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Umeå universitet
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Personalbild Peter Andersen
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Peter Andersen

Jag är professor och överläkare i neurologi och började forska om ALS 1992. Jag forskar om orsaken till ALS/FTD och leder även läkemedelsstudier där vi utvärderar nya läkemedel.

Vetenskaplig meritering: Docent
0000-0003-0094-5429

Kontakt

E-post
peter.andersen@umu.se
Telefon
070-647 69 13

Verksam som

Anknytning
Professor, överläkare vid Institutionen för klinisk vetenskap Enhet: Neurovetenskaper
Plats
Norrlands universitetssjukhus, Umeå universitet, Klinisk vetenskap Umeå universitet, Klinisk vetenskap, 901 85 Umeå

ALS kan komma smygande med en försvagning i en hand, ett ben eller i tungan. Sjukdomen dödar nervceller som styr musklerna. Kroppen blir allt mer förlamad och sjukdomen leder till döden. Orsaken söker nu Peter Andersen och hans forskargrupp vid Umeå universitet, långt inne i våra celler - med förhoppningen att kunna hitta en så kallad genterapi som ska kunna stoppa sjukdomen. I fokus står genen SOD1 och resultat från en kartläggning av ALS-släkter i Norrland.

Video: ALS-forskning som kan stoppa sjukdomsutvecklingen

Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention
Lancet Neurology, Elsevier 2025, Vol. 24, (1) : 77-86
Benatar, Michael; Robertson, Janice; Andersen, Peter Munch
Oligogenic structure of amyotrophic lateral sclerosis has genetic testing, counselling and therapeutic implications
Journal of Neurology, Neurosurgery and Psychiatry
Iacoangeli, Alfredo; Dilliott, Allison A.; Al Khleifat, Ahmad; et al.
Safety and efficacy of arimoclomol in patients with early amyotrophic lateral sclerosis (ORARIALS-01): a randomised, double-blind, placebo-controlled, multicentre, phase 3 trial
Lancet Neurology, Elsevier 2024, Vol. 23, (7) : 687-699
Benatar, Michael; Hansen, Thomas; Rom, Dror; et al.
The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Nature Reviews Neurology, Springer Nature 2024, Vol. 20, (6) : 364-376
Benatar, Michael; Wuu, Joanne; Huey, Edward D.; et al.
Upregulated miR-10b-5p as a potential miRNA signature in amyotrophic lateral sclerosis patients
Frontiers in Cellular Neuroscience, Frontiers Media S.A. 2024, Vol. 18
Dash, Banaja P.; Freischmidt, Axel; Helferich, Anika M.; et al.
Precisionsmedicinsk genterapi har bromsat utveckling av ALS: [SOD1 gene therapy delays ALS disease progression]
Läkartidningen, Läkartidningen Förlag AB 2024, Vol. 121
Forsberg, Karin; Karlsborg, Merete; Salvesen, Lisette; et al.
Specific analysis of SOD1 enzymatic activity in CSF from ALS patients with and without SOD1 mutations
Neurobiology of Disease, Elsevier 2024, Vol. 202
Leykam, Laura; Forsberg, Karin; Nordström, Ulrika; et al.
Adolescents' challenging and grief-filled transitions when living with a parent with ALS: a qualitative interpretive study
Social Science and Medicine, Elsevier 2024, Vol. 354
Malmström, Nina; Öhlén, Joakim; Jakobsson Larsson, Birgitta; et al.
Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS
Annals of Clinical and Translational Neurology, John Wiley & Sons 2024, Vol. 11, (7) : 1775-1786
Marriott, Heather; Spargo, Thomas P.; Al Khleifat, Ahmad; et al.
Small striatal huntingtin inclusions in patients with motor neuron disease with reduced penetrance and intermediate HTT gene expansions
Human Molecular Genetics, Oxford University Press 2024, Vol. 33, (22) : 1966-1974
Roos, Anna-Karin; Stenvall, Erica; Kockum, Emmy Skelton; et al.
High levels of neurofilament light and YKL-40 in cerebrospinal fluid are related to poor outcome in ALS
Journal of the Neurological Sciences, Elsevier 2024, Vol. 463
Rosén, Christoffer; Mitre, Bernardo; Nellgård, Bengt; et al.
European academy of neurology (EAN) guideline on the management of amyotrophic lateral sclerosis in collaboration with European reference network for neuromuscular diseases (ERN EURO-NMD)
European Journal of Neurology, John Wiley & Sons 2024, Vol. 31, (6)
Van Damme, Philip; Al-Chalabi, Ammar; Andersen, Peter M.; et al.
Tofersen decreases neurofilament levels supporting the pathogenesis of the SOD1 p.D91A variant in amyotrophic lateral sclerosis patients
