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Umeå universitet
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Personalbild Beatrice Melin

Beatrice Melin

Forskar om hjärntumörer. Huvudprojektledare för PREDICT fall-kohort. 

Kontakt

E-post
beatrice.melin@umu.se
Telefon
090-786 61 42, 073-091 80 28

Verksam vid

Anknytning
Professor, överläkare vid Institutionen för strålningsvetenskaper Enhet: Onkologi
Plats
27C, Målpunkt QC11, NUS, Norrlands universitetssjukhus Umeå universitet, 901 87 Umeå

Vår forskargrupp försöker förstå varför man får hjärntumör och hur det genetiska landskapet utvecklas från en normal cell till tumör.
Läs mer om Beatrice Melins forskargrupp

Common germline risk variants impact somatic alterations and clinical features across cancers
Cancer Research, American Association for Cancer Research 2023, Vol. 83, (1) : 20-27
Namba, Shinichi; Saito, Yuki; Kogure, Yasunori; et al.
Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines
Scientific Reports, Springer Nature 2023, Vol. 13
Rosenbaum, Adam; Dahlin, Anna M.; Andersson, Ulrika; et al.
Distinct metabolic hallmarks of WHO classified adult glioma subtypes
Neuro-Oncology, Oxford University Press 2022, Vol. 24, (9) : 1454-1468
Björkblom, Benny; Wibom, Carl; Eriksson, Maria; et al.
Robusta biomarkörer för prediktion av risk och sjukdom: en utvärdering av reproducerbarheten hos de stora kommersiella omik-plattformarna
Umeå universitet 2022
Rentoft, Matilda; Melin, Beatrice S.; Wibom, Carl; et al.
Assessment of the EarlyCDT-Lung test as an early biomarker of lung cancer in ever-smokers: A retrospective nested case-control study in two prospective cohorts
International Journal of Cancer
Wu, Wendy Yi-Ying; Haider, Zahra; Feng, Xiaoshuang; et al.
Pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα and sIL-6R are associated with glioma risk: A nested case–control study of repeated samples
Cancer Medicine, John Wiley & Sons 2022, Vol. 11, (4) : 1016-1025
Wu, Wendy Yi-Ying; Späth, Florentin; Wibom, Carl; et al.
High risk of cardiovascular side effects after treatment of Hodgkin's lymphoma: is there a need for intervention in long-term survivors?
Upsala Journal of Medical Sciences, Upsala Medical Society 2021, Vol. 126
Andersson, Anne; Enblad, Gunilla; Erlanson, Martin; et al.
Large-scale cross-cancer fine-mapping of the 5p15.33 region reveals multiple independent signals
Human Genetics and Genomics Advances, Cell Press 2021, Vol. 2, (3)
Chen, Hongjie; Majumdar, Arunabha; Wang, Lu; et al.
Technological readiness and implementation of genomic-driven precision medicine for complex diseases
Journal of Internal Medicine, John Wiley & Sons 2021, Vol. 290, (3) : 602-620
Franks, P.W.; Melén, E.; Friedman, M.; et al.
Partitioned glioma heritability shows subtype-specific enrichment in immune cells
Neuro-Oncology, Oxford University Press 2021, Vol. 23, (8) : 1304-1314
Ostrom, Quinn T.; Edelson, Jacob; Byun, Jinyoung; et al.
A search for modifying genetic factors in CHEK2:c.1100delC breast cancer patients
Scientific Reports, Nature Research 2021, Vol. 11, (1)
Wendt, Camilla; Muranen, Taru A.; Mielikäinen, Lotta; et al.
Public support for healthcare-mediated disclosure of hereditary cancer risk information: Results from a population-based survey in Sweden
Hereditary Cancer in Clinical Practice, Springer Nature 2020, Vol. 18
Andersson, Andreas; Hawranek, Carolina; Öfverholm, Anna; et al.
A genome-wide association study on medulloblastoma
Journal of Neuro-Oncology, Springer 2020, Vol. 147, (2) : 309-315
Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.
Cross-cancer cross-tissue Transcriptome-wide Association Study (TWAS) of 11 cancers identifies 56 novel genes
Genetic Epidemiology, John Wiley & Sons 2020, Vol. 44, (5) : 481-481
Feng, Helian; Majumdar, Arunabha; Pasaniuc, Bogdan; et al.
Identification of Pre-Diagnostic Metabolic Patterns for Glioma Using Subset Analysis of Matched Repeated Time Points
Cancers, MDPI 2020, Vol. 12, (11)
Jonsson, Pär; Antti, Henrik; Späth, Florentin; et al.
Perinatal and familial risk factors for soft tissue sarcomas in childhood through young adulthood: a population-based assessment in 4 million live births
