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Personalbild Andrei Chabes

Andrei Chabes

dNTP: genomets byggstenar

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Verksam vid

Anknytning
Professor vid Institutionen för medicinsk kemi och biofysik Roll: Katalogansvarig, Prefekt
Plats
KBC building, H6, Campus, Umeå, A6-42-21 Umeå universitet, 901 87 Umeå
Anknytning
Anknuten som professor till Molekylär Infektionsmedicin, Sverige (MIMS)
Plats
Medicinsk kemi och biofysik, 90187 Umeå

DNA byggs ihop av fyra olika byggstenar - dATP, dTTP, dGTP, och dCTP- som gemensamt även kallas dNTP. Målet med mitt projekt är att förstå hur förändringar i mängden DNA-byggstenar i cellen påverkar genomstabilitet, åldrande och uppkomsten av sjukdomar, samt utveckla metoder för att bota dessa sjukdomar genom riktade förändringar av DNA-byggstensnivåerna.

Våra senaste publikationer:

Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR and Chabes A (2020) Elimination of rNMPs from mitochondrial DNA has no effect on its stability. PNAS 117:14306-14313  

Sushma S, Koolmeister C, Tran P, Nilsson AK, Larsson NG and Chabes A (2020) Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos. Nature Metabolism 

doi.org/10.1038/s42255-020-0264-z

Alla publikationer i PubMed (senaste först) och i Google Scholar (mest citerade först).

 

 

Nucleic Acids Research, Oxford Academic 2020, Vol. 48, (8) : 4274-4297
Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; et al.
Comptes rendus. Biologies, Académie des Sciences 2020, Vol. 343, (1) : 9-21
Coquel, F.; Silva, M. J.; Techer, H.; et al.
Cell reports, Elsevier 2020, Vol. 31, (6)
Davenne, Tamara; Klintman, Jenny; Sharma, Sushma; et al.
Molecular Cell, Elsevier 2020, Vol. 78, (3) : 496-410.e4
Forey, Romain; Poveda, Ana; Sharma, Sushma; et al.
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
Nature Metabolism, Nature Publishing Group 2020, Vol. 2, (8) : 673-675
Sharma, Sushma; Koolmeister, Camilla; Tran, Phong; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313
Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.
FEBS Open Bio, WILEY 2019, Vol. 9 : 21-21
Chabes, Andrei
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (8) : 3986-3995
Garbacz, Marta A.; Cox, Phillip B.; Sharma, Sushma; et al.
Molecular Cell, Elsevier 2019, Vol. 76, (5) : 784-+
Nicholls, Thomas J.; Spåhr, Henrik; Jiang, Shan; et al.
PLoS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (1) : 237-252
Schmidt, Tobias T.; Sharma, Sushma; Reyes, Gloria X.; et al.
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
Nature Communications, Nature Publishing Group 2019, Vol. 10
Xing, Xuanxuan; Kane, Daniel P.; Bulock, Chelsea R.; et al.
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (21)
Bacal, Julien; Moriel-Carretero, María; Pardo, Benjamin; et al.
Nature, Vol. 557, (7703) : 57-61
Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; et al.
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (11)
Kong, Ziqing; Jia, Shaodong; Chabes, Anna Lena; et al.
Genes & Development, Vol. 32, (11-12) : 822-835
Lanz, Michael Charles; Oberly, Susannah; Sanford, Ethan James; et al.
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (17)
Li, Shuqi; Xu, Zhiyun; Xu, Jiawei; et al.
PLoS Genetics, PUBLIC LIBRARY SCIENCE 2018, Vol. 14, (1)
Peng, Xiao P.; Lim, Shelly; Li, Shibai; et al.
G3: Genes, Genomes, Genetics, Vol. 8, (8) : 2551-2558
van Mourik, Paula M; de Jong, Jannie; Sharma, Sushma; et al.
Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
Molecular Cell, Elsevier 2017, Vol. 68, (2) : 446-455
Gan, Haiyun; Yu, Chuanhe; Devbhandari, Sujan; et al.
Oncogene, Macmillan Publishers Ltd. 2017, Vol. 36, (42) : 5808-5818
Garzón, J.; Rodríguez, R.; Kong, Ziqing; et al.
Nucleic Acids Research, Vol. 45, (3) : 1200-1218
Kochenova, Olga V; Bezalel-Buch, Rachel; Tran, Phong; et al.
PLoS Genetics, Vol. 13, (10)
Maicher, André; Gazy, Inbal; Sharma, Sushma; et al.
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : E4442-E4451
Schmidt, Tobias T; Reyes, Gloria; Gries, Kerstin; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Nucleic Acids Research, Vol. 44, (9) : 4222-4232
Kenigsberg, Ephraim; Yehuda, Yishai; Marjavaara, Lisette; et al.
Cell reports, Vol. 17, (6) : 1657-1670
Liew, Li Phing; Lim, Zun Yi; Cohen, Matan; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (17) : 4723-4728
Rentoft, Matilda; Lindell, Kristoffer; Tran, Phong; et al.
Nucleic Acids Research, Vol. 44, (4) : 1669-1680
Watt, Danielle L.; Buckland, Robert J.; Lujan, Scott A.; et al.
OncoTarget, Vol. 6, (14) : 12587-12602
Barfeld, Stefan J; Fazli, Ladan; Persson, Margareta; et al.
Yeast, Wiley-Blackwell 2015, Vol. 32, (Suppl. 1) : S56-S56
Earp, Caroline; Rowbotham, Samuel; Marjavaara, Lisette; et al.
Biology open, Vol. 4, (12) : 1739-1743
Earp, Caroline; Rowbotham, Samuel; Merényi, Gábor; et al.
DNA Replikation: Methods and Protocols, New York: Springer-Verlag New York 2015 : 113-121
Jia, Shaodong; Marjavaara, Lisette; Buckland, Robert; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2467-E2476
Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; et al.
Nature Structural & Molecular Biology, Vol. 22, (4) : 291-U35
Williams, Jessica S; Clausen, Anders R; Lujan, Scott A; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2457-E2466
Williams, Lindsey N; Marjavaara, Lisette; Knowels, Gary M; et al.
PLOS Genetics, Vol. 10, (12)
Buckland, Robert J; Watt, Danielle L; Chittoor, Balasubramanyam; et al.
Scientific Reports, Macmillan Publishers Ltd. 2014, Vol. 4 : 5539-
Domkin, Vladimir; Chabes, Andrei
PLOS Genetics, Public library science 2014, Vol. 10, (10) : e1004667-
Lin, Chia-Yeh; Wu, Meng-Ying; Gay, Sophie; et al.
Nucleic Acids Research, Oxford University Press 2014, Vol. 42, (10) : 6314-6325
Rubinstein, Linda; Ungar, Lior; Harari, Yaniv; et al.
Molecular Cell, Vol. 54, (4) : 691-697
Yoshida, Kazumasa; Bacal, Julien; Desmarais, Damien; et al.
Molecular Cell, Vol. 56, (4) : 551-563
Yu, Chuanhe; Gan, Haiyun; Han, Junhong; et al.
Genetics, The Genetics Society 2013, Vol. 193, (4) : 1095-1105
Gupta, Amitabha; Sharma, Sushma; Reichenbach, Patrick; et al.
Molecular and Cellular Biology, Vol. 33, (16) : 3202-3213
Hoch, Nicolas C; Chen, Eric S-W; Buckland, Robert; et al.
Nucleic Acids Research, Oxford University Press 2013, Vol. 41, (22) : 10371-10378
Tsaponina, Olga; Chabes, Andrei

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Forskningsledare
Andrei Chabes