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Understanding bacterial physiology and pathogenicity

At Umeå University, we are studying different aspects of bacterial physiology and their interactions with their surroundings such as hosts. We use pathogenic bacteria causing infections at different locations in the human body but also non-pathogenic bacteria to understand fundamental aspects of the bacterial life.

With different State-of-the-art techniques, such as electron microscopy, we are able to visualize the innermost of the bacteria and even macromolecular structures. Using genetic techniques, for instance CRISPR-Cas9, genes and genetic elements playing a role during bacterial growth and infection can be identified in both the host and the bacteria.

Through a strong cross-disciplinary network involving bacteriologists and chemists, new antibacterial substances are being identified that can impair bacterial pathogenicity.

Features

The aim is to develop new antibiotics

Felipe Cava wants to learn more about the small and complex microbes.

Research groups

Clas Ahlm
Type of project Research group
Jan Oscarsson Lab
Our group is studying the mechanisms of the bacterium A. actinomycetemcomitans in connection with periodontal diseases.
Type of project Research group
Ulrika Westerlind Lab
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Type of project Research group
Johan Trygg - Chemometrics Lab
Our research focus on advanced data analytics in life science and use modern data science and engineering tools to develop computational models to...
Type of project Research group
Gerhard Gröbner Lab
Our group uses NMR methods to understand the function of biological membranes and their proteins and their role in various diseases.
Type of project Research group
Anders Johansson Lab
Anders Johansson's research group works with infection epidemiology - to track infection and understand how bacteria and viruses are spread.
Type of project Research group
Marie-Louise Hammarström Lab
Our group studies colorektal cancer and biomarkers for prognosis.
Type of project Research group
Natuschka Lee lab
Our research is about the role of the microbiome in bees.
Type of project Research group
Mikael Elofsson lab
Using a chemistry based multidisciplinary approach we explore various aspects of bacterial virulence.
Type of project Research group
Johan Normark lab
Our research is about host immunological and metabolomic responses to acute infections and vaccination.
Type of project Research group
Joacim Rocklöv Lab
The group researches what drives the growth and spread of infectious diseases globally.
Type of project Research group
Nicklas Strömberg Lab
We study why some people suffer from chronic infectious diseases and how dental care can be individualized.
Type of project Research group
Karina Persson Lab
Our group studies structure and function of proteins involved in bacterial virulence.
Type of project Research group
Madeleine Ramstedt Lab
Our group studies interactions between bacteria and materials.
Type of project Research group
Elisabeth Sauer-Eriksson Lab
Our research aims to design and identify substances that can inhibit bacterial virulence and dismantle their mechanism of action.
Type of project Research group
Christian Hedberg Lab
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Type of project Research group
Åsa Gylfe Lab
We research about novel antibacterial strategies for treatment of Chlamydia.
Type of project Research group
Yaowen Wu Lab
Chemical and chemo-optogenetic approach on autophagy and membrane trafficking regulated by small GTPases.
Type of project Research group
Niklas Arnberg Lab
The overall purpose of our research is to identify molecules and mechanisms that viruses need to bind to and enter host cells. This is of importanc...
Type of project Research group
Matthew Francis Lab
The Francis laboratory has a strong interest in understanding the physiology and pathogenesis of bacteria.
Type of project Research group
Peter Lind Lab
Modelling to predict the evolution of biofilm mutants and antibiotic resistance in Pseudomonas bacteria
Type of project Research group
Debra Milton Lab
Our group studies virulence and survival of the fish bacteria Vibrio anguillarum.
Type of project Research group
Hans Wolf-Watz Group
The Type III secretion system of pathogenic Yersinia
Type of project Research group
Johan Henriksson Lab
Our group aims at integrating all known and hypothesized regulatory mechanisms about T cells in a single predictive model.
Type of project Research group
Jonas Barandun Lab
We study macromolecular complexes of specialized pathogenic organisms.
Type of project Research group
Ellen Bushell Lab
