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Umeå universitet
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Patrik Danielson

Professor i anatomi

Överläkare i ögonsjukdomar

Dekan för Medicinska fakulteten

Kontakt

E-post
patrik.danielson@umu.se
Plats
Besöksadress, se karta
Telefon
090-786 58 93, 070-336 80 30

Verksam vid

Anknytning
Professor, överläkare vid Institutionen för medicinsk och translationell biologi Enhet: Lärare A-flygeln, Grupp Patrik Danielson
Anknytning
Anknuten som professor till Kansliet för medicin

Dekans sekreterare:  Anna Olson

____________________________


Professor i anatomi vid Umeå universitet och överläkare i ögonsjukdomar vid Norrlands universitetssjukhus,
samt Dekan för Medicinska fakulteten.

Publikationslista:
Google Scholar-profil för Patrik Danielson

Forskningsprojekt:
Mekanismer för ärrbildning och vävnadsnedbrytning i kollagenrik vävnad


____________________________



CV  |  Curriculum Vitae  |  PATRIK DANIELSON


Personligt

Född 1980, uppvuxen i Kramfors, Ångermanland.


Akademiska meriter och anställningar

  • 2016 | Professor/Överläkare, anatomi/specialist i ögonsjukdomar
  • 2014 | Professor i anatomi
  • 2012 | Docent i anatomi
  • 2009 | Universitetslektor i anatomi
  • 2007 | Medicine doktor (Med.dr), anatomi
  • 2007 | Leg. läkare
  • 2005 | Läkarexamen


Förtroendeuppdrag (urval)

  • Dekan, Medicinska fakulteten, Umeå universitet, 2017-
  • Ledamot, Regeringskansliets rådgivande grupp för life science, 2024-
  • Styrelseledamot, Svenska Sällskapet för Medicinsk Forskning (SSMF), 2019-
  • Ordförande, Nationella styrgruppen för ALF-avtalet, 2021
  • Ledamot (regeringsutsedd), Nationella styrgruppen för ALF-avtalet, 2015-18; 2019-2022 (adjungerad från 2023)
  • Ledamot (regeringsutsedd), Kommittén för kliniska studier, Vetenskapsrådet, 2018-2020
  • Ledamot, Svenska Läkaresällskapets nämnd, 2015-18
  • Prodekan, Medicinska fakulteten, Umeå universitet, 2014-17
  • Ledamot (lärarrepresentant), medicinska fakultetsnämnden, Umeå universitet, 2011-14
  • Ledamot (studeranderepresentant), universitetsstyrelsen, Umeå universitet, 2002-04
  • Ledamot (studeranderepresentant), medicinska fakultetsnämnden, Umeå universitet, 2001-04


Nationella forskningsanslag (som huvudsökande; urval)

  • 2018-21 | Vetenskapsrådet: 4 800 tkr
  • 2014-17 | Vetenskapsrådet: 5 044 tkr
  • 2010-12 | Vetenskapsrådet: 2 100 tkr
  • 2017-23 | Ögonfonden: 1 160 tkr
  • 2011-15 | Svenska Läkaresällskapet: 1 200 tkr
  • 2011-17 | Cronqvists stiftelse: 900 tkr


Vetenskapliga publikationer

Länk till Google Scholar-profil


Priser och utmärkelser

  • European Society of Ophthalmology (SOE) Speaker of the Year på Svenska Ögonläkarföreningens Årsmöte 2017
  • Svenska Läkaresällskapets pris för bästa translationella forskning 2013
  • Umeå universitets karriärbidrag 2011
  • Kungl. Skytteanska Samfundets pris till yngre forskare vid Medicinska fakulteten 2010
  • Hedersmedlem på livstid i Umeå Medicinska Studentkår 2007

 

 

 

 

Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk
International Journal of Molecular Sciences, MDPI 2022, Vol. 23, (19)
Zhou, Xin; Li, Junhong; Backman, Ludvig J.; et al.
Microstructured collagen films for 3D corneal stroma modelling
Connective Tissue Research, Taylor & Francis Group 2022, Vol. 63, (5) : 443-452
Prittinen, Juha; Zhou, Xin; Bano, Fouzia; et al.
Activation of NF-κB signaling via cytosolic mitochondrial RNA sensing in kerotocytes with mitochondrial DNA common deletion
Scientific Reports, Nature Publishing Group 2021, Vol. 11, (1)
Zhou, Xin; Backman, Ludvig J.; Danielson, Patrik
Acetylcholine decreases formation of myofibroblasts and excessive extracellular matrix production in an in vitro human corneal fibrosis model
Journal of Cellular and Molecular Medicine (Print), John Wiley & Sons 2020, Vol. 24, (8) : 4850-4862
Sloniecka, Marta; Danielson, Patrik
Regulation of Keratocyte Phenotype and Cell Behavior by Substrate Stiffness
ACS Biomaterials Science & Engineering, American Chemical Society (ACS) 2020, Vol. 6, (9) : 5162-5171
Chen, Jialin; Backman, Ludvig J.; Zhang, Wei; et al.
Sustained Release of TPCA-1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin-1β Signaling
Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2020, Vol. 9, (17)
Zhang, Wei; Chen, Jialin; Qu, Mingli; et al.
Induction of Fibroblast Senescence During Mouse Corneal Wound Healing
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2019, Vol. 60, (10) : 3669-3679
Wang, Xiaolei; Qu, Mingli; Li, Jing; et al.
Substance P induces fibrotic changes through activation of the RhoA/ROCK pathway in an in vitro human corneal fibrosis model
Journal of Molecular Medicine, Springer Berlin/Heidelberg 2019, Vol. 97, (10) : 1477-1489
Sloniecka, Marta; Danielson, Patrik
Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes
British Journal of Ophthalmology, BMJ Publishing Group Ltd 2018, Vol. 102, (4) : 562-569
Chen, Jialin; Zhang, Wei; Backman, Ludvig J.; et al.
Ascorbic Acid Promotes the Stemness of Corneal Epithelial Stem/Progenitor Cells and Accelerates Epithelial Wound Healing in the Cornea
Stem Cells Translational Medicine, WILEY 2017, Vol. 6, (5) : 1356-1365
Chen, Jialin; Lan, Jie; Liu, Dongle; et al.
Corneal Epithelium-Derived Neurotrophic Factors Promote Nerve Regeneration
Investigative Ophthalmology and Visual Science, ASSOC RESEARCH VISION OPHTHALMOLOGY INC 2017, Vol. 58, (11) : 4695-4702
Di, Guohu; Qi, Xia; Zhao, Xiaowen; et al.
Glutamate signaling through the NMDA receptor reduces the expression of scleraxis in plantaris tendon derived cells
BMC Musculoskeletal Disorders, Vol. 18
Spang, Christoph; Backman, Ludvig J.; Le Roux, Sandrine; et al.
Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model
Stem Cell Research & Therapy, BIOMED CENTRAL LTD 2017, Vol. 8
Chen, Jialin; Zhang, Wei; Kelk, Peyman; et al.
Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model
Advanced Healthcare Materials, Wiley-VCH Verlagsgesellschaft 2017, Vol. 6, (5)
Zhang, Wei; Chen, Jialin; Backman, Ludvig J.; et al.
Antiapoptotic Effect of Acetylcholine in Fas-Induced Apoptosis in Human Keratocytes
Investigative Ophthalmology and Visual Science, Vol. 57, (14) : 5892-5902
Sloniecka, Marta; Backman, Ludvig J.; Danielson, Patrik
Ciliary Neurotrophic Factor Promotes the Migration of Corneal Epithelial Stem/progenitor Cells by Up-regulation of MMPs through the Phosphorylation of Akt
Scientific Reports, Vol. 6
Chen, Jialin; Chen, Peng; Backman, Ludvig J.; et al.
Substance P Enhances Keratocyte Migration and Neutrophil Recruitment through Interleukin-8
