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Genreglering och 3D-kromatinorganisation i glioblastom

Wallenberg Molecular Medicine Fellow: Cancer

Läs om Silvias forskning på hennes engelska sida.


Utvalda publikationer:

- Bahr C*, von Paleske L*, Uslu VV*, Silvia Remeseiro, Takayama N, Ng SW, Murison A, Langenfeld K, Petretich M, Scognamiglio R, Zeisberger P, Benk AS, Amit I, Zandstra PW, Lupien M, Dick JE, Trumpp A, Spitz F. A Myc enhancer cluster regulates normal and leukaemic haemotopoietic stem cell hierarchies. Nature (2018) 553:515-520.

- Silvia Remeseiro*, Andreas Hörnblad*, François Spitz. Gene regulation during development in the light of topologically associating domains. Wiley Interdisciplinary Reviews Developmental Biology (2016). 5(2):169-85.

- Symmons O, Pan L, Silvia Remeseiro, Aktas T, Klein F, Huber W, Spitz F. The Shh Topological Domain Facilitates the Action of Remote Enhancers by Reducing the Effects of Genomic Distances. Developmental Cell (2016) 39(5):529-543.

- Silvia Remeseiro, Cuadrado A, Carretero M, Martínez P, Drosopoulos WC, Cañamero M, Schildkraut CL, Blasco MA, Losada A. Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres. The EMBO Journal (2012) 31:2076-2089.

- Silvia Remeseiro*, Cuadrado A*, Gómez-López G, Pisano DG, Losada A. A unique role of cohesin-SA1 in gene regulation and development. The EMBO Journal (2012) 31:2090-2102.

- Cuadrado A, Silvia Remeseiro, Graña O, Pisano DG, Losada A. The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Research (2015) 43(6):3056-3067.

- Silvia Remeseiro, Cuadrado A, Kawauchi S, Calof AL, Lander AD, Losada A. Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome. Biochimica et Biophysica Acta (2013) 3;1832(12):2097-2102.

- Cuadrado A, Silvia Remeseiro, Gómez-López G, Pisano DG, Losada A. The specific contributions of cohesin-SA1 to cohesion and gene expression: implications for cancer and development. Cell Cycle (2012) 11(12):2233-8.

- Silvia Remeseiro, Cuadrado A, Losada A. Cohesin in development and disease. Development (2013) 140(18):3715-8.

- Silvia Remeseiro and Ana Losada. Cohesin, a chromatin engagement ring. Current Opinion in Cell Biology (2013) 25(1):63-71.

- Carretero M, Silvia Remeseiro, Losada A. Cohesin ties up the genome. Current Opinion in Cell Biology (2010) 22(6):781-7.

- Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodríguez-Acebes S, Silvia Remeseiro, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O. A proteomic characterization of factors enriched at nascent DNA molecules. Cell Reports (2013) 3(4):1105-16.

- Baquero-Montoya C, Gil-Rodríguez M, Teresa-Rodrigo M, Hernández-Marcos M, Bueno-Lozano G, Bueno-Martínez I, Silvia Remeseiro, Fernández-Hernández R, Bassecourt-Serra M, Rodríguez de Alba M, Queralt E, Losada A, Puisac B, Ramos F, Pié J. Could a patient with SMC1A duplication be classified as a human cohesinopathy? Clinical Genetics (2013) May 17. Doi: 10.1111/cge. 12194, 2014:85:446-451.

- Ruiz-Romero C, Carreira V, Rego I, Silvia Remeseiro, López-Armada MJ, Blanco FJ. Proteomic analysis of human osteoarthritic chondrocytes reveals protein changes in stress and glycolysis. Proteomics (2008) 8:495-507.


Tre nya WCMM Fellows vid Medicinska fakulteten
Tre nya WCMM Fellows vid Medicinska fakulteten

Nytillträdda gruppledare ska forska om glioblastom, prostatacancer och antimikrobiell resistens