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Umeå universitet
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Huvudmenyn dold.

Nasim Sabouri

Vi studerar hur genomintegritet bevaras och konsekvenserna av att ändra programmet för DNA-replikation.

Vetenskaplig meritering: Docent

Kontakt

E-post
nasim.sabouri@umu.se
Telefon
072-566 25 05

Verksam vid

Anknytning
Universitetslektor vid Institutionen för medicinsk kemi och biofysik Roll: Studierektor, Ställföreträdande prefekt
Plats
KB. A5, Campus, Umeå Umeå universitet, 901 87 Umeå

En av utmaningarna inom cancerbiologin är att förstå vad som händer när molekylära mekanismer i en normal cell blir dysfunktionella och orsakar cancer. Att upprätthålla genomstabilitet under DNA-syntesen är avgörande för att förebygga sjukdomar. Vi studerar hur genomintegritet bevaras och konsekvenserna av att ändra programmet för DNA-replikation.

A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
Nucleic Acids Research, Oxford University Press 2023, Vol. 51, (12) : 6264-6285
Deiana, Marco; Andrés Castán, José María; Josse, Pierre; et al.
Parallel G-quadruplex DNA structures from nuclear and mitochondrial genomes trigger emission enhancement in a nonfluorescent nano-aggregated fluorine-boron-based dye
Journal of Physical Chemistry Letters, American Chemical Society (ACS) 2023, Vol. 14, (7) : 1862-1869
Deiana, Marco; Chand, Karam; Chorell, Erik; et al.
A beginner's handbook to identify and characterize i-motif DNA
Methods in enzymology
Sengupta, Pallabi; Jamroskovic, Jan; Sabouri, Nasim
Site-selected thionated benzothioxanthene chromophores as heavy-atom-free small-molecule photosensitizers for photodynamic therapy
Communications Chemistry, Springer Nature 2022, Vol. 5
Deiana, Marco; Josse, Pierre; Dalinot, Clément; et al.
Probing the folding pathways of four-stranded intercalated cytosine-rich motifs at single base-pair resolution
Biochimie, Elsevier 2022, Vol. 199 : 81-91
Jamroskovic, Jan; Deiana, Marco; Sabouri, Nasim
Light-induced in situ chemical activation of a fluorescent probe for monitoring intracellular G-quadruplex structures
Nanoscale, Royal Society of Chemistry 2021, Vol. 13, (32) : 13795-13808
Deiana, Marco; Mosser, Maëlle; Le Bahers, Tangui; et al.
A Minimalistic Coumarin Turn-On Probe for Selective Recognition of Parallel G-Quadruplex DNA Structures
ACS Chemical Biology, American Chemical Society (ACS) 2021, Vol. 16, (8) : 1365-1376
Deiana, Marco; Obi, Ikenna; Andréasson, Måns; et al.
The RGG domain in the C-terminus of the DEAD box helicases Dbp2 and Ded1 is necessary for G-quadruplex destabilization
Nucleic Acids Research, Oxford University Press 2021, Vol. 49, (14) : 8339-8354
Yan, Kok-Phen; Obi, Ikenna; Sabouri, Nasim
A Site-Specific Self-Assembled Light-up Rotor Probe for Selective Recognition and Stabilization of c-MYC G-Quadruplex DNA
Nanoscale, Royal Society of Chemistry 2020, Vol. 12, (24) : 12950-12957
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
A Light‐up Logic Platform for Selective Recognition of Parallel G‐Quadruplex Structures via Disaggregation‐Induced Emission
Angewandte Chemie International Edition, Wiley-VCH Verlagsgesellschaft 2020, Vol. 59, (2) : 896-902
Deiana, Marco; Chand, Karam; Jamroskovic, Jan; et al.
Unravelling the cellular emission fingerprint of the benchmark G-quadruplex-interactive compound Phen-DC3
Chemical Communications, Royal Society of Chemistry 2020, Vol. 56, (91) : 14251-14254
Deiana, Marco; Jamroskovic, Jan; Obi, Ikenna; et al.
Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization
Journal of the American Chemical Society, Vol. 142, (6) : 2876-2888
Jamroskovic, Jan; Doimo, Mara; Chand, Karam; et al.
Stabilization of G-quadruplex DNA structures in Schizosaccharomyces pombe causes single-strand DNA lesions and impedes DNA replication
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (19) : 10998-11015
Obi, Ikenna; Rentoft, Matilda; Singh, Vandana; et al.
The Relation Between Position and Chemical Composition of Bis-Indole Substituents Determines Their Interactions With G-Quadruplex DNA
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2020, Vol. 26, (43) : 9561-9572
Prasad, Bagineni; Das, Rabindra Nath; Jamroskovic, Jan; et al.
Identification of putative G-quadruplex DNA structures in S. pombe genome by quantitative PCR stop assay
