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Understanding bacterial physiology and pathogenicity

At Umeå University, we are studying different aspects of bacterial physiology and their interactions with their surroundings such as hosts. We use pathogenic bacteria causing infections at different locations in the human body but also non-pathogenic bacteria to understand fundamental aspects of the bacterial life.

With different State-of-the-art techniques such as electron microscopy, we are able to visualize the innermost of the bacteria and even macromolecular structures. Using genetic techniques, for instance CRISPR-Cas9, genes and genetic elements playing a role during bacterial growth and infection can be identified in both the host and the bacteria.

Through a strong cross-disciplinary network involving bacteriologists and chemists, new antibacterial substances are being identified that can impair bacterial pathogenicity.

Features

Studying the interplay between host cell and pathogen

Barbara Sixt wants to know how human cells can fight pathogenic bacteria.

Research groups

Irfan Ahmad Lab
Our aim is to illustrate molecular mechanisms by which bacteria acquire tolerance to commonly used antibiotics.
Type of project Research group
Bacterial membrane vesicles as a biomedical engineering platform
financed by the Swedish Research Council.
Type of project Research project
Duration 1 January 2023 until 31 December 2027
Microbial protein-lipid interactions: Role in host pathogenesis and biotechnological applications
financed by the Swedish Research Council.
Type of project Research project
Duration 1 January 2023 until 31 December 2026
Johan Wikner Lab
Our research is focused on control of Prokaryotes (Bacteria and Archea) and their abundance, growth, and respiration in the Sea.
Type of project Research group
Eric Libby lab
: My research addresses a single fundamental question: how do simple organisms evolve into complex ones?
Type of project Research group
Aftab Nadeem Lab
Bacteria secreted effector molecules: Role in host pathogenesis and biotechnological applications.
Type of project Research group
Laura Carroll Lab
We develop and utilize bioinformatic approaches to monitor and combat the spread of bacterial pathogens.
Type of project Research group
Kemal Avican Lab
We use an experimental systems biology approach to study microbial infections.
Type of project Research group
Oleg Alexeyev Lab
Our group researches biofilms of bacteria.
Type of project Research group
Ulrika Westerlind lab
We study molecular tools to map bacteria interactions with the host mucin O-glycome.
Type of project Research group
Andre Mateus lab
The André Mateus lab is interested in understanding how proteins function and interact in the species of the human gut microbiome.
Type of project Research group
Clas Ahlm
We study disease mechanisms in two severe viral infections, hantavirus hemorrhagic fever and COVID-19, to understand disease mechanisms and be able...
Type of project Research group
Jan Oscarsson Lab
Our group is studying the mechanisms of the bacterium A. actinomycetemcomitans in connection with periodontal diseases.
Type of project Research group
Johan Trygg - Chemometrics Lab
Advanced data analytics in life science is becoming a core element in modern data driven life science research. Our research focus on data from...
Type of project Research group
Gerhard Gröbner Lab
Our group uses NMR methods to understand the function of biological membranes and their proteins and their role in various diseases.
Type of project Research group
Anders Johansson Lab
Anders Johansson's research group works with infection epidemiology - to track infection and understand how bacteria and viruses are spread.
Type of project Research group
Marie-Louise Hammarström Lab
Our group studies colorectal cancer and biomarkers for prognosis.
Type of project Research group
Natuschka Lee lab
Our lab conducts research into relevant microbes for our environment and health.
Type of project Research group
Mikael Elofsson lab
The group develops antiviral and antibacterial compounds.
Type of project Research group
Uwe Sauer Lab
We use structural biology and bioinformatics methods to understand important biological processes such as protein folding and stability, structural...
Type of project Research group
Johan Normark lab
Our research is about host immunological and metabolomic responses to acute infections and vaccination.
Type of project Research group
Joacim Rocklöv Lab
The group researches what drives the growth and spread of infectious diseases globally.
Type of project Research group
Nicklas Strömberg Lab
Type of project Research group
Karina Persson Lab
Our group studies structure and function of proteins involved in bacterial virulence.
Type of project Research group
Madeleine Ramstedt Lab
Our group studies interactions between bacteria and materials.
Type of project Research group
Elisabeth Sauer-Eriksson Lab
Our research aims to design and identify substances that can inhibit bacterial virulence and dismantle their mechanism of action.
Type of project Research group
Christian Hedberg Lab
We develop of chemical tools to dissect infection mechanisms at molecular level.
Type of project Research group
Åsa Gylfe Lab
We research about novel antibacterial strategies for treatment of Chlamydia.
Type of project Research group
Yaowen Wu Lab
Elucidation of autophagy and membrane trafficking regulated by small GTPases using chemical and chemo-optogenetic approaches
Type of project Research group
Niklas Arnberg Lab
The overall purpose of our research is to identify molecules and mechanisms that viruses need to bind to and enter host cells. This is of importanc...
Type of project Forskargrupp
Matthew Francis Lab
The Francis laboratory has a strong interest in understanding the physiology and pathogenesis of bacteria.
