Umeå universitet
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Personalbild Julia Otten

Julia Otten

Endokrinolog med forskningsfokus typ 2 diabetes

Kontakt

E-post
Julia.Otten@umu.se
Telefon

Verksam vid

Anknytning
Biträdande universitetslektor, kombinerad med klinisk tjänstgöring vid Institutionen för folkhälsa och klinisk medicin Enhet: Avdelningen för medicin
Plats
1A, målpunkt B41, plan 4, Norrlands universitetssjukhus

Jag är endokrinolog och arbetar som överläkare på medicincentrum samt som biträdande universitetslektor. Jag forskar om behandling av typ 2 diabetes med diet och träning samt om prediktion av prediabetes och diabetes.


Vid typ 2 diabetes är både insulinkänslighet och insulinsekretion nedsatt. Båda är redan avvikande vid prediabetes och möjligen även innan dess. Jag undersöker om insulinkänslighet eller insulinsekretion försämras först och hur båda ökar risken att utveckla prediabetes och typ 2 diabetes. Är det möjligt att insulinkänslighet och insulinsekretion normaliseras igen och en individ med typ 2 diabetes går i diabetesremission?


Jag undersöker kända och mindre kända komplikationer till typ 2 diabetes såsom ateroskleros, fettinlagring i lever och hjärtat, lungfunktionsnedsättning och förändrad hormonproduktion av glucagon-like peptide-1 (GLP-1) och glukagon. Jag genomför interventionsstudier med Paleolitisk kost, träning och kostersättning för individer med typ 2 diabetes för att undersöka om de ovan beskrivna komplikationer är reversibla.


Jag handleder doktorander, läkarstudenter som skriver sina examensarbeten och ST-läkare som skriver sina projektarbeten.

