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Umeå universitet
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Personalbild Per Stål

Per Stål

Per Stål är professor i anatomi. Hans forskning är inriktad på cellulära och molekylära förändringar i friska och sjuka muskler och nerver.

Pedagogisk meritering: Meriterad lärare

Kontakt

E-post
per.stal@umu.se
Telefon
090-786 76 04, 070-648 85 31

Verksam vid

Anknytning
Professor vid Institutionen för medicinsk och translationell biologi Enhet: Grupp Per Stål, Lärare A-flygeln
Plats
Umeå universitet, 901 87 Umeå

Professor Per Stål är forskningsledare vid laboratoriet för muskelbiologi. Hans forskargrupp bedriver translationell forskning om muskler och nerver hos människa med fokus på cellulära och molekylära förändringar som sker vid fysisk aktivitet, olika sjukdomstillstånd, läkning, och åldrande. Syftet med forskningen är att öka förståelsen för normal muskel- och nervfunktion och biologiska processer involverade i neuromuskulära sjukdomar. Tyngdpunkten ligger på förändringar i cellmembran, cytoskeletala och kontraktila proteiner, mikrovaskularisering och signalämnen involverade i tillväxt, skydd och regenerering. Forskningens långsiktiga mål är att hitta nya och effektiva behandlingsstrategier vid neuromuskulära skador. För sitt engagemang i muskelforskning erhöll Docent Per Stål 2012 Messner Foundation Award och  2018 Thuréus Award.
Per Stål är kvalificerad som meriterad lärare och undervisar inom läkar-, tandläkar-, och sjuksköterskeprogrammet. Han har erhållit ett flertal utmärkelser av studenter och från Umeå universitet för sina undervisningsinsatser.