International Journal of Cancer, John Wiley & Sons 2020, Vol. 146, (3) : 791-802
Lupo, Philip J.; Luna-Gierke, Ruth E.; Chambers, Tiffany M.; et al.
Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics
International Journal of Cancer, John Wiley & Sons 2020, Vol. 146, (3) : 739-748
Ostrom, Quinn T.; Egan, Kathleen M.; Nabors, L. Burt; et al.
Lack of association between modifiable exposures and glioma risk: a Mendelian randomization analysis
Neuro-Oncology, OXFORD UNIV PRESS INC 2020, Vol. 22, (2) : 207-215
Saunders, Charlie N.; Cornish, Alex J.; Kinnersley, Ben; et al.
Travel time to care does not affect survival for patients with colorectal cancer in northern Sweden: A data linkage study from the Risk North database
PLOS ONE, Public Library of Science 2020, Vol. 15, (8)
Sjöström, Olle; Dahlin, Anna M.; Silander, Gustav; et al.
A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
PLOS ONE, Public Library Science 2020, Vol. 15, (9)
Svensson, Daniel; Rentoft, Matilda; Dahlin, Anna M.; et al.
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers
Nature Communications, Nature Publishing Group 2020, Vol. 11, (1)
Zhang, Yan Dora; Hurson, Amber N.; Zhang, Haoyu; et al.
Aspirin, NSAIDs, and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-analysis
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research (AACR) 2019, Vol. 28, (3) : 555-562
Amirian, E. Susan; Ostrom, Quinn T.; Armstrong, Georgina N.; et al.
The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
Cancer Causes and Control, Springer 2019, Vol. 30, (2) : 177-185
Andersson, Ulrika; Degerman, Sofie; Dahlin, Anna M.; et al.
Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma
Cancer Research, American Association for Cancer Research 2019, Vol. 79, (8) : 2065-2071
Atkins, Isabelle; Kinnersley, Ben; Ostrom, Quinn T.; et al.
Reproductive Factors, Exogenous Hormone Use, and Risk of B-Cell Non-Hodgkin Lymphoma in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition
American Journal of Epidemiology, OXFORD UNIV PRESS INC 2019, Vol. 188, (2) : 274-281
Costas, Laura; Lujan-Barroso, Leila; Benavente, Yolanda; et al.
Genetic Variants in the 9p21.3 Locus Associated with Glioma Risk in Children, Adolescents, and Young Adults: A Case-Control Study
Cancer Epidemiology, Biomarkers and Prevention, American Association for Cancer Research 2019, Vol. 28, (7) : 1252-1258
Dahlin, Anna M.; Wibom, Carl; Andersson, Ulrika; et al.
Using germline variants to estimate glioma and subtype risks
Neuro-Oncology, Oxford University Press 2019, Vol. 21, (4) : 451-461
Eckel-Passow, Jeanette E.; Decker, Paul A.; Kosel, Matt L.; et al.
The BRCA1 exon 13 duplication: clinical characteristics of 22 families in Northern Sweden
Familial Cancer, Springer 2019, Vol. 18, (1) : 37-42
Edwinsdotter Ardnor, Christina; Rosén, Anna; Ljuslinder, Ingrid; et al.
Survival of glioma patients in relation to mobile phone use in Denmark, Finland and Sweden
Journal of Neuro-Oncology, Springer 2019, Vol. 141, (1) : 139-149
Olsson, Ann; Bouaoun, Liacine; Auvinen, Anssi; et al.
Previously identified common glioma risk SNPs are associated with familial glioma
Cancer Research, Vol. 79, (13)
Ostrom, Quinn T.; Armstrong, Georgina; Amos, Christopher I.; et al.
Sex-specific gene and pathway modeling of inherited glioma risk
Neuro-Oncology, Oxford University Press 2019, Vol. 21, (1) : 71-82
Ostrom, Quinn T.; Coleman, Warren; Huang, William; et al.
Soft-tissue sarcoma in adolescents and young adults compared with older adults: a report among 5000 patients from the Scandinavian Sarcoma Group Central Register
Cancer, American Cancer Society 2019, Vol. 125, (20) : 3595-3602
Papworth, Karin E.; Arroyo, Vidal M.; Styring, Emelie; et al.
A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis
PLOS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study
Journal of Neuro-Oncology, Springer 2019, Vol. 145, (2) : 287-294
Sjöberg, Rickard L; Wu, Wendy Yi-Ying; Dahlin, Anna M.; et al.
Immune marker changes and risk of multiple myeloma: a nested case-control study using repeated prediagnostic blood samples