Molecular Pharmacology, Vol. 89, (2) : 215-225
Sloniecka, Marta; Le Roux, Sandrine; Zhou, Qingjun; et al.
Acetylcholine enhances keratocyte proliferation through muscarinic receptor activation.
International Immunopharmacology, Vol. 29, (1) : 57-62
Słoniecka, Marta; Backman, Ludvig J; Danielson, Patrik
Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ
PLOS ONE, Public library science 2015, Vol. 10, (7)
Sloniecka, Marta; Le Roux, Sandrine; Boman, Peter; et al.
Mutations in Collagen, Type XVII, Alpha 1 (COL17A1) Cause Epithelial Recurrent Erosion Dystrophy (ERED)
Human Mutation, John Wiley & Sons 2015, Vol. 36, (4) : 463-473
Jonsson, Frida; Byström, Berit; Davidson, Alice E.; et al.
Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor.
Diabetes, Vol. 63, (12) : 4262-4274
Yang, Lingling; Di, Guohu; Qi, Xia; et al.
Substance P reduces TNF-α-induced apoptosis in human tenocytes through NK-1 receptor stimulation
British Journal of Sports Medicine, BMJ Publishing Group Ltd 2014, Vol. 48, (19) : 1414-1420
Backman, Ludvig J.; Eriksson, Daniella E.; Danielson, Patrik
Akt-mediated anti-apoptotic effects of substance P in Anti-Fas-induced apoptosis of human tenocytes
Journal of Cellular and Molecular Medicine (Print), Wiley-Blackwell 2013, Vol. 17, (6) : 723-733
Backman, Ludvig J; Danielson, Patrik
Alpha-2 adrenergic stimulation triggers Achilles tenocyte hypercellularity: comparison between two model systems
Scandinavian Journal of Medicine and Science in Sports, John Wiley & Sons 2013, Vol. 23, (6) : 687-696
Backman, Ludvig J; Andersson, Gustav; Fong, Gloria; et al.
Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway
Cell and Tissue Research, Springer-Verlag New York 2013, Vol. 351, (3) : 465-475
Fong, Gloria; Backman, Ludvig; Andersson, Gustav; et al.
Sports and exercise-related tendinopathies: a review of selected topical issues by participants of the second International Scientific Tendinopathy Symposium (ISTS) Vancouver 2012
British Journal of Sports Medicine, London, England: BMJ Publishing Group 2013, Vol. 47, (9) : 536-+
Scott, Alex; Docking, Sean; Vicenzino, Bill; et al.
Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes
Journal of Orthopaedic Research, HOBOKEN, NJ, USA: Wiley-Blackwell 2013, Vol. 31, (1) : 91-98
Fong, Gloria; Backman, Ludvig J.; Hart, David A.; et al.
Teaming up to beat tendon pain: clinical and research excellence own the podium at ISTS (International Scientific Tendinopathy Symposium).
British Journal of Sports Medicine, London, England: British Medical Journal Publishing Group 2013, Vol. 47, (9) : 532-532
Danielson, Patrik; Scott, Alex
In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon
Histology and Histopathology, Vol. 27, (9) : 1239-1246
Bagge, Johan; Danielson, Patrik; Forsgren, Sture
Endogenous substance P production in the Achilles tendon increases with loading in an in vivo model of tendinopathy: peptidergic elevation preceding tendinosis-like tissue changes
Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 133-140
Backman, Ludvig; Andersson, Gustav; Wennstig, Gabriel; et al.
Low range of ankle dorsiflexion predisposes for patellar tendinopathy in junior elite basketball players: a 1-year prospective study
American Journal of Sports Medicine, Vol. 39, (12) : 2626-2633
Backman, Ludvig J; Danielson, Patrik
Mechanical force modulates scleraxis expression in bioartificial tendons
Journal of Musculoskeletal and Neuronal Interactions - JMNI, International Society of Musculoskeletal and Neuronal Interactions 2011, Vol. 11, (2) : 124-132
Scott, A; Danielson, Patrik; Abraham, T; et al.