Desmin gene expression is not ubiquitous in all upper airway myofibers and the pattern differs between healthy and sleep apnea subjects
European Journal of Medical Research, BioMed Central (BMC) 2024, Vol. 29, (1)
Stål, Per; Nord, Hanna; von Hofsten, Jonas; et al.
Daily vocal exercise is necessary for peak performance singing in a songbird
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Adam, Iris; Riebel, Katharina; Stål, Per; et al.
Unique fiber phenotype composition and metabolic properties of the stapedius and tensor tympani muscles in the human middle ear
Journal of Anatomy, John Wiley & Sons 2023, Vol. 243, (1) : 39-50
Rönnblom, Anton; Thornell, Lars-Eric; Shah, Farhan; et al.
Skeletal muscle morphology, satellite cells, and oxidative profile in relation to physical function and lifelong endurance training in very old men
Journal of applied physiology, American Physiological Society 2023, Vol. 134, (2) : 264-275
Skoglund, Elisabeth; Stål, Per; Lundberg, Tommy R.; et al.
Myopathy of the upper airway in snoring and obstructive sleep apnea
Laryngoscope Investigative Otolaryngology (LIO), John Wiley & Sons 2022, Vol. 7, (2) : 636-645
Shah, Farhan; Stål, Per
Effects of low-load/high-repetition resistance training on exercise capacity, health status and limb muscle adaptation in patients with severe COPD: a randomized controlled trial
Chest, Elsevier 2021, Vol. 159, (5) : 1821-1832
Nyberg, Andre; Martin, Mickael; Saey, Didier; et al.
Forces Required for Isolated Malleus Shaft Fractures
Otology and Neurotology, Wolters Kluwer 2021, Vol. 42, (10) : 1515-1520
Rönnblom, Anton; Niklasson, Anders; Werner, Mimmi; et al.
Reduced mitochondrial DNA and OXPHOS protein content in skeletal muscle of children with cerebral palsy
Developmental Medicine & Child Neurology, John Wiley & Sons 2021, Vol. 63, (10) : 1204-1212
von Walden, Ferdinand; Vechetti, Ivan J., Jr.; Englund, Davis; et al.
Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy
Frontiers in Pediatrics , Frontiers Media S.A. 2020, Vol. 8
von Walden, Ferdinand; Fernandez-Gonzalo, Rodrigo; Pingel, Jessica; et al.
Effect and feasibility of non-linear periodized resistance training in people with COPD: study protocol for a randomized controlled trial
Trials, BioMed Central (BMC) 2019, Vol. 20, (1)
Frykholm, Erik; Klijn, Peter; Saey, Didier; et al.
Neurotrophic factor BDNF is upregulated in soft palate muscles of snorers and sleep apnea patients
Laryngoscope Investigative Otolaryngology (LIO), Wiley Periodicals, Inc. 2019, Vol. 4, (1) : 174-180
Shah, Farhan; Forsgren, Sture; Holmlund, Thorbjörn; et al.
Desmin and dystrophin abnormalities in upper airway muscles of snorers and patients with sleep apnea
Respiratory Research, BioMed Central 2019, Vol. 20
Shah, Farhan; Franklin, Karl A; Holmlund, Thorbjörn; et al.
Tooth extraction and subsequent dental implant placement in Sprague-Dawley rats induce differential changes in anterior digastric myofibre size and myosin heavy chain isoform expression
Archives of Oral Biology, Elsevier 2019, Vol. 99 : 141-149
Shah, Farhan; Stål, Per; Li, Jian; et al.
De novo dNTP production is essential for normal postnatal murine heart development
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
Muscle changes in patients with diabetes and chronic exertional compartment syndrome before and after treatment with fasciotomy
Muscle and Nerve, John Wiley & Sons 2018, Vol. 57, (2) : 229-239
Edmundsson, David S.; Toolanen, Göran L.; Stål, Per S.
Axon and Schwann Cell Degeneration in Nerves of Upper Airway Relates to Pharyngeal Dysfunction in Snorers and Patients With Sleep Apnea
Chest, Elsevier 2018, Vol. 154, (5) : 1091-1098
Shah, Farhan; Holmlund, Thorbjörn; Levring Jäghagen, Eva; et al.
Muscle contractures in patients with cerebral palsy and acquired brain injury are associated with extracellular matrix expansion, pro-inflammatory gene expression, and reduced rRNA synthesis
Muscle and Nerve, Wiley-Blackwell 2018, Vol. 58, (2) : 277-285
Von Walden, Ferdinand; Gantelius, Stefan; Liu, Chang; et al.
Bilateral muscle fiber and nerve influences by TNF-alpha in response to unilateral muscle overuse: studies on TNF receptor expressions
BMC Musculoskeletal Disorders, Vol. 18, (1)
Renström, Lina; Stål, Per; Song, Yafeng; et al.
Unique expression of cytoskeletal proteins in human soft palate muscles
Journal of Anatomy, Wiley-Blackwell 2016, Vol. 228, (3) : 487-494
Shah, Farhan; Berggren, Diana; Holmlund, Thorbjörn; et al.
Collagen content in the vastus lateralis and the soleus muscle following a 90-day bed rest period with or without resistance exercises
MLTJ - Muscles Ligaments and Tendons Journal, Vol. 5, (4) : 305-309
Nielsen, Rasmus Oestergaard; Schjerling, Peter; Tesch, Per; et al.
Fibre typing of intrafusal fibres
Journal of Anatomy, John Wiley & Sons 2015, Vol. 227, (2) : 136-156
Thornell, Lars-Eric; Carlsson, Lena; Eriksson, Per-Olof; et al.
Unilateral muscle overuse causes bilateral changes in muscle fiber composition and vascular supply
PLOS ONE, Vol. 9, (12) : e116455-
Song, Yafeng; Forsgren, Sture; Liu, Jing-Xia; et al.
Inhibitors of endopeptidase and angiotensin-converting enzyme lead to an amplification of the morphological changes and an upregulation of the substance P system in a muscle overuse model
BMC Musculoskeletal Disorders, BioMed Central 2014, Vol. 15 : 126-
Song, Yafeng; Stål, Per S; Yu, Ji-Guo; et al.
Effects of long term supplementation of anabolic androgen steroids on human skeletal muscle
PLOS ONE, Public Library Science 2014, Vol. 9, (9)
Yu, Ji-Guo; Bonnerud, Patrik; Eriksson, Anders; et al.
TNF-alpha in an Overuse Muscle Model - Relationship to Muscle Fiber Necrosis/Regeneration, the NK-1 Receptor and an Occurrence of Bilateral Involvement
