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Umeå universitet
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Personalbild Peter Andersen

Peter Andersen

Jag är professor och överläkare i neurologi och började forska om ALS 1992. Jag forskar om orsaken till ALS/FTD och leder även läkemedelsstudier där vi utvärderar nya läkemedel.

Kontakt

E-post
peter.andersen@umu.se
Telefon
090-786 55 00

Verksam vid

Anknytning
Professor, överläkare vid Institutionen för klinisk vetenskap Enhet: Neurovetenskaper
Plats
Norrlands universitetssjukhus, Umeå universitet, Klinisk vetenskap Umeå universitet, Klinisk vetenskap, 901 85 Umeå

ALS kan komma smygande med en försvagning i en hand, ett ben eller i tungan. Sjukdomen dödar nervceller som styr musklerna. Kroppen blir allt mer förlamad och sjukdomen leder till döden. Orsaken söker nu Peter Andersen och hans forskargrupp vid Umeå universitet, långt inne i våra celler - med förhoppningen att kunna hitta en så kallad genterapi som ska kunna stoppa sjukdomen. I fokus står genen SOD1 och resultat från en kartläggning av ALS-släkter i Norrland.

Video: ALS-forskning som kan stoppa sjukdomsutvecklingen

Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.
Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Nature Communications, Nature Publishing Group 2023, Vol. 14, (1)
Megat, Salim; Mora, Natalia; Sanogo, Jason; et al.
Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS
Journal of Neurochemistry, John Wiley & Sons 2023, Vol. 164, (1) : 77-93
Nordström, Ulrika; Lang, Lisa; Ekhtiari Bidhendi, Elaheh; et al.
Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis
Neurobiology of Aging, Elsevier 2023, Vol. 122 : 76-87
Tazelaar, Gijs H.P.; Hop, Paul J.; Seelen, Meinie; et al.
Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Yilmaz, Rüstem; Grehl, Torsten; Eckrich, Lukas; et al.
Caregivers’ divergent perspectives on patients’ well-being and attitudes towards hastened death in Germany, Poland and Sweden
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2022, Vol. 23, (3-4) : 252-262
Andersen, Peter M.; Kuźma-Kozakiewicz, Magdalena; Keller, Jürgen; et al.
Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity
Brain, Oxford University Press 2022, Vol. 145, (10) : 3500-3508
Benatar, Michael; Granit, Volkan; Andersen, Peter M.; et al.
Design of a randomized, placebo-controlled, phase 3 trial of tofersen initiated in clinically presymptomatic SOD1 variant carriers: the Atlas study
Neurotherapeutics, Springer 2022, Vol. 19 : 1248-1258
Benatar, Michael; Wuu, Joanne; Andersen, Peter M.; et al.
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
Brain, Oxford University Press 2022, Vol. 145, (1) : 27-44
Benatar, Michael; Wuu, Joanne; McHutchison, Caroline; et al.
SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity
Scientific Reports, Nature Publishing Group 2022, Vol. 12, (1)
Berdynski, Mariusz; Miszta, Przemysław; Safranow, Krzysztof; et al.
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
Neurogenetics, Springer 2022, Vol. 23 : 59-65
Brenner, David; Müller, Kathrin; Lattante, Serena; et al.
Infantile SOD1 deficiency syndrome caused by a homozygous SOD1 variant with absence of enzyme activity
Brain, Oxford University Press 2022, Vol. 145, (3) : 872-878
Ezer, Shlomit; Daana, Muhannad; Park, Julien H.; et al.
A novel homozygous p.Ser69Pro SOD1 mutation causes severe young-onset ALS with decreased enzyme activity
Journal of Neurology
Fahmy, Nagia; Müller, Kathrin; Andersen, Peter Munch; et al.
Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS
Cells, MDPI 2022, Vol. 11, (7)
Günther, René; Pal, Arun; Williams, Chloe; et al.
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Science Translational Medicine, American Association for the Advancement of Science 2022, Vol. 14, (633)
Hop, Paul J.; Zwamborn, Ramona A.J.; Hannon, Eilis; et al.