Effect of the New Nordic Diet compared with usual care on glucose control in gestational diabetes mellitus: Study protocol for the randomized controlled trial intervention with new Nordic DIet in women with GestatiOnal diabetes mellitus (iNDIGO)
Contemporary Clinical Trials, Elsevier 2022, Vol. 115
Karlsson, T.; Augustin, H.; Lindqvist, Maria; et al.
Improved peripheral and hepatic insulin sensitivity after lifestyle interventions in type 2 diabetes is associated with specific metabolomic and lipidomic signatures in skeletal muscle and plasma
Metabolites, MDPI 2021, Vol. 11, (12)
Chorell, Elin; Otten, Julia; Stomby, Andreas; et al.
Using a paleo ratio to assess adherence to paleolithic dietary recommendations in a randomized controlled trial of individuals with type 2 diabetes
Nutrients, MDPI 2021, Vol. 13, (3) : 1-15
Mårtensson, Alexander; Stomby, Andreas; Tellström, Anna; et al.
The liver-alpha-cell axis after a mixed meal and during weight loss in type 2 diabetes
Endocrine Connections, Bioscientifica 2021, Vol. 10, (9) : 1101-1110
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Fasting C-peptide at type 2 diabetes diagnosis is an independent risk factor for total and cancer mortality
Diabetes/Metabolism Research Reviews
Otten, Julia; Tavelin, Björn; Söderberg, Stefan; et al.
Association between nutritional profiles of foods underlying Nutri-Score front-of-pack labels and mortality: EPIC cohort study in 10 European countries
BMJ. British Medical Journal, BMJ Publishing Group Ltd 2020, Vol. 370
Deschasaux, Melanie; Huybrechts, Inge; Julia, Chantal; et al.
Insulin resistance at type 2 diabetes diagnosis, not impaired beta cell function, is associated with total mortality
Diabetologia, Springer 2020, Vol. 63, (SUPPL 1) : S41-S41
Otten, Julia; Tavelin, Björn; Söderberg, Stefan; et al.
Diet-induced weight loss alters hepatic glucocorticoid metabolism in type 2 diabetes mellitus
European Journal of Endocrinology, Bioscientifica 2020, Vol. 182, (4) : 447-457
Stomby, Andreas; Otten, Julia; Ryberg, Mats; et al.
The associations of major foods and fibre with risks of ischaemic and haemorrhagic stroke: a prospective study of 418 329 participants in the EPIC cohort across nine European countries
European Heart Journal, Oxford University Press 2020, Vol. 41, (28) : 2632-2640
Tong, Tammy Y. N.; Appleby, Paul N.; Key, Timothy J.; et al.
Exercise Training Adds Cardiometabolic Benefits of a Paleolithic Diet in Type 2 Diabetes Mellitus
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Wiley-Blackwell 2019, Vol. 8, (2)
Otten, Julia; Andersson, Jonas; Ståhl, Jens; et al.
Postprandial levels of GLP-1, GIP, and glucagon after two years of weight loss with a Paleolithic diet: a randomized controlled trial in healthy obese women
European Journal of Endocrinology, Bioscientifica 2019, Vol. 180, (6) : 417-427
Otten, Julia; Ryberg, Mats; Mellberg, Caroline; et al.
Treadmill workstations in office workers who are overweight or obese: a randomised controlled trial
The Lancet Public Health, The Lancet Publishing Group 2018, Vol. 3, (11)
Bergman, Frida; Wahlström, Viktoria; Stomby, Andreas; et al.
The liver-alpha-cell axis during weight loss in type 2 diabetes
Diabetologia, Springer 2018, Vol. 61 : S97-S98
Otten, Julia; Stomby, Andreas; Waling, M.; et al.
A heterogeneous response of liver and skeletal muscle fat to the combination of a Paleolithic diet and exercise in obese individuals with type 2 diabetes: a randomised controlled trial
Diabetologia, Springer 2018, Vol. 61, (7) : 1548-1559
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Weight loss by two different diets increases the postprandial response of GLP-1 but only the Paleolithic diet increases the postprandial response of GIP
Diabetologia, Springer 2017, Vol. 60 : S233-S233
Otten, Julia; Ryberg, Mats; Mellberg, Caroline; et al.
Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes
Cell Symposia Exercise Metabolism, 21-23 May, 2017, Gothenburg, Sweden
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Exercise training reverses the effect of a Paleolithic diet on liver fat and intramyocellular lipid content in patients with type 2 diabetes
Endokrindagarna, 1-3 februari 2017, Uppsala, Sweden
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes
Diabetes/Metabolism Research Reviews, Vol. 33, (1)
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
A Paleolithic Diet with and without Combined Aerobic and Resistance Exercise Increases Functional Brain Responses and Hippocampal Volume in Subjects with Type 2 Diabetes
Frontiers in Aging Neuroscience, Vol. 9
Stomby, Andreas; Otten, Julia; Ryberg, Mats; et al.
Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention
International Journal of Cardiology, Vol. 216 : 92-96
Andersson, Jonas; Mellberg, Caroline; Otten, Julia; et al.
Effects of a Paleolithic diet and exercise on liver fat, muscle fat and insulin sensitivity
Umeå University medical dissertations, 1839
Otten, Julia
Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention
International Journal of Obesity, Vol. 40, (5) : 747-753
Otten, Julia; Mellberg, Caroline; Ryberg, Mats; et al.
Effects of a paleolithic diet with and without supervised exercise on liver fat and insulin sensitivity: a randomised controlled trial in individuals with type 2 diabetes
Diabetologia, SPRINGER 2016, Vol. 59 : S10-S10
Otten, Julia; Stomby, Andreas; Ryberg, Mats; et al.
Effects of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes
Endokrindagarna, Stockholm, Sweden
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis. Are there not some surrogate indexes lost in this story? Reply to Bastard JP, Rabasa-Lhoret R, Laville M and Disse E [letter]
Diabetologia, Vol. 58, (2) : 416-417
Otten, Julia; Ahren, Bo; Olsson, Tommy
Surrogate measures of insulin sensitivity vs the hyperinsulinaemic-euglycaemic clamp: a meta-analysis
Diabetologia, Springer 2014, Vol. 57, (9) : 1781-1788
Otten, Julia; Ahren, Bo; Olsson, Tommy
Diet influence on peripheral and hepatic insulin sensitivity.
Keystone symposium "Genetic and Molecular Basis of Obesity and Body Weight Regulation", Santa Fe, New Mexico, 29 Jan-3 Feb
Otten, Julia; Mellberg, Caroline; Hauksson, J; et al.
Långsiktiga effekter av kostförändringar på leverfett och insulinkänslighet hos postmenopausala överviktiga kvinnor.
Endokrindagarna i Örebro organiserat av Svenska Endokrinologföreningen, 1-3 februari
Otten, Julia; Mellberg, Caroline; Hauksson, J; et al.
Decreased liver fat during a two-year diet intervention was not associated with improvement in hepatic insulin sensitivity
Mellberg, Caroline; Otten, Julia; Ryberg, Mats; et al.
Exercise Training Reverses the Effect of a Paleolithic Diet on Liver Fat and Intramyocellular Lipid Content in Patients with Type 2 Diabetes
Otten, Julia; Stomby, Andreas; Waling, Maria; et al.
Visa publikationer i DiVA

Jag undervisar på termin 4 och termin 6 på läkarprogrammet, apotekar- och receptarieprogrammet, dietistprogrammet, sköterskeutbildningen och diabetessköterskeutbildningen. Jag föreläser regelbundet om typ 2 diabetes-behandling för läkare och sjuksköterskor i primärvården.