Physical activity level in Achilles tendinosis is associated with blood levels of pain-related factors: a pilot study
Scandinavian Journal of Medicine and Science in Sports, Vol. 21, (6) : E430-E438
Bagge, Johan; Gaida, JE; Danielson, Patrik; et al.
Substance P accelerates hypercellularity and angiogenesis in tendon tissue and enhances paratendinitis in response to Achilles tendon overuse in a tendinopathy model
British Journal of Sports Medicine, Loughborough: British Assoc. of Sport and Medicine 2011, Vol. 45, (13) : 1017-1022
Andersson, Gustav; Backman, Ludvig; Scott, Alexander; et al.
Substance P is a mechanoresponsive, autocrine regulator of human tenocyte proliferation
PLOS ONE, San Francisco, USA: Public Library of Science 2011, Vol. 6, (11) : e27209-
Backman, Ludvig; Fong, Gloria; Andersson, Gustav; et al.
Immunohistochemical evidence of local production of catecholamines in cells of the muscle origins at the lateral and medial humeral epicondyles: of importance for the development of tennis and golfer's elbow?
British Journal of Sports Medicine, Vol. 43, (4) : 269-275
Zeisig, Eva; Ljung, B-O; Alfredson, Håkan; et al.
Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases
Orthopedic Reviews, Vol. 1, (1) : 39-46
Forsgren, Sture; Alfredson, Håkan; Bjur, Dennis; et al.
Reviving the "biochemical" hypothesis for tendinopathy: new findings suggest the involvement of locally produced signal substances
British Journal of Sports Medicine, BMJ Publishing Group 2009, Vol. 43, (4) : 265-268
Danielson, Patrik
Immunohistochemical and in situ hybridization observations favor a local catecholamine production in the human Achilles tendon
Histology and Histopathology, Vol. 23, (2) : 197-208
Bjur, Dennis; Danielson, Patrik; Alfredson, Håkan; et al.
Marked sympathetic component in the perivascular innervation of the dorsal paratendinous tissue of the patellar tendon in arthroscopically treated tendinosis patients.
Knee Surgery, Sports Traumatology, Arthroscopy, Vol. 16, (6) : 621-6
Danielson, Patrik; Andersson, Gustav; Alfredson, Håkan; et al.
Presence of a non-neuronal cholinergic system and occurrence of up- and down-regulation in expression of M2 muscarinic acetylcholine receptors: new aspects of importance regarding Achilles tendon tendinosis (tendinopathy)
Cell and Tissue Research, Vol. 331, (2) : 385-400
Bjur, Dennis; Danielson, Patrik; Alfredson, Håkan; et al.
Presence of substance P and the neurokinin-1 receptor in tenocytes of the human Achilles tendon
Regulatory Peptides, Vol. 150, (1-3) : 81-87
Andersson, Gustav; Danielson, Patrik; Alfredson, Håkan; et al.
Den kroniskt smärtande senan - histopatologi.
Idrottsskador - frontlinjen inom behandling och rehablitering, Laholm: Centrum för idrottsforskning 2007 : 267-274
Forsgren, Sture; Bjur, Dennis; Danielson, Patrik; et al.
Extensive expression of markers for acetylcholine synthesis and of M2 receptors in tenocytes in therapy-resistant chronic painful patellar tendon tendinosis - a pilot study.
Life Sciences, Vol. 80, (24-25) : 2235-2238
Danielson, Patrik; Andersson, Gustav; Alfredson, Håkan; et al.
In situ hybridization studies confirming recent findings of the existence of a local nonneuronal catecholamine production in human patellar tendinosis.
Microscopy research and technique (Print), Vol. 70, (10) : 908-911
Danielson, Patrik; Alfredson, Håkan; Forsgren, Sture
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Framförallt deskriptiv och topografisk anatomi inom cirkulations- och respirationsorganens system för läkarstuderande termin 1, 2 och 3.