The group studies parasite-host interactions that govern malaria infection and disease.
Type of project Research group
Barbara Sixt Group
Cell-autonomous immunity and bacterial evasion strategies
Type of project Research group
Felipe Cava Group
Bacterial cell wall composition and its contribution to long-standing and emerging infectious diseases.
Type of project Research group
Jörgen Johansson Lab
Our group study stress regulatory mechanisms and RNA-mediated regulation in the bacterial pathogen Listeria monocytogen.
Type of project Research group
Ulrich von Pawel-Rammingen Group
Streptococcal IgG degrading proteases: Important virulence factors and biotechnological tools
Type of project Research group
Maria Fällman Lab
Molecular mechanisms involved in bacterial persistence in host tissue.
Type of project Research group
Bernt Eric Uhlin Lab
Regulatory networks in commensal and pathogenic Escherichia coli.
Type of project Research group
Åke Forsberg Lab
Molecular mechanism of Type III secretion systems.
Type of project Research group
Björn Schröder lab
Gut microbiota and intestinal mucosal barrier function.
Type of project Research group
Andrea Puhar lab
Endogenous danger signals in infection and inflammation.
Type of project Research group
David Cisneros Lab
Molecular mechanisms of human bacterial symbionts is our focus.
Type of project Research group
Oliver Billker Lab
The Billker lab studies how different species of Plasmodium, the parasites that cause malaria, spread between a human or animal host and mosquitoes...
Type of project Research group
Mattias Forsell Lab
We characterize how human B cells in circulation and tissues are affected by underlying disease.
Type of project Research group
Birgitta Evengård Lab
Our group studies infectious diseases and climate change in the north.
Type of project Research group
Ignacio Mir-Sanchis Lab
Our group studies antimicrobial resistance - phage therapy.
Type of project Research group
Fredrik Elgh Lab
The group's research is about the herpes virus and its role in the development of Alzheimer's disease.
Type of project Research group
Anders Sjöstedt
The type VI secretion system of Francisella tularensis –  elucidation of its structure and assembly/disassembly control.
Type of project Research group
Structure, assembly and cellular organization of the cytoskeleton
use electron microscopy methods to study cytoskeleton structure, assembly and spatial organization in cells and bacteria
Type of project Research group
Saskia Erttmann Lab
Insight into inflammatory diseases – understanding the molecular mechanisms during the onset and resolution of inflammation.
Type of project Research group
Ronnie Berntsson Lab
The group studies structural biology of type 4 secretion systems.
Type of project Research group
Biophysics and Biophotonics group
The group develops and applies advanced optical techniques to study biological systems, including how bacteria attach to surfaces.
Type of project Research group
Sven Bergström Lab
The group is studying the infectious and virulence properties of Borrelia spirochete and the intracellular parasite Chlamydia.
Type of project Research group
Changchun Chen lab
We are investigating acute and chronic oxygen sensation in the nematode C. elegans.
Type of project Research group
Victoria Shingler Lab
We do research about bacterial signal-sensing and Integration.
Type of project Research group
Jürgen Schleucher Lab
We have a biophysical approach to study both proteins and nucleic acids and tree rings in relation to climate change.
Type of project Research group
Anders Hofer Lab
We study the biosynthetic pathways of nucleotides in Trypanosoma brucei, Giardia lamblia, Borrelia burgdorferi and other pathogens.
Type of project Research group
Lars-Anders Carlson Lab
Our group studies structure and mechanism of viral replication complexes.
Type of project Research group
Research group of Thomas Borén
My group studies helicobacter pylori, adhesion and patho-adaptation.
Type of project Research group
Teresa Frisan Lab
We study the role of bacterial genotoxins in modulation of intestinal mucosa homeostasis.
Type of project Research group
Sun Nyunt Wai Lab
Exploring modulation of host cell signaling mediated by secreted bacterial factors.
Type of project Research group
Anna Arnqvist Lab
Our group studies mechanisms for stochastic and tightly controlled regulation of Helicobacter pylori adhesins.
Type of project Research group
Development of antivirals against Rift Valley fever virus
The purpose is to develop and establish in vivo efficacy for small molecule antivirals against Rift Valley fever virus (RVFV), an emerging...
Type of project Research project
Duration 1 January 2017 until 31 December 2017