Journal of Clinical & Cellular Immunology, Vol. 4, (2)
Renström, Lina; Song, Yafeng; Stål, Per; et al.
Marked effects of tachykinin in myositis both in the experimental side and contralaterally: studies on NK-1 receptor expressions in an animal model
ISRN Inflammation, Vol. 2013, (907821)
Song, Yafeng; Stål, Per; Yu, Jiguo; et al.
Bilateral increase in expression and concentration of tachykinin in a unilateral rabbit muscle overuse model that leads to myositis
BMC Musculoskeletal Disorders, BioMed Central 2013, Vol. 14
Song, Yafeng; Stål, Per; Yu, Jiguo; et al.
Re-evaluation of sarcolemma injury and muscle swelling in human skeletal muscles after eccentric exercise
PLOS ONE, Vol. 8, (4)
Yu, Ji-Guo; Liu, Jing-Xia; Carlsson, Lena; et al.
Effects on contralateral muscles after unilateral electrical muscle stimulation and exercise
PLOS ONE, Public Library Science 2012, Vol. 7, (12) : e52230-
Song, Yafeng; Forsgren, Sture; Yu, Jiguo; et al.
Abnormal Mitochondria Organization and Oxidative Activity in the Palate Muscles of Long-Term Snorers with Obstructive Sleep Apnea
Respiration, S. Karger 2012, Vol. 83, (5) : 407-417
Stål, Per S; Johansson, Bengt
Stiffness and thickness of Fascia do not explain chronic exertional compartment syndrome
Clinical Orthopaedics and Related Research, Vol. 469, (12) : 3495-3500
Dahl, Morten; Hansen, Philip; Stål, Per; et al.
Human extraocular muscles in ALS
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2010, Vol. 51, (7) : 3494-3501
Ahmadi, Mahboobah; Liu, Jing-Xia; Brännström, Thomas; et al.
Evidence for low muscle capillary supply as a pathogenic factor in chronic compartment syndrome
Scandinavian Journal of Medicine and Science in Sports, Copenhagen: Munksgaard 2010, Vol. 20, (6) : 805-813
Edmundsson, David; Toolanen, Göran; Thornell, Lars-Eric; et al.
Capillary supply in relation to myosin heavy chain fibre composition of human intrinsic tongue muscles
Cells Tissues Organs, Vol. 192, (5) : 303-313
Granberg, I; Lindell, Björn; Eriksson, Per-Olof; et al.
Capillary supply of the soft palate muscles is reduced in long-term habitual snorers
Respiration, Vol. 77, (3) : 303-310
Stål, Per; Lindman, Rolf; Johansson, Bengt
Myocardial capillary supply is limited in hypertrophic cardiomyopathy: a morphological analysis
International Journal of Cardiology, Vol. 126, (2) : 252-257
Johansson, Bengt; Mörner, Stellan; Waldenström, Anders; et al.
Decreased capillarization and a shift to fast myosin heavy chain IIx in the biceps brachii muscle from young adults with spastic paresis
Journal of the Neurological Sciences, Elsevier 2007, Vol. 253, (1-2) : 25-33
Pontén, Eva M.; Stål, Per S.
Uncoordinated expression of myosin heavy chains and myosin-binding protein C isoforms in human extraocular muscles
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology 2006, Vol. 47, (10) : 4188-4193
Kjellgren, Daniel; Stål, Per; Larsson, Lars; et al.
Fibre composition of human intrinsic tongue muscles.
Cells Tissues Organs, Vol. 173, (3) : 147-161
Stål, Per; Marklund, Susanna; Thornell, Lars-Eric; et al.
Abnormal palatopharyngeal muscle morphology in sleep-disordered breathing
Journal of the Neurological Sciences, Elsevier 2002, Vol. 195, (1) : 11-23, Article Number: PII S0022-510X(01)00676-1
Lindman, Rolf; Stål, Per S
Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms
Journal of Muscle Research and Cell Motility, Vol. 23, (4) : 317-326
Yu, F; Stål, Per; Thornell, Lars-Eric; et al.
Changes in a rat facial muscle after facial nerve injury and repair
Muscle and Nerve, John Wiley & Sons 2001, Vol. 24, (9) : 1202-1212
Jergović, D; Stål, Per; Lidman, D; et al.
Morphological characterization of the levator veli palatini muscle in children born with cleft palates
The Cleft Palate-Craniofacial Journal, Vol. 38, (5) : 438-448
Lindman, Rolf; Paulin, Gunnar; Stål, Per S
Characterisation of human soft palate muscles with respect to fibre types, myosins and capillary supply.
Journal of Anatomy, Vol. 197 ( Pt 2) : 275-90
Stål, Per; Lindman, R
Muscle changes in diabetics with chronic compartment syndrome
Edmundsson, David; Toolanen, Göran; Stål, Per
Effects and mechanisms of supramaximal High-Intensity Interval Training on extrapulmonary manifestations in people with and without Chronic Obstructive Pulmonary Disease (COPD-HIIT): study protocol for a multi-centre, randomized controlled trial
Jakobsson, Johan; Burtin, Chris; Hedlund, Mattias; et al.
Capillarization and myosin composition in spastic biceps brachii muscle
Pontén, Eva; Stål, Per
Upregulated expression of brain-derived neurotrophic factor in soft palate muscles of snorers and obstructive sleep apnea patients
Shah, Farhan; Forsgren, Sture; Holmlund, Thorbjörn; et al.
Desmin and dystrophin myopathy in the upper airway of snoring and obstructive sleep apnea patients
Shah, Farhan; Franklin, Karl; Holmlund, Thorbjörn; et al.
Axon and Schwann cell degeneration in nerves of upper airway relates to pharyngeal dysfunction in snorers and sleep apnea patients
Shah, Farhan; Holmlund, Thorbjörn; Levring Jäghagen, Eva; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Per Stål-forskargrupp
Gruppmedlem
Umeå Translational Respiratory EXercise group (U-TREX)

Forskningsprojekt

1 januari 2016 till 1 januari 2023
ENDURE/PREDQUAD
10 oktober 2013
Neuromuskulära skador i övre luftvägarna vid obstruktiv sömnapné (OSA)
Film: Per Stål, professor i anatomi
Per Stål, professor i anatomi

Per Stål undersöker hur faktorer som skada, sjukdom, träning, medicinsk behandling och ålder påverkar processer i skelettmuskler.

Fokus på muskler hos friska och sjuka

Per Ståls forskning är fokuserad på att öka kunskapen om frisk och sjuk muskulatur.