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Personalbild Christian Hedberg

Christian Hedberg

Kontakt

E-post
christian.hedberg@umu.se
Telefon
090-786 56 84

Verksam vid

Anknytning
Professor vid Kemiska institutionen
Plats
KB.C4, Linnaeus väg 10, (rum: B4.01.07) Umeå universitet, 901 87 Umeå
Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
Nature Communications, Nature Research 2021, Vol. 12, (1)
Du, Jiqing; Wrisberg, Marie-Kristin von; Gulen, Burak; et al.
Specificity of AMPylation of the human chaperone BiP is mediated by TPR motifs of FICD
Nature Communications, Springer Nature 2021, Vol. 12, (1)
Fauser, Joel; Gulen, Burak; Pogenberg, Vivian; et al.
In Vivo Imaging of the Macrophage Migration Inhibitory Factor in Liver Cancer with an Activity-Based Probe
Analytical Chemistry, American Chemical Society (ACS) 2021, Vol. 93, (4) : 2152-2159
Shao, Chenwen; Hedberg, Christian; Qian, Yong
Intravital Dynamic and Correlative Imaging of Mouse Livers Reveals Diffusion-Dominated Canalicular and Flow-Augmented Ductular Bile Flux
Hepatology, John Wiley & Sons 2021, Vol. 73, (4) : 1531-1550
Vartak, Nachiket; Guenther, Georgia; Joly, Florian; et al.
Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
Science Advances, American Association for the Advancement of Science 2020, Vol. 6, (20)
Ernst, Stefan; Ecker, Felix; Kaspers, Marietta S.; et al.
Identification of targets of AMPylating Fic enzymes by co-substrate-mediated covalent capture
Nature Chemistry, Nature Publishing Group 2020, Vol. 12, (8) : 732-739
Gulen, Burak; Rosselin, Marie; Fauser, Joel; et al.
Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
iScience, Cambridge: Cell Press 2020, Vol. 23, (12)
Hoepfner, Dorothea; Fauser, Joel; Kaspers, Marietta S.; et al.
Structural Basis for GTP versus ATP Selectivity in the NMP Kinase AK3
Biochemistry, American Chemical Society (ACS) 2020, Vol. 59, (38) : 3570-3581
Rogne, Per; Dulko-Smith, Beata; Goodman, Jack; et al.
Principles of ATP and GTP Selectivity in NMP Kinases
Biophysical Journal, Cell Press 2020, Vol. 118, (3) : 193A-193A
Rogne, Per; Sauer-Eriksson, Elisabeth; Sauer, Uwe H.; et al.
Photoactivated Colibactin Probes Induce Cellular DNA Damage
Angewandte Chemie International Edition, Vol. 58, (5) : 1417-1421
Moodie, Lindon W. K.; Hubert, Madlen; Zhou, Xin; et al.
Exploring the Substrate Scope of the Bacterial Phosphocholine Transferase AnkX for Versatile Protein Functionalization
ChemBioChem (Print), Wiley-VCH Verlagsgesellschaft 2019, Vol. 20, (18) : 2336-2340
Ochtrop, Philipp; Ernst, Stefan; Itzen, Aymelt; et al.
Positive and Negative Substrate Interference Supported by Coinciding Enzyme Residues
Biophysical Journal, CELL PRESS 2019, Vol. 116, (3) : 485A-485A
Wolf-Watz, Magnus; Rogne, Per; Sauer-Eriksson, A. Elisabeth; et al.
An amphipathic cyclic tetrapeptide scaffold containing halogenated β2,2-amino acids with activity against multiresistant bacteria
Journal of Peptide Science, John Wiley & Sons 2018, Vol. 24, (10)
Paulsen, Marianne H.; Karlsen, Eskil Andre; Ausbacher, Dominik; et al.
Molecular mechanism of ATP versus GTP selectivity of adenylate kinase
Proceedings of the National Academy of Sciences of the United States of America, Vol. 115, (12) : 3012-3017
Rogne, Per; Rosselin, Marie; Grundström, Christin; et al.
Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives
Journal of Organic Chemistry, American Chemical Society (ACS) 2018, Vol. 83, (8) : 4792-4799
Shukla, Lakshmi; Moodie, Lindon W. K.; Kindahl, Tomas; et al.
Tetrahydroisoquinolines: New Inhibitors of Neutrophil Extracellular Trap (NET) Formation
ChemBioChem (Print), Wiley-VCH Verlagsgesellschaft 2017, Vol. 18, (10) : 888-893
Martinez, Nancy E.; Zimmermann, Tobias J.; Goosmann, Christian; et al.
Palladium-Mediated Approach to Coumarin-Functionalized Amino Acids
Organic Letters, American Chemical Society (ACS) 2017, Vol. 19, (11) : 2797-2800
Moodie, Lindon W. K.; Chammaa, Samy; Kindahl, Tomas; et al.
Unraveling the Phosphocholination Mechanism of the Legionella pneumophila Enzyme AnkX
Biochemistry, American Chemical Society (ACS) 2016, Vol. 55, (31) : 4375-4385
Gavriljuk, Konstantin; Schartner, Jonas; Seidel, Hans; et al.
Activity-Based Proteome Profiling Probes Based on Woodward's Reagent K with Distinct Target Selectivity
Angewandte Chemie International Edition, Vol. 55, (27) : 7766-7771
Qian, Yong; Schuermann, Marc; Janning, Petra; et al.
The α-hydroxyketone LAI-1 regulates motility, Lqs-dependent phosphorylation signaling and gene expression of Legionella pneumophila
Molecular Microbiology, Wiley-Blackwell 2016, Vol. 99, (4) : 778-793
Schell, Ursula; Simon, Sylvia; Sahr, Tobias; et al.
Molecular perspectives on protein adenylylation
ACS Chemical Biology, American Chemical Society (ACS) 2015, Vol. 10, (1) : 12-21
Hedberg, Christian; Itzen, Aymelt
Enzymatic phosphocholination as a tool for protein labeling
The FEBS Journal, Vol. 282 : 12-12
Heller, K; Ochtrop, Philipp; Albers, Michael; et al.
Covalent Protein Labeling by Enzymatic Phosphocholination
Angewandte Chemie International Edition, Vol. 54, (35) : 10327-10330
Heller, Katharina; Ochtrop, Philipp; Albers, Michael F.; et al.
A Concise Total Synthesis of Breitfussin A and B
Organic Letters, Vol. 17, (1) : 122-125
Pandey, Sunil Kumar; Guttormsen, Yngve; Haug, Bengt Erik; et al.
Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway
PLoS Pathogens, Vol. 11, (12)
Simon, Sylvia; Schell, Ursula; Heuer, Natalie; et al.
Exploring the substrate scope of the phosphocholine transferase AnkX for versatile protein functionalisation
Ochtrop, Philipp; Ernst, Stefan; Itzen, Aymelt; et al.
Identification of cellular protein targets for the Legionella pneumophila phosphocholinating effector AnkX
Ochtrop, Philipp; Swart, Leonie; Simon, Sylvia; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Christian Hedberg Lab

Forskningsprojekt

1 januari 2020 till 31 december 2023
Undersökande av bakteriella toxiner substratspecificitet via reaktivt protein – proteom profilering, RP3
1 januari 2020 till 31 december 2022
CryptO – Selektiv kemoterapi mot kryptosporidios i idisslare