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Umeå universitet
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Personalbild Erik Johansson

Erik Johansson

Kontakt

E-post
erik.tm.johansson@umu.se
Telefon
090-786 66 38

Verksam vid

Anknytning
Professor vid Institutionen för medicinsk kemi och biofysik
Plats
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå
2020
A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
PLoS ONE, Public Library Science 2020, Vol. 15, (9)
Svensson, Daniel; Rentoft, Matilda; Dahlin, Anna M.; et al.
2019
Structural consequence of the most frequently recurring cancer-associated substitution in DNA polymerase epsilon
Nature Communications, Nature Publishing Group 2019, Vol. 10
Parkash, Vimal; Kulkarni, Yashraj; ter Beek, Josy; et al.
2019
A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis
PLoS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
2019
Structural evidence for an essential Fe–S cluster in the catalytic core domain of DNA polymerase ϵ
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (11) : 5712-5722
ter Beek, Josy; Parkash, Vimal; Bylund, Göran; et al.
2018
A mechanism for preventing asymmetric histone segregation onto replicating DNA strands
Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
2016
Strand displacement synthesis by yeast DNA polymerase epsilon
Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (17) : 8229-8240
Ganai, Rais A.; Zhang, Xiao-Ping; Heyer, Wolf-Dietrich; et al.
2016
DNA Replication - A Matter of Fidelity
Molecular Cell, Vol. 62, (5) : 745-755
Ganai, Rais Ahmad; Johansson, Erik
2016
Heterozygous colon cancer-associated mutations of SAMHD1 have functional significance
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (17) : 4723-4728
Rentoft, Matilda; Lindell, Kristoffer; Tran, Phong; et al.
2015
Switching between polymerase and exonuclease sites in DNA polymerase ε
Nucleic Acids Research, Oxford University Press 2015, Vol. 43, (2) : 932-942
Ganai, Rais Ahmad; Bylund, Göran; Johansson, Erik
2015
Yeast DNA Polymerase epsilon Catalytic Core and Holoenzyme Have Comparable Catalytic Rates
Journal of Biological Chemistry, USA: 2015, Vol. 290, (6) : 3825-3835
Ganai, Rais Ahmad; Osterman, Pia; Johansson, Erik
2015
Mammalian POLQ, Chromosome Stability and DNA Double-Strand Break Repair
Environmental and Molecular Mutagenesis, Vol. 56 : S48-S48
Yousefzadeh, M. J.; Wyatt, D. W.; Takata, K.; et al.
2014
Structural basis for processive DNA synthesis by yeast DNA polymerase ε
Nature Structural & Molecular Biology, Nature Publishing Group 2014, Vol. 21, (1) : 49-56
Hogg, Matthew; Osterman, Pia; Bylund, Göran; et al.
2014
Mechanism of suppression of chromosomal instability by DNA polymerase POLQ
PLOS Genetics, Public library science 2014, Vol. 10, (10) : e1004654-
Yousefzadeh, Matthew J; Wyatt, David W; Takata, Kei-Ichi; et al.
2013
DNA och cancerutveckling
Cancerforskning på nya vägar: en bok från Froskningens dag 2013, Medicinska fakulteten vid Umeå universitet, Umeå: Umeå universitet 2013 : 15-22
Johansson, Erik
2013
Replicative DNA polymerases
Cold Spring Harbor Perspectives in Biology, Vol. 5, (6) : a012799-
Johansson, Erik; Dixon, Nicholas
2012
DNA Polymerase ε
The eukaryotic replisome: a guide to protein structure and function, Springer Science+Business Media B.V. 2012 : 237-57
Hogg, Matthew; Johansson, Erik
2012
Promiscuous DNA synthesis by human DNA polymerase θ
Nucleic Acids Research, Vol. 40, (6) : 2611-2622
Hogg, Matthew; Sauer-Eriksson, A Elisabeth; Johansson, Erik
2012
The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability
Nucleic Acids Research, Vol. 40, (22) : 11545-11553
Isoz, Isabelle; Persson, Ulf; Volkov, Kirill; et al.
2012
RNase H2-Initiated Ribonucleotide Excision Repair
Molecular Cell, Vol. 47, (6) : 980-986
Sparks, Justin L; Chon, Hyongi; Cerritelli, Susana M; et al.
2012
Proofreading of ribonucleotides inserted into DNA by yeast DNA polymerase ɛ.
DNA Repair, Vol. 11, (8) : 649-656
Williams, Jessica S; Clausen, Anders R; Nick McElhinny, Stephanie A; et al.
2011
A top-down view on DNA replication and recombination from 9,000 feet above sea level
Genome Biology, BioMed Central 2011, Vol. 12, (4)
Johansson, Erik; Speck, Christian; Chabes, Andrei
2011
Replication of ribonucleotide-containing DNA templates by yeast replicative polymerases
DNA Repair, Vol. 10, (8) : 897-902
Watt, Danielle L; Johansson, Erik; Burgers, Peter M; et al.
2010
Mismatch repair-independent increase in spontaneous mutagenesis in yeast lacking non-essential subunits of DNA polymerase ε
PLoS genetics, Public Library of Science 2010, Vol. 6, (11) : e1001209-
Aksenova, Anna; Volkov, Kirill; Maceluch, Jaroslaw; et al.
2010
The eukaryotic replicative DNA polymerases take shape.
TIBS -Trends in Biochemical Sciences. Regular ed., Elsevier 2010, Vol. 35, (6) : 339-347
Johansson, Erik; MacNeill, Stuart A
2010
Genome instability due to ribonucleotide incorporation into DNA
Nature Chemical Biology, Vol. 6, (10) : 774-81
Nick McElhinny, Stephanie A; Kumar, Dinesh; Clark, Alan B; et al.
2010
