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Fungi with parasitic lifestyle can cause disease or death

In Umeå we study fungal organisms in a variety of contexts: As robust and simple model organisms to elucidate cellular processes, as producers of chemical compounds used in industry and medicine (for instance antibiotics), as inhabitants and contributors to different ecosystems, and as infectious agents which cause disease in plants, animals and humans.

Fungi are traditionally considered as plant-like organisms but are evolutionarily more closely related to animals. They are omnipresent eukaryotic organisms inhabiting most areas of our planet from deep waters to dry deserts and even the gastrointestinal tract of higher animals as part of the microbiota.

Scientists have identified about 100,000 different fungal species, however, it is estimated that probably more than 1.5 million species exist. Fungi are heterotrophs, meaning that they need to take up and metabolize external nutrients in order to gain energy for growth and reproduction. They are unable to photosynthesize.

Fungal organism can grow as hyphae in which individual cells stay connected to form a mycelium. Yeast fungi grow separately as individual cells to form diffuse biomasses. The majority of fungi are decomposers and grow on decaying organic matter. As decomposers fungi are essential contributors for the cycling of biomaterials. Other fungi form critical symbioses, such as for instance mycorrhizae, which are part of the root systems where they supply essential nutrients to the plant

Nevertheless, some fungi have a parasitic lifestyle and grow on living organisms to either cause disease or death. Several thousand plant-pathogenic species are known with smut and rust fungi among them. Only several hundred species cause disease in humans. Human mycoses affect mainly immunocompromised individuals. However, these infections are frequently severe with a high level of morbidity and mortality. Inefficient diagnostics and therapeutics with toxic side effects urge us to study fungal pathogenesis and to develop better antifungal drugs.

Features

The aim is to develop new antibiotics

Felipe Cava wants to learn more about the small and complex microbes.