Haematologica, Ferrata Storti Foundation 2019, Vol. 104, (12) : 2456-2464
Späth, Florentin; Wibom, Carl; Krop, Esmeralda; et al.
Malignant primary brain and other central nervous system tumors diagnosed in Canada from 2009 to 2013
Neuro-Oncology, Oxford University Press 2019, Vol. 21, (3) : 360-369
Walker, Emily V.; Davis, Faith G.; Shaw, Amanda; et al.
The Genetic Architecture of Gliomagenesis-Genetic Risk Variants Linked to Specific Molecular Subtypes
Cancers, MDPI 2019, Vol. 11, (12)
Wu, Wendy Yi-Ying; Johansson, Gunnar; Wibom, Carl; et al.
Soft tissue sarcoma clinical presentation, treatment, and survival in adolescents and young adults compared to older adults: A report from the Scandinavian Sarcoma Group
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (13)
Arroyo, Vidal M.; Lupo, Philip J.; Melin, Beatrice S.; et al.
Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study
Journal of Neurology, Springer 2018, Vol. 265, (6) : 1432-1442
Berntsson, Shala G.; Merrell, Ryan T.; Amirian, E. Susan; et al.
PRE-DIAGNOSTIC PLASMA METABOLITES LINKED TO FUTURE BRAIN TUMOR DEVELOPMENT
Neuro-Oncology, OXFORD UNIV PRESS INC 2018, Vol. 20 : 288-289
Björkblom, Benny; Jonsson, Pär; Späth, Florentin; et al.
Prognostic factors and primary treatment for Waldenstrom macroglobulinemia: a Swedish Lymphoma Registry study
British Journal of Haematology, WILEY 2018, Vol. 183, (4) : 564-577
Brandefors, Lena; Melin, Beatrice S.; Lindh, Jack; et al.
Epigenome-wide association study of adiposity and future risk of obesity-related diseases
International Journal of Obesity, Nature Publishing Group 2018, Vol. 42, (12) : 2022-2035
Campanella, Gianluca; Gunter, Marc J.; Polidoro, Silvia; et al.
Impact of atopy on risk of glioma: a Mendelian randomisation study
BMC Medicine, BioMed Central 2018, Vol. 16
Disney-Hogg, Linden; Cornish, Alex J.; Sud, Amit; et al.
Influence of obesity-related risk factors in the aetiology of glioma
British Journal of Cancer, Nature Publishing Group 2018, Vol. 118, (7) : 1020-1027
Disney-Hogg, Linden; Sud, Amit; Law, Philip J.; et al.
USING GERMLINE VARIANTS TO PREDICT GLIOMA RISK AND IDENTIFY GLIOMA SUBTYPE PRE-OPERATIVELY
Neuro-Oncology, OXFORD UNIV PRESS INC 2018, Vol. 20 : 82-82
Eckel-Passow, Jeanette; Decker, Paul; Kosel, Matthew; et al.
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden
Acta Oncologica, Taylor & Francis 2018, Vol. 57, (2) : 187-194
Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; et al.
Elucidating the molecular pathogenesis of familial glioma
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (13)
Jacobs, Daniel I.; Fukumura, Kazutaka; Bainbridge, Matthew N.; et al.
PREVIOUSLY IDENTIFIED COMMON GLIOMA RISK SNPs ARE ASSOCIATED WITH FAMILIAL GLIOMA
Neuro-Oncology, OXFORD UNIV PRESS INC 2018, Vol. 20 : 108-108
Ostrom, Quinn; Armstrong, Georgina; Amos, Christopher; et al.
Evaluating glioma risk associated with extent of European admixture in African-Americans and Latinos
Cancer Research, American Association for Cancer Research 2018, Vol. 78, (13)
Ostrom, Quinn T.; Egan, Kathleen M.; Nabors, L. Burt; et al.
Age‐specific genome‐wide association study in glioblastoma identifies increased proportion of 'lower grade glioma'‐like features associated with younger age
International Journal of Cancer, WILEY 2018, Vol. 143, (10) : 2359-2366
Ostrom, Quinn T.; Kinnersley, Ben; Armstrong, Georgina; et al.
Visa publikationer i DiVA

Forskargrupper

Forskningsledare
Beatrice Melin
Gruppmedlem
U-CAN (Uppsala-Umeå Comprehensive Cancer Consortium)

Forskningsprojekt

2 september 2019 till 30 november 2023
DIRECT-studien - Genetisk riskinfo för att förebygga cancer
1 september 2010
U-CAN
Slump, arv eller miljö - varför får man hjärntumör?

Varför drabbas man av hjärntumör, hade det gått att förhindra? Beatrice Melins forskning rör en sorts hjärntum...

Predict - for early detection of cancer

Within the framework of the new national strategy for Life Science, RCC Norr, Umeå University (UmU) and Region Västerbotten have started a development project on biomarkers - substances in the blood that can be identified early in patients with cancer.