Clinical trials in pediatric ALS: a TRICALS feasibility study
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis Group 2022, Vol. 23, (7-8) : 481-488
Kliest, Tessa; Van Eijk, Ruben P.A.; Al-Chalabi, Ammar; et al.
Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
European Journal of Neurology, John Wiley & Sons 2022, Vol. 29, (4) : 1279-1283
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; et al.
The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
Brain, Oxford University Press 2022, Vol. 145, (12) : 4440-4447
Mehta, Puja R.; Iacoangeli, Alfredo; Opie-Martin, Sarah; et al.
De novo mutations in SOD1 are a cause of ALS
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2022, Vol. 93 : 201-206
Müller, Kathrin; Oh, Ki-Wook; Nordin, Angelica; et al.
Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients
Genes, MDPI 2022, Vol. 13, (1)
Osmanovic, Alma; Gogol, Isabel; Martens, Helge; et al.
The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis
Brain, Oxford University Press 2022, Vol. 145, (4) : 1207-1210
Salmon, Kristiana; Kiernan, Matthew C.; Kim, Seung H.; et al.
PEX11β and FIS1 cooperate in peroxisome division independent of Mitochondrial Fission Factor
Journal of Cell Science, The Company of Biologists 2022, Vol. 135, (13)
Schrader, Tina A.; Carmichael, Ruth E.; Islinger, Markus; et al.
Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Behzadi, Arvin; Pujol-Calderón, Fani; Tjust, Anton E.; et al.
Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
Lancet Neurology, Elsevier 2021, Vol. 20, (10) : 821-831
Cudkowicz, Merit; Genge, Angela; Maragakis, Nicholas; et al.
A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis
Brain, Oxford University Press 2021, Vol. 144, (4) : 1214-1229
Freischmidt, Axel; Goswami, Anand; Limm, Katharina; et al.
Motor neuron disease beginning with frontotemporal dementia: clinical features and progression
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2021, Vol. 22, (7-8) : 508-516
Gromicho, Marta; Kuzma-Kozakiewicz, Magdalena; Szacka, Katarzyna; et al.
SCFD1 expression quantitative trait loci in amyotrophic lateral sclerosis are differentially expressed
Brain Communications, Oxford University Press 2021, Vol. 3, (4)
Iacoangeli, Alfredo; Fogh, Isabella; Selvackadunco, Sashika; et al.
Peripheral administration of SOD1 aggregates does not transmit pathogenic aggregation to the CNS of SOD1 transgenic mice
Acta neuropathologica communications, BioMed Central 2021, Vol. 9, (1)
Keskin, Isil; Ekhtiari Bidhendi, Elaheh; Marklund, Matthew; et al.
Putative founder effect in the Polish, Iranian and United States populations for the L144SSOD1mutation associated with slowly uniform phenotype of amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2021, Vol. 22, (1-2) : 80-85
Kuzma-Kozakiewicz, Magdalena; Andersen, Peter M.; Elahi, Elahe; et al.
The Effect of SMN Gene Dosage on ALS Risk and Disease Severity
Annals of Neurology, John Wiley & Sons 2021, Vol. 89, (4) : 686-697
Moisse, Matthieu; Zwamborn, Ramona A. J.; van Vugt, Joke; et al.
Extensive heterogeneity in patients with ALS with mutations in SOD1 in France
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2021, Vol. 92, (9) : 914-914
Munch Andersen, Peter
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Nature Genetics, Nature Publishing Group 2021, Vol. 53, (12) : 1636-1648
van Rheenen, Wouter; van der Spek, Rick A. A.; Bakker, Mark K.; et al.
Impact of comorbidities and co-medication on disease onset and progression in a large German ALS patient group
Journal of Neurology, Springer 2020, Vol. 267, (7) : 2130-2141
Diekmann, Kristin; Kuzma-Kozakiewicz, Magdalena; Piotrkiewicz, Maria; et al.
ALS kan vara en prionsjukdom: Inklusioner av felvecklat SOD1-protein tycks finnas hos patienter med alla typer av ALS
Läkartidningen, Läkartidningen Förlag AB 2020, Vol. 117
