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Umeå universitet
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Huvudmenyn dold.

Robin Fåhraeus

Kontakt

E-post
robin.fahraeus@umu.se

Verksam som

Anknytning
Professor vid Institutionen för medicinsk biovetenskap
Plats
By 6M, Sjukhusområdet Umeå universitet, 901 85 Umeå
Cancer-associated synonymous mutations target mRNA structures and protein activity
Trends in Cancer
Fahraeus, Robin
Cancer-associated synonymous mutations reveal stress signal–dependent mRNA folding that selectively modulates protein function
RNA: A publication of the RNA Society, Cold Spring Harbor Laboratory Press (CSHL) 2026, Vol. 32, (7) : 1147-1155
Gnanasundram, Sivakumar Vadivel; Wang, Lixiao; Chen, Sa; et al.
MDM2 suppresses c-Myc synthesis by binding to the 5’ mRNA translation regulatory sequence
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2026, Vol. 123, (26)
Habault, Justine; Salomao, Norman; Wang, Lixiao; et al.
The p53 mRNA exhibits riboswitch-like features under DNA damage conditions
iScience, Elsevier 2025, Vol. 28, (10)
Chen, Sa; Wang, Lixiao; Malbert-Colas, Laurence; et al.
Reduced structural rigidity of MDMX protein enhances binding to TP53 mRNA
Bioscience Reports, Portland Press 2025, Vol. 45, (11) : 683-696
Kucerikova, Martina; Bonczek, Ondrej; Olivares-Illana, Vanesa; et al.
A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47
British Journal of Cancer, Springer Nature 2025, Vol. 133 : 970-975
Sajwan, Rhythm; Wang, Lixiao; Casar-Borota, Olivera; et al.
The codon context provides cis-acting immune evasion for the human papilloma virus (HPV) E6
RNA: A publication of the RNA Society, Cold Spring Harbor Laboratory Press (CSHL) 2025, Vol. 31, (12) : 1735-1748
Thermou, Aikaterini; Daskalogianni, Chrysoula; Wang, Lixiao; et al.
Translation of bi-directional transcripts enhances MHC-I peptide diversity
Frontiers in Immunology, Frontiers Media S.A. 2025, Vol. 16
Zavadil, Filip; Henek, Tomas; Habault, Justine; et al.
Has translation in the nucleus found its purpose?
Nature reviews. Molecular cell biology, Springer Nature 2024, Vol. 25, (1) : 1-2
Fåhraeus, Robin
The DNA damage sensor ATM kinase interacts with the p53 mRNA and guides the DNA damage response pathway
Molecular Cancer, Springer Nature 2024, Vol. 23, (1)
Karakostis, Konstantinos; Malbert-Colas, Laurence; Thermou, Aikaterini; et al.
Thermal stress, p53 structures and learning from elephants
Cell Death Discovery, Springer Nature 2024, Vol. 10, (1)
Karakostis, Konstantinos; Padariya, Monikaben; Thermou, Aikaterini; et al.
Re-appraising the evidence for the source, regulation and function of p53-family isoforms
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (20) : 12112-12129
López, Ignacio; Valdivia, Irene Larghero; Vojtesek, Borivoj; et al.
In search of the cell biology for self- versus non-self- recognition
Current Opinion in Immunology, Vol. 83
Apcher, Sebastien; Vojtesek, Borek; Fåhraeus, Robin
The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures
Cell Death and Differentiation, Springer Nature 2023, Vol. 30 : 1072-1081
Fusée, Leila; Salomao, Norman; Ponnuswamy, Anand; et al.
Reduced murine double minute 2 and 4 protein, but not messenger RNA, expression is associated with more severe disease in myelodysplastic syndromes and acute myeloblastic leukaemia
British Journal of Haematology, John Wiley & Sons 2023, Vol. 201, (2) : 234-248
Salomao, Norman; Maslah, Nabih; Giulianelli, Anouk; et al.
Major histocompatibility class I antigenic peptides derived from translation of pre-mRNAs generate immune tolerance
Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences 2023, Vol. 120, (7)
Sroka, Ewa Maria; Lavigne, Mathilde; Pla, Marika; et al.
