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Umeå universitet
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Personalbild Francesca Aguilo

Francesca Aguilo

Min forskning fokuserar på RNA-modifieringar.

Kontakt

E-post
francesca.aguilo@umu.se
Telefon

Verksam vid

Anknytning
Universitetslektor vid Institutionen för molekylärbiologi Enhet: Grupp Francesca Aguilo
Plats
6K och 6L, Sjukhusområdet Umeå universitet, 901 87 Umeå
Anknytning
Anknuten som övrig/annan befattning till Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM)
Plats
Umeå universitet, 901 87 Umeå

Målet med vår nuvarande forskning är att dechiffrera nya epigenetiska och RNA-baserade mekanismer som påverkar globalt genuttryck. Detta innefattar processen genom vilken informationen från en gen används vid syntesen till funktionell genprodukt, och dess implikation i cellöde och cancerinitiering och -progression.

Mer att läsa
Nya fynd runt pluripotens i embryonala stamceller

METTL3 regulates breast cancer-associated alternative splicing switches
Oncogene
Achour, Cyrinne; Bhattarai, Devi Prasad; Groza, Paula; et al.
Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation
Nature Communications, Springer Nature 2023, Vol. 14, (1)
Xu, An; Liu, Mo; Huang, Mo-Fan; et al.
m6A RNA immunoprecipitation followed by high-throughput sequencing to map N6-Methyladenosine
Post-transcriptional gene regulation, Humana Press 2022 : 355-362
Bhattarai, Devi Prasad; Aguilo, Francesca
MODOMICS: a database of RNA modification pathways. 2021 update
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (D1) : D231-D235
Boccaletto, Pietro; Stefaniak, Filip; Ray, Angana; et al.
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export
EMBO Reports, John Wiley & Sons 2022, Vol. 23, (3)
Malla, Sandhya; Bhattarai, Devi Prasad; Groza, Paula; et al.
A mark of disease: How mRNA modifications shape genetic and acquired pathologies
RNA: A publication of the RNA Society, Cold Spring Harbor Laboratory Press (CSHL) 2021, Vol. 27, (4) : 367-389
Destefanis, Eliana; Avşar, Gülben; Groza, Paula; et al.
Regulatory roles of RNA modifications in breast cancer
NAR Cancer, Oxford University Press 2021, Vol. 3, (3)
Kumari, Kanchan; Groza, Paula; Aguilo, Francesca
LSD1: Expanding functions in stem cells and differentiation
Cells, MDPI 2021, Vol. 10, (11)
Martinez-Gamero, Carlos; Malla, Sandhya; Aguilo, Francesca
FTO-mediated cytoplasmic m6Am demethylation adjusts stem-like properties in colorectal cancer cell
Nature Communications, Nature Publishing Group 2021, Vol. 12, (1)
Relier, Sébastien; Ripoll, Julie; Guillorit, Hélène; et al.
Long Noncoding RNAs as Players in Breast Tumorigenesis
The chemical biology of long noncoding RNAs, Springer 2020 : 385-403
Achour, Cyrinne; Aguilo, Francesca
Steering pluripotency and differentiation with N6-methyladenosine RNA modification
Biochimica et Biophysica Acta. Gene Regulatory Mechanisms, Elsevier 2019, Vol. 1862, (3) : 394-402
Malla, Sandhya; Melguizo-Sanchis, Dario; Aguilo, Francesca
Long non-coding RNA and Polycomb: an intricate partnership in cancer biology
Frontiers in Bioscience, Vol. 23 : 2106-2132
Achour, Cyrinne; Aguilo, Francesca
The N6-Methyladenosine RNA modification in pluripotency and reprogramming
Current Opinion in Genetics and Development, Elsevier 2017, Vol. 46 : 77-82
Aguilo, Francesca; Walsh, Martin J.
THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation
Stem Cell Reports, CELL PRESS 2017, Vol. 9, (1) : 92-107
Aguilo, Francesca; Zakirova, Zuchra; Nolan, Katie; et al.
The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer
Nucleic Acids Research, Oxford University Press 2017, Vol. 45, (19) : 11106-11120
Rengasamy, Madhumitha; Zhang, Fan; Vashisht, Ajay; et al.
Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease
Long non-coding RNAs in human disease, Springer 2016 : 29-39
Aguilo, Francesca; Di Cecilia, Serena; Walsh, Martin J
Deposition of 5-Methylcytosine on Enhancer RNAs Enables the Coactivator Function of PGC-1α
Cell reports, Vol. 14, (3) : 479-492
Aguilo, Francesca; Li, SiDe; Balasubramaniyan, Natarajan; et al.
RBM5-AS1 Is Critical for Self-Renewal of Colon Cancer Stem-like Cells
Cancer Research, Vol. 76, (19) : 5615-5627
Di Cecilia, Serena; Zhang, Fan; Sancho, Ana; et al.
ZNF217/ZFP217 Meets Chromatin and RNA
TIBS -Trends in Biochemical Sciences. Regular ed., Vol. 41, (12) : 986-988
Lee, Dung-Fang; Walsh, Martin J.; Aguiló, Francesca
Structure-Guided Discovery of Selective Antagonists for the Chromodomain of Polycomb Repressive Protein CBX7
ACS Medicinal Chemistry Letters, Vol. 7, (6) : 601-605
Ren, Chunyan; Smith, Steven G.; Yap, Kyoko; et al.
Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming.
Cell Stem Cell, Vol. 17, (6) : 689-704
Aguilo, Francesca; Zhang, Fan; Sancho, Ana; et al.
CHD6 regulates the topological arrangement of the CFTR locus
Human Molecular Genetics, Vol. 24, (10) : 2724-2732
Sancho, Ana; Li, SiDe; Paul, Thankam; et al.
Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation.
EMBO Journal, Vol. 32, (7)
Martin, Nadine; Popov, Nikolay; Aguilo, Francesca; et al.
Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling.
Cell Stem Cell, Vol. 11, (2)
Lee, Dung-Fang; Su, Jie; Ang, Yen-Sin; et al.
Prdm16 is a physiologic regulator of hematopoietic stem cells.
Blood, Vol. 117, (19)
Aguilo, Francesca; Avagyan, Serine; Labar, Amy; et al.
Long noncoding RNA, polycomb, and the ghosts haunting INK4b-ARF-INK4a expression.
Cancer Research, Vol. 71, (16)
Aguilo, Francesca; Zhou, Ming-Ming; Walsh, Martin J
Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-β2 and FLT3 in hematopoiesis.
Blood, Vol. 118, (23)
Avagyan, Serine; Aguilo, Francesca; Kamezaki, Kenjiro; et al.
Transcriptional regulation of the human acetoacetyl-CoA synthetase gene by PPARgamma.
Biochemical Journal, Vol. 427, (2)
Aguiló, Francesca; Camarero, Nuria; Relat, Joana; et al.
LSD1 interacts with CHD7 to regulate the chromatin landscape in mouse embryonic stem cells
Malla, Sandhya; Kumari, Kanchan; Martinez Gamero, Carlos; et al.
The catalytic-independent function of LSD1 modulates the epigenetic landscape of mouse embryonic stem cells
Malla, Sandhya; Kumari, Kanchan; Martinez Gamero, Carlos; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Francesca Aguilo
Försöker förstå vad som är fel i en cancercell

Nytt fält inom forskningen vill döda cancerceller - utan att röra kroppens normala celler.