Forsberg, Karin; Tjust, Anton E.; Zetterström, Per; et al.
Commentary: Effects of ALS-associated TANK binding kinase 1 mutations on protein-protein interactions and kinase activity
Frontiers in Neuroscience, Frontiers Media S.A. 2020, Vol. 14
Freischmidt, Axel; Brenner, David; Ludolph, Albert C.; et al.
Rare heterozygous DHTKD1 variants in patients with amyotrophic lateral sclerosis
European Journal of Human Genetics, Springer Nature 2020, Vol. 28 : 428-429
Gogol, I.; Osmanovic, A.; Martens, H.; et al.
Potential Preventive Strategies for Amyotrophic Lateral Sclerosis
Frontiers in Neuroscience, Frontiers Media S.A. 2020, Vol. 14
Kuraszkiewicz, B.; Goszczynska, H.; Podsiadly-Marczykowska, T.; et al.
Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome
Circulation, Lippincott Williams & Wilkins 2020, Vol. 142, (4) : 324-338
Lahrouchi, Najim; Tadros, Rafik; Crotti, Lia; et al.
Aggregate-selective antibody attenuates seeded aggregation but not spontaneously evolving disease in SOD1 ALS model mice
Acta neuropathologica communications, BMC 2020, Vol. 8, (1)
Lehmann, Manuela; Marklund, Matthew; Bolender, Anna-Lena; et al.
Deficits in verbal fluency in presymptomatic C9orf72 mutation gene carriers-a developmental disorder
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2020, Vol. 91, (11) : 1195-1200
Lulé, Dorothée E.; Müller, Hans-Peter; Finsel, Julia; et al.
Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS
New England Journal of Medicine, Massachusetts Medical Society 2020, Vol. 383, (2) : 109-119
Miller, Timothy; Cudkowicz, Merit; Shaw, Pamela J.; et al.
Inflammatory profiles relate to survival in subtypes of amyotrophic lateral sclerosis
Neurology: Neuroimmunology and neuroinflammation, Wolters Kluwer 2020, Vol. 7, (3)
Olesen, Mads Nikolaj; Wuolikainen, Anna; Nilsson, Anna Christine; et al.
Gut microbiota-specific IgA+ B cells traffic to the CNS in active multiple sclerosis
Science immunology, American Association for the Advancement of Science 2020, Vol. 5, (53)
Pröbstel, Anne-Katrin; Zhou, Xiaoyuan; Baumann, Ryan; et al.
SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden
Neurobiology of Aging, ELSEVIER SCIENCE INC 2020, Vol. 87 : 139.e9-139.e15
Yilmaz, Rüstem; Müller, Kathrin; Brenner, David; et al.
Phenotype in an Infant with SOD1 Homozygous Truncating Mutation
New England Journal of Medicine, Massachusetts Medical Society 2019, Vol. 381, (5) : 486-488
Andersen, Peter M.; Hempel, Maja; Santer, René; et al.
Neurofilaments in pre-symptomatic ALS and the impact of genotype
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2019, Vol. 20, (7-8) : 538-548
Benatar, Michael; Wuu, Joanne; Lombardi, Vittoria; et al.
Mutant SOD1 aggregates from human ventral horn transmit templated aggregation and fatal ALS-like disease
Brain Pathology, John Wiley & Sons 2019, Vol. 29 : 90-90
Brännström, Thomas; Andersen, Peter M.; Bergh, Johan; et al.
Genotypes of amyotrophic lateral sclerosis in Mongolia
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2019, Vol. 90, (11) : 1300-1302
Daria, Tselmen; Müller, Kathrin; Oidovdorj, Gansuvd; et al.
Misfolded SOD1 inclusions in patients with mutations in C9orf72 and other ALS/FTD-associated genes
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2019, Vol. 90, (8) : 861-869
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Pakkenberg, Bente; et al.
The molecular pathogenesis of superoxide dismutase 1-linked ALS is promoted by low oxygen tension
Acta Neuropathologica, New York: Springer 2019, Vol. 138, (1) : 85-101
Keskin, Isil; Forsgren, Elin; Lehmann, Manuela; et al.
Visa publikationer i DiVA

Undervisar läkarstuderande på termin 9 och termin 10 i neurologi (nervsystemets sjukdomar).

Kunskap om hopklibbade proteiner kan lösa ALS-gåtan

Peter Andersen har funnit mekanismer som kan göra det möjligt att behandla eller till och med förebygga ALS.