mRNA translation from an antigen presentation perspective: A tribute to the works of Nilabh Shastri
Molecular Immunology, Elsevier 2022, Vol. 141 : 305-308
Apcher, Sebastien; Tovar-Fernadez, Maria; Ducellier, Sarah; et al.
Cryptic in vitro ubiquitin ligase activity of HDMX towards p53 is probably regulated by an induced fit mechanism
Bioscience Reports, Portland Press 2022, Vol. 42, (7)
Calderon-González, Karla Gisel; Medina-Medina, Ixaura; Haronikova, Lucia; et al.
Targeting Oncogenic Pathways in the Era of Personalized Oncology: A Systemic Analysis Reveals Highly Mutated Signaling Pathways in Cancer Patients and Potential Therapeutic Targets
Cancers, MDPI 2022, Vol. 14, (3)
Karagiannakos, Alexandros; Adamaki, Maria; Tsintarakis, Antonis; et al.
The Elephant Evolved p53 Isoforms that Escape MDM2-Mediated Repression and Cancer
Molecular biology and evolution, Oxford University Press 2022, Vol. 39, (7)
Padariya, Monikaben; Jooste, Mia-Lyn; Hupp, Ted; et al.
Substrate-specific presentation of MHC class I-restricted antigens via autophagy pathway
Cellular Immunology, Elsevier 2022, Vol. 374
Tovar Fernandez, Maria C.; Sroka, Ewa M.; Lavigne, Mathilde; et al.
The nascent polypeptide-associated complex (NAC) controls translation initiation in cis by recruiting nucleolin to the encoding mRNA
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (17) : 10110-10122
Zheng, Alice J L; Thermou, Aikaterini; Daskalogianni, Chrysoula; et al.
The different activities of RNA G-quadruplex structures are controlled by flanking sequences
Life Science Alliance, Rockefeller University Press 2022, Vol. 5, (2)
Zheng, Alice J.-L.; Thermou, Aikaterini; Gallardo, Pedro Guixens; et al.
Low potential of circulating interleukin 1 receptor antagonist as a prediction marker for squamous cell carcinoma of the head and neck
Journal of Oral Pathology & Medicine, John Wiley & Sons 2021, Vol. 50, (8) : 785-794
Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.
P53 mRNA metabolism links with the DNA damage response
Genes, MDPI 2021, Vol. 12, (9)
Gnanasundram, Sivakumar Vadivel; Bonczek, Ondrej; Wang, Lixiao; et al.
Resistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?
Cellular & Molecular Biology Letters (Druk), BioMed Central 2021, Vol. 26, (1)
Haronikova, Lucia; Bonczek, Ondrej; Zatloukalova, Pavlina; et al.
Molecular and Biochemical Techniques for Deciphering p53-MDM2 Regulatory Mechanisms
Biomolecules, MDPI 2021, Vol. 11, (1)
Karakostis, Konstantinos; Lopez, Ignacio; Pena-Balderas, Ana M.; et al.
Identification of a stable, non-canonically regulated nrf2 form in lung cancer cells
Antioxidants, MDPI 2021, Vol. 10, (5)
Mikac, Sara; Rychłowski, Michał; Dziadosz, Alicja; et al.
Molecular determinants and specificity of mrna with alternatively-spliced upf1 isoforms, influenced by an insertion in the 'regulatory loop'
International Journal of Molecular Sciences, MDPI 2021, Vol. 22, (23)
Padariya, Monikaben; Fåhraeus, Robin; Hupp, Ted; et al.
Viruses, cancer and non-self recognition
Open Biology, The Royal Society 2021, Vol. 11, (3)
Padariya, Monikaben; Kalathiya, Umesh; Mikac, Sara; et al.
Structural determinants of peptide-dependent TAP1-TAP2 transit passage targeted by viral proteins and altered by cancer-associated mutations
Computational and Structural Biotechnology Journal, Elsevier 2021, Vol. 19 : 5072-5091
Padariya, Monikaben; Kote, Sachin; Mayordomo, Marcos; et al.
Functional interfaces, biological pathways, and regulations of interferon-related dna damage resistance signature (Irds) genes
Biomolecules, MDPI 2021, Vol. 11, (5)
Padariya, Monikaben; Sznarkowska, Alicja; Kote, Sachin; et al.
What do we need to know and understand about p53 to improve its clinical value?