DNA Repair, Vol. 82
Jamroskovic, Jan; Obi, Ikenna; Movahedi, Anahita; et al.
The Pif1 signature motif of Pfh1 is necessary for both protein displacement and helicase unwinding activities, but is dispensable for strand-annealing activity
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (16) : 8516-8531
Mohammad, Jani B.; Wallgren, Marcus; Sabouri, Nasim
Flexible Versus Rigid G-Quadruplex DNA Ligands: Synthesis of Two Series of Bis-indole Derivatives and Comparison of Their Interactions with G-Quadruplex DNA
Chemistry - A European Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 24, (31) : 7926-7938
Prasad, Bagineni; Jamroskovic, Jan; Bhowmik, Sudipta; et al.
Synthesis of phenanthridine spiropyrans and studies of their effects on G-quadruplex DNA
Organic and biomolecular chemistry, Royal Society of Chemistry 2017, Vol. 15, (15) : 3265-3275
Livendahl, Madeleine; Jamroskovic, Jan; Hedenström, Mattias; et al.
The functions of the multi‑tasking Pfh1Pif1 helicase
Current Genetics, Vol. 63, (4) : 621-626
Sabouri, Nasim
Identification of Compounds that Selectively Stabilize Specific G-Quadruplex Structures by Using a Thioflavin T-Displacement Assay as a Tool
Chemistry - A European Journal, Vol. 22, (52) : 18932-18943
Jamroskovic, Jan; Livendahl, Madeleine; Eriksson, Jonas; et al.
Design and Synthesis of 2,2'-Diindolylmethanes to Selectively Target Certain G-Quadruplex DNA Structures
Chemistry - A European Journal, Vol. 22, (37) : 13004-13009
Livendahl, Madeleine; Jamroskovic, Jan; Ivanova, Svetlana; et al.
Pfh1 Is an Accessory Replicative Helicase that Interacts with the Replisome to Facilitate Fork Progression and Preserve Genome Integrity
PLOS Genetics, Copernicus GmbH 2016, Vol. 12, (9)
McDonald, Karin R.; Guise, Amanda J.; Pourbozorgi-Langroudi, Parham; et al.
G-rich telomeric and ribosomal DNA sequences from the fission yeast genome form stable G-quadruplex DNA structures in vitro and are unwound by the Pfh1 DNA helicase
Nucleic Acids Research, Oxford University Press 2016, Vol. 44, (13) : 6213-6231
Wallgren, Marcus; Mohammad, Jani B.; Yan, Kok-Phen; et al.
The Pif1 family helicase Pfh1 facilitates telomere replication and has an RPA-dependent role during telomere lengthening
DNA Repair, Vol. 24 : 80-86
McDonald, Karin R; Sabouri, Nasim; Webb, Christopher J; et al.
In vivo occupancy of mitochondrial single-stranded DNA binding protein supports the strand displacement mode of DNA replication
PLOS Genetics, Vol. 10, (12) : e1004832-
Miralles Fusté, Javier; Shi, Yonghong; Wanrooij, Sjoerd; et al.
The essential Schizosaccharomyces pombe Pfh1 DNA helicase promotes fork movement past G-quadruplex motifs to prevent DNA damage
BMC Biology, Vol. 12, (1)
Sabouri, Nasim; Capra, John A; Zakian, Virginia A
DNA replication through hard-to-replicate sites, including both highly transcribed RNA Pol II and Pol III genes, requires the S. pombe Pfh1 helicase
Genes & Development, Vol. 26, (6) : 581-593
Sabouri, Nasim; McDonald, Karin R; Webb, Christopher J; et al.
Unwinding the functions of the Pif1 family helicases
DNA Repair, Vol. 9, (3) : 237-249
Bochman, Matthew L; Sabouri, Nasim; Zakian, Virginia A
Translesion synthesis of abasic sites by yeast DNA polymerase epsilon
The Journal of biological chemistry, Vol. 284, (46) : 31555-31563
Sabouri, Nasim; Johansson, Erik
Evidence for lesion bypass by yeast replicative DNA polymerases during DNA damage
Nucleic Acids Research, Vol. 36, (17) : 5660-5667
Sabouri, Nasim; Viberg, Jörgen; Kumar, Dinesh; et al.
Structure of Saccharomyces cerevisiae DNA polymerase epsilon by cryo-electron microscopy.
Nature Structural & Molecular Biology, Vol. 13, (1) : 35-43
Asturias, Francisco J; Cheung, Iris K; Sabouri, Nasim; et al.
Idling by DNA polymerase delta maintains a ligatable nick during lagging-strand DNA replication.
Genes & Development, Vol. 18, (22) : 2764-2773
Garg, Parie; Stith, Carrie M; Sabouri, Nasim; et al.
Biochemical analysis of the strand annealing activity of the S. pombe Pif1 helicase
Mohammad, Jani B.; Sabouri, Nasim
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Nasim Sabouri Lab
Fyrsträngat DNA i ny typ av cancerbehandling

Nasim Sabouris forskning ligger till grund för arbete med att utveckla nya typer av läkemedel mot cancer.