Communications Medicine, Springer Nature 2024, Vol. 4, (1)
Weishaupt, Jochen H.; Körtvélyessy, Péter; Schumann, Peggy; et al.
Cognitive deficits in ALS patients with SOD1 mutations
Journal of Clinical and Experimental Neuropsychology, Routledge 2024, Vol. 46, (7) : 669-682
Winroth, Ivar; Börjesson, Arne; Andersen, Peter M.; et al.
Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival
Frontiers in Cellular Neuroscience, Frontiers Media S.A. 2023, Vol. 17
Adey, Brett N.; Cooper-Knock, Johnathan; Al Khleifat, Ahmad; et al.
Myofiber type shift in extraocular muscles in amyotrophic lateral sclerosis
Investigative Ophthalmology and Visual Science, Association for Research in Vision and Ophthalmology (ARVO) 2023, Vol. 64, (5)
Behzadi, Arvin; Tjust, Anton Erik; Liu, Jing-Xia; et al.
Quality of life and depression in patients with amyotrophic lateral sclerosis – does the country of origin matter?
BMC Palliative Care, BioMed Central (BMC) 2023, Vol. 22, (1)
Ciećwierska, Katarzyna; Lulé, Dorothée; Bielecki, Maksymilian; et al.
Clinical testing panels for ALS: global distribution, consistency, and challenges
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 420-435
Dilliott, Allison A.; Al Nasser, Ahmad; Elnagheeb, Marwa; et al.
Metabolic alterations precede neurofilament changes in presymptomatic ALS gene carriers
EBioMedicine, Elsevier 2023, Vol. 90
Dorst, Johannes; Weydt, Patrick; Brenner, David; et al.
A novel homozygous p.Ser69Pro SOD1 mutation causes severe young-onset ALS with decreased enzyme activity
Journal of Neurology, Springer 2023, Vol. 270 : 1770-1773
Fahmy, Nagia; Müller, Kathrin; Andersen, Peter Munch; et al.
Determining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 475-484
Finsel, Julia; Winroth, Ivar; Ciećwierska, Katarzyna; et al.
Widespread CNS pathology in amyotrophic lateral sclerosis homozygous for the D90A SOD1 mutation
Acta Neuropathologica, Springer-Verlag New York 2023, Vol. 145, (1) : 13-28
Forsberg, Karin; Graffmo, Karin Sixtensdotter; Stenvall, Erica; et al.
Validity and reliability measures of the Swedish Karolinska version of the Edinburgh Cognitive and Behavioral ALS Screen (SK-ECAS)
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (7-8) : 713-718
Foucher, Juliette; Winroth, Ivar; Lovik, Anikó; et al.
Living with a parent with ALS - adolescents' need for professional support from the adolescents' and the parents' perspectives
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (7-8) : 727-735
Malmström, Nina; Jakobsson Larsson, Birgitta; Nilsson, Stefan; et al.
Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Nature Communications, Nature Publishing Group 2023, Vol. 14, (1)
Megat, Salim; Mora, Natalia; Sanogo, Jason; et al.
Mutant SOD1 aggregates formed in vitro and in cultured cells are polymorphic and differ from those arising in the CNS
Journal of Neurochemistry, John Wiley & Sons 2023, Vol. 164, (1) : 77-93
Nordström, Ulrika; Lang, Lisa; Ekhtiari Bidhendi, Elaheh; et al.
The motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1
Brain Communications, Oxford University Press 2023, Vol. 5, (1)
Park, Julien H.; Nordström, Ulrika; Tsiakas, Konstantinos; et al.
Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis
Neurobiology of Aging, Elsevier 2023, Vol. 122 : 76-87
Tazelaar, Gijs H.P.; Hop, Paul J.; Seelen, Meinie; et al.
Genetic variability in sporadic amyotrophic lateral sclerosis
Brain, Oxford University Press 2023, Vol. 146, (9) : 3760-3769
Van Daele, Sien Hilde; Moisse, Matthieu; van Vugt, Joke J F A; et al.
Frequency of C9orf72 and SOD1 mutations in 302 sporadic ALS patients from three German ALS centers
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2023, Vol. 24, (5-6) : 414-419
Yilmaz, Rüstem; Grehl, Torsten; Eckrich, Lukas; et al.
Live cell imaging of ATP levels reveals metabolic compartmentalization within motoneurons and early metabolic changes in FUS ALS motoneurons
Cells, MDPI 2023, Vol. 12, (10)
Zimyanin, Vitaly L.; Pielka, Anna-Maria; Glaß, Hannes; et al.
Caregivers’ divergent perspectives on patients’ well-being and attitudes towards hastened death in Germany, Poland and Sweden
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis 2022, Vol. 23, (3-4) : 252-262
