Model of Amyotrophic Lateral Sclerosis
PLOS ONE, Vol. 9, (10)
Vahid, Harandi M.; Susanne, Lindquist; Shrikant, Shantilal Kolan; et al.
The role of pro-inflammatory S100A9 in Alzheimer's disease amyloid-neuroinflammatory cascade
Acta Neuropathologica, Vol. 127, (4) : 507-522
Wang, Chao; Klechikov, Alexey G.; Gharibyan, Anna L.; et al.
Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis
Human Molecular Genetics, Vol. 22, (1) : 51-60
Graffmo, Karin S.; Forsberg, Karin; Bergh, Johan; et al.
Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors
PLOS ONE, Vol. 8, (2) : e57473-
Liu, Jing-Xia; Brännström, Thomas; Andersen, Peter M; et al.
Fatal neuroinflammation in a case of multiple sclerosis with anti-natalizumab antibodies
Neurology, Vol. 80, (10) : 965-967
Svenningsson, Anders; Dring, Ann Marie; Fogdell-Hahn, Anna; et al.
Composition of soluble misfolded superoxide Dismutase-1 in murine models of Amyotrophic Lateral Sclerosis
Neuromolecular medicine, Vol. 15, (1) : 147-158
Zetterström, Per; Graffmo, Karin S.; Andersen, Peter M; et al.
Cisplatin Resistance in Malignant Pleural Mesothelioma
Mesotheliomas: Synonyms and Definition, Epidemiology, Etiology, Pathogenesis, Cyto-Histopathological Features, Clinic, Diagnosis, Treatment, Prognosis, Zagreb: InTech 2012 : 169-186
Behnam-Mothlag, Parviz; Tyler, Andreas; Brännström, Thomas; et al.
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Neuro-Oncology, Oxford University Press 2012, Vol. 14, (Suppl 3) : 69-69
Ghasimi, Soma; Haapasalo, H.; Eray, M.; et al.
Immunohistochemical analysis of LRIG proteins in meningiomas: correlation between estrogen receptor status and LRIG expression
Journal of Neuro-Oncology, Vol. 108, (3) : 435-441
Ghasimi, Soma; Haapasalo, Hannu; Eray, Mine; et al.
Radioligand binding to brain dopamine and serotonin receptors and transporters in Parkinson's disease: relation to gene polymorphisms
International Journal of Neuroscience, New York: Gordon and Breach 2012, Vol. 122, (3) : 124-132
Güzey, Cüneyt; Allard, Per; Brännström, Thomas; et al.
EGFR expression and glioblastoma outcome
Neuro-Oncology, Oxford: Oxford University Press 2012, Vol. 14, (Suppl. 3) : 19-19
Sjöström, Sara; Ghasimi, Soma; Broholm, H.; et al.
Microbubbles of air may occur in the organs of hemodialysis patients
ASAIO journal (1992), Vol. 58, (2) : 177-179
Stegmayr, Bernd; Brännström, Thomas; Forsberg, Ulf; et al.
Unaffected motor endplate occupancy in eye muscles of ALS G93A mouse model
Frontiers in bioscience (Scholar edition), Frontiers in Bioscience 2012, Vol. 4 : 1547-1555
Tjust, Anton E; Brännstrom, Thomas; Pedrosa Domellöf, Fatima
EGFR gene variants are associated with specific somatic aberrations in glioma
Neuro-Oncology, Vol. 14, (Suppl. 3) : 46-46
Wibom, Carl; Ghasimi, Soma; Van Loo, P.; et al.
EGFR gene variants are associated with specific somatic aberrations in glioma
PLOS ONE, plosone.org 2012, Vol. 7, (12) : e47929-
Wibom, Carl; Ghasimi, Soma; Van Loo, Peter; et al.
DNA-repair gene variants are associated with glioblastoma survival
Acta Oncologica, Informa Healthcare 2012, Vol. 51, (3) : 325-332
Wibom, Carl; Sjöström, Sara; Henriksson, Roger; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
ALS-forskning Umeå
Styrgrupp
StratNeuro
Forskningsledare
Thomas Brännströms labb
Gruppmedlem
Medical Humanities Network
Thomas Brännström sitter vid sitt mikroskop och ler mot kameran med ett glas med vävnadssnitt i handen.
Thomas Brännström: Lokal kunskap guidar behandling av ALS

Symtom vid ALS är att musklerna förtvinar - då har sjukdomen säkert funnits i kroppen sedan ett decennium.

Thomas Brännström: Klumpar av protein en orsak till ALS

Klumpar av protein i nervcellerna finns hos alla patienter med ALS.