Abundant ribonucleotide incorporation into DNA by yeast replicative polymerases.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, (11) : 4949-4954
Nick McElhinny, Stephanie A; Watts, Brian E; Kumar, Dinesh; et al.
2009
Translesion synthesis of abasic sites by yeast DNA polymerase epsilon
The Journal of biological chemistry, Vol. 284, (46) : 31555-31563
Sabouri, Nasim; Johansson, Erik
2008
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
Nucleic Acids Research, Vol. 36, (17) : 5660-5667
Sabouri, Nasim; Viberg, Jörgen; Kumar, Dinesh; et al.
2008
Uracil recognition by replicative DNA polymerases is limited to the archaea, not occurring with bacteria and eukarya.
Nucleic Acids Research, Vol. 36, (3) : 705-711
Wardle, Josephine; Burgers, Peter M J; Cann, Isaac K O; et al.
2007
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.
Nucleic Acids Research, Vol. 35, (19) : 6588-6597
Chilkova, Olga; Stenlund, Peter; Isoz, Isabelle; et al.
2007
Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon.
Nucleic Acids Research, Vol. 35, (9) : 3076-3086
Pursell, Zachary F; Isoz, Isabelle; Lundström, Else-Britt; et al.
2007
Yeast DNA polymerase epsilon participates in leading-strand DNA replication.
Science, Vol. 317, (5834) : 127-130
Pursell, Zachary F; Isoz, Isabelle; Lundström, Else-Britt; et al.
2006
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.
Nature Structural & Molecular Biology, Vol. 13, (1) : 35-43
Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; et al.
2005
Saccharomyces cerevisiae DNA polymerase delta: high fidelity for base substitutions but lower fidelity for single- and multi-base deletions.
Journal of biological chemistry, Vol. 280, (33) : 29980-7
Fortune, John M; Pavlov, Youri I; Welch, Carrie M; et al.
2004
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.
Genes & Development, Vol. 18, (22) : 2764-2773
Garg, Parie; Stith, Carrie M; Sabouri, Nasim; et al.
2004
The Pol32 subunit of DNA polymerase delta contains separable domains for processive replication and proliferating cell nuclear antigen (PCNA) binding.
Journal of biological chemistry, Vol. 279, (3) : 1907-15
Johansson, Erik; Garg, Parie; Burgers, Peter M J
2004
Enzymatic switching for efficient and accurate translesion DNA replication.
Nucleic Acids Research, Vol. 32, (15) : 4665-75
McCulloch, Scott D; Kokoska, Robert J; Chilkova, Olga; et al.
2003
The quaternary structure of DNA polymerase epsilon from Saccharomyces cerevisiae.
Journal of Biological Chemistry, Vol. 278, (16) : 14082-14086
Chilkova, Olga; Jonsson, Bengt-Harald; Johansson, Erik
2003
Unique error signature of the four-subunit yeast DNA polymerase epsilon.
Journal of Biological Chemistry, Vol. 278, (44) : 43770-43780
Shcherbakova, Polina V; Pavlov, Youri I; Chilkova, Olga; et al.
2001
Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.
Genes & Development, Vol. 15, (8) : 945-54
Haracska, L; Unk, I; Johnson, R E; et al.
2001
Structure of DNA polymerase delta from Saccharomyces cerevisiae.
Journal of Biological Chemistry, Vol. 276, (47) : 43824-8
Johansson, Erik; Majka, J; Burgers, P M
2001
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)n trinucleotide repeat sequence.
Journal of Biological Chemistry, Vol. 276, (19) : 16439-46
Kamath-Loeb, A S; Loeb, L A; Johansson, Erik; et al.
2000
Functional interaction between the Werner Syndrome protein and DNA polymerase delta.
Proceedings or the National Academy of Sciences U S A, Vol. 97, (9) : 4603-8
Kamath-Loeb, A S; Johansson, Erik; Burgers, P M; et al.
1998
Two YY-1-binding proximal elements regulate the promoter strength of the TATA-less mouse ribonucleotide reductase R1 gene.
Journal of Biological Chemistry, Vol. 273, (45) : 29816-21
Johansson, Erik; Hjortsberg, K; Thelander, Lars
1996
Induction of the mouse ribonucleotide reductase R1 and R2 genes in response to DNA damage by UV light.
Journal of Biological Chemistry, Vol. 271, (39) : 23698-704
Filatov, D; Björklund, Stefan; Johansson, Erik; et al.
1995
The TATA-less promoter of mouse ribonucleotide reductase R1 gene contains a TFII-I binding initiator element essential for cell cycle-regulated transcription.
Journal of Biological Chemistry, Vol. 270, (50) : 30162-7
Johansson, Erik; Skogman, E; Thelander, Lars
1994
Gene structure and regulation of the expression of the R1 and R2 subunits of mouse ribonucleotide reductase.
Advances in Experimental Medicine and Biology, Vol. 370 : 721-4
Johansson, Erik; Björklund, Stefan; Thelander, Lars
1993
Structure and promoter characterization of the gene encoding the large subunit (R1 protein) of mouse ribonucleotide reductase.
Proceedings of the National Academy of Science U S A, Vol. 90, (23) : 11322-6
Björklund, Stefan; Hjortsberg, K; Johansson, Erik; et al.
Modulation of strand displacement synthesis of DNA polymerase ε byprocessive 3'- 5' exonuclease activity.
Ganai, Rais Ahmad; Johansson, Erik
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Erik Johansson

Forskningsprojekt

1 juli 2000 till 31 december 2021
Kopiering och reparation av cellens arvsmassa