Type of project Research group
Peter Lind Lab
Modelling to predict the evolution of biofilm mutants and antibiotic resistance in Pseudomonas bacteria
Type of project Research group
Debra Milton Lab
Our group studies virulence and survival of the fish bacteria Vibrio anguillarum.
Type of project Research group
Hans Wolf-Watz lab
Research about type III secretion system of pathogenic Yersinia.
Type of project Research group
Johan Henriksson Lab
Our group aims at integrating all known and hypothesized regulatory mechanisms about T cells in a single predictive model.
Type of project Research group
Jonas Barandun Lab
We study macromolecular complexes of specialized pathogenic organisms.
Type of project Research group
Ellen Bushell Lab
The group studies parasite-host interactions that govern malaria infection and disease.
Type of project Research group
Barbara Sixt Group
Cell-autonomous immunity and bacterial evasion strategies
Type of project Research group
Felipe Cava Group
Bacterial cell wall composition and its contribution to long-standing and emerging infectious diseases.
Type of project Research group
Jörgen Johansson Lab
Our group study stress regulatory mechanisms and RNA-mediated regulation in the bacterial pathogen Listeria monocytogen.
Type of project Research group
Ulrich von Pawel-Rammingen labGroup
Streptococcal IgG degrading proteases: Important virulence factors and biotechnological tools.
Type of project Research group
Maria Fällman Lab
Our research aims at understanding molecular mechanisms behind the ability of bacteria to adapt to different environments. The diverse and complex...
Type of project Research group
Bernt Eric Uhlin Lab
Bacterial fitness mechanisms of the versatile pathogenic variants of Escherichia coli and the emerging opportunistic pathogen Acinetobacter...
Type of project Profilområde
Åke Forsberg Lab
Our group studies molecular mechanism of Type III secretion systems.
Type of project Research group
Björn Schröder lab
Diet, gut microbiota and intestinal mucosal barrier function.
Type of project Research group
Andrea Puhar lab
Endogenous danger signals in infection and inflammation.
Type of project Research group
David Cisneros Lab
Molecular mechanisms of human bacterial symbionts is our focus.
Type of project Research group
Oliver Billker Lab
The Billker lab studies how different species of Plasmodium, the parasites that cause malaria, spread between a human or animal host and mosquitoes...
Type of project Research group
Immunity after infection or vaccination
Mattias Forsell
Type of project Research group
Birgitta Evengård Lab
Our group studies infectious diseases and climate change in the north.
Type of project Research group
Ignacio Mir-Sanchis Lab
Our group studies antimicrobial resistance - phage therapy.
Type of project Research group
Fredrik Elgh Lab
The group's research is about the herpes virus and its role in the development of Alzheimer's disease.
Type of project Research group
Anders Sjöstedt
The type VI secretion system of Francisella tularensis –  elucidation of its structure and assembly/disassembly control.
Type of project Research group
Linda Sandblad lab
Use electron microscopy methods to study cytoskeleton structure, assembly and spatial organization in cells and bacteria.
Type of project Research group
Saskia Erttmann Lab
Unraveling the molecular mechanisms during the microbial-driven onset and resolution of inflammation
Type of project Research group
Ronnie Berntsson Lab
The group studies structural biology of type 4 secretion systems.
Type of project Research group
Magnus Andersson - Biophysics and Biophotonics group
The group develops and applies advanced optical techniques to study biological systems, including how bacteria attach to surfaces.
Type of project Research group
Sven Bergström Lab
The group is studying the infectious and virulence properties of Borrelia spirochete and the intracellular parasite Chlamydia.
Type of project Research group
Changchun Chen lab
We are investigating acute and chronic oxygen sensation in the nematode C. elegans.
Type of project Research group
Victoria Shingler Lab
Our research concerns bacterial signal-sensing and Integration.
Type of project Research group
Jürgen Schleucher Lab
We have a biophysical approach to study both proteins and nucleic acids and tree rings in relation to climate change.
Type of project Research group
Anders Hofer Lab
We study the biosynthetic pathways of nucleotides in pathogens and mammalian cells with the purposes of understanding how cells from different...
Type of project Research group
Lars-Anders Carlson Lab
Our group studies structure and mechanism of viral replication complexes.
Type of project Research group
Thomas Borén lab
My group studies helicobacter pylori, adhesion and patho-adaptation.
Type of project Research group
Teresa Frisan Lab
We study the role of bacterial genotoxins in modulation of intestinal mucosa homeostasis.
Type of project Research group
Sun Nyunt Wai Lab
Exploring modulation of host cell signaling mediated by secreted bacterial factors.
Type of project Research group
Anna Arnqvist Lab
Our group studies mechanisms for stochastic and tightly controlled regulation of Helicobacter pylori adhesins.
Type of project Research group
Development of antivirals against Rift Valley fever virus
The purpose is to develop and establish in vivo efficacy for small molecule antivirals against Rift Valley fever virus (RVFV), an emerging...
Type of project Research project
Duration 1 January 2017 until 31 December 2017
Surface analysis of microorganisms using cryo-XPS
The surface chemical composition of microorganisms can be analyzed using several different methods. We have been developing methodology for cryogen...
Type of project Research project
Duration 1 January 2010