Research groups

Clas Ahlm
Type of project Research group
Anders Johansson Lab
Anders Johansson's research group works with infection epidemiology - to track infection and understand how bacteria and viruses are spread.
Type of project Research group
Natuschka Lee lab
Our research is about the role of the microbiome in bees.
Type of project Research group
Johan Normark lab
Our research is about host immunological and metabolomic responses to acute infections and vaccination.
Type of project Research group
Constantin Urban Lab
Our group is interested in the basic processes of infections with pathogenic fungi.
Type of project Research group
Åsa Gylfe Lab
We research about novel antibacterial strategies for treatment of Chlamydia.
Type of project Research group
Yaowen Wu Lab
Chemical and chemo-optogenetic approach on autophagy and membrane trafficking regulated by small GTPases.
Type of project Research group
Niklas Arnberg Lab
The overall purpose of our research is to identify molecules and mechanisms that viruses need to bind to and enter host cells. This is of importanc...
Type of project Research group
Ya-Fang Mei Lab
Our research group studies novel oncolytic adenovirus 11p vectors in the treatment of human solid tumors.
Type of project Research group
Matthew Francis Lab
The Francis laboratory has a strong interest in understanding the physiology and pathogenesis of bacteria.
Type of project Research group
Peter Lind Lab
Modelling to predict the evolution of biofilm mutants and antibiotic resistance in Pseudomonas bacteria
Type of project Research group
Debra Milton Lab
Our group studies virulence and survival of the fish bacteria Vibrio anguillarum.
Type of project Research group
Hans Wolf-Watz Group
The Type III secretion system of pathogenic Yersinia
Type of project Research group
Johan Henriksson Lab
Our group aims at integrating all known and hypothesized regulatory mechanisms about T cells in a single predictive model.
Type of project Research group
Jonas Barandun Lab
We study macromolecular complexes of specialized pathogenic organisms.
Type of project Research group
Ellen Bushell Lab
The group studies parasite-host interactions that govern malaria infection and disease.
Type of project Research group
Felipe Cava Group
Bacterial cell wall composition and its contribution to long-standing and emerging infectious diseases.
Type of project Research group
Jörgen Johansson Lab
Our group study stress regulatory mechanisms and RNA-mediated regulation in the bacterial pathogen Listeria monocytogen.
Type of project Research group
Ulrich von Pawel-Rammingen Group
Streptococcal IgG degrading proteases: Important virulence factors and biotechnological tools
Type of project Research group
Maria Fällman Lab
Molecular mechanisms involved in bacterial persistence in host tissue.
Type of project Research group
Åke Forsberg Lab
Molecular mechanism of Type III secretion systems.
Type of project Research group
Marta Bally – Research group, Physical Virology
Virus-membrane interactions.
Type of project Research group
Josefsson prostate cancer group
Type of project Research group
Björn Schröder lab
Gut microbiota and intestinal mucosal barrier function.
Type of project Research group
David Cisneros Lab
Molecular mechanisms of human bacterial symbionts is our focus.
Type of project Research group
Oliver Billker Lab
The Billker lab studies how different species of Plasmodium, the parasites that cause malaria, spread between a human or animal host and mosquitoes...
Type of project Research group
Mattias Forsell Lab
We characterize how human B cells in circulation and tissues are affected by underlying disease.
Type of project Research group
Birgitta Evengård Lab
Our group studies infectious diseases and climate change in the north.
Type of project Research group
Anne-Marie Fors Connolly Lab
Puumala Orthohantavirus causes Hemorrhagic fever with renal syndrome (HFRS), in Sweden known as “Sorkfeber”. The disease is characterized by low...
Type of project Research group
Ignacio Mir-Sanchis Lab
Our group studies antimicrobial resistance - phage therapy.
Type of project Research group
Fredrik Elgh Lab
The group's research is about the herpes virus and its role in the development of Alzheimer's disease.
Type of project Research group
Anna Överby Wernstedt lab
The Överby lab is focusing on different aspects of tick-borne encephalitis virus from molecular virology and host pathogen interactions to...
Type of project Research group
Magnus Evander Lab
We study viruses that are transmitted from animals or mosquitoes. Also, we develop antiviral drugs.
Type of project Research group
Gisa Gerold Lab
Our group studies how virus entry into cells: host protein networks guiding virus infection and how we can block them
Type of project Research group
Structure, assembly and cellular organization of the cytoskeleton
use electron microscopy methods to study cytoskeleton structure, assembly and spatial organization in cells and bacteria
Type of project Research group
Saskia Erttmann Lab
Insight into inflammatory diseases – understanding the molecular mechanisms during the onset and resolution of inflammation.
Type of project Research group
Ronnie Berntsson Lab
The group studies structural biology of type 4 secretion systems.
Type of project Research group
Biophysics and Biophotonics group
The group develops and applies advanced optical techniques to study biological systems, including how bacteria attach to surfaces.
Type of project Research group
Sven Bergström Lab
The group is studying the infectious and virulence properties of Borrelia spirochete and the intracellular parasite Chlamydia.
Type of project Research group
Richard Lundmark Lab
The research group studies membrane sculpting machineries.
Type of project Research group
Changchun Chen lab
We are investigating acute and chronic oxygen sensation in the nematode C. elegans.
Type of project Research group
Victoria Shingler Lab
We do research about bacterial signal-sensing and Integration.
Type of project Research group
Jürgen Schleucher Lab
We have a biophysical approach to study both proteins and nucleic acids and tree rings in relation to climate change.
Type of project Research group
Research group of Nasim Sabouri
Maintenance of genome integrity by DNA helicases
Type of project Research group
Anders Hofer Lab
We study the biosynthetic pathways of nucleotides in Trypanosoma brucei, Giardia lamblia, Borrelia burgdorferi and other pathogens.
Type of project Research group
Lars-Anders Carlson Lab
Our group studies structure and mechanism of viral replication complexes.
Type of project Research group
Research group of Thomas Borén
My group studies helicobacter pylori, adhesion and patho-adaptation.
Type of project Research group
Teresa Frisan Lab
We study the role of bacterial genotoxins in modulation of intestinal mucosa homeostasis.
Type of project Research group
Sun Nyunt Wai Lab
Exploring modulation of host cell signaling mediated by secreted bacterial factors.
Type of project Research group
Development of antivirals against Rift Valley fever virus
The purpose is to develop and establish in vivo efficacy for small molecule antivirals against Rift Valley fever virus (RVFV), an emerging...
Type of project Research project
Duration 1 January 2017 until 31 December 2017