Andersen, Peter M.; Kuźma-Kozakiewicz, Magdalena; Keller, Jürgen; et al.
Mild motor impairment as prodromal state in amyotrophic lateral sclerosis: a new diagnostic entity
Brain, Oxford University Press 2022, Vol. 145, (10) : 3500-3508
Benatar, Michael; Granit, Volkan; Andersen, Peter M.; et al.
Design of a randomized, placebo-controlled, phase 3 trial of tofersen initiated in clinically presymptomatic SOD1 variant carriers: the Atlas study
Neurotherapeutics, Springer 2022, Vol. 19 : 1248-1258
Benatar, Michael; Wuu, Joanne; Andersen, Peter M.; et al.
Preventing amyotrophic lateral sclerosis: insights from pre-symptomatic neurodegenerative diseases
Brain, Oxford University Press 2022, Vol. 145, (1) : 27-44
Benatar, Michael; Wuu, Joanne; McHutchison, Caroline; et al.
SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity
Scientific Reports, Nature Publishing Group 2022, Vol. 12, (1)
Berdynski, Mariusz; Miszta, Przemysław; Safranow, Krzysztof; et al.
FUS mutations dominate TBK1 mutations in FUS/TBK1 double-mutant ALS/FTD pedigrees
Neurogenetics, Springer 2022, Vol. 23 : 59-65
Brenner, David; Müller, Kathrin; Lattante, Serena; et al.
Infantile SOD1 deficiency syndrome caused by a homozygous SOD1 variant with absence of enzyme activity
Brain, Oxford University Press 2022, Vol. 145, (3) : 872-878
Ezer, Shlomit; Daana, Muhannad; Park, Julien H.; et al.
Alteration of Mitochondrial Integrity as Upstream Event in the Pathophysiology of SOD1-ALS
Cells, MDPI 2022, Vol. 11, (7)
Günther, René; Pal, Arun; Williams, Chloe; et al.
Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS
Science Translational Medicine, American Association for the Advancement of Science 2022, Vol. 14, (633)
Hop, Paul J.; Zwamborn, Ramona A.J.; Hannon, Eilis; et al.
Clinical trials in pediatric ALS: a TRICALS feasibility study
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Taylor & Francis Group 2022, Vol. 23, (7-8) : 481-488
Kliest, Tessa; Van Eijk, Ruben P.A.; Al-Chalabi, Ammar; et al.
Respiratory onset of amyotrophic lateral sclerosis in a pregnant woman with a novel SOD1 mutation
European Journal of Neurology, John Wiley & Sons 2022, Vol. 29, (4) : 1279-1283
Masrori, Pegah; Ospitalieri, Simona; Forsberg, Karin; et al.
The impact of age on genetic testing decisions in amyotrophic lateral sclerosis
Brain, Oxford University Press 2022, Vol. 145, (12) : 4440-4447
Mehta, Puja R.; Iacoangeli, Alfredo; Opie-Martin, Sarah; et al.
De novo mutations in SOD1 are a cause of ALS
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2022, Vol. 93 : 201-206
Müller, Kathrin; Oh, Ki-Wook; Nordin, Angelica; et al.
Heterozygous DHTKD1 Variants in Two European Cohorts of Amyotrophic Lateral Sclerosis Patients
Genes, MDPI 2022, Vol. 13, (1)
Osmanovic, Alma; Gogol, Isabel; Martens, Helge; et al.
The importance of offering early genetic testing in everyone with amyotrophic lateral sclerosis
Brain, Oxford University Press 2022, Vol. 145, (4) : 1207-1210
Salmon, Kristiana; Kiernan, Matthew C.; Kim, Seung H.; et al.
PEX11β and FIS1 cooperate in peroxisome division independent of mitochondrial fission factor
Journal of Cell Science, The Company of Biologists 2022, Vol. 135, (13)
Schrader, Tina A.; Carmichael, Ruth E.; Islinger, Markus; et al.
Extensive heterogeneity in patients with ALS with mutations in SOD1 in France
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group Ltd 2021, Vol. 92, (9) : 914-914
Andersen, Peter Munch
Neurofilaments can differentiate ALS subgroups and ALS from common diagnostic mimics
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Behzadi, Arvin; Pujol-Calderón, Fani; Tjust, Anton E.; et al.
Safety and efficacy of oral levosimendan in people with amyotrophic lateral sclerosis (the REFALS study): a randomised, double-blind, placebo-controlled phase 3 trial
Lancet Neurology, Elsevier 2021, Vol. 20, (10) : 821-831
Cudkowicz, Merit; Genge, Angela; Maragakis, Nicholas; et al.
Visa publikationer i DiVA

Undervisar läkarstuderande på termin 9 och termin 10 i neurologi (nervsystemets sjukdomar).

Kunskap om hopklibbade proteiner kan lösa ALS-gåtan

Peter Andersen har funnit mekanismer som kan göra det möjligt att behandla eller till och med förebygga ALS.