Journal of Pathology, John Wiley & Sons 2021, Vol. 254, (4) : 443-453
Salomao, Norman; Karakostis, Konstantinos; Hupp, Ted; et al.
Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck
Oncology Letters, Spandidos Publications 2020, Vol. 20, (2) : 1709-1718
Boldrup, Linda; Coates, Philip; Gu, Xiaolian; et al.
Alternative Mechanisms of p53 Action During the Unfolded Protein Response
Cancers, Vol. 12, (2)
Fusee, Leila T. S.; Marin, Monica; Fåhraeus, Robin; et al.
MDM2's dual mRNA binding domains co-ordinate its oncogenic and tumour suppressor activities
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (12) : 6775-6787
Gnanasundram, Sivakumar Vadivel; Malbert-Colas, Laurence; Chen, Sa; et al.
Transfer-RNA-Derived Fragments Are Potential Prognostic Factors in Patients with Squamous Cell Carcinoma of the Head and Neck
Genes, MDPI 2020, Vol. 11, (11)
Gu, Xiaolian; Wang, Lixiao; Coates, Philip J.; et al.
PD-L1 in squamous cell carcinoma of the oral tongue shows gender-specific association with prognosis
Oral Diseases, John Wiley & Sons 2020, Vol. 26, (7) : 1414-1423
Wilms, Torben; Gu, Xiaolian; Boldrup, Linda; et al.
High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue
The journal of pathology. Clinical research, John Wiley & Sons 2019, Vol. 5, (4) : 240-247
Gu, Xiaolian; Boldrup, Linda; Coates, Philip J.; et al.
Copy number variation: A prognostic marker for young patients with squamous cell carcinoma of the oral tongue
Journal of Oral Pathology & Medicine, John Wiley & Sons 2019, Vol. 48, (1) : 24-30
Gu, Xiaolian; Coates, Philip J.; Boldrup, Linda; et al.
AP001056.1, A Prognosis-Related Enhancer RNA in Squamous Cell Carcinoma of the Head and Neck
Cancers, MDPI 2019, Vol. 11, (3)
Gu, Xiaolian; Wang, Lixiao; Boldrup, Linda; et al.
The p53 mRNA: an integral part of the cellular stress response
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (7) : 3257-3271
Haronikova, Lucia; Olivares-Illana, Vanesa; Wang, Lixiao; et al.
Shaping the regulation of the p53 mRNA tumour suppressor: the co-evolution of genetic signatures
BMC Cancer, BioMed Central 2019, Vol. 19, (1)
Karakostis, Konstantinos; Fåhraeus, Robin
A single synonymous mutation determines the phosphorylation and stability of the nascent protein
Journal of Molecular Cell Biology, Oxford University Press 2019, Vol. 11, (3) : 187-199
Karakostis, Konstantinos; Gnanasundram, Sivakumar Vadivel; Lopez, Ignacio; et al.
Nuclear processing of nascent transcripts determines synthesis of full-length proteins and antigenic peptides
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (6) : 3086-3100
Martins, Rodrigo Prado; Malbert-Colas, Laurence; Lista, Maria Jose; et al.
Allosteric changes in HDM2 by the ATM phosphomimetic S395D mutation: implications on HDM2 function
Biochemical Journal, PORTLAND PRESS LTD 2019, Vol. 476 : 3401-3411
Uhrik, Lukas; Wang, Lixiao; Haronikova, Lucia; et al.
The Role of TLRs in Anti-cancer Immunity and Tumor Rejection
Frontiers in Immunology, Frontiers Media S.A. 2019, Vol. 10
Urban-Wojciuk, Zuzanna; Khan, Mohd M.; Oyler, Benjamin L.; et al.
Peptide Channeling: The Key to MHC Class I Immunosurveillance?
Trends in Cell Biolology, Elsevier 2019, Vol. 29, (12) : 929-939
Yewdell, Jonathan W.; Dersh, Devin; Fåhraeus, Robin
Translation Stress Regulates Ribosome Synthesis and Cell Proliferation
International Journal of Molecular Sciences, MDPI 2018, Vol. 19, (12)
Gnanasundram, Sivakumar Vadivel; Fåhraeus, Robin
In Cellulo Protein-mRNA Interaction Assay to Determine the Action of G-Quadruplex-Binding Molecules
Molecules, MDPI 2018, Vol. 23, (12)
Martins, Rodrigo Prado; Findakly, Sarah; Daskalogianni, Chrysoula; et al.
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Forskningsledare
